Journal Club Pack - Circulation Research
... although we have previously shown that phenotypic switching of cultured SMC is dependent on Krupplelike factor (KLF)4. Objective: The goals of the present studies were to ascertain if (1) injury-induced repression of SM22α gene after vascular injury is mediated through KLF4 binding to the G/C Repres ...
... although we have previously shown that phenotypic switching of cultured SMC is dependent on Krupplelike factor (KLF)4. Objective: The goals of the present studies were to ascertain if (1) injury-induced repression of SM22α gene after vascular injury is mediated through KLF4 binding to the G/C Repres ...
Replication origin plasticity, Taylor-made: inhibition vs
... investigators went on to inhibit the checkpoint-signaling pathway with caffeine, which is known to inhibit at least two critical mediators of the S-phase checkpoint cascade. This caused a dramatic increase in the density of newly fired replication origins, whether or not aphidicolin was present. App ...
... investigators went on to inhibit the checkpoint-signaling pathway with caffeine, which is known to inhibit at least two critical mediators of the S-phase checkpoint cascade. This caused a dramatic increase in the density of newly fired replication origins, whether or not aphidicolin was present. App ...
The molecular evolution of development
... with morphological differences between taxa.(3,4) This developmental genetic approach is complemented by efforts among evolutionary geneticists who study the molecular evolution of developmental systems, focusing principally on issues of evolutionary history and dynamics.(9,10) The molecular evoluti ...
... with morphological differences between taxa.(3,4) This developmental genetic approach is complemented by efforts among evolutionary geneticists who study the molecular evolution of developmental systems, focusing principally on issues of evolutionary history and dynamics.(9,10) The molecular evoluti ...
PDF
... A major activator of gt and kni expression is Caudal (Cad), which forms a posterior-anterior protein gradient, being translationally repressed by Bicoid in the anterior part of the embryo (Rivera-Pomar and Jackle, 1996). Whereas the maternal cad RNA was present in normal amounts in wol embryos (Fig. ...
... A major activator of gt and kni expression is Caudal (Cad), which forms a posterior-anterior protein gradient, being translationally repressed by Bicoid in the anterior part of the embryo (Rivera-Pomar and Jackle, 1996). Whereas the maternal cad RNA was present in normal amounts in wol embryos (Fig. ...
Midterm 1 from 2011
... You create a series of synthetic enhancers (see below) and place each one in front of a lacZ reporter gene and introduce each into flies via P-element transposition. You then observe the pattern of lacZ expression in embryos of the transgenic lines that you establish. Synthetic enhancer A (SynR5A) – ...
... You create a series of synthetic enhancers (see below) and place each one in front of a lacZ reporter gene and introduce each into flies via P-element transposition. You then observe the pattern of lacZ expression in embryos of the transgenic lines that you establish. Synthetic enhancer A (SynR5A) – ...
BioACTS Quarter THREE
... nitrogen bases from ONE parent strand as letters: compare and contrast it to ONE other lab teams base sequence. ...
... nitrogen bases from ONE parent strand as letters: compare and contrast it to ONE other lab teams base sequence. ...
One vitellogenin gene in an ocean of many: The molecular ecology
... forms of aquaglyceroporin were aqp3, -7, -9 and -10, with aqp3 on a sister branch to aqp9, and aqp7 clustering with aqp10 (Figure S6). In each subclass, the sarcopterygian aquaglyceroporins were robustly separated from the actinopterygian counterparts, with single orthologs retrieved from the genome ...
... forms of aquaglyceroporin were aqp3, -7, -9 and -10, with aqp3 on a sister branch to aqp9, and aqp7 clustering with aqp10 (Figure S6). In each subclass, the sarcopterygian aquaglyceroporins were robustly separated from the actinopterygian counterparts, with single orthologs retrieved from the genome ...
Cancer Prone Disease Section Familial platelet disorder with predisposition to
... the runt homology domain (RHD), because of its homology to Drosophila Runt protein, which mediates both DNA binding and heterodimerization with CBFbeta, and a carboxyl(C)-terminal region responsible for transcriptional regulation. Heterodimerization with CBFbeta enhances its DNAbinding capacity and ...
... the runt homology domain (RHD), because of its homology to Drosophila Runt protein, which mediates both DNA binding and heterodimerization with CBFbeta, and a carboxyl(C)-terminal region responsible for transcriptional regulation. Heterodimerization with CBFbeta enhances its DNAbinding capacity and ...
Antigenic diversity of Theileria major piroplasm surface protein gene
... The results of the sequence and phylogenetic analyses suggest that the isolate from Jeju black cattle is closely related to T. sergenti (type B2) and T. buffeli (type B1), although this is based on a comparison of only part of the MPSP gene [7]. The MPSP gene should be sequenced completely to allow ...
... The results of the sequence and phylogenetic analyses suggest that the isolate from Jeju black cattle is closely related to T. sergenti (type B2) and T. buffeli (type B1), although this is based on a comparison of only part of the MPSP gene [7]. The MPSP gene should be sequenced completely to allow ...
Abstract - Biotechniques.org
... while 96% of cases occur before the age of 10 (2). In NB, unlike most postmitotic neurons, abnormal expression or activation of proteins that stimulate cell cycle progression or DNA replication does not result in apoptosis. NBs often express high levels of the proto-oncogene N-myc, which is a key ac ...
... while 96% of cases occur before the age of 10 (2). In NB, unlike most postmitotic neurons, abnormal expression or activation of proteins that stimulate cell cycle progression or DNA replication does not result in apoptosis. NBs often express high levels of the proto-oncogene N-myc, which is a key ac ...
Chapter 13: Heredity
... Mendelian genetics is the Punnett (PUN ut) square. In a Punnett square, letters represent dominant and recessive alleles. An uppercase letter stands for a dominant allele. A lowercase letter stands for a recessive allele. The letters are a form of code. They show the genotype (JEE nuh tipe), or gene ...
... Mendelian genetics is the Punnett (PUN ut) square. In a Punnett square, letters represent dominant and recessive alleles. An uppercase letter stands for a dominant allele. A lowercase letter stands for a recessive allele. The letters are a form of code. They show the genotype (JEE nuh tipe), or gene ...
Genetic and Physical Mapping of a Type 1 Diabetes Susceptibility
... ype 1 diabetes is an autoimmune disease characterized by the T-cell–mediated destruction of the insulin-secreting -cells of the pancreatic islets (1,2). It is a complex disease involving numerous susceptibility genes and environmental factors, which may act as triggers of the autoimmune response. Mu ...
... ype 1 diabetes is an autoimmune disease characterized by the T-cell–mediated destruction of the insulin-secreting -cells of the pancreatic islets (1,2). It is a complex disease involving numerous susceptibility genes and environmental factors, which may act as triggers of the autoimmune response. Mu ...
Retrovirus Integration Database (RID): a public database for
... select the “Submit Query” button to display the query result. Users can limit their query by choosing an option in the “Query option” section. For example, a nucleotide position range on a specific chromosome can be chosen to search for integration sites within a specific region of the host genome o ...
... select the “Submit Query” button to display the query result. Users can limit their query by choosing an option in the “Query option” section. For example, a nucleotide position range on a specific chromosome can be chosen to search for integration sites within a specific region of the host genome o ...
University of Groningen Regulation of hepatobiliary transport
... that the induction of Mdr2 gene expression and of Mdr2 Pgp function is part of the PPARαcontrolled fasting response in the liver of the mouse. The PPARα-dependent increase in expression of the putative hepatobiliary cholesterol transport genes Abcg5 and Abcg8 upon fasting was not associated with inc ...
... that the induction of Mdr2 gene expression and of Mdr2 Pgp function is part of the PPARαcontrolled fasting response in the liver of the mouse. The PPARα-dependent increase in expression of the putative hepatobiliary cholesterol transport genes Abcg5 and Abcg8 upon fasting was not associated with inc ...
Plant–nematode interactions
... plant-parasitic nematodes Broad investigations of the genomes and gene products of plant-parasitic nematodes are also underway. More than 200 000 nematode ESTs from 28 nematode species, excluding C. elegans but including 19 animal- and seven plant-parasitic nematode species, have been produced [42]. ...
... plant-parasitic nematodes Broad investigations of the genomes and gene products of plant-parasitic nematodes are also underway. More than 200 000 nematode ESTs from 28 nematode species, excluding C. elegans but including 19 animal- and seven plant-parasitic nematode species, have been produced [42]. ...
Genomic data mining
... Functions available allow extraction of identifiers from different sources including Ensembl IDs, several microarray platforms, UniProt, RefSeq [21], and EntrezGene [22]. Genome sequences can be retrieved by specific chromosomal coordinates for a given species, allowing a user to mine regions they d ...
... Functions available allow extraction of identifiers from different sources including Ensembl IDs, several microarray platforms, UniProt, RefSeq [21], and EntrezGene [22]. Genome sequences can be retrieved by specific chromosomal coordinates for a given species, allowing a user to mine regions they d ...
Genetic association between the PRKCH gene encoding protein
... higher levels in resting T cells (CD4ⴙ or CD8ⴙ) than in B cells (CD19ⴙ) or monocytes (CD14ⴙ) and was significantly down-regulated through immune responses. Conclusion. Our results provide evidence of the involvement of PRKCH as a susceptibility gene for RA in the Japanese population. Dysregulation o ...
... higher levels in resting T cells (CD4ⴙ or CD8ⴙ) than in B cells (CD19ⴙ) or monocytes (CD14ⴙ) and was significantly down-regulated through immune responses. Conclusion. Our results provide evidence of the involvement of PRKCH as a susceptibility gene for RA in the Japanese population. Dysregulation o ...
SNPs - Biology, Genetics and Bioinformatics Unit
... SNPs may occur at any position in the above gene structure and based on its location it can be classified as: intronic, exonic or promoter region etc. ...
... SNPs may occur at any position in the above gene structure and based on its location it can be classified as: intronic, exonic or promoter region etc. ...
Scientist finds the gene that determines major sensitivity to bitter taste
... world. Those millions of Europeans, Asians, and individuals from other populations around the world who are non-tasters descended from a common ancestor who emerged from Africa far back in prehistory. Human DNA sequences are overwhelmingly similar, with some small, but sometimes important difference ...
... world. Those millions of Europeans, Asians, and individuals from other populations around the world who are non-tasters descended from a common ancestor who emerged from Africa far back in prehistory. Human DNA sequences are overwhelmingly similar, with some small, but sometimes important difference ...
A Novel Multigene Family May Encode Odorant Receptors: A
... cDNAs defines a new multigene family that shares sequence and structural properties with the seven transmembrane domain superfamily of neurotransmitter and hormone receptors. This novel family, however, exhibits features different from any other member of the receptor superfamily thus far identified ...
... cDNAs defines a new multigene family that shares sequence and structural properties with the seven transmembrane domain superfamily of neurotransmitter and hormone receptors. This novel family, however, exhibits features different from any other member of the receptor superfamily thus far identified ...
Supplementary Methods 1. Generation and post
... ‘basal’ level or levels that maximizes the total likelihood of all segments given that breakpoint. We then choose the optimal breakpoint by finding the breakpoint whose best model has the minimal BIC. In theory, one could continue to iterate between deconstruction and background estimation until the ...
... ‘basal’ level or levels that maximizes the total likelihood of all segments given that breakpoint. We then choose the optimal breakpoint by finding the breakpoint whose best model has the minimal BIC. In theory, one could continue to iterate between deconstruction and background estimation until the ...
Genetic Portrait of a Yeast
... Mutations can be isolated in diploids, then analyzed in haploids Conditional mutants can be isolated Recombination frequencies are high, facilitating molecular manipulations Genome size is small and number of genes low, so analysis and manipulations of the whole genome are possible Copyright © The M ...
... Mutations can be isolated in diploids, then analyzed in haploids Conditional mutants can be isolated Recombination frequencies are high, facilitating molecular manipulations Genome size is small and number of genes low, so analysis and manipulations of the whole genome are possible Copyright © The M ...
File
... Mutations that involve changes in one or a few nucleotides are known as point mutations because they occur at a single point in the DNA sequence. They generally occur during replication. If a gene in one cell is altered, the alteration can be passed on to every cell that develops from the original o ...
... Mutations that involve changes in one or a few nucleotides are known as point mutations because they occur at a single point in the DNA sequence. They generally occur during replication. If a gene in one cell is altered, the alteration can be passed on to every cell that develops from the original o ...
Mismatch Repair Error Implies Chargaff`s Second Parity Rule
... down to the bottom branches. In such cases, Hypothesis (d) assumes that they do not always distinguish the replicative strand from the template strand 100% of the time, and make strand recognition errors independent of the replicating bases in question. Thus, for 0 < c < 1 fraction of time, however ...
... down to the bottom branches. In such cases, Hypothesis (d) assumes that they do not always distinguish the replicative strand from the template strand 100% of the time, and make strand recognition errors independent of the replicating bases in question. Thus, for 0 < c < 1 fraction of time, however ...