Single-copy nuclear genes resolve the phylogeny of the
... often placed as sister to Mecopterida and the latter traditionally included either within, or as sister to, Coleoptera [9,10]. The consensus view is that most morphological features of Hymenoptera and Strepsiptera are too highly modified to unequivocally resolve their phylogenetic positions [11,12]. ...
... often placed as sister to Mecopterida and the latter traditionally included either within, or as sister to, Coleoptera [9,10]. The consensus view is that most morphological features of Hymenoptera and Strepsiptera are too highly modified to unequivocally resolve their phylogenetic positions [11,12]. ...
NeuroGeM, a knowledgebase of genetic modifiers
... SCA3 but not in AD and vice versa. Similarly, the correlation analysis also reveals that modifiers and non-modifiers are more similar between SCA3 and SCA7 than between these two ataxias and SCA1, which has not been reported before. As the number of genes that could be used to calculate the MCC vari ...
... SCA3 but not in AD and vice versa. Similarly, the correlation analysis also reveals that modifiers and non-modifiers are more similar between SCA3 and SCA7 than between these two ataxias and SCA1, which has not been reported before. As the number of genes that could be used to calculate the MCC vari ...
Article The Landscape of Realized Homologous
... (Perez-Losada et al. 2006; Vos 2009), ranging from clonal species (Smith et al. 2006) to those that exchange 10% or more of their DNA within a single 4-year human infection (Cao et al. 2014). This variation presents specific challenges for effective comparison between species. We recently developed ...
... (Perez-Losada et al. 2006; Vos 2009), ranging from clonal species (Smith et al. 2006) to those that exchange 10% or more of their DNA within a single 4-year human infection (Cao et al. 2014). This variation presents specific challenges for effective comparison between species. We recently developed ...
... Infection with H. pylori has been associated with both types of gastric cancer. H. pylori is an essential cause of gastric cancer, albeit not the only factor required to cause cancer. These bacteria were first observed in the human stomach in the 19th century but were only isolated and cultured in t ...
A catalogue of imprinted genes and parent-of
... reported (2–4). Since this time, numerous genes have been shown to be subject to genomic imprinting, a process through which the expression of a gene is dependent on the sex of the parent from which it was inherited. Additionally, we now recognize several phenotypes in humans, mice and other animals ...
... reported (2–4). Since this time, numerous genes have been shown to be subject to genomic imprinting, a process through which the expression of a gene is dependent on the sex of the parent from which it was inherited. Additionally, we now recognize several phenotypes in humans, mice and other animals ...
Week 41 (2015-10-05)
... than one hundred of the tens of thousands of purported biomarkers have been independently validated. We propose the need for a new paradigm in biobanking; simply pursuing larger numbers of participants, larger networks of biobanks and higher sample integrity will not, in itself, transform the succes ...
... than one hundred of the tens of thousands of purported biomarkers have been independently validated. We propose the need for a new paradigm in biobanking; simply pursuing larger numbers of participants, larger networks of biobanks and higher sample integrity will not, in itself, transform the succes ...
Molecular insights into RNA and DNA helicase evolution from the
... RNA is made in a similar way to DNA, but it is usually present as a single strand that folds into a three-dimensional structure that is held in shape by regions of the molecule interacting with each other. Before DNA and RNA can perform their essential tasks in cells, enzymes called helicases must s ...
... RNA is made in a similar way to DNA, but it is usually present as a single strand that folds into a three-dimensional structure that is held in shape by regions of the molecule interacting with each other. Before DNA and RNA can perform their essential tasks in cells, enzymes called helicases must s ...
Loss of the GP46/M-2 surface membrane
... shown) indicated comparable amounts of D N A in all samples. L. ma/or and L. donovani chromosomes of 930 and 850 kb exhibited strong hybridization comparable to that seen in L. amazonensis LTB0016. A 950-kb chromosome in L, tarentolae showed moderate hybridization comparable to that seen with some l ...
... shown) indicated comparable amounts of D N A in all samples. L. ma/or and L. donovani chromosomes of 930 and 850 kb exhibited strong hybridization comparable to that seen in L. amazonensis LTB0016. A 950-kb chromosome in L, tarentolae showed moderate hybridization comparable to that seen with some l ...
Introduction to Molecular Diagnostics
... Many of our bodily processes, both normal and abnormal, as well as health or disease states, are driven by the interaction of our genes and the proteins they produce that carry out specific functions within the body. Therefore, the ability to quickly and accurately assess an individual’s health at t ...
... Many of our bodily processes, both normal and abnormal, as well as health or disease states, are driven by the interaction of our genes and the proteins they produce that carry out specific functions within the body. Therefore, the ability to quickly and accurately assess an individual’s health at t ...
Human cytochromes P450 in health and disease
... Table 2. Functions and/or diseases associated with mutations in a CYP gene. ‘Metabolism of eicosanoids’ includes arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid (no P450 enzyme has been examined for all possible eicosanoid substrates). As discussed in the text, variants in genes of ...
... Table 2. Functions and/or diseases associated with mutations in a CYP gene. ‘Metabolism of eicosanoids’ includes arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid (no P450 enzyme has been examined for all possible eicosanoid substrates). As discussed in the text, variants in genes of ...
Genetic risk factors for chronic obstructive pulmonary disease
... of exposure to cigarette smoke. However, this is extremely unlikely because of age- and gender-related differences in the prevalence of smoking. In addition, most patients with COPD do not come to medical attention until their fifth or sixth decade, by which time it is usually impossible to obtain p ...
... of exposure to cigarette smoke. However, this is extremely unlikely because of age- and gender-related differences in the prevalence of smoking. In addition, most patients with COPD do not come to medical attention until their fifth or sixth decade, by which time it is usually impossible to obtain p ...
Cloning and Functional Characterization of a Phospholipid
... 97: 6487–6492). The LRO1 gene that encodes the PDAT was identified in yeast (Saccharomyces cerevisiae) and shown to have homology with animal lecithin:cholesterol acyltransferase. A search of the Arabidopsis genome database identified the protein encoded by the At5g13640 gene as the closest homolog ...
... 97: 6487–6492). The LRO1 gene that encodes the PDAT was identified in yeast (Saccharomyces cerevisiae) and shown to have homology with animal lecithin:cholesterol acyltransferase. A search of the Arabidopsis genome database identified the protein encoded by the At5g13640 gene as the closest homolog ...
Extrapolation to the whole human genome
... given by Lander, et al., 2001; the higher from the size given by Venter, et al., 2001.) Also, as for processed pseudogenes, we estimate a predicted range of ~9,60010,400 non-processed pseudogenes in the human genome, extrapolating from the chromosome 22 data. Using the gene-poor chromosome 21, a muc ...
... given by Lander, et al., 2001; the higher from the size given by Venter, et al., 2001.) Also, as for processed pseudogenes, we estimate a predicted range of ~9,60010,400 non-processed pseudogenes in the human genome, extrapolating from the chromosome 22 data. Using the gene-poor chromosome 21, a muc ...
20 Years after finding the Duchenne Gene
... Monaco, while trying to explain this finding, came up with the reading frame-hypothesis in 1988, which, with some exceptions, is now the proven basis for the exon-skipping technology. In fact, this now very promising method to restore the reading frame was discussed and proposed as a possible therap ...
... Monaco, while trying to explain this finding, came up with the reading frame-hypothesis in 1988, which, with some exceptions, is now the proven basis for the exon-skipping technology. In fact, this now very promising method to restore the reading frame was discussed and proposed as a possible therap ...
The CNS midline cells and spitz class genes are required for proper
... sim embryos, ming/lacZ expression is severely reduced especially in all the midline cells and 90% of medial NBs 2-1, 3-1, 4-1, and 5-1, intermediate NBs 1-2 and 2-2, and lateral NB 2-4 as shown in Figure 4B (n=150). On the other hand, ming/lacZ expression in NBs 5-2, 6-1, and 7-1 still remains. At s ...
... sim embryos, ming/lacZ expression is severely reduced especially in all the midline cells and 90% of medial NBs 2-1, 3-1, 4-1, and 5-1, intermediate NBs 1-2 and 2-2, and lateral NB 2-4 as shown in Figure 4B (n=150). On the other hand, ming/lacZ expression in NBs 5-2, 6-1, and 7-1 still remains. At s ...
CNVs vs. SNPs: Understanding Human Structural Variation in Disease
... Exhaustive analysis of human single nucleotide polymorphisms or SNPs has led to the identification of interesting genetic markers for certain disorders. But these small changes are not the whole picture. Copy number variations or CNVs, which are the gain or lo ...
... Exhaustive analysis of human single nucleotide polymorphisms or SNPs has led to the identification of interesting genetic markers for certain disorders. But these small changes are not the whole picture. Copy number variations or CNVs, which are the gain or lo ...
Genetics Practice Problems**** Class Copy
... 1. In mice, coat color is determined by a gene, B, which has black and brown alleles. Black is completely dominant over brown. However, there is a second gene, C, which also affects color. Mice must have at least one dominant allele of this gene in order to show any color (black or brown); if they d ...
... 1. In mice, coat color is determined by a gene, B, which has black and brown alleles. Black is completely dominant over brown. However, there is a second gene, C, which also affects color. Mice must have at least one dominant allele of this gene in order to show any color (black or brown); if they d ...
Bio 6 – Principles of Genetic Inheritance Lab Overview
... parents. However the process of passing on genes from one generation to the next is more complex than it may appear. The simplest form of genetic inheritance involves asexual reproduction. This is the case when a single parent organism passes its genes to offspring which are basically clones of the ...
... parents. However the process of passing on genes from one generation to the next is more complex than it may appear. The simplest form of genetic inheritance involves asexual reproduction. This is the case when a single parent organism passes its genes to offspring which are basically clones of the ...
Familial spontaneous pneumothorax and mutation CASE STUDY
... Mutations in FLCN cause the BHD syndrome and mutations have been identified along the entire length of the gene (exons 4, 5, 6, 7, 9, 11, 12, 13 and 14) [4]. The isolated pneumothorax phenotype has previously been reported in association with mutations on exon 4 [5] and exons 9 and 12 [6]. It is pos ...
... Mutations in FLCN cause the BHD syndrome and mutations have been identified along the entire length of the gene (exons 4, 5, 6, 7, 9, 11, 12, 13 and 14) [4]. The isolated pneumothorax phenotype has previously been reported in association with mutations on exon 4 [5] and exons 9 and 12 [6]. It is pos ...
Quantitative RT-PCR Platform to Measure Transcript Levels of C and
... Gene expression analysis is key to understanding how environmental factors impact upon biological ...
... Gene expression analysis is key to understanding how environmental factors impact upon biological ...
MayerFrankiPoster
... there are many more modifications to be made. One of these involves the gene cpcB that codes for a protein, called phycocyanin, that captures light energy in the photosynthetic process. Phycocyanin efficiently captures solar energy, but also prevents cyanobacterial cultures from growing to high dens ...
... there are many more modifications to be made. One of these involves the gene cpcB that codes for a protein, called phycocyanin, that captures light energy in the photosynthetic process. Phycocyanin efficiently captures solar energy, but also prevents cyanobacterial cultures from growing to high dens ...
IS Elements
... genomic position and inserted into another by an enzyme, the transposase, which is usually encoded by the transposon itself. • A replicative transposon is copied during the process of transposition. • A retrotransposon produces RNA molecules that are reverse-transcribed (by an enzyme-reverse transcr ...
... genomic position and inserted into another by an enzyme, the transposase, which is usually encoded by the transposon itself. • A replicative transposon is copied during the process of transposition. • A retrotransposon produces RNA molecules that are reverse-transcribed (by an enzyme-reverse transcr ...
The role of mutagenesis in defining genes in behaviour
... phenotypes in mutants produced spontaneously, through gene targeting (reverse genetics) or through screening chemically-mutagenised animals (forward genetics). In the latter category, several programmes have been initiated in concerted efforts to study phenodeviants using largescale mutagenesis scre ...
... phenotypes in mutants produced spontaneously, through gene targeting (reverse genetics) or through screening chemically-mutagenised animals (forward genetics). In the latter category, several programmes have been initiated in concerted efforts to study phenodeviants using largescale mutagenesis scre ...
Gene interactions and stroke risk in children with
... proportions, the 3 stroke subgroups examined may not meet these expectations if disease associations are present. Thus, any genotypic ratio distortion resulting from a strong disease association between a particular gene locus and stroke subgroup will be necessarily balanced by the other 2 stroke su ...
... proportions, the 3 stroke subgroups examined may not meet these expectations if disease associations are present. Thus, any genotypic ratio distortion resulting from a strong disease association between a particular gene locus and stroke subgroup will be necessarily balanced by the other 2 stroke su ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.