American College of Medical Genetics standards
... should consider the extent of clinical characterization of individuals represented in the database. Each population series is selected based on defined criteria, usually outlined in the primary reference. Consider how these individuals were selected for inclusion and how likely it is that the clinic ...
... should consider the extent of clinical characterization of individuals represented in the database. Each population series is selected based on defined criteria, usually outlined in the primary reference. Consider how these individuals were selected for inclusion and how likely it is that the clinic ...
Myosin Heavy Chain Expression in the Red
... Spatial and temporal variations in MHC expression do occur in fish, however. Fish genomes, like those of other vertebrates, encode multiple myosin genes (Schiaffino and Reggiani, ’96); for example, as many as 28 MHC genes are present in carp (Gerlach et al., ’90). Expression of individual myosin iso ...
... Spatial and temporal variations in MHC expression do occur in fish, however. Fish genomes, like those of other vertebrates, encode multiple myosin genes (Schiaffino and Reggiani, ’96); for example, as many as 28 MHC genes are present in carp (Gerlach et al., ’90). Expression of individual myosin iso ...
SARS Outbreaks in Ontario, Hong Kong and Singapore: the role of
... can we increase agricultural production? • Control human diseases. How can we control diseases by developing personalized medicine? ...
... can we increase agricultural production? • Control human diseases. How can we control diseases by developing personalized medicine? ...
DNA
... • DNA was later discovered to be the molecule that makes up the inherited genetic material • Experiments performed by Fredrick Griffith in 1928 and experiments with bacteriophages in 1952 led to this ...
... • DNA was later discovered to be the molecule that makes up the inherited genetic material • Experiments performed by Fredrick Griffith in 1928 and experiments with bacteriophages in 1952 led to this ...
Keratins and skin disorders
... Another message to emerge from increasing documentation of keratin mutations is that there is an extensive degree of phenotypic variation within the pathology of keratin diseases [4,6]. Firstly, there are profound differences in the phenotypes that result from mutation in different keratin genes, in ...
... Another message to emerge from increasing documentation of keratin mutations is that there is an extensive degree of phenotypic variation within the pathology of keratin diseases [4,6]. Firstly, there are profound differences in the phenotypes that result from mutation in different keratin genes, in ...
Triplet repeat primed PCR assay for the screening and diagnosis of
... Screening for expanded allels in FA and SCA types 1, 2, 3, 6, 7, 8, & 17 by TP PCR gave either a single peak with a flat baseline denoting a homozygous genotype (Figure 1), two peaks showing the sample to be heterozygous (Figure 2) or an expanded allele that the sample carries an expanded allele (Fi ...
... Screening for expanded allels in FA and SCA types 1, 2, 3, 6, 7, 8, & 17 by TP PCR gave either a single peak with a flat baseline denoting a homozygous genotype (Figure 1), two peaks showing the sample to be heterozygous (Figure 2) or an expanded allele that the sample carries an expanded allele (Fi ...
PDF
... and polarized light sensors (Hardie, 1985). According to their differentiated function, R1-6 innervate the first OL neuropil, which is the lamina, whereas R7 and R8 axons run across the lamina to innervate the neuropil beneath, which is the medulla. Next, the lobula and lobula plate (together called ...
... and polarized light sensors (Hardie, 1985). According to their differentiated function, R1-6 innervate the first OL neuropil, which is the lamina, whereas R7 and R8 axons run across the lamina to innervate the neuropil beneath, which is the medulla. Next, the lobula and lobula plate (together called ...
Protein relative abundance patterns associated with sucrose
... Background: The etiology of dental caries is multifactorial, but frequent consumption of free sugars, notably sucrose, appears to be a major factor driving the supragingival microbiota in the direction of dysbiosis. Recent 16S rRNA-based studies indicated that caries-associated communities were less ...
... Background: The etiology of dental caries is multifactorial, but frequent consumption of free sugars, notably sucrose, appears to be a major factor driving the supragingival microbiota in the direction of dysbiosis. Recent 16S rRNA-based studies indicated that caries-associated communities were less ...
From DNA to diversity: molecular genetics and the evolution of
... morphological spectrum afrom small-scale differences within or between species, to the large-scale differences that distinguish higher taxa. We have provided selected references for further reading at the end of each chapter. By no means should these citations (or this book) be taken as the primary ...
... morphological spectrum afrom small-scale differences within or between species, to the large-scale differences that distinguish higher taxa. We have provided selected references for further reading at the end of each chapter. By no means should these citations (or this book) be taken as the primary ...
Algorithms for Finding Gene Clusters
... clusters if the multiple chromosomes are simply concatenated, in the latter case gene clusters might be missed if the circular pieces are cut at some arbitrary point. We handle this problem by adapting the original algorithm to multichromosomal permutations as well as circular permutations. For prok ...
... clusters if the multiple chromosomes are simply concatenated, in the latter case gene clusters might be missed if the circular pieces are cut at some arbitrary point. We handle this problem by adapting the original algorithm to multichromosomal permutations as well as circular permutations. For prok ...
Database search and pairwise alignments
... mutations that may have some effects on the alignment ...that is, the denominator of the fraction is given by the total number of substitutions in the tree, multiplied by two, multiplied by the frequency of the particular amino acid, multiplied by a scale factor equal to 100 The scale factor 100 is ...
... mutations that may have some effects on the alignment ...that is, the denominator of the fraction is given by the total number of substitutions in the tree, multiplied by two, multiplied by the frequency of the particular amino acid, multiplied by a scale factor equal to 100 The scale factor 100 is ...
The molecular genetics of von Willebrand disease
... Types 2B and 2M disease represent gain- and loss-ofplatelet dependent function variants, respectively. Type 2B VWD shows a loss of high molecular weight VWF plasma multimers and, most characteristically, an enhanced sensitivity to ristocetin-induced platelet agglutination of platelet rich plasma. In ...
... Types 2B and 2M disease represent gain- and loss-ofplatelet dependent function variants, respectively. Type 2B VWD shows a loss of high molecular weight VWF plasma multimers and, most characteristically, an enhanced sensitivity to ristocetin-induced platelet agglutination of platelet rich plasma. In ...
The Role of Melanocortin-1 Receptor Polymorphism in Skin Cancer
... Cultured human melanocytes have been found to express high affinity receptors for the a-MSH ligand on their surface with approximately 700 binding sites per cell (32–34). Primary melanocyte cultures are an ideal system in which to study human pigmentary differences. Under appropriate growth conditions ...
... Cultured human melanocytes have been found to express high affinity receptors for the a-MSH ligand on their surface with approximately 700 binding sites per cell (32–34). Primary melanocyte cultures are an ideal system in which to study human pigmentary differences. Under appropriate growth conditions ...
Locked Nucleic Acid (LNA™)
... Figure 4. LNA™ in situ hybridization probes give stronger signals than DNA probes. The intensities of four ISH probes targeting rRNA from E. coli were compared. All probes had the same 19 nt sequence but the LNA™ probes had 1-3 LNA™ subsitutions. LNA™ 3 produced 22 times higher intensity than the DN ...
... Figure 4. LNA™ in situ hybridization probes give stronger signals than DNA probes. The intensities of four ISH probes targeting rRNA from E. coli were compared. All probes had the same 19 nt sequence but the LNA™ probes had 1-3 LNA™ subsitutions. LNA™ 3 produced 22 times higher intensity than the DN ...
here
... E: For example, it ignores the potential influence of environmental factors that may trigger or increase the risk of developing OCD, which is suggested by the diathesis-stress model. E: This is an issue because it has been found that over half the OCD patients in a study conducted by Cromer et al (2 ...
... E: For example, it ignores the potential influence of environmental factors that may trigger or increase the risk of developing OCD, which is suggested by the diathesis-stress model. E: This is an issue because it has been found that over half the OCD patients in a study conducted by Cromer et al (2 ...
BMC Developmental Biology
... not been studied. Our data demonstrate that the overexpression of Dll1 throughout epithelial somites of transgenic mice does not alter somite polarity but affects the development of intervertebral joints, IVDs and proximal ribs. This suggests a role of restricted Dll1 expression in caudal epithelial ...
... not been studied. Our data demonstrate that the overexpression of Dll1 throughout epithelial somites of transgenic mice does not alter somite polarity but affects the development of intervertebral joints, IVDs and proximal ribs. This suggests a role of restricted Dll1 expression in caudal epithelial ...
AHSGE Project Objectives
... 6a. Identify and describe the four stages of mitosis. 6b. Describe the function of mitosis as it relates to the reproduction, growth, and repair of cells. 6c. Identify and describe the eight stages of meiosis. 6d. Describe the function of meiosis as it relates to reproduction. Be sure to include ho ...
... 6a. Identify and describe the four stages of mitosis. 6b. Describe the function of mitosis as it relates to the reproduction, growth, and repair of cells. 6c. Identify and describe the eight stages of meiosis. 6d. Describe the function of meiosis as it relates to reproduction. Be sure to include ho ...
Dynamics and genetic diversification of Escherichia coli
... primary means of energy generation in contrast to respiration. Furthermore, the rates and spectra of spontaneous mutations that arise during anaerobic growth differ to those under aerobic growth. A long-term selection experiment was undertaken to investigate the genetic changes that underpin how the ...
... primary means of energy generation in contrast to respiration. Furthermore, the rates and spectra of spontaneous mutations that arise during anaerobic growth differ to those under aerobic growth. A long-term selection experiment was undertaken to investigate the genetic changes that underpin how the ...
The Underlying Similarity of Diversity Measures Used in
... cluster theory this is called the statistic scatter, see [7]. Now, since the Hamming distance is symmetric, and is equal to 0 if the strings are the same, only the lower triangle in a chromosome-pairs table need be considered when computing the diversity. Consequently the all-possible-pairs diversit ...
... cluster theory this is called the statistic scatter, see [7]. Now, since the Hamming distance is symmetric, and is equal to 0 if the strings are the same, only the lower triangle in a chromosome-pairs table need be considered when computing the diversity. Consequently the all-possible-pairs diversit ...
A Fitness-Independent Evolvability Measure for Evolutionary
... most existing evolvability measures are more or less fitnessdependent. Hence, it would be interesting to examine evolvability of developmental models independent of a problemspecific fitness function. In addition, most existing evolvability measures are suggested for discrete direct or developmental ...
... most existing evolvability measures are more or less fitnessdependent. Hence, it would be interesting to examine evolvability of developmental models independent of a problemspecific fitness function. In addition, most existing evolvability measures are suggested for discrete direct or developmental ...
COMMISSION ON GENETIC RESOURCES FOR FOOD AND
... question of liability” as one of the most appropriate for further work and decided that it should be taken into consideration when designing the Commission’s Multi-Year Programme of Work. This background study paper gives an overview of current research regarding the full range of possible effects o ...
... question of liability” as one of the most appropriate for further work and decided that it should be taken into consideration when designing the Commission’s Multi-Year Programme of Work. This background study paper gives an overview of current research regarding the full range of possible effects o ...
WUS and STM in shoot meristem regulation
... with XbaI and transcribed with T3 RNA polymerase (Promega; Madison, USA). For the KNAT2 antisense riboprobe, plasmid pCKI-30 (kindly provided by J. Traas) which contains the full-length KNAT2 cDNA was linearized with XhoI and transcribed with T7 RNA polymerase; for the sense probe, pCKI-30 was linea ...
... with XbaI and transcribed with T3 RNA polymerase (Promega; Madison, USA). For the KNAT2 antisense riboprobe, plasmid pCKI-30 (kindly provided by J. Traas) which contains the full-length KNAT2 cDNA was linearized with XhoI and transcribed with T7 RNA polymerase; for the sense probe, pCKI-30 was linea ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.