training handout - Science Olympiad
... Pleiotrophy – the action of an allele (gene) affects many parts of the body as sickle cell anemia Variable expressivity – an allele (gene) can be expressed differently in different people ...
... Pleiotrophy – the action of an allele (gene) affects many parts of the body as sickle cell anemia Variable expressivity – an allele (gene) can be expressed differently in different people ...
Transcription and the Central Dogma
... • RNA polymerase is processive; once enzyme attaches to DNA, it can copy >10,000 nucleotides without falling off. • In eukaryotes, there are 3 RNA polymerases: – One for rRNA – One for tRNAs and some rRNA – One for all mRNAs and some small RNAs (involved in RNA processing) ...
... • RNA polymerase is processive; once enzyme attaches to DNA, it can copy >10,000 nucleotides without falling off. • In eukaryotes, there are 3 RNA polymerases: – One for rRNA – One for tRNAs and some rRNA – One for all mRNAs and some small RNAs (involved in RNA processing) ...
Bi190 Advanced Genetics 2011 Lecture 11/ho10 Genome to Function
... fraction (20%-40%) of genes are essential or have discernable phenotypes. One can analyze phenotypes more carefully, or look at genetic interactions, or run selection experiments, e.g. with bar-coded yeast deletion strains. Targeted knockouts are best made by gene replacement, using the Rothstein me ...
... fraction (20%-40%) of genes are essential or have discernable phenotypes. One can analyze phenotypes more carefully, or look at genetic interactions, or run selection experiments, e.g. with bar-coded yeast deletion strains. Targeted knockouts are best made by gene replacement, using the Rothstein me ...
Unit Three “Cell Proliferation and Genetics”
... which is the DNA in the nucleus, enables the efficient operation of the remainder of the cell is via Protein Synthesis • Recall that proteins maintain the proper function of the cell by acting as enzyme that regulate the vital chemical reactions of the cell • In essence, DNA makes RNA makes Protein ...
... which is the DNA in the nucleus, enables the efficient operation of the remainder of the cell is via Protein Synthesis • Recall that proteins maintain the proper function of the cell by acting as enzyme that regulate the vital chemical reactions of the cell • In essence, DNA makes RNA makes Protein ...
Non-coding RNAs
... • Protein-coding genes (mRNA): around 20500 (as of 10/2012) • Non-coding RNAs Ribosomal RNA (rRNA) Transfer RNA (tRNA) Small nuclear RNA (SnRNA) Small nucleolar RNA (SnoRNA) microRNA (miRNA) Other non-coding RNAs (Xist, 7SK, etc.) • Pseudogenes ...
... • Protein-coding genes (mRNA): around 20500 (as of 10/2012) • Non-coding RNAs Ribosomal RNA (rRNA) Transfer RNA (tRNA) Small nuclear RNA (SnRNA) Small nucleolar RNA (SnoRNA) microRNA (miRNA) Other non-coding RNAs (Xist, 7SK, etc.) • Pseudogenes ...
Systematic Implications of DNA variation in subfamily
... Early methods relied on chromatography to separate complex mixtures of secondary metabolites, detect them, and then compare between taxa “spot botanists” – very phenetic Better separation and identification methods developed – used pathway stages as cladistic characters - phytochemistry Move away fr ...
... Early methods relied on chromatography to separate complex mixtures of secondary metabolites, detect them, and then compare between taxa “spot botanists” – very phenetic Better separation and identification methods developed – used pathway stages as cladistic characters - phytochemistry Move away fr ...
BSC 219
... The DNA sequences and some proteins in the complex are variable between promoters. Prokaryotic initiation relies only upon the relative strength of the promoter sequences at recruiting Sigma factor and RNA Polymerase to the promoter. ...
... The DNA sequences and some proteins in the complex are variable between promoters. Prokaryotic initiation relies only upon the relative strength of the promoter sequences at recruiting Sigma factor and RNA Polymerase to the promoter. ...
DNA Biology - De Anza College
... – One end has anticodon(complementary to codon) – Other end has correct amino acid ...
... – One end has anticodon(complementary to codon) – Other end has correct amino acid ...
FIRST GENERATION of CONNECTIVITY MAP small molecules
... connectivity map can be used for: - drugs with common mechanism of action (HDAC inhibitors) - discover unknown mechanism of action (gedunin) - identify potential new therapeutics the genomic signature are often conserved across different cell types and different origins but there are also several li ...
... connectivity map can be used for: - drugs with common mechanism of action (HDAC inhibitors) - discover unknown mechanism of action (gedunin) - identify potential new therapeutics the genomic signature are often conserved across different cell types and different origins but there are also several li ...
practical sheet
... — Randomly split your data in a training set and a test set. Use 2/3 of the sample for the training set. — Adjust a logistic regression model regularized by a Lasso penalty (α = 1) — Adjust a logistic regression model regularized by an Elastic-net penalty. Use various values, say {.25, .5, .75, .95} ...
... — Randomly split your data in a training set and a test set. Use 2/3 of the sample for the training set. — Adjust a logistic regression model regularized by a Lasso penalty (α = 1) — Adjust a logistic regression model regularized by an Elastic-net penalty. Use various values, say {.25, .5, .75, .95} ...
RISE AND FALL OF GENE FAMILIES Dynamics of Their Expansion
... http://www.bio.davidson.edu/courses/GENOMICS/method/shotgun.html ...
... http://www.bio.davidson.edu/courses/GENOMICS/method/shotgun.html ...
Overview of Human Linkage Analysis Terry Speed
... phenocopies. The terms polygenic and oligogenic are also used, but these do have more specific meanings. There is some evidence that using a range of made-up models can help map genes for complex traits, but no-one really knows. Affected only methods are widely used, with variance component methods ...
... phenocopies. The terms polygenic and oligogenic are also used, but these do have more specific meanings. There is some evidence that using a range of made-up models can help map genes for complex traits, but no-one really knows. Affected only methods are widely used, with variance component methods ...
PS401 – Lec 10
... Eukaryotic Genomic Resources – location of Plant Genomes Central with information from various plant genome projects. Map Viewer – Displays genome assemblies using chromosome map views. ...
... Eukaryotic Genomic Resources – location of Plant Genomes Central with information from various plant genome projects. Map Viewer – Displays genome assemblies using chromosome map views. ...
Biology 10.2 Review Genes to Proteins
... Mutations in gametes can be passed on to offspring of he affected individual, but mutations in body cells affect only the individual in which they occur. ...
... Mutations in gametes can be passed on to offspring of he affected individual, but mutations in body cells affect only the individual in which they occur. ...
Supplementary Figure Legends
... Supplementary Figure S3. Cell cycle dynamics of Ki-67 expression are similar in ...
... Supplementary Figure S3. Cell cycle dynamics of Ki-67 expression are similar in ...
Biology 10.2 Review Genes to Proteins
... Mutations in gametes can be passed on to offspring of he affected individual, but mutations in body cells affect only the individual in which they occur. ...
... Mutations in gametes can be passed on to offspring of he affected individual, but mutations in body cells affect only the individual in which they occur. ...
Reading assessment for Unit 2
... a. allow direct comparisons of two samples on a single array b. have high chip-to-chip reproducibility c. allow only one sample per array d. b and c only e. none of the above 3. Microarray based methods may soon become eclipsed by a. Northern blot technology b. purely computational approaches to bio ...
... a. allow direct comparisons of two samples on a single array b. have high chip-to-chip reproducibility c. allow only one sample per array d. b and c only e. none of the above 3. Microarray based methods may soon become eclipsed by a. Northern blot technology b. purely computational approaches to bio ...
Chapter 8
... DNA - Macromolecule - Small chromosomes-- Million nucleotide wide - Atcg; base pairs - Complementary; 2 strands, anti parallel - Double helix - Hydrogen bonds; at core - Dehydration synthesis - Starting point 3' prime to 5' prime - Run chemical opposite direct. - 5' phosphate - 3' hydroxyl - Deoxyri ...
... DNA - Macromolecule - Small chromosomes-- Million nucleotide wide - Atcg; base pairs - Complementary; 2 strands, anti parallel - Double helix - Hydrogen bonds; at core - Dehydration synthesis - Starting point 3' prime to 5' prime - Run chemical opposite direct. - 5' phosphate - 3' hydroxyl - Deoxyri ...
From reads to genes in less than 10 R commands
... input and outputs mapping results to the hard disk – Number of subreads selected and consensus threshold • Control mapping sensitivity and specificity – Output uniquely mapped reads • Break ties using Edit distance and mapping quality scores – Ouput multiple best mapping locations – Detect ind ...
... input and outputs mapping results to the hard disk – Number of subreads selected and consensus threshold • Control mapping sensitivity and specificity – Output uniquely mapped reads • Break ties using Edit distance and mapping quality scores – Ouput multiple best mapping locations – Detect ind ...
Leukaemia Section t(7;19)(q34;p13) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Several helix-loop-helix (HLH) proteins are proposed to function as transcriptionnal regulatory factors based on their ability to bind in vitro the E-box motif of transcriptional enhancers. The enhancer binding HLH proteins include E47 and E12, two distinct but related polypeptides encoded by E2A ge ...
... Several helix-loop-helix (HLH) proteins are proposed to function as transcriptionnal regulatory factors based on their ability to bind in vitro the E-box motif of transcriptional enhancers. The enhancer binding HLH proteins include E47 and E12, two distinct but related polypeptides encoded by E2A ge ...
Chapter 12 - North Mac Schools
... Two tRNA with “anticodon” that complement the strand are attached to mRNA by the ribosome. ...
... Two tRNA with “anticodon” that complement the strand are attached to mRNA by the ribosome. ...
Messenger RNA (mRNA)
... b. RNA begins transcription at special sequences of DNA called promoters. The promoter contains an initiation site where transcription of the gene begins. Phase 2: Elongation a. RNA is single stranded so only 1 of the 2 DNA strands need to be copied. The strand that serves as the template is the sen ...
... b. RNA begins transcription at special sequences of DNA called promoters. The promoter contains an initiation site where transcription of the gene begins. Phase 2: Elongation a. RNA is single stranded so only 1 of the 2 DNA strands need to be copied. The strand that serves as the template is the sen ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.