Additional Table 1. Genotype and phenotype of the
... kb, 14,823,878-15,041,954, genomic yes build hg 18). One gene involved (MACROD2 ). No parental studies were performed. The clinical significance of these copy number variants is unclear. ...
... kb, 14,823,878-15,041,954, genomic yes build hg 18). One gene involved (MACROD2 ). No parental studies were performed. The clinical significance of these copy number variants is unclear. ...
The pleiotropic structure of the genotype–phenotype
... gene has N pleiotropic effects” is meaningless, because N depends on the number and kind of phenotypic traits that have been recorded in a study. There are of course many and deep problems with defining the units of phenotypic variations27, as briefly discussed in the next section. here, we only wan ...
... gene has N pleiotropic effects” is meaningless, because N depends on the number and kind of phenotypic traits that have been recorded in a study. There are of course many and deep problems with defining the units of phenotypic variations27, as briefly discussed in the next section. here, we only wan ...
Product description P018-G1 SHOX-v03 - MRC
... binding site (Barca-Tierno et al. 2011) or due to impurities in the DNA. - Not all copy number changes detected by the “SHOX-area” probes will affect SHOX gene function. Analysis of family members may be required for correct interpretation of results. Limitations of the procedure: − MLPA cannot dete ...
... binding site (Barca-Tierno et al. 2011) or due to impurities in the DNA. - Not all copy number changes detected by the “SHOX-area” probes will affect SHOX gene function. Analysis of family members may be required for correct interpretation of results. Limitations of the procedure: − MLPA cannot dete ...
In silico method for inferring genotypes in pedigrees
... simulated genotypes for eight SNPs within an 8-cM region and a trait-determining SNP with a minor allele frequency of 0.3 that explained either 50% or 5% (H2) of the total phenotypic variance. The associated SNP was placed between the 4th and the 5th SNP (for details, see Supplementary Methods). ...
... simulated genotypes for eight SNPs within an 8-cM region and a trait-determining SNP with a minor allele frequency of 0.3 that explained either 50% or 5% (H2) of the total phenotypic variance. The associated SNP was placed between the 4th and the 5th SNP (for details, see Supplementary Methods). ...
wmgenes2 - Cucurbit Breeding
... Three major genes control seed coat color: r (Poole et al., 1941), t (McKay, 1936), and w (Poole et al., 1941) for red, tan, and white seed coat, respectively. The genes interact to produce six phenotypes: black (RR TT WW); clump (RR TT ww); tan (RR tt WW); white with tan tip (RR tt ww); red (rr tt ...
... Three major genes control seed coat color: r (Poole et al., 1941), t (McKay, 1936), and w (Poole et al., 1941) for red, tan, and white seed coat, respectively. The genes interact to produce six phenotypes: black (RR TT WW); clump (RR TT ww); tan (RR tt WW); white with tan tip (RR tt ww); red (rr tt ...
Microarray Analysis
... Linz, by way of genomics data processing algorithms developed by the researchers and licensed by GNS.” ...
... Linz, by way of genomics data processing algorithms developed by the researchers and licensed by GNS.” ...
Warren, ST and Ashley, CT: Triplet repeat expansion mutations: The example of fragile X syndrome. Annual Review of Neuroscience 18:77-99 (1995).
... functional importance of its protein product, FMRP. Initial data base searches at both the nucleotide and amino acid levels, however, produced no significant homologies with any previously reported sequences and provided no immedi ate clues as to the normal function of this predicted protein (see b ...
... functional importance of its protein product, FMRP. Initial data base searches at both the nucleotide and amino acid levels, however, produced no significant homologies with any previously reported sequences and provided no immedi ate clues as to the normal function of this predicted protein (see b ...
Functional Diversiication within the Family of B
... any LLM domain containing proteins outside of the B-GATA family (Fig. 1; Supplemental Fig. S1). In each case, the LLM domain was positioned at the very C terminus of the B-GATAs, and the proteins shared substantial amino acid conservation within the LLM domain (69.9%) as well as within the GATA DNA- ...
... any LLM domain containing proteins outside of the B-GATA family (Fig. 1; Supplemental Fig. S1). In each case, the LLM domain was positioned at the very C terminus of the B-GATAs, and the proteins shared substantial amino acid conservation within the LLM domain (69.9%) as well as within the GATA DNA- ...
Modified uridine at wobble position in tRNA of
... Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). Although modified nucleosides are pr ...
... Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). Although modified nucleosides are pr ...
Engineering of polyketide biosynthetic pathways for bioactive
... yielded a novel chlorinated molecule 2-chloro-resveratrol. This demonstrated that biosynthetic enzymes from different sources can be recombined like legos to make various plant natural products, which is more efficient (2-3 days) than traditional extraction from plants (months to years). Phenylalani ...
... yielded a novel chlorinated molecule 2-chloro-resveratrol. This demonstrated that biosynthetic enzymes from different sources can be recombined like legos to make various plant natural products, which is more efficient (2-3 days) than traditional extraction from plants (months to years). Phenylalani ...
as a PDF - CiteSeerX
... B-DNA versus non-B-DNA (51), and organization, can affect homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of sys ...
... B-DNA versus non-B-DNA (51), and organization, can affect homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of sys ...
Xenopus Spinal Neurons Express Kv2 Potassium Channel
... yielding only one amino acid change (Fig. 1B). Because most of the nucleotide differences between the PCR products and the library cDNAs conserve the ainino acid sequence, it is unlikely that the PCR variants are attributable to random errors introduced by reverse transcriptase or Taq polymerase. It ...
... yielding only one amino acid change (Fig. 1B). Because most of the nucleotide differences between the PCR products and the library cDNAs conserve the ainino acid sequence, it is unlikely that the PCR variants are attributable to random errors introduced by reverse transcriptase or Taq polymerase. It ...
Genetic factors affecting dental caries risk
... concentrate in specific groups of individuals. The phenomenon is termed as polarization and its cause remains obscure, representing one of the epidemiological disease aspects in which a portion of the population is in most need of treatment.2 The Vipeholm study provided evidence of an individual’s r ...
... concentrate in specific groups of individuals. The phenomenon is termed as polarization and its cause remains obscure, representing one of the epidemiological disease aspects in which a portion of the population is in most need of treatment.2 The Vipeholm study provided evidence of an individual’s r ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
... repair events by MutSb on clustered short CAG/CTG slip-outs is arrested [42]. Arrested repair along these clusters may allow for strand displacement, slippage, further out-of-register mispairing, and repair synthesis resulting in expansions on un-repaired clustered slip-outs [42]. Reiterations of su ...
... repair events by MutSb on clustered short CAG/CTG slip-outs is arrested [42]. Arrested repair along these clusters may allow for strand displacement, slippage, further out-of-register mispairing, and repair synthesis resulting in expansions on un-repaired clustered slip-outs [42]. Reiterations of su ...
Scenario 4 - people.vcu.edu
... • Gene present in Prochlorococcus MED4 MED4 is naturally adapted to grow in high light. • Ortholog absent in Prochlorococcus MIT9313 MIT9313 is naturally adapted to grow in low light ...
... • Gene present in Prochlorococcus MED4 MED4 is naturally adapted to grow in high light. • Ortholog absent in Prochlorococcus MIT9313 MIT9313 is naturally adapted to grow in low light ...
the hemophilia gene, click here
... Hemophilia is a disease that results from changes to the genetic code for a clotting factor. In many cases it is possible to trace a family history of hemophilia. However, in about one-third of new patients, hemophilia appears to occur in that family for the first time. There is now good evidence to ...
... Hemophilia is a disease that results from changes to the genetic code for a clotting factor. In many cases it is possible to trace a family history of hemophilia. However, in about one-third of new patients, hemophilia appears to occur in that family for the first time. There is now good evidence to ...
Bacterial canker and blast of stone fruit trees, caused by
... was originally described as Pseudomonas syringae pv. avellanae (19,21). Further evidence obtained from fatty acids methyl ester analysis, whole-cell protein profiles, and sequence comparisons of the 16S rRNA gene changed the Pseudomonas syringae ...
... was originally described as Pseudomonas syringae pv. avellanae (19,21). Further evidence obtained from fatty acids methyl ester analysis, whole-cell protein profiles, and sequence comparisons of the 16S rRNA gene changed the Pseudomonas syringae ...
ARTICLES
... the reaction described above after 15 min (Supplementary Fig. 2 online); however, it was still possible that the difference in the decoding ability of each tRNAAla GGC was so small that the apparent translation efficiency was not sensitive enough to reflect to the actual value under such conditions. ...
... the reaction described above after 15 min (Supplementary Fig. 2 online); however, it was still possible that the difference in the decoding ability of each tRNAAla GGC was so small that the apparent translation efficiency was not sensitive enough to reflect to the actual value under such conditions. ...
PDF
... At the 32-cell stage, we used TE and ICM cells isolated from intact embryos as the 1/32FS controls. We observed that Oct4 transcript abundance was significantly lower in 1/32LS blastomeres than in the ICM cells but higher than that in TE cells (Fig. 1E,F). ICM cells and 1/32LS blastomeres had, respe ...
... At the 32-cell stage, we used TE and ICM cells isolated from intact embryos as the 1/32FS controls. We observed that Oct4 transcript abundance was significantly lower in 1/32LS blastomeres than in the ICM cells but higher than that in TE cells (Fig. 1E,F). ICM cells and 1/32LS blastomeres had, respe ...
Developmental fate and lineage commitment of singled mouse
... At the 32-cell stage, we used TE and ICM cells isolated from intact embryos as the 1/32FS controls. We observed that Oct4 transcript abundance was significantly lower in 1/32LS blastomeres than in the ICM cells but higher than that in TE cells (Fig. 1E,F). ICM cells and 1/32LS blastomeres had, respe ...
... At the 32-cell stage, we used TE and ICM cells isolated from intact embryos as the 1/32FS controls. We observed that Oct4 transcript abundance was significantly lower in 1/32LS blastomeres than in the ICM cells but higher than that in TE cells (Fig. 1E,F). ICM cells and 1/32LS blastomeres had, respe ...
DANIELE GHEZZI Matr. N°. 708361 Identification and
... Each human cell has thousands of mitochondria and within each single mitochondrion are present multiple copies (2 to 10) of mtDNA. Usually all these copies are identical, a status known as homoplasmy. However it is possible that errors occur during replication or repair of mtDNA, leading to the form ...
... Each human cell has thousands of mitochondria and within each single mitochondrion are present multiple copies (2 to 10) of mtDNA. Usually all these copies are identical, a status known as homoplasmy. However it is possible that errors occur during replication or repair of mtDNA, leading to the form ...
Arabidopsis onset of leaf death mutants identify a regulatory
... ethylene treatment, visible yellowing was not observed in plants younger than 17 days. Thereafter visible yellowing was induced in cotyledons and the cotyledons became yellow in all the plants older than 24 days. Thus exogenous ethylene does promote the cotyledon yellowing, but its effects depend on ...
... ethylene treatment, visible yellowing was not observed in plants younger than 17 days. Thereafter visible yellowing was induced in cotyledons and the cotyledons became yellow in all the plants older than 24 days. Thus exogenous ethylene does promote the cotyledon yellowing, but its effects depend on ...
Functional Characterization of Nine Norway
... 2002). While many terpenoids exist as pairs of enantiomers (Fig. 1), TPS exhibit preferential catalysis toward one stereoisomer resulting in mostly optically pure product profiles (Davis and Croteau, 2000; Phillips et al., 2003). The exact structural features that determine substrate specificity and ...
... 2002). While many terpenoids exist as pairs of enantiomers (Fig. 1), TPS exhibit preferential catalysis toward one stereoisomer resulting in mostly optically pure product profiles (Davis and Croteau, 2000; Phillips et al., 2003). The exact structural features that determine substrate specificity and ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.