Drysdale_pheno_CSH
... Using Observable + attribute + value + qualif ier + pm ontology term: Phenotype: (with asl2 ) adult | viability | viable | recessive Phenotype: (with asl3 ) adult | viabilit y | viable | recessive Phenotype: adult | femal e_fertilit y | female_sterile | recessive ...
... Using Observable + attribute + value + qualif ier + pm ontology term: Phenotype: (with asl2 ) adult | viability | viable | recessive Phenotype: (with asl3 ) adult | viabilit y | viable | recessive Phenotype: adult | femal e_fertilit y | female_sterile | recessive ...
Spinocerebellar ataxia type 1 (SCA1): Phenotype-genotype
... Sequence analysis revealed that the 14 normal SCA1 alleles with 29 and 30 triplets as well as the alleles with 35 ± 38 triplets are interrupted by the sequence CAT CAG CAT. In alleles with 39 ± 41 triplets the interruption is missing in six of seven cases. DNA sequences are summarised in Table 1. Al ...
... Sequence analysis revealed that the 14 normal SCA1 alleles with 29 and 30 triplets as well as the alleles with 35 ± 38 triplets are interrupted by the sequence CAT CAG CAT. In alleles with 39 ± 41 triplets the interruption is missing in six of seven cases. DNA sequences are summarised in Table 1. Al ...
An Analytically Tractable Model for Competitive Speciation
... selection, frequency-dependent selection due to competition, and sexual selection due to assortative mating. In the genetically explicit version of the model, these forces act on two or three different traits, each of which is influenced by multiple loci. Our aim in this study is to gain a more thor ...
... selection, frequency-dependent selection due to competition, and sexual selection due to assortative mating. In the genetically explicit version of the model, these forces act on two or three different traits, each of which is influenced by multiple loci. Our aim in this study is to gain a more thor ...
Unequal Crossing-over in Unique PABP2 Mutations in Japanese
... repeats are responsible for a number of hereditary neuromuscular diseases.7,14,15 These pathologic repeat expansions can be explained by the slippage model. However, it has been proposed that tracts of approximately 25 to 35 perfect trinucleotide repeats are required for instability and expansion vi ...
... repeats are responsible for a number of hereditary neuromuscular diseases.7,14,15 These pathologic repeat expansions can be explained by the slippage model. However, it has been proposed that tracts of approximately 25 to 35 perfect trinucleotide repeats are required for instability and expansion vi ...
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... If your two alleles are different (he te roz ygous , e.g. Bb), the trait associated with only one of these will be visible (dominant) while the other will be hidden (recessive). E.g. B is dominant, b is recessive. Sperm ...
... If your two alleles are different (he te roz ygous , e.g. Bb), the trait associated with only one of these will be visible (dominant) while the other will be hidden (recessive). E.g. B is dominant, b is recessive. Sperm ...
SUSTAINABLE EVOLUTIONARY ALGORITHMS AND SCALABLE
... EVOLUTIONARY SYNTHESIS OF DYNAMIC SYSTEMS By Jianjun Hu This dissertation concerns the principles and techniques for scalable evolutionary computation to achieve better solutions for larger problems with more computational resources. It suggests that many of the limitations of existent evolutionary ...
... EVOLUTIONARY SYNTHESIS OF DYNAMIC SYSTEMS By Jianjun Hu This dissertation concerns the principles and techniques for scalable evolutionary computation to achieve better solutions for larger problems with more computational resources. It suggests that many of the limitations of existent evolutionary ...
Using Genetic Algorithms with Sexual or Asexual Transposition: a
... selected individuals (Simões et al. 1999a; 1999c). The authors introduce two distinct manners of using the sexual mechanism: simple and tournament-based transposition. Asexual transposition proposed by Simões et al. 2000 works in the same individual. Previous work used the transposition mechanism as ...
... selected individuals (Simões et al. 1999a; 1999c). The authors introduce two distinct manners of using the sexual mechanism: simple and tournament-based transposition. Asexual transposition proposed by Simões et al. 2000 works in the same individual. Previous work used the transposition mechanism as ...
Resolving Individuals Contributing Trace Amounts of DNA to Highly
... Before we discuss resolving mixtures, we summarize ‘genotype calling’ in the context of data from a single individual at a single SNP. SNP genotyping algorithms typically begin by transforming normalized data into a ratio or polar coordinates. For simplicity, we will utilize a ratio transformation Y ...
... Before we discuss resolving mixtures, we summarize ‘genotype calling’ in the context of data from a single individual at a single SNP. SNP genotyping algorithms typically begin by transforming normalized data into a ratio or polar coordinates. For simplicity, we will utilize a ratio transformation Y ...
Future Generation Computer Systems
... local search procedure. Before the generated chromosome can be inserted into the population, a check is performed to ensure that the new chromosome is unique. In this way, we ensure that no member of the initial population is over-represented. This chromosome generation process is repeated, each tim ...
... local search procedure. Before the generated chromosome can be inserted into the population, a check is performed to ensure that the new chromosome is unique. In this way, we ensure that no member of the initial population is over-represented. This chromosome generation process is repeated, each tim ...
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis
... fig. 1 in the online supplementary material). However, this finding was not replicated in the analyses of self-reported asthma or allergic asthma, and it is therefore likely a spurious result. None of the risk estimates for EPHX1 genotypes or other phenotypes differed from 1.0 in any of the three as ...
... fig. 1 in the online supplementary material). However, this finding was not replicated in the analyses of self-reported asthma or allergic asthma, and it is therefore likely a spurious result. None of the risk estimates for EPHX1 genotypes or other phenotypes differed from 1.0 in any of the three as ...
Lethal Mutations and Balanced Lethal Systems in
... Induction and detection of recessive lethal mutations. Conidia, untreated or irradiated to 5 % survival, were plated on MM and incubated 3-4 days. For each diploid 200 colonies were taken, IOO control and IOO following treatment; colonies which showed morphological abnormality were excluded. Each su ...
... Induction and detection of recessive lethal mutations. Conidia, untreated or irradiated to 5 % survival, were plated on MM and incubated 3-4 days. For each diploid 200 colonies were taken, IOO control and IOO following treatment; colonies which showed morphological abnormality were excluded. Each su ...
Tandem Genetic Duplications in Phage and Bacteria
... tion method should yield duplications that are the best indicators of the sizes and frequencies of spontaneous duplications. COINHERITANCE OF ALLELIC MARKERS A variety of detection schemes in volve genetic crosses that select for simultaneous inheritance of two alleles of a single locus. These alle ...
... tion method should yield duplications that are the best indicators of the sizes and frequencies of spontaneous duplications. COINHERITANCE OF ALLELIC MARKERS A variety of detection schemes in volve genetic crosses that select for simultaneous inheritance of two alleles of a single locus. These alle ...
Inbreeding in Cattle
... Lines of genetically different individuals may be developed using inbreeding. Later, the genetically different lines may be used in crosses. Examples of this practice are evident in the seed corn and poultry industries. Producers interested in developing inbred lines should be cautioned. Response ac ...
... Lines of genetically different individuals may be developed using inbreeding. Later, the genetically different lines may be used in crosses. Examples of this practice are evident in the seed corn and poultry industries. Producers interested in developing inbred lines should be cautioned. Response ac ...
Mosaic: A Position-Effect Variegation Eye
... proportion of individuals with a high proportion of pigmented eye relative to 228C (p . F 5 0.0168; Figure 2). On the other hand, replicate was not a significant independent variable. Therefore rearing at an elevated temperature suppressed Mos variegation. In order to observe the phenotypic interact ...
... proportion of individuals with a high proportion of pigmented eye relative to 228C (p . F 5 0.0168; Figure 2). On the other hand, replicate was not a significant independent variable. Therefore rearing at an elevated temperature suppressed Mos variegation. In order to observe the phenotypic interact ...
Parasexual Genetics in Dictyostelium discoideum
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
Lactose tolerance
... What is the probablity that the Null hypothesis is true? Does this mean that the result is statistically significant? Were any of the results for these positions statistically significant? If so, which one(s)? If all of the lactase-persistent individuals in the world have the same genetic change tha ...
... What is the probablity that the Null hypothesis is true? Does this mean that the result is statistically significant? Were any of the results for these positions statistically significant? If so, which one(s)? If all of the lactase-persistent individuals in the world have the same genetic change tha ...
Applying Mendel`s Principles
... principles and learned that they applied not just to pea plants but to other organisms as well. The basic principles of Mendelian genetics can be used to study the inheritance of human traits and to calculate the probability of certain traits appearing in the next generation. ...
... principles and learned that they applied not just to pea plants but to other organisms as well. The basic principles of Mendelian genetics can be used to study the inheritance of human traits and to calculate the probability of certain traits appearing in the next generation. ...
11-2 Genetics Notes
... The principle of independent assortment states that genes for different traits can segregate independently during the formation of gametes. ...
... The principle of independent assortment states that genes for different traits can segregate independently during the formation of gametes. ...
Quantitative Trait Analysis in Plants
... • Must consider the distribution of the phenotypes relative to o The marker o The QTL that is linked to it • Fig. 3A o Shows the marker (M1) and a QTL (Q1) relationship o Parents have Contrasting marker (M1 vs. m1) and QTL (Q1 vs. q1) genotypes o F1 will generate four different gamete types. o Lin ...
... • Must consider the distribution of the phenotypes relative to o The marker o The QTL that is linked to it • Fig. 3A o Shows the marker (M1) and a QTL (Q1) relationship o Parents have Contrasting marker (M1 vs. m1) and QTL (Q1 vs. q1) genotypes o F1 will generate four different gamete types. o Lin ...
PDF
... for paracrine secretion) with the prototypical members, FGF1 and 2 (Ornitz and Itoh 2001). During embryonic and fetal development of the mouse, Fgf5 is first expressed in the extraembryonic ectoderm of the epiblast and then restricted to differentiating myotomes, skeletal muscles, and neurons (Haub ...
... for paracrine secretion) with the prototypical members, FGF1 and 2 (Ornitz and Itoh 2001). During embryonic and fetal development of the mouse, Fgf5 is first expressed in the extraembryonic ectoderm of the epiblast and then restricted to differentiating myotomes, skeletal muscles, and neurons (Haub ...
Genetic drift
Genetic drift (or allelic drift) is the change in the frequency of a gene variant (allele) in a population due to random sampling of organisms.The alleles in the offspring are a sample of those in the parents, and chance has a role in determining whether a given individual survives and reproduces. A population's allele frequency is the fraction of the copies of one gene that share a particular form. Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation.When there are few copies of an allele, the effect of genetic drift is larger, and when there are many copies the effect is smaller. In the early twentieth century vigorous debates occurred over the relative importance of natural selection versus neutral processes, including genetic drift. Ronald Fisher, who explained natural selection using Mendelian genetics, held the view that genetic drift plays at the most a minor role in evolution, and this remained the dominant view for several decades. In 1968, Motoo Kimura rekindled the debate with his neutral theory of molecular evolution, which claims that most instances where a genetic change spreads across a population (although not necessarily changes in phenotypes) are caused by genetic drift. There is currently a scientific debate about how much of evolution has been caused by natural selection, and how much by genetic drift.