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Complete atomic model of the bacterial flagellar filament by electron
Complete atomic model of the bacterial flagellar filament by electron

... The bacterial flagellar filament is a helical propeller for bacterial locomotion. It is a helical assembly of a single protein, flagellin, and its tubular structure is formed by 11 protofilaments in two distinct conformations, L- and R-type, for supercoiling. The X-ray crystal structure of a flagell ...
Redox cycling”
Redox cycling”

Jak napsat abstrakt do sborníku
Jak napsat abstrakt do sborníku

... types of polyethylen glycol (PEG) on solubilization of hypericin (Hyp) in aqueous solutions. By means of UV-VIS absorption and fluorescence spectroscopy we have studied the effect of length, molecular weight and concentration of PEG on the transition of aggregate form of Hyp to its monomeric form. H ...
Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP
Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP

... Therefore, these critical apoptosis regulators have been recognized as attractive targets for the development of innovative therapies in the treatment of cancer and neurodegenerative diseases.5–7 The IAP proteins contain one to three zinc-binding baculoviral IAP repeat (BIR) domains that are require ...
Enzyme - MACscience
Enzyme - MACscience

... Enzymes have a specific region where the substrate binds and where catalysis occurs. This is called the active site. The active site is usually a cleft or pocket at the surface of the enzyme. Substrate modification occurs at the active site. Enzymes are substrate-specific, although specificity varie ...
Molecular Clocks
Molecular Clocks

... The rate of this reaction is preset by the sequence and structure of the peptide or protein and associated peptides or proteins as genetically specified in the DNA. The rate may also be modified by changes in protein structure and solvent conditions in-vivo. This rate can be set to have a half-time ...
Redox cycling
Redox cycling

...  Redox reactions are reversible and most redox active compounds may have either pro- or antioxidant properties, acting as either “oxidant” or “reductant”, depending upon overall conditions  The redox potential is one determinant for reactions occurring with a redox active compound, but enzyme meta ...
7.1 CHEMICAL SYSTEMS IN EQUILIBRIUM: Dynamic Equilibrium in
7.1 CHEMICAL SYSTEMS IN EQUILIBRIUM: Dynamic Equilibrium in

... According to Le Chatelier's Principle, if you increase the pressure the system will respond by favouring the reaction which produces fewer molecules. That will cause the pressure to fall again. In order to get as much ammonia as possible in the equilibrium mixture, you need as high a pressure as pos ...
Full-Text PDF
Full-Text PDF

... conversions from their simple precursors. Also, what plausible conditions on the Hadean Earth could generate such molecules, as well as concentrate them, leading to the formation of their corresponding biopolymers. Once the biopolymers formed, the next steps would have been the formation of cellular ...
Chapter 14 - Moore Public Schools
Chapter 14 - Moore Public Schools

... • The reaction proceeds to the right until equilibrium is restored. • At the new equilibrium position, you will have more of the products than before, less of the non-added reactants than before, and less of the added ...
COP9 signalosome turns the key on protein degradation
COP9 signalosome turns the key on protein degradation

Document
Document

... because the reactants run out or because the system has reached equilibrium ...
Chapter
Chapter

... because the reactants run out or because the system has reached equilibrium ...
Chapter 4-5
Chapter 4-5

... e.g. 0 for H in H2 2. ON of a monatomic ion = charge on ion e.g. +1 for Na+ , and –2 for sulfur S23. An atom in polyatomic ion or in a molecular compound usually has the same ON it would have if it were a monatomic ion e.g. (OH-) O = -2 and H = +1 4. ON for Hydrogen (H) is +1 in all compounds except ...
Chapter 14 (Kinetics) – Slides and Practice
Chapter 14 (Kinetics) – Slides and Practice

... because the reactants run out or because the system has reached equilibrium ...
Stereochemistry and Mechanism of Reactions Catalyzed by
Stereochemistry and Mechanism of Reactions Catalyzed by

... substrate amino acid and the cofactor to an enzyme-bound Schiff s base between pyridoxal phosphate and cr-aminoacrylic acid as a universal intermediate. This intermediate can follow various reaction paths, giving the different observed products. In this paper we report results which clarify various ...
chemical reactions and stoichiometry chemical reactions and
chemical reactions and stoichiometry chemical reactions and

... In chemical reactions, the amount of each element is always conserved. This is consistent with the statements of Dalton’s atomic theory. In addition, the total amount of electrical charge is always conserved. This is the law of conservation of charge. A balanced chemical equation describes a chemica ...
Metabolomic and flux‐balance analysis of age‐related decline of
Metabolomic and flux‐balance analysis of age‐related decline of

... sources of carbohydrate fuel in flight muscles in many Diptera, such as bees and blowflies (Childress et al, 1970; Suarez et al, 2005), and are most likely to be so in D. melanogaster as well. The large deposits of glycogen in flight muscle of flies, the depletion of these reserves after prolonged flight ...
Prof. Kamakaka`s Lecture 5 Notes
Prof. Kamakaka`s Lecture 5 Notes

... Forces involved in protein folding and structure are also involved in catalysis- enzymesubstrate specificity Trypsin hydrolyses proteins by cleaving peptide bond adjacent to Lys/Arg. Aspartate residue in trypsin active site mediates ionic interaction with Lys /Arg and this arranges protein residue a ...
1.8 M - Thierry Karsenti
1.8 M - Thierry Karsenti

... and the energy laws that govern them. Most chemical reactions and virtually all biological processes take place not between pure solids, liquids or gases, but rather among ions and molecules dissolved in water or other solvents (i.e. in solution). In this module we will therefore examine the various ...
Magic of Chemical Reactions 2. - mt
Magic of Chemical Reactions 2. - mt

... What are the steps of writing a chemical equation? 1. The symbols or molecular formulae of the reactants are written on the left hand side and products are on the right hand side. 2. Reactants and products are connected with an arrow () pointing towards product side. 3. Whenever there are two or mo ...
Molecular evolution of the melanocortin 1-receptor - Funpec-RP
Molecular evolution of the melanocortin 1-receptor - Funpec-RP

... (Crandall and Hillis, 1997). Similarly, models of variable dN/dS rate ratios among sites may provide important insights into functional constraints at various amino acid sites and may be used to detect sites under positive selection (Nielsen and Yang, 1998). Thus, in this study we investigated patte ...
Controlling reaction specificity in pyridoxal phosphate
Controlling reaction specificity in pyridoxal phosphate

... occurs through a series of steps in which the unprotonated amino group of the substrate attacks the protonated Schiff base formed between a lysine side chain in the active site and the aldehyde group of PLP, followed by proton transfers and collapse to a Schiff base between the substrate and PLP, th ...
Chemistry
Chemistry

... one response which you want to mark on the Response Sheet. In case you feel that there is more than one correct response, mark the response which you consider the best. In any case, choose ONLY ONE response for each item. 5. In case you find any discrepancy in this test booklet in any question(s) or ...
Organic Reactions in Organised Media
Organic Reactions in Organised Media

... that are formed, the rate of such reactions is low unless special measures are taken. Typical reactions facing such a problem are nucleophilic substitution reactions between a lipophilic organic compound and an inorganic ion, hydrolysis of organic compounds by caustic, many electrophilic substitutio ...
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Multi-state modeling of biomolecules

Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behaviour of biological molecules or complexes that can adopt a large number of possible functional states.Biological signaling systems often rely on complexes of biological macromolecules that can undergo several functionally significant modifications that are mutually compatible. Thus, they can exist in a very large number of functionally different states. Modeling such multi-state systems poses two problems: The problem of how to describe and specify a multi-state system (the ""specification problem"") and the problem of how to use a computer to simulate the progress of the system over time (the ""computation problem""). To address the specification problem, modelers have in recent years moved away from explicit specification of all possible states, and towards rule-based formalisms that allow for implicit model specification, including the κ-calculus, BioNetGen, the Allosteric Network Compiler and others. To tackle the computation problem, they have turned to particle-based methods that have in many cases proved more computationally efficient than population-based methods based on ordinary differential equations, partial differential equations, or the Gillespie stochastic simulation algorithm. Given current computing technology, particle-based methods are sometimes the only possible option. Particle-based simulators further fall into two categories: Non-spatial simulators such as StochSim, DYNSTOC, RuleMonkey, and NFSim and spatial simulators, including Meredys, SRSim and MCell. Modelers can thus choose from a variety of tools; the best choice depending on the particular problem. Development of faster and more powerful methods is ongoing, promising the ability to simulate ever more complex signaling processes in the future.
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