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CHE 4310 Fall 2011
CHE 4310 Fall 2011

... 2. Show the three reactions in the citric acid cycle in which NADH is produced, including the structures. None of these reactions involves molecular oxygen (O2), but all three reactions are strongly inhibited by anaerobic conditions; explain why. ...
CHE 4310 Fall 2011
CHE 4310 Fall 2011

... 2. Show the three reactions in the citric acid cycle in which NADH is produced, including the structures. None of these reactions involves molecular oxygen (O2), but all three reactions are strongly inhibited by anaerobic conditions; explain why. ...
AgudaCraciunAtalay_FINAL
AgudaCraciunAtalay_FINAL

... spectrum of models, the nodes in the graph could be just a set of genes (and no other kinds of objects), with certain pairs of genes linked by undirected edges if these pairs are known to “interact” or are “associated” in some way. Sometimes the nodes could be proteins and the edges represent physic ...
Genetic Control of Growth
Genetic Control of Growth

... By the end of this lesson you should be able to:  Describe the Jacob-Monod hypothesis of gene action in bacteria.  Explain lactose metabolism in Escherichia coli.  Describe the role played by genes in the control of metabolic pathways.  Know what PKU is and how it is caused.  Describe how cell ...
Types of Biochemical Reactions
Types of Biochemical Reactions

... Exothermic reactions in organisms are called catabolic reactions. These reactions break down molecules into smaller units and release energy. An example of a catabolic reaction is the breakdown of glucose, which releases energy that cells need to carry out life processes. Endothermic reactions in or ...
Three dimensions of expression profiling: the micro (subcellular
Three dimensions of expression profiling: the micro (subcellular

... contain many different types of data. For S.cerevisiae these include data on mRNA levels, mutant phenotypes, protein localization, protein levels and protein interactions. We are using such data to elucidate mechanisms of eukaryotic transcription regulation. On its own, each data type is useful for ...
Ch. 2-4 Review
Ch. 2-4 Review

... d. it speeds up a particular chemical reaction. e. it occurs in only one type of cell. ...
Can sequence determine function? | Genome Biology | Full Text
Can sequence determine function? | Genome Biology | Full Text

... encode proteins that participate in related metabolic functions. In other cases, ‘phylogenomic’ analyses [4] may allow ...
Click to the presentation
Click to the presentation

... Novel Biosynthetic Pathways Discovered: Pyruvate to 3HP pathways discovered using only the reaction rules involved in the known pathways to 3HP ...
Analysis of metabolic pathways and fluxes in a newly discovered
Analysis of metabolic pathways and fluxes in a newly discovered

here - Biology 100
here - Biology 100

... Which of the following is/are true concerning metabolic pathways? a. The products of a metabolic reaction will always contain more energy than did the reactants. b. They occur in an orderly series of chemical reactions. c. They may cause the formation or breakdown of molecules. d. They are able to s ...
Bioinformatics areas
Bioinformatics areas

... but have no clue what happens inside the program – Tool shapers (informaticians): know the algorithms and how the tool works but have no clue about the biology ...
CELLULAR RESPIRATION Fates of Pyruvate from glycolysis (2
CELLULAR RESPIRATION Fates of Pyruvate from glycolysis (2

... CELLULAR RESPIRATION Metabolism—the sum of all biochemical reactions in an organism or cell. a) anabolic—synthesis of compounds; an example is photosynthesis b) catabolic—breakdown of compounds; an example is cellular respiration Metabolic pathways—are the steps (enzymes, substrates and products) us ...
BIOLOGY 311C - Brand Spring 2009
BIOLOGY 311C - Brand Spring 2009

Chemistry of Life
Chemistry of Life

... 22. Use a diagram to illustrate the polarity of water molecules. Explain how this polarity results in the formation of hydrogen bonds between water molecules. 23. Summarize the important characteristics of water. 24. Describe the pH scale. What does it measure? 25. Which is more acidic, a solution w ...
Oxidative Metabolism - Plant Energy Biology
Oxidative Metabolism - Plant Energy Biology

... -induced by addition of compounds that affect plastid function •Aox1b and Aox1d are expressed are very low levels ...
PRODUCT FACT SHEET - Taylormade Horse Supplies
PRODUCT FACT SHEET - Taylormade Horse Supplies

... The anaerobic work creates a buildup of waste products, acid, and heat. This subsequently alters the cell by preventing the cell’s enzymes from functioning and the myofilaments from efficiently contracting. The cell membranes may then be damaged if the horse is forced to continue work, which allows ...
Ch7METABOLISM
Ch7METABOLISM

... we eat or “refuel” to supply this energy. If we are starving or fasting, the body must use fuel reserves from its own tissues  Glycogen is used first, along with some fat breakdown. Glycogen is exhausted within several hours.  Low blood glucose serves as a signal to promote further fat breakdown  ...
General - Bioinformatics Research Group at SRI International
General - Bioinformatics Research Group at SRI International

... X = total number of reactions in P Y = enzymes catalyzing number of reactions for which there is evidence in O Z = number of Y reactions that are used in other pathways in O ...
Science study guide for Ch
Science study guide for Ch

... 3. A trait that is expressed when an organism receives genes for two different forms of a trait is called dominant. 4. An organism that has two different genes for the same trait is a hybrid. 5. A trait that is not expressed when an organism receives genes for two different forms of a trait is calle ...
Bioinformatics Tools
Bioinformatics Tools

... • Transcriptome can be extended to include all transcribed elements, including non-coding RNAs used for structural and regulatory purposes. ...
Acid-Base Disorders
Acid-Base Disorders

... alkalosis from a diuretic used to treat the chronic lung disease. • Formulas are available for calculating the appropriate metabolic or respiratory compensation for the six primary simple acid-base disorders. • Appropriate compensation is expected in a simple disorder; it is not optional. • If a pat ...
Document
Document

... • Look at the slides that follow containing the list of reactions on which to focus. • Re-read the indicated pages where each reaction is described in Creighton. Look at related power point slides and examples discussed in class. • Put together a summary sheet with each reaction in as much detail as ...
L5 Metabolism Part2 Fa08
L5 Metabolism Part2 Fa08

... – Binds to enzyme away from active site – Changes conformation of enzyme/active site ...
Archaea possess genes and several metabolic pathways
Archaea possess genes and several metabolic pathways

... Archaea, and that eukaryotes arose through fusion of an archaean and eubacterium, which became the nucleus and cytoplasm. This explains various genetic similarities but runs into difficulties when it comes to explaining cell structure. Despite this visual similarity to bacteria, archaea possess gene ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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