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Clinical Applications of Enzymes
Clinical Applications of Enzymes

... A 36-year old man was admitted to a hospital following episodes of nausea, vomiting, and general malaise. His urine was darker than usual. Upon examination it was discovered that his liver was enlarged and tender to palpation. Liver function tests were abnormal; plasma ALT was 1500 IU/L (Alanine ami ...
Document
Document

... • How can just four nucleotides (A, U, C, and G) be translated into so many different amino acids? • The same way 26 letters of the alphabet can be translated into so many words. – ape – pea The four letters of RNA are put together in different combinations to form many different “words” –A U C G ...
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... weight of protein amino acids is nearer to 128. • Because a molecule of water (Mr 18) is removed to create each peptide bond, the average molecular weight of an amino acid residue in a protein is about 128 -18 = 110. ...
Phosphoketolase pathway dominates in
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Exam_2005 - The University of Sydney
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Principles of BIOCHEMISTRY - Illinois State University
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effect of short time exposure of rats to extreme low temperature on
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Review Report
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... exists. Amino acids isolated from carbonaceous meteorites (which are thought to be abiotic in origin) are racemic, so somewhere along the road, a (perhaps fortuitous) choice was made by the first common ancestor of all existing life forms to use this set of stereoisomers. The structures of the twent ...
Synergistic Effects of Branched
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16. Energy Metabolism
16. Energy Metabolism

... depending on economic factors, climate, geographical location, development of agriculture and other technologies, and the cultural habits and energy requirements of different peoples. Our examples are chosen largely from the diets eaten in the United States, Canada, and many parts of Europe, where t ...
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Citric acid cycle



The citric acid cycle – also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle – is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates, fats and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP). In addition, the cycle provides precursors of certain amino acids as well as the reducing agent NADH that is used in numerous other biochemical reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.The name of this metabolic pathway is derived from citric acid (a type of tricarboxylic acid) that is consumed and then regenerated by this sequence of reactions to complete the cycle. In addition, the cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the TCA cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria which lack mitochondria, the TCA reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion.
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