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Project name: Release of Neutrophil Extracellular Traps (NETs) in
Project name: Release of Neutrophil Extracellular Traps (NETs) in

... Neutrophils are the major antimicrobial phagocytes of the innate immune system. They are one of the first effector cells to arrive at the site of infection and play critical roles in pathogen clearance, recruitment, as well as in activation of other immune cells. To combat microbes, neutrophils empl ...
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... antigens (peptides) to naïve T cells MHC I -> produced by almost all nucleated cells, present antigen to CD8+ cytotoxic T lymphocytes (CTL) MHC II -> produced by “professional” antigen presenting cells, present antigen to CD4+ lymphocytes (T helper cells) ...
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... (neutrophiles), macrophages, and monocytes. • move by ameboid motion. • contain lysosomes that possess digestive enzymes (lysozyme, proteases, nucleases, lipases) and noxious chemicals. • engulf pathogens within vesicles that fuse with lysosome to become phagolysosome. ...


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... kDa; interact with anionic lipids of bacterial membrane and make pores in it; can also inhibit synthesis of DNA and proteins hydrolases, e.g. elastase – serine protease: can damage bacteria and cleave virulence factors, but also cause harm to host tissues (cleaves the proteins of extracellular matri ...
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Jeannie Taylor Microbiology Due: 11/15/2013 Assignment #7
Jeannie Taylor Microbiology Due: 11/15/2013 Assignment #7

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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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