WRL2903.tmp
... Anti-foreign and anti-anti-self in allo-antisera Lymphocytes can be used as experimental antigens. Immunizations with foreign lymphocytes have played a central role in the development of immunogenetics. MHC molecules are important antigens on lymphocyte surfaces. When a mouse is immunized with lymph ...
... Anti-foreign and anti-anti-self in allo-antisera Lymphocytes can be used as experimental antigens. Immunizations with foreign lymphocytes have played a central role in the development of immunogenetics. MHC molecules are important antigens on lymphocyte surfaces. When a mouse is immunized with lymph ...
Induction of inhibitory central nervous system-derived and
... dendritic cell subtype. Both granulocyte-macrophage colony-stimulating factor and chemokine (C–C motif) ligand 2 were previously suggested to recruit ‘inflammatory’ monocyte-derived dendritic cells to the central nervous system during experimental autoimmune encephalomyelitis. We show that intra-cer ...
... dendritic cell subtype. Both granulocyte-macrophage colony-stimulating factor and chemokine (C–C motif) ligand 2 were previously suggested to recruit ‘inflammatory’ monocyte-derived dendritic cells to the central nervous system during experimental autoimmune encephalomyelitis. We show that intra-cer ...
Cytotoxic T-Lymphocyte–Defined Human Minor
... HE USE OF T-CELL–depleted bone marrow (BM) for major histocompatibility complex (MHC)-matched allogeneic BM transplantation (BMT) confers a reduced incidence of graft-versus-host disease (GVHD) but a higher probability of leukemic relapse compared with the use of unmodified BM.1-7 This observation a ...
... HE USE OF T-CELL–depleted bone marrow (BM) for major histocompatibility complex (MHC)-matched allogeneic BM transplantation (BMT) confers a reduced incidence of graft-versus-host disease (GVHD) but a higher probability of leukemic relapse compared with the use of unmodified BM.1-7 This observation a ...
dependent regulation of intestinal immunity and homeostasis
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
transplantation - Shandong University
... • Discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions – H-genes (histocompatibility genes), H-2 gene – Human transplantation antigens (HLA) ----MHC ...
... • Discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions – H-genes (histocompatibility genes), H-2 gene – Human transplantation antigens (HLA) ----MHC ...
Homeostasis and function of T cells in healthy - UvA-DARE
... CD8+ T cells 4. We and others have shown that the presence of large numbers of these CD27ˉCD45RA+ and CD57+CD28ˉ CD8+ T cells, which are largely overlapping populations, is associated with latent cytomegalovirus (CMV) infection 5-8. Therefore CMV infection may contribute to immunosenescence. It is g ...
... CD8+ T cells 4. We and others have shown that the presence of large numbers of these CD27ˉCD45RA+ and CD57+CD28ˉ CD8+ T cells, which are largely overlapping populations, is associated with latent cytomegalovirus (CMV) infection 5-8. Therefore CMV infection may contribute to immunosenescence. It is g ...
Characterization of mesenchymal stem cells under the stimulation of
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
BIOH122
... o Widely distributed throughout the body o Primary lymphatic organs • provide environment for stem cells to divide and mature into B and T lymphocytes Red bone marrow gives rise to mature B cells Thymus is the site where pre-T cells from red marrow ...
... o Widely distributed throughout the body o Primary lymphatic organs • provide environment for stem cells to divide and mature into B and T lymphocytes Red bone marrow gives rise to mature B cells Thymus is the site where pre-T cells from red marrow ...
STACHYS OCYMASTRUM RETICULOENDOTHELIAL SYSTEM PHAGOCYTIC ACTIVITY Research Article
... Recent findings have elucidated the cellular signaling pathways and molecular mechanisms that mediate hormetic responses which typically involve transcription factors such as Nrf-2 and NF-κB. As a result, cells increase their production of cytoprotective and restorative proteins. including growth fa ...
... Recent findings have elucidated the cellular signaling pathways and molecular mechanisms that mediate hormetic responses which typically involve transcription factors such as Nrf-2 and NF-κB. As a result, cells increase their production of cytoprotective and restorative proteins. including growth fa ...
the role of the c5a receptor in host defense against listeria
... Host response to Listeria monocytogenes Considerable work has also gone into the characterization of the host response to Lm. Much of it has focused on the adaptive immune response. A T cell response involving both CD4+ and CD8+ T cells is required for sterilizing immunity during a primary infectio ...
... Host response to Listeria monocytogenes Considerable work has also gone into the characterization of the host response to Lm. Much of it has focused on the adaptive immune response. A T cell response involving both CD4+ and CD8+ T cells is required for sterilizing immunity during a primary infectio ...
The Glutasyn Story
... importantly, cysteine, which gives this molecule its biological activity. GSH is found in almost all the cells of animals and humans. GSH can not be transported into the cells and it must be manufactured within the cells. The only way to do this is by supplying the appropriate building blocks (precu ...
... importantly, cysteine, which gives this molecule its biological activity. GSH is found in almost all the cells of animals and humans. GSH can not be transported into the cells and it must be manufactured within the cells. The only way to do this is by supplying the appropriate building blocks (precu ...
The Schwann cell
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
Mouse and human FcR effector functions
... their (apparent) main function consists of internalizing (endocytosis or phagocytosis), intracellular routing, transcytosis (by polarized cells), or recycling of immunoglobulins. Notably, internalization of immunoglobulins is a common role for all mFcRs; the only exceptions being mFcRn and mTRIM21 t ...
... their (apparent) main function consists of internalizing (endocytosis or phagocytosis), intracellular routing, transcytosis (by polarized cells), or recycling of immunoglobulins. Notably, internalization of immunoglobulins is a common role for all mFcRs; the only exceptions being mFcRn and mTRIM21 t ...
Table 1. CELLULAR COMPONENTS OF THE IMMUNE SYSTEM
... lymphocytes are distinguished by their site of differentiation; T cells mature in the thymus, and B cells in the bone marrow. They are also distinguished by their antigen receptors. Leukocytes that are derived from the myeloid stem cells include the monocytes, and neutrophils, eosinophils and basoph ...
... lymphocytes are distinguished by their site of differentiation; T cells mature in the thymus, and B cells in the bone marrow. They are also distinguished by their antigen receptors. Leukocytes that are derived from the myeloid stem cells include the monocytes, and neutrophils, eosinophils and basoph ...
Differential expression of surface membrane Trypanosoma congolense
... varying increases (and decreases in some cases) in phagocytic and secretory activities as well as surface antigen/receptor expression (Adams & Hamilton 1984, 1987; Nathan 1987). Among more than 30 specific antigens/receptors expressed by resting or activated M are the major histocompartibility (M ...
... varying increases (and decreases in some cases) in phagocytic and secretory activities as well as surface antigen/receptor expression (Adams & Hamilton 1984, 1987; Nathan 1987). Among more than 30 specific antigens/receptors expressed by resting or activated M
Disruption of Dendritic Cell Instruction Virus and Its Avirulent Vaccine
... a result of migration to the lymph nodes or apoptosis (8, 9). Virulent VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essent ...
... a result of migration to the lymph nodes or apoptosis (8, 9). Virulent VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essent ...
ABBREVIATIONS ........................................................................... 3 INTRODUCTION............................................................................. 5
... In addition, nearly all nucleated cells express MHC I, which can present endogenous and nonself molecules. The absence of MHC I on foetal cells found in close contact to the maternal blood in placenta are discussed to be one of the mechanisms for the foetus to avoid recognition by the maternal immu ...
... In addition, nearly all nucleated cells express MHC I, which can present endogenous and nonself molecules. The absence of MHC I on foetal cells found in close contact to the maternal blood in placenta are discussed to be one of the mechanisms for the foetus to avoid recognition by the maternal immu ...
Acute effects of tobacco smoke on human
... noted that other particles, such as allergens or infectious agents, do not lead to selective recruitment of this DC subpopulation into human airways [17, 18]. Therefore, tobacco smoke appears to be a unique stimulus for mDC recruitment. It is remarkable that recruitment of mDCs into the airways coul ...
... noted that other particles, such as allergens or infectious agents, do not lead to selective recruitment of this DC subpopulation into human airways [17, 18]. Therefore, tobacco smoke appears to be a unique stimulus for mDC recruitment. It is remarkable that recruitment of mDCs into the airways coul ...
as a PDF
... sentinels for innate immune detection of pathogenic infections, by recognizing various conserved molecular motifs termed “pathogen-associated molecular patterns” (PAMPs) [3]. PRRs activate production of various cytokines and chemokines, allowing adaptation of the host environment for mounting an ide ...
... sentinels for innate immune detection of pathogenic infections, by recognizing various conserved molecular motifs termed “pathogen-associated molecular patterns” (PAMPs) [3]. PRRs activate production of various cytokines and chemokines, allowing adaptation of the host environment for mounting an ide ...
Evolutionary insights into the origin of innate and adaptive immune
... from protists to humans, must defend themselves from attack by predators. From the time when life began around 3,500 million years ago, all living cells have evolved mechanisms and strategies to optimally defend themselves, while the invaders also need to survive by evading these immune defenses. Th ...
... from protists to humans, must defend themselves from attack by predators. From the time when life began around 3,500 million years ago, all living cells have evolved mechanisms and strategies to optimally defend themselves, while the invaders also need to survive by evading these immune defenses. Th ...
Phagocyte
Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.