Epitope Masking in a Murine Model Independently from Red Cell
... RhD) were shown to inhibit the Ab response to the RhD Ag expressed on the same cell (9), cementing the concept that RBC clearance rather than epitope masking likely explains the AMIS effect with allogeneic erythrocytes. Observations in mice injected with SRBCs unfortunately cannot directly address t ...
... RhD) were shown to inhibit the Ab response to the RhD Ag expressed on the same cell (9), cementing the concept that RBC clearance rather than epitope masking likely explains the AMIS effect with allogeneic erythrocytes. Observations in mice injected with SRBCs unfortunately cannot directly address t ...
Interaction of human mesenchymal stem cells with cells involved in
... of both naive and memory antigen-specific T cells in response to their cognate peptide.15 This immunosuppressive activity of mouse MSC was not dependent on the secretion of inhibitory soluble factors and did not require the presence of CD4+CD25+ regulatory cells.15 However, recently published data d ...
... of both naive and memory antigen-specific T cells in response to their cognate peptide.15 This immunosuppressive activity of mouse MSC was not dependent on the secretion of inhibitory soluble factors and did not require the presence of CD4+CD25+ regulatory cells.15 However, recently published data d ...
Progression of cutaneous squamous cell carcinoma
... HPV protein expression occurs in a minority of SCC In order to control for the potential role for HPV, a random subset of neoplasms was chosen for HPV protein expression analysis by immunohistochemistry (14 immunocompetent patients’ neoplasms, 13 OTRs’ neoplasms). Prevalence of HPV protein expressio ...
... HPV protein expression occurs in a minority of SCC In order to control for the potential role for HPV, a random subset of neoplasms was chosen for HPV protein expression analysis by immunohistochemistry (14 immunocompetent patients’ neoplasms, 13 OTRs’ neoplasms). Prevalence of HPV protein expressio ...
Filip Čulo
... diagnostic methods. One part of studying this area focusing on different autoantibodies in autoimmune diseases was performed in Central Hematology and Immunology Laboratory, St. Antoine Hospital, Paris. The paper describing the antimitochondrial antibodies in hepatitis patients was the very first on ...
... diagnostic methods. One part of studying this area focusing on different autoantibodies in autoimmune diseases was performed in Central Hematology and Immunology Laboratory, St. Antoine Hospital, Paris. The paper describing the antimitochondrial antibodies in hepatitis patients was the very first on ...
Blood Physiology
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: 1. It contains many nonspecific lipase and displays the powerful phagocytosis. ...
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: 1. It contains many nonspecific lipase and displays the powerful phagocytosis. ...
Introduction to AIS
... that the immune system behaves dynamically even in the absence of external antigen • Many continuous versions of this algorithm, mainly due to immunologists ...
... that the immune system behaves dynamically even in the absence of external antigen • Many continuous versions of this algorithm, mainly due to immunologists ...
here - The Kennedy Institute of Rheumatology
... cohorts in inflammatory arthritis, osteoarthritis, cancer and inflammatory bowel disease. Use of patient tissue samples is a crucial component of our discovery science aimed at unravelling complex disease mechanisms to identify new drug targets or approaches for patient stratification. The power of ...
... cohorts in inflammatory arthritis, osteoarthritis, cancer and inflammatory bowel disease. Use of patient tissue samples is a crucial component of our discovery science aimed at unravelling complex disease mechanisms to identify new drug targets or approaches for patient stratification. The power of ...
Medical Veterinary Entomology
... self-damage, whereas the absence of larvae in a heavily symptomatic host probably implies that the larvae abandoned the host a few days before the necropsy examination (Jacquiet et al., 2005). However, these contradictory findings suggest that variations in genetic resistance and susceptibility exis ...
... self-damage, whereas the absence of larvae in a heavily symptomatic host probably implies that the larvae abandoned the host a few days before the necropsy examination (Jacquiet et al., 2005). However, these contradictory findings suggest that variations in genetic resistance and susceptibility exis ...
the influence of chosen microenvironmental factors on toll
... Many recent studies increased awareness that the cellular microenvironment has an important role in establishing proper cell functions. The extracellular matrix is not only meant for structural support but can, through specific receptors, induce signalling cascades, which can influence cell behaviou ...
... Many recent studies increased awareness that the cellular microenvironment has an important role in establishing proper cell functions. The extracellular matrix is not only meant for structural support but can, through specific receptors, induce signalling cascades, which can influence cell behaviou ...
10276005
... responses [9]. Volunteer and epidemiologic studies demonstrate that clinically apparent infection with V. cholerae confers long-term protection of at least 3 years against subsequent disease [10-11]. The best-studied marker of protective immunity is the vibriocidal antibody, a complement-dependent b ...
... responses [9]. Volunteer and epidemiologic studies demonstrate that clinically apparent infection with V. cholerae confers long-term protection of at least 3 years against subsequent disease [10-11]. The best-studied marker of protective immunity is the vibriocidal antibody, a complement-dependent b ...
12146013
... and opposes various environmental assaults to protect the skin which is an important part of the immune system.The delivery of water soluble compounds such as peptides, proteins and vaccines,transdermal route overcome the barrier properties of stratum corneum of the skin. The capillaries, lymphatic, ...
... and opposes various environmental assaults to protect the skin which is an important part of the immune system.The delivery of water soluble compounds such as peptides, proteins and vaccines,transdermal route overcome the barrier properties of stratum corneum of the skin. The capillaries, lymphatic, ...
Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis
... non-acute transforming retroviruses induce cancer in cells of hematopoietic origin, one exception is the murine betaretrovirus MMTV, which causes mammary epithelial cell tumors. MMTV was first characterized in the 1930s as a milk-transmitted agent associated with mammary tumors in mice [2] and thus ...
... non-acute transforming retroviruses induce cancer in cells of hematopoietic origin, one exception is the murine betaretrovirus MMTV, which causes mammary epithelial cell tumors. MMTV was first characterized in the 1930s as a milk-transmitted agent associated with mammary tumors in mice [2] and thus ...
Chapter 4 Dendritic cells secrete and target MHC class II carrying
... abundantly display MHC class II as well as other molecules that are involved in antigen presentation, including MHC class I, co-stimulatory molecules and integrins (10, 11). Exosomes isolated from the culture media of antigen-loaded DC have been demonstrated to elicit both CD4+ and CD8+ T cell respo ...
... abundantly display MHC class II as well as other molecules that are involved in antigen presentation, including MHC class I, co-stimulatory molecules and integrins (10, 11). Exosomes isolated from the culture media of antigen-loaded DC have been demonstrated to elicit both CD4+ and CD8+ T cell respo ...
Tuberculous Meningitis - TB-IPCP
... • Survives in host by elaborating its own immunological niche • Delays initiation of adaptive immunity (delays DC response to CCR7 to lymph node • Adaptive immunity ability to clear organism reduced: – Reduced MHC11 ass Ag presentation – Reduced activation by IGN gamma – Lipoxin 4A generated (anti-i ...
... • Survives in host by elaborating its own immunological niche • Delays initiation of adaptive immunity (delays DC response to CCR7 to lymph node • Adaptive immunity ability to clear organism reduced: – Reduced MHC11 ass Ag presentation – Reduced activation by IGN gamma – Lipoxin 4A generated (anti-i ...
ThaoSpr2013
... (see Fig. 1). The biological role of normal mucin is to lubricate, hydrate, carry out cell signaling and cell protection from pathogen invasions. Tumor cells also produce a version of mucin protein. The tumor MUC1 mucin is expressed on cancers of glandular epithelial origins, such as breast, pancrea ...
... (see Fig. 1). The biological role of normal mucin is to lubricate, hydrate, carry out cell signaling and cell protection from pathogen invasions. Tumor cells also produce a version of mucin protein. The tumor MUC1 mucin is expressed on cancers of glandular epithelial origins, such as breast, pancrea ...
Inflammation and cancer: interweaving microRNA, free radical
... the connection between inflammation and cancer is rapidly improving. Whether an inflammatory immune response is pro- or antitumorigenic is a delicate balance between the adaptive and innate immune system (Figure 1). A healthy and regulated adaptive immune response is regarded as anti-tumorigenic, wh ...
... the connection between inflammation and cancer is rapidly improving. Whether an inflammatory immune response is pro- or antitumorigenic is a delicate balance between the adaptive and innate immune system (Figure 1). A healthy and regulated adaptive immune response is regarded as anti-tumorigenic, wh ...
Neonatal Chlamydial Infection Induces Mixed T-Cell
... features of allergic asthma including airway eosinophil accumulation, mucus cell hyperplasia/metaplasia, and airway hyperresponsiveness (AHR) (3, 4). The mechanisms underlying the development of aberrant Th2 responses in the airways are unknown but may involve a reduction in microbial exposure and l ...
... features of allergic asthma including airway eosinophil accumulation, mucus cell hyperplasia/metaplasia, and airway hyperresponsiveness (AHR) (3, 4). The mechanisms underlying the development of aberrant Th2 responses in the airways are unknown but may involve a reduction in microbial exposure and l ...
Immunologic Aspects of Hypoplastic Myelodysplastic Syndrome
... overexpressed in MDS.28 TRAIL, usually not present in healthy marrows, induces apoptosis by activating agonistic receptors 1 and 2 and decoy receptors 3 and 4.9 In MDS, TRAIL preferentially targets abnormal clonal cells with aberrant chromosomes, inducing apoptosis.28 The expression of TRAIL agonist ...
... overexpressed in MDS.28 TRAIL, usually not present in healthy marrows, induces apoptosis by activating agonistic receptors 1 and 2 and decoy receptors 3 and 4.9 In MDS, TRAIL preferentially targets abnormal clonal cells with aberrant chromosomes, inducing apoptosis.28 The expression of TRAIL agonist ...
full text pdf
... occurs at sites of inflammation, infection, or injury. In addition, large amounts of ATP are readily released into the extracellular space from damaged cells at such sites. Thus, it is assumed that the ATP/P2X7 receptor pathway regulates the inflammatory response under acidic extracellular condition ...
... occurs at sites of inflammation, infection, or injury. In addition, large amounts of ATP are readily released into the extracellular space from damaged cells at such sites. Thus, it is assumed that the ATP/P2X7 receptor pathway regulates the inflammatory response under acidic extracellular condition ...
WAPT - Wits University
... With respect to the complement system: - List the proteins which make up the system and their functions - Describe the activation of the system in the context of the classical and alternate pathways Describe the processes that make up the inflammatory response with reference to - the cells invol ...
... With respect to the complement system: - List the proteins which make up the system and their functions - Describe the activation of the system in the context of the classical and alternate pathways Describe the processes that make up the inflammatory response with reference to - the cells invol ...
Probiotics Applications in Autoimmune Diseases
... understand the mechanism by which gut microflora interacts with the epithelial mucosa lining up the intestinal tract. Over the last decade, there have been growing interests in studying the mechanism by which enterocytes interact with gut microflora. The epithelial mucosa is inhabited by significant ...
... understand the mechanism by which gut microflora interacts with the epithelial mucosa lining up the intestinal tract. Over the last decade, there have been growing interests in studying the mechanism by which enterocytes interact with gut microflora. The epithelial mucosa is inhabited by significant ...
Copyright Information of the Article Published Online TITLE
... death worldwide[1]. The projected global burden of CRC is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030[2]. The combined use of irinotecan, oxaliplatin and oral form of 5fluorouracil (5-FU) has shown significant therapeutic efficacy in human CRC. In ad ...
... death worldwide[1]. The projected global burden of CRC is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030[2]. The combined use of irinotecan, oxaliplatin and oral form of 5fluorouracil (5-FU) has shown significant therapeutic efficacy in human CRC. In ad ...
cancer
... resulting in subsequent mutations. Some of the chemicals that cause cancer are byproducts of an industrialized society, such as asbestos, vinyl chloride, and benzene; hydrocarbons in cigarette smoke and fireplace soot; and substances in dyes and pesticides. Natural carcinogens include aflatoxin, pro ...
... resulting in subsequent mutations. Some of the chemicals that cause cancer are byproducts of an industrialized society, such as asbestos, vinyl chloride, and benzene; hydrocarbons in cigarette smoke and fireplace soot; and substances in dyes and pesticides. Natural carcinogens include aflatoxin, pro ...
SITC 2015 Special Edition Immune Monitor – November 2015
... genetic or phenotypic groups in patients. In the case of Precision Immunology, this is based on immunological phenotypes, which are of particular interest for the application of new immunologicallybased cancer therapies. For example, recent approvals have illustrated that PD-L1 expression at tumor s ...
... genetic or phenotypic groups in patients. In the case of Precision Immunology, this is based on immunological phenotypes, which are of particular interest for the application of new immunologicallybased cancer therapies. For example, recent approvals have illustrated that PD-L1 expression at tumor s ...
An Evaluation of the Efficiency of Lymphocytic Choriomeningitis Virus- In Vivo by
... 4.6 Applications of our model to immunotherapy........................................................ 81 4.7 The role of apoptosis in generating immunity ........................................................ 83 ...
... 4.6 Applications of our model to immunotherapy........................................................ 81 4.7 The role of apoptosis in generating immunity ........................................................ 83 ...