Recent Advances in Understanding Immunity
... research group has investigated the role of some structural and metabolic components in bacterial pathogenesis using the disrupting gene approach to obtain new attenuated vaccine strains. Additionally, we have dissected some of the pathways involved in Brucella recognition by innate immune receptors ...
... research group has investigated the role of some structural and metabolic components in bacterial pathogenesis using the disrupting gene approach to obtain new attenuated vaccine strains. Additionally, we have dissected some of the pathways involved in Brucella recognition by innate immune receptors ...
Extracellular Matrix Composition Reveals Complex and Dynamic
... gland’s unique development across its several distinct functional states, depending on reproductive state. Unlike most organs, which develop to morphological maturity during embryogenesis, the majority of mammary ductal morphogenesis occurs with the onset of ovarian function. Further, with each estr ...
... gland’s unique development across its several distinct functional states, depending on reproductive state. Unlike most organs, which develop to morphological maturity during embryogenesis, the majority of mammary ductal morphogenesis occurs with the onset of ovarian function. Further, with each estr ...
Deep Insight Section Macrophages in human cancer: Current and future aspects
... profiles. It is yet unclear whether similarities between certain tumor-associated macrophages and the M1-like or M2-like macrophages are due to the different types of tumors that were investigated, as proposed by some researchers, or whether there might be a "M1-like/M2like switch" during tumor prog ...
... profiles. It is yet unclear whether similarities between certain tumor-associated macrophages and the M1-like or M2-like macrophages are due to the different types of tumors that were investigated, as proposed by some researchers, or whether there might be a "M1-like/M2like switch" during tumor prog ...
New Title - AIS IGCSE Science
... attack bacteria. There are many types of white blood cells, and they perform a wide variety of important functions. Some protect the body by acting as phagocytes, or “eating cells,” that engulf and digest bacteria and other disease-causing microorganisms. Some white blood cells react to foreign subs ...
... attack bacteria. There are many types of white blood cells, and they perform a wide variety of important functions. Some protect the body by acting as phagocytes, or “eating cells,” that engulf and digest bacteria and other disease-causing microorganisms. Some white blood cells react to foreign subs ...
Phylogenetic evidence for adaptive evolution of dengue viruses in
... mutation subject only to genetic drift, resulting in an ω ratio 1. Most previous analyses of ω ratios have relied on multiple pairwise comparisons of each sequence in a data set. Although informative, such methods are hampered by a lack of independence, do not consider that individual codons may d ...
... mutation subject only to genetic drift, resulting in an ω ratio 1. Most previous analyses of ω ratios have relied on multiple pairwise comparisons of each sequence in a data set. Although informative, such methods are hampered by a lack of independence, do not consider that individual codons may d ...
Recombinant Vaccinia Viruses as Live Vaccines . .. 362
... variety of foreign antigens, particularly eukaryotic viral glycoproteins, have been used to immunise experimental animals. Following dermal inoculation a local vaccinial lesion appears, which heals in 2-3 weeks. During this time no viraemia has been found (Smith et al. 1983 a) and the virus does not ...
... variety of foreign antigens, particularly eukaryotic viral glycoproteins, have been used to immunise experimental animals. Following dermal inoculation a local vaccinial lesion appears, which heals in 2-3 weeks. During this time no viraemia has been found (Smith et al. 1983 a) and the virus does not ...
PDF - Paragon Bioservices
... production of cytokines and chemokines that direct inflammation and promote the induction of adaptive immunity. Accordingly, exposure to flagellin, either by natural infection or immunization, results in high levels of serum anti-flagellin antibodies and robust CD4+ T-cell responses [4,15,16]. The powe ...
... production of cytokines and chemokines that direct inflammation and promote the induction of adaptive immunity. Accordingly, exposure to flagellin, either by natural infection or immunization, results in high levels of serum anti-flagellin antibodies and robust CD4+ T-cell responses [4,15,16]. The powe ...
OPEN ACCESS Current Opinion in Plant Biology review paper
... exist with distinct and diverse functions, including small ubiquitin-like modifier (SUMO). Ubiquitin-like proteins are characterized as such by sharing a similar structure and enzymatic mechanism of conjugation with ubiquitin. Proteomic analyses of SUMO-modified proteins in Arabidopsis have identifi ...
... exist with distinct and diverse functions, including small ubiquitin-like modifier (SUMO). Ubiquitin-like proteins are characterized as such by sharing a similar structure and enzymatic mechanism of conjugation with ubiquitin. Proteomic analyses of SUMO-modified proteins in Arabidopsis have identifi ...
Full-Text PDF
... immune-compromised models lacking mature FDCs reveal deficits in peripheral prion pathogenesis. As such a positive relationship has been firmly established between the immune-competence of the host and ability to support prion pathogenesis. As with most infectious agents, typical pathogenesis occurs ...
... immune-compromised models lacking mature FDCs reveal deficits in peripheral prion pathogenesis. As such a positive relationship has been firmly established between the immune-competence of the host and ability to support prion pathogenesis. As with most infectious agents, typical pathogenesis occurs ...
Copyright Information of the Article Published Online TITLE New
... triphosphate (GTP) to produce cyclic 3′, 5′ guanosine monophosphate (cGMP). The protection of cGMP-dependent protein kinase (PKG) activated by cGMP results in the activation of PI3K and the phosphorylation of p38 MAPK, leading to the activation of vacuolar H+-ATPases (V-ATPases), which lead to the e ...
... triphosphate (GTP) to produce cyclic 3′, 5′ guanosine monophosphate (cGMP). The protection of cGMP-dependent protein kinase (PKG) activated by cGMP results in the activation of PI3K and the phosphorylation of p38 MAPK, leading to the activation of vacuolar H+-ATPases (V-ATPases), which lead to the e ...
Dryness - skyn ICELAND
... and perfected by the CNS and endocrine system (Figure 1). This primordial HPA in the integument was composed of CRF, POMC, and steroid signaling pathways that act in concert with the innate immune system in order to create the optimal response against pathogens and other stressors and protect intern ...
... and perfected by the CNS and endocrine system (Figure 1). This primordial HPA in the integument was composed of CRF, POMC, and steroid signaling pathways that act in concert with the innate immune system in order to create the optimal response against pathogens and other stressors and protect intern ...
2011 RSV - Emory Department of Pediatrics
... variability and physical and pathological manifestations of the disease without identified organisms • 1955: Walter Reed researchers isolated a virus from the nasal secretions of young chimpanzees named chimpanzee coryza agent (CCA) • 1956 Robert Chanock isolated CCA from 2 infants with characte ...
... variability and physical and pathological manifestations of the disease without identified organisms • 1955: Walter Reed researchers isolated a virus from the nasal secretions of young chimpanzees named chimpanzee coryza agent (CCA) • 1956 Robert Chanock isolated CCA from 2 infants with characte ...
Gene Therapy to Treat Cardiovascular Disease
... concentration, among others.31–34 The best cocktail of permeability and vasodilatory agents to increase uptake of the gene therapy vector is currently unknown. An advantage of intracoronary perfusion is the ability to deliver more globally across the myocardium than is achievable with intramyocardia ...
... concentration, among others.31–34 The best cocktail of permeability and vasodilatory agents to increase uptake of the gene therapy vector is currently unknown. An advantage of intracoronary perfusion is the ability to deliver more globally across the myocardium than is achievable with intramyocardia ...
Cervicovaginal microbiome dysbiosis is associated with proteome
... inflammation and other changes to the mucosal barrier are thought to play important roles but human data are scarce. We compared the human cervicovaginal proteome by mass-spectrometry of 50 Rwandan female sex workers who had previously been clustered into four VMB groups using a 16S phylogenetic mic ...
... inflammation and other changes to the mucosal barrier are thought to play important roles but human data are scarce. We compared the human cervicovaginal proteome by mass-spectrometry of 50 Rwandan female sex workers who had previously been clustered into four VMB groups using a 16S phylogenetic mic ...
Full-Text PDF
... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
CD161 defines the subset of FoxP3+ T cells capable of producing
... Figure 2. CD1611FoxP31CD41 T cells are suppressive and anergic in vitro. Treg were sorted by flow cytometry. (A) Sorting strategy for subpopulations of Treg defined by CD25hiCD127lo, and CD161 expression (a, CD161–; b, CD1611), with representative sort purity of $90% purity for both subsets for FoxP ...
... Figure 2. CD1611FoxP31CD41 T cells are suppressive and anergic in vitro. Treg were sorted by flow cytometry. (A) Sorting strategy for subpopulations of Treg defined by CD25hiCD127lo, and CD161 expression (a, CD161–; b, CD1611), with representative sort purity of $90% purity for both subsets for FoxP ...
production and quality control of monoclonal antibodies
... to establish that blood borne viruses such as HIV, hepatitis B and hepatitis C were not in the process of incubation. If these conditions can not be completely fulfilled, this should be justified and it should be demonstrated that the cell bank system is devoid of any relevant viruses (e.g. HIV 1/2, ...
... to establish that blood borne viruses such as HIV, hepatitis B and hepatitis C were not in the process of incubation. If these conditions can not be completely fulfilled, this should be justified and it should be demonstrated that the cell bank system is devoid of any relevant viruses (e.g. HIV 1/2, ...
R e v i s i ó n
... fight against them. In order to do so, lymphocytes need to recirculate constantly through different secondary lymphoid organs and leukocytes in general need to adhere and go through anatomic barriers including the endothelium and ECM to reach the inflammatory foci (2). Thus, leukocytes, that circula ...
... fight against them. In order to do so, lymphocytes need to recirculate constantly through different secondary lymphoid organs and leukocytes in general need to adhere and go through anatomic barriers including the endothelium and ECM to reach the inflammatory foci (2). Thus, leukocytes, that circula ...
Microbiology
... Coley’s toxin (gram-negative bacteria) stimulates TNF Vaccines used against ...
... Coley’s toxin (gram-negative bacteria) stimulates TNF Vaccines used against ...
Neutrophil function in the healing wound: adding insult to injury?
... produce reactive oxygen intermediates, which help combat infections. The wound bed becomes hypoxic shortly after closure. Neutrophils could be compromised in their generation of oxygen intermediates during this time if the wound was rapidly closed, diminishing their effectiveness against bacterial i ...
... produce reactive oxygen intermediates, which help combat infections. The wound bed becomes hypoxic shortly after closure. Neutrophils could be compromised in their generation of oxygen intermediates during this time if the wound was rapidly closed, diminishing their effectiveness against bacterial i ...
Contraception - University of Missouri Animal Sciences
... •MI=the administration of a vaccine that enters body via mucosal membrane lining body cavities (gastrointestinal & urogenital tract, nasal passages) •Mucosal M-cells bring the immunogen from vaccine in contact with mucosal immune cells (lymphocytes); these lymphocytes produce antibodies (secretory I ...
... •MI=the administration of a vaccine that enters body via mucosal membrane lining body cavities (gastrointestinal & urogenital tract, nasal passages) •Mucosal M-cells bring the immunogen from vaccine in contact with mucosal immune cells (lymphocytes); these lymphocytes produce antibodies (secretory I ...
Impaired expression of Toll-like receptor 2 in nontuberculous mycobacterial lung disease Y.J. Ryu*
... develop NTM lung disease are likely to have ...
... develop NTM lung disease are likely to have ...
Introduction to the Skin
... Necrolytic migratory erythema – often occurs in groin area. It is a red, blistering rash that spreads across the skin. It is strongly associated with glucagonoma, but also liver disease + intestinal malabsorption. Common warts – common skin disease caused by HPV which causes rapid growth of cells on ...
... Necrolytic migratory erythema – often occurs in groin area. It is a red, blistering rash that spreads across the skin. It is strongly associated with glucagonoma, but also liver disease + intestinal malabsorption. Common warts – common skin disease caused by HPV which causes rapid growth of cells on ...