Allo-HLA reactivity of virus-specific memory T cells is common
... After informed consent was given in accordance with the Declaration of Helsinki, peripheral blood (PB) was obtained from different persons. All experiments were approved by the Leiden University Medical Center ethics committee. Mononuclear cells (MNCs) were isolated by Ficoll-Isopaque separation and ...
... After informed consent was given in accordance with the Declaration of Helsinki, peripheral blood (PB) was obtained from different persons. All experiments were approved by the Leiden University Medical Center ethics committee. Mononuclear cells (MNCs) were isolated by Ficoll-Isopaque separation and ...
PDF - Theranostics
... most successful of the current generation of clinical vectors, with highly promising Phase I and Phase II clinical data being reported in melanoma[42] and HCC[33], and with systemic delivery demonstrated in the clinic[32]; (iii) vaccinia’s large genome means that a variety of different oncolytic con ...
... most successful of the current generation of clinical vectors, with highly promising Phase I and Phase II clinical data being reported in melanoma[42] and HCC[33], and with systemic delivery demonstrated in the clinic[32]; (iii) vaccinia’s large genome means that a variety of different oncolytic con ...
Fungal Keratitis
... • ii. Injury by animal tail is another mode of infection. • iii. Patients who are immunosuppressed systemically or locally such as patients suffering from dry eye, herpetic keratitis, bullous keratopathy or postoperative cases of keratoplasty. ...
... • ii. Injury by animal tail is another mode of infection. • iii. Patients who are immunosuppressed systemically or locally such as patients suffering from dry eye, herpetic keratitis, bullous keratopathy or postoperative cases of keratoplasty. ...
A crucial role for B cells in neuroinvasive scrapie
... the role of T cells, we used mice with targeted disruption of the genes encoding CD4 (ref. 9), CD8 (ref. 10), b2-microglobulin11 or perforin12. Selective ablation of B lymphocytes was studied in mMT mice13, which have a targeted disruption of the transmembrane exon of the immunoglobulin m-chain gene ...
... the role of T cells, we used mice with targeted disruption of the genes encoding CD4 (ref. 9), CD8 (ref. 10), b2-microglobulin11 or perforin12. Selective ablation of B lymphocytes was studied in mMT mice13, which have a targeted disruption of the transmembrane exon of the immunoglobulin m-chain gene ...
Deletion of the Zinc-Binding Motif of CD13
... tubules. CD13/APN exemplifies a group of cell-surface peptidases that have been found on discrete subsets of hematopoietic cells. While CD13/APN expression is restricted to myeloid progenitors and mature monocytes, macrophages, and granulocytes within the hematopoietic system, other membrane-bound p ...
... tubules. CD13/APN exemplifies a group of cell-surface peptidases that have been found on discrete subsets of hematopoietic cells. While CD13/APN expression is restricted to myeloid progenitors and mature monocytes, macrophages, and granulocytes within the hematopoietic system, other membrane-bound p ...
Basophils, IgE, and Autoantibody-Mediated Kidney
... plays a crucial role in this recruitment process (50). Because IL-3 is produced primarily by activated T cells (13), Ag-induced T cell activation within local lymphoid tissues seems to be the primary underlying factor. In addition, recruitment is transient, only found between days 3 and 4 post-Ag ch ...
... plays a crucial role in this recruitment process (50). Because IL-3 is produced primarily by activated T cells (13), Ag-induced T cell activation within local lymphoid tissues seems to be the primary underlying factor. In addition, recruitment is transient, only found between days 3 and 4 post-Ag ch ...
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific
... adaptedagainst for this figure. adjuvant. By usage of antibodies directed surface molecules selectively expressed on one DC subset (here differentially colored in red, green, and blue), the type of immune response can be further regulated due to different functions of the DC subsets. Templates from ...
... adaptedagainst for this figure. adjuvant. By usage of antibodies directed surface molecules selectively expressed on one DC subset (here differentially colored in red, green, and blue), the type of immune response can be further regulated due to different functions of the DC subsets. Templates from ...
Initiation and Regulation of Type 2 Immunity and Inflammation at
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
NIH Executive Summary of Stem Cell Issues
... to explore human pluripotent stem cells from embryos and fetal tissue, a flurry of new information was emerging about a class of stem cells that have been in clinical use for years—so-called adult stem cells. An adult stem cell is an undifferentiated cell that is found in a differentiated (specializ ...
... to explore human pluripotent stem cells from embryos and fetal tissue, a flurry of new information was emerging about a class of stem cells that have been in clinical use for years—so-called adult stem cells. An adult stem cell is an undifferentiated cell that is found in a differentiated (specializ ...
Virus-Bacteria Interactions: An Emerging Topic in Human Infection
... facilitating the disease process [8]. Under in vitro conditions, viruses may be able to directly bind to their target cell type and undergo replication with ease. However, this strategy may prove problematic in the gastrointestinal tract where a large number of bacteria occupy tissue surfaces, direc ...
... facilitating the disease process [8]. Under in vitro conditions, viruses may be able to directly bind to their target cell type and undergo replication with ease. However, this strategy may prove problematic in the gastrointestinal tract where a large number of bacteria occupy tissue surfaces, direc ...
UNIVERSIDAD DE MURCIA FACULTAD DE BIOLOGÍA
... There is considerable interaction between Ly and phagocytes (Male and Roitt, 1996). For example, some phagocytes capture and degrade antigens and present them to T cells attached to the surface major histocompatibility complex (MHC) in a form suitable for them to recognize. This process is called an ...
... There is considerable interaction between Ly and phagocytes (Male and Roitt, 1996). For example, some phagocytes capture and degrade antigens and present them to T cells attached to the surface major histocompatibility complex (MHC) in a form suitable for them to recognize. This process is called an ...
Lymphatic System People often talk about swollen glands but what
... system that carries out your immune responses - fights infection and protects you from bacteria and viruses. Your lymphatic system is vital to your health. Lymph nodes are oval structures located along the length of lymphatic vessels. They range in size from 1 to 25 mm in length. Lymph nodes are sca ...
... system that carries out your immune responses - fights infection and protects you from bacteria and viruses. Your lymphatic system is vital to your health. Lymph nodes are oval structures located along the length of lymphatic vessels. They range in size from 1 to 25 mm in length. Lymph nodes are sca ...
humanized antibodies - Assets - Cambridge
... cell-mediated lysis-triggering effector cascades whereas IgG2 and IgG4 are preferred for target neutralization. In fact, most of the humanized antibodies on the market are of the IgG1 subtype (Table 1.1). In some cases, the effector functions of the constant regions are removed by modifying the Fc s ...
... cell-mediated lysis-triggering effector cascades whereas IgG2 and IgG4 are preferred for target neutralization. In fact, most of the humanized antibodies on the market are of the IgG1 subtype (Table 1.1). In some cases, the effector functions of the constant regions are removed by modifying the Fc s ...
The Thymus Gland
... two lobes generally differ in size; they are occasionally united, so as to form a single mass; and sometimes separated by an intermediate lobe. The thymus is of a pinkish-gray color, soft, and lobulated on its surfaces. It is about 5 cm in length, 4 cm in breadth below, and about 6 mm in thickness. ...
... two lobes generally differ in size; they are occasionally united, so as to form a single mass; and sometimes separated by an intermediate lobe. The thymus is of a pinkish-gray color, soft, and lobulated on its surfaces. It is about 5 cm in length, 4 cm in breadth below, and about 6 mm in thickness. ...
Nerve activates contraction
... Human cells have many surface proteins Our immune cells do not attack our own proteins Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
... Human cells have many surface proteins Our immune cells do not attack our own proteins Our cells in another person’s body can trigger an immune response because they are foreign Restricts donors for transplants Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
Lung interstitial macrophages alter dendritic Research article
... results in immunological tolerance. Indeed, a subset of pulmonary myeloid DCs is able to produce the tolerogenic cytokine IL-10 after innocuous antigen uptake and, therefore, stimulate the development of antigen-specific Tregs (1, 2). Similarly, lung plasmacytoid DCs protect against aberrant immune ...
... results in immunological tolerance. Indeed, a subset of pulmonary myeloid DCs is able to produce the tolerogenic cytokine IL-10 after innocuous antigen uptake and, therefore, stimulate the development of antigen-specific Tregs (1, 2). Similarly, lung plasmacytoid DCs protect against aberrant immune ...
The New England Journal of Medicine Volume 336 - hem
... cases attributable to drug use was only 15 percent (and chloramphenicol was not a risk factor).58 Although a putative inciting antigen can be implicated on the basis of a history of exposure, drug-induced hematopoietic failure is difficult to study, because it is idiosyncratic. Animal models do not ...
... cases attributable to drug use was only 15 percent (and chloramphenicol was not a risk factor).58 Although a putative inciting antigen can be implicated on the basis of a history of exposure, drug-induced hematopoietic failure is difficult to study, because it is idiosyncratic. Animal models do not ...
Classification: Biological Sciences, Plant Biology. The receptor
... Plants employ receptor kinases (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to sense pathogen-associated molecular patterns (PAMPs) typical of whole classes of microbes. After ligand perception, many leucine-rich repeat (LRR)-containing PRRs interact with the LRR-R ...
... Plants employ receptor kinases (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to sense pathogen-associated molecular patterns (PAMPs) typical of whole classes of microbes. After ligand perception, many leucine-rich repeat (LRR)-containing PRRs interact with the LRR-R ...
department of molecular biology and immunology
... and diseases caused by known pathogens have reestablished themselves. Many of these infections result in life-threatening diseases. To complicate matters, many of these infectious agents have developed resistance to antibiotics routinely used in treatments. Thus, prevention and treatment of these in ...
... and diseases caused by known pathogens have reestablished themselves. Many of these infections result in life-threatening diseases. To complicate matters, many of these infectious agents have developed resistance to antibiotics routinely used in treatments. Thus, prevention and treatment of these in ...
Regenerative Medicine Annual Report
... chronic and/or life-threatening diseases are palliative. Others delay disease progression and the onset of complications associated with the underlying illness. Very few therapies in use today are capable of curing or significantly changing the course of disease. The result is a healthcare system bu ...
... chronic and/or life-threatening diseases are palliative. Others delay disease progression and the onset of complications associated with the underlying illness. Very few therapies in use today are capable of curing or significantly changing the course of disease. The result is a healthcare system bu ...
biomaterials ent 311/4
... Immune response evaluation is not a component of the standards currently in vivo tissue compatibility assessment. However, ASTM, ISO and FDA currently have working groups developing guidance documents for immune response evaluation. Synthetic material are not generally immunogenic However, immune re ...
... Immune response evaluation is not a component of the standards currently in vivo tissue compatibility assessment. However, ASTM, ISO and FDA currently have working groups developing guidance documents for immune response evaluation. Synthetic material are not generally immunogenic However, immune re ...
lymphatic system
... Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate t ...
... Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate t ...
lymphatic system
... a.Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate ...
... a.Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate ...
