Doctoral thesis from the Department of Immunology,
... According to the WHO, the interaction between the twin pandemics of human immunodeficiency virus (HIV) and tuberculosis (TB) could soon become a "threat to global health security," particularly with the emergence of almost untreatable strains of Mycobacterium tuberculosis. Understanding the mechanis ...
... According to the WHO, the interaction between the twin pandemics of human immunodeficiency virus (HIV) and tuberculosis (TB) could soon become a "threat to global health security," particularly with the emergence of almost untreatable strains of Mycobacterium tuberculosis. Understanding the mechanis ...
Sleeping sickness and the central nervous system* V.W. PENTREATH P.J. BAUGH
... damage, and elevated interleukin-1 (I L-1) induces sleep and fever. Unfortunately, experimental evidence is not yet available to determine whether the increases in mANA are associated with increased release of these substances into the extracellular spaces and CSF. In a study of the CSF of late-stag ...
... damage, and elevated interleukin-1 (I L-1) induces sleep and fever. Unfortunately, experimental evidence is not yet available to determine whether the increases in mANA are associated with increased release of these substances into the extracellular spaces and CSF. In a study of the CSF of late-stag ...
Analysis of the Original Antigenic Sin Antibody Response to the
... membrane protein (MOMP) of the priming and challenge C. trachomatis serovars and that the recall response to the original serovar is correlated with the extent of sequence sharing between the two serovars [16]. They also demonstrated that OAS antibody responses are associated with the development of ...
... membrane protein (MOMP) of the priming and challenge C. trachomatis serovars and that the recall response to the original serovar is correlated with the extent of sequence sharing between the two serovars [16]. They also demonstrated that OAS antibody responses are associated with the development of ...
Salwa Hindawi MSc, MRCPath, CTM Medical Director of Blood
... patients developed anti-K while two (22.2%) had non-specific antibody. One patient developed anti-D (11.1%) and anti-E (11.1%). Two had anti-D (11.1%) and anti-C while the other one (11.1%) developed anti-E and anti-K. ...
... patients developed anti-K while two (22.2%) had non-specific antibody. One patient developed anti-D (11.1%) and anti-E (11.1%). Two had anti-D (11.1%) and anti-C while the other one (11.1%) developed anti-E and anti-K. ...
y 7 - DocCheck
... the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the ...
... the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the ...
Biological Activities of Complement
... is formed in the presence of a small-molecular-weight proteinase, factor D. This complex, itself containing component C3, then activates further component C3 in a similar fashion to the classical pathway, the catalytic component being factor B. If the fragment C3b produced is deposited on a surface, ...
... is formed in the presence of a small-molecular-weight proteinase, factor D. This complex, itself containing component C3, then activates further component C3 in a similar fashion to the classical pathway, the catalytic component being factor B. If the fragment C3b produced is deposited on a surface, ...
Thesis - KI Open Archive
... differentiated the non-responders from the responders before DSC intervention. Although the expression of HLA-DR decreased over time in the CD4+ compartment of the responders, the same group had increasing expression of CCR9 in several cell subsets, including CD4+ T cells, B cells, and monocytes. Th ...
... differentiated the non-responders from the responders before DSC intervention. Although the expression of HLA-DR decreased over time in the CD4+ compartment of the responders, the same group had increasing expression of CCR9 in several cell subsets, including CD4+ T cells, B cells, and monocytes. Th ...
acute phase response
... structurally related peptides: interleukin-la (IL-1a); interleukin-lp (IL-β) receptor antagonist for IL1. The two known IL-1 forms (a and P) - the products of different genes. They differ in their amino acid sequence, but have a similar three-dimensional structure. Interleukins interact with the sam ...
... structurally related peptides: interleukin-la (IL-1a); interleukin-lp (IL-β) receptor antagonist for IL1. The two known IL-1 forms (a and P) - the products of different genes. They differ in their amino acid sequence, but have a similar three-dimensional structure. Interleukins interact with the sam ...
Plasma Membrane Profiling Defines an Expanded Class of
... cell surface expression of ligands for NK cell activating receptors. The HCMV glycoprotein UL141 plays a major role in such protection via interaction with TRAIL death receptors, as well as CD155 (PVR, necl5) and CD112 (PVRL2, nectin-2) which are both ligands for the ubiquitous NK activating recepto ...
... cell surface expression of ligands for NK cell activating receptors. The HCMV glycoprotein UL141 plays a major role in such protection via interaction with TRAIL death receptors, as well as CD155 (PVR, necl5) and CD112 (PVRL2, nectin-2) which are both ligands for the ubiquitous NK activating recepto ...
Abstract Introduction: This article summaries key exercise
... experience acute physiological stress reflected by muscle microtrauma, oxidative stress, and systemic inflammation (1-3). Concomitant with these stressors are widespread perturbations in innate and adaptive immunity including decreases in natural killer (NK) cell cytotoxic activity, granulocyte resp ...
... experience acute physiological stress reflected by muscle microtrauma, oxidative stress, and systemic inflammation (1-3). Concomitant with these stressors are widespread perturbations in innate and adaptive immunity including decreases in natural killer (NK) cell cytotoxic activity, granulocyte resp ...
Introduction to Diagnostic and Therapeutic Monoclonal Antibodies
... purer, less problematic products. Antibody-related products may find utility in nuclear pharmacy because targets of the original products are useful not only for general medical reasons, but also imaging and therapeutic uses. The most straight-forward scenario is that of a target (epitope) on a huma ...
... purer, less problematic products. Antibody-related products may find utility in nuclear pharmacy because targets of the original products are useful not only for general medical reasons, but also imaging and therapeutic uses. The most straight-forward scenario is that of a target (epitope) on a huma ...
Prospects of new vaccines for resurgent and emergent diseases
... British Medical Bulletin 1998,54 (No 3) 557-568 ...
... British Medical Bulletin 1998,54 (No 3) 557-568 ...
GAS6 is a key homeostatic immunological regulator of host
... against the oral biofilm results in periodontal diseases, and can facilitate intravascular dissemination of microorganisms throughout the body that is associated with adverse systemic conditions (6). Therefore, understanding the immune mechanisms engaged by the oral mucosal epithelium to maintain im ...
... against the oral biofilm results in periodontal diseases, and can facilitate intravascular dissemination of microorganisms throughout the body that is associated with adverse systemic conditions (6). Therefore, understanding the immune mechanisms engaged by the oral mucosal epithelium to maintain im ...
Xenopus in the Amphibian Ancestral Organization of the MHC
... genes or they arose in the tetrapod lineage after its divergence from bony fish. The Xenopus sequences were used in a phylogenetic analysis, and the trees solidify the hypothesis that the DM class II genes are as old as classical class II␣ and class II (Ref. 42 and Fig. 1). Thus, we think it is mor ...
... genes or they arose in the tetrapod lineage after its divergence from bony fish. The Xenopus sequences were used in a phylogenetic analysis, and the trees solidify the hypothesis that the DM class II genes are as old as classical class II␣ and class II (Ref. 42 and Fig. 1). Thus, we think it is mor ...
Gut Bacteria Metabolism Impacts Immune Recovery in HIV
... gut environment. However, our findings provide also evidences suggesting the contribution of gut bacteria to ART-mediated immune recovery. Changes in the gut ecosystem in HIV-infected patients undergoing ART may thus be both a consequence and a potential cause of the recovery of mucosal and systemic ...
... gut environment. However, our findings provide also evidences suggesting the contribution of gut bacteria to ART-mediated immune recovery. Changes in the gut ecosystem in HIV-infected patients undergoing ART may thus be both a consequence and a potential cause of the recovery of mucosal and systemic ...
The parasitic wasp Cotesia congregata uses multiple mechanisms
... would likely result in the death of the emerging wasp. To test whether this defensive strike is suppressed during emergence, we used von Frey filaments (Stoelting, Wood Dale, Illinois, USA) to deliver a known force to the skin, using a method modified from McMackin et al. (2016). At the first sign o ...
... would likely result in the death of the emerging wasp. To test whether this defensive strike is suppressed during emergence, we used von Frey filaments (Stoelting, Wood Dale, Illinois, USA) to deliver a known force to the skin, using a method modified from McMackin et al. (2016). At the first sign o ...
Vascular, glial, and lymphatic immune gateways of the central
... (for skin) or CCL25 and MAdCAM-1 (mucosal cell adhesion molecule −1) (for gut); these ligands are upregulated on the inflamed vascular endothelial cells in the skin or gut microvessels. Trafficking of lymphocytes to selected tissues provides a mechanism for segregating specialized adaptive immune re ...
... (for skin) or CCL25 and MAdCAM-1 (mucosal cell adhesion molecule −1) (for gut); these ligands are upregulated on the inflamed vascular endothelial cells in the skin or gut microvessels. Trafficking of lymphocytes to selected tissues provides a mechanism for segregating specialized adaptive immune re ...
- Salford Royal NHS Foundation Trust
... increase in CD8 cells. ICL patients have higher proportion of activated (HLADR) CD4, but not CD8 T cells. The studies of patients with ICL showed that among CD4 T-cells, naıve CD45RA T-cells are more severely diminished than the memory CD45RO population. Some reports described a high percentage of g ...
... increase in CD8 cells. ICL patients have higher proportion of activated (HLADR) CD4, but not CD8 T cells. The studies of patients with ICL showed that among CD4 T-cells, naıve CD45RA T-cells are more severely diminished than the memory CD45RO population. Some reports described a high percentage of g ...
Chapter 11 INTERLEUKIN-2 IN THE TREATMENT OF` RENAL CELL
... Although the initial trials suggesting a benefit from IL-2 explored its use in combination with LAK cells, a few trials at the NCI suggested that IL-2 alone (without LAK cells) might have activity against cancers in experimental and clinical settings.31Randomized trials33'34 were therefore performed ...
... Although the initial trials suggesting a benefit from IL-2 explored its use in combination with LAK cells, a few trials at the NCI suggested that IL-2 alone (without LAK cells) might have activity against cancers in experimental and clinical settings.31Randomized trials33'34 were therefore performed ...
acute systemic inflammation
... assay [19]. A very sensitive bio-assay for HGF was developed, and this assay did not respond to IL-1, indicating that HGF had to be another cytokine. After cloning of cDNA, HGF was discovered to be identical with a new cytokine named interleukin-6 [20]. In many in vitro and in vivo studies that foll ...
... assay [19]. A very sensitive bio-assay for HGF was developed, and this assay did not respond to IL-1, indicating that HGF had to be another cytokine. After cloning of cDNA, HGF was discovered to be identical with a new cytokine named interleukin-6 [20]. In many in vitro and in vivo studies that foll ...
- Royal College of Surgeons
... proteins that form part of the immune response. And these HLA molecules are involved in the recognition of self and non-self. So as I have described they allow us to survey, if you like, any potential infections that we may have. If we do have an infection then they weren't small fragments of that v ...
... proteins that form part of the immune response. And these HLA molecules are involved in the recognition of self and non-self. So as I have described they allow us to survey, if you like, any potential infections that we may have. If we do have an infection then they weren't small fragments of that v ...
Publications_files/Sabiiti et al review 2012
... factor permitting the attachment of yeast to host cell and subsequent infiltration of, and damage to, the host intracellular environment [44]. In vitro experiments have also provided insight into how the capsule virulence factor promotes the ability of Cryptococcus to cause infection at the lung bar ...
... factor permitting the attachment of yeast to host cell and subsequent infiltration of, and damage to, the host intracellular environment [44]. In vitro experiments have also provided insight into how the capsule virulence factor promotes the ability of Cryptococcus to cause infection at the lung bar ...
Full-Text PDF
... tissue-specific and ubiquitous elements in the promoter [1,2,56]. Amongst these were sites for the specificity protein 1 (Sp1) transcription factor, which are present in many housekeeping genes. Recent findings show that overexpression of Sp1, which is associated with tumorigenesis, can induce RNase ...
... tissue-specific and ubiquitous elements in the promoter [1,2,56]. Amongst these were sites for the specificity protein 1 (Sp1) transcription factor, which are present in many housekeeping genes. Recent findings show that overexpression of Sp1, which is associated with tumorigenesis, can induce RNase ...
among HLA-G, myeloid APCs, and regulatory cells
... HLA-G1 to HLA-G4; and 3 soluble, HLA-G5 to HLA-G7) that are generated by alternate splicing of a unique primary transcript (Figure 1). Soluble and membrane-bound HLA-G isoforms have similar functions. B2M-associated HLA-G1 and HLA-G5 are structurally similar to classic HLA class I molecules. However ...
... HLA-G1 to HLA-G4; and 3 soluble, HLA-G5 to HLA-G7) that are generated by alternate splicing of a unique primary transcript (Figure 1). Soluble and membrane-bound HLA-G isoforms have similar functions. B2M-associated HLA-G1 and HLA-G5 are structurally similar to classic HLA class I molecules. However ...