Publications_files/Sabiiti et al review 2012
... factor permitting the attachment of yeast to host cell and subsequent infiltration of, and damage to, the host intracellular environment [44]. In vitro experiments have also provided insight into how the capsule virulence factor promotes the ability of Cryptococcus to cause infection at the lung bar ...
... factor permitting the attachment of yeast to host cell and subsequent infiltration of, and damage to, the host intracellular environment [44]. In vitro experiments have also provided insight into how the capsule virulence factor promotes the ability of Cryptococcus to cause infection at the lung bar ...
Role of the Endocannabinoid System in the Neuroendocrine
... expressed in immune cells in the periphery and act to modulate immune function [16]. CB2 receptors are also expressed in tonsils, bone marrow, thymus, pancreas, adult rat retina, and peripheral nerve terminals in the mouse vas deferens [17]. However, it has currently been demonstrated the expression ...
... expressed in immune cells in the periphery and act to modulate immune function [16]. CB2 receptors are also expressed in tonsils, bone marrow, thymus, pancreas, adult rat retina, and peripheral nerve terminals in the mouse vas deferens [17]. However, it has currently been demonstrated the expression ...
KUOPION YLIOPISTON JULKAISUJA C. LUONNONTIETEET JA YMPÄRISTÖTIETEET 264
... TNF-α secretion in PBMCs from healthy donors was used to identify the less calcemic 1α,25(OH)216-ene-20-cyclopropyl-vitamin-D3 (BXL-62) as a VDR agonist with superior TNF-α inhibitory activity (IC50:1.5x10-15M), compared to 1α,25(OH)2D3 (IC50:8x10-9M). This higher anti-inflammatory potency from BXL- ...
... TNF-α secretion in PBMCs from healthy donors was used to identify the less calcemic 1α,25(OH)216-ene-20-cyclopropyl-vitamin-D3 (BXL-62) as a VDR agonist with superior TNF-α inhibitory activity (IC50:1.5x10-15M), compared to 1α,25(OH)2D3 (IC50:8x10-9M). This higher anti-inflammatory potency from BXL- ...
Trinity™ Multipotential Cellular Bone Matrix
... reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in situ source of osteoprogenitor cells throughout a lifetime.14 Whet ...
... reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in situ source of osteoprogenitor cells throughout a lifetime.14 Whet ...
chapter 4-i Cytokine responses in very low birth weight infants receiving glutamine-
... Very low birth weight (VLBW) infants are susceptible to glutamine depletion, as placental supply ceases at birth, tolerance of enteral nutrition is limited and parenteral nutrition does not contain glutamine for solubility and stability reasons. In studies in VLBW infants, Neu et al.1 and our group2 ...
... Very low birth weight (VLBW) infants are susceptible to glutamine depletion, as placental supply ceases at birth, tolerance of enteral nutrition is limited and parenteral nutrition does not contain glutamine for solubility and stability reasons. In studies in VLBW infants, Neu et al.1 and our group2 ...
Enrichment of IFN-γ producing cells in different murine adipose
... increased gene expression was markedly impaired in the p40-deficient mice. Overall, these results show that NK cells but also diverse T cell populations mediate a prompt and widespread production of IFN-γ in the adipose tissue of N. caninum infected mice. The involvement of the adipose tissue in imm ...
... increased gene expression was markedly impaired in the p40-deficient mice. Overall, these results show that NK cells but also diverse T cell populations mediate a prompt and widespread production of IFN-γ in the adipose tissue of N. caninum infected mice. The involvement of the adipose tissue in imm ...
Quantitative and qualitative profiles of circulating monocytes may
... among HD, LTBI subjects and cured TB patients. We then evaluated whether the increased ML ratio found in patients with active TB disease was dependent on changes in the numbers of lymphocytes, monocytes or both. As shown in Table 2 and Fig 1B, the higher ML ratio found in patients with active TB dis ...
... among HD, LTBI subjects and cured TB patients. We then evaluated whether the increased ML ratio found in patients with active TB disease was dependent on changes in the numbers of lymphocytes, monocytes or both. As shown in Table 2 and Fig 1B, the higher ML ratio found in patients with active TB dis ...
Lecture_5
... The TCR repertoire differs from individual to individual • The specificity of self/non-self peptide binding to MHC molecules determined by pockets that only bind certain amino acid side chains • MHC genes are extremely polymorphic and alleles encode pockets with specificities for different amino ac ...
... The TCR repertoire differs from individual to individual • The specificity of self/non-self peptide binding to MHC molecules determined by pockets that only bind certain amino acid side chains • MHC genes are extremely polymorphic and alleles encode pockets with specificities for different amino ac ...
Toxoplasma gondii effectors are master regulators of the
... broadly conserved across microbial species (Box 1) (recently reviewed in [9]). IL-12 in turn activates NK and T cells to secrete interferon g (IFNg) [10]. The latter activates effector mechanisms for intracellular elimination of Toxoplasma, including the activation of interferon-regulated GTPases (I ...
... broadly conserved across microbial species (Box 1) (recently reviewed in [9]). IL-12 in turn activates NK and T cells to secrete interferon g (IFNg) [10]. The latter activates effector mechanisms for intracellular elimination of Toxoplasma, including the activation of interferon-regulated GTPases (I ...
National Institute of Allergy and Infectious Diseases
... Xenopus is the only genus where polyploid as well as diploid species exist naturally, and can be artificially produced with various degrees of polyploidy (2N to 8N), enabling an experimental approach to studying the consequences of whole genome duplication (i.e., study the fate of duplicated genes), ...
... Xenopus is the only genus where polyploid as well as diploid species exist naturally, and can be artificially produced with various degrees of polyploidy (2N to 8N), enabling an experimental approach to studying the consequences of whole genome duplication (i.e., study the fate of duplicated genes), ...
Barcelona-Cincinnati technique for limbal transplantation
... in the donor eye, and enables another biopsy to be taken if the first fails. However, as no healthy conjunctiva is transplanted, improvement of local microenvironment conditions by reducing conjunctival inflammation and replacing goblet cells is limited. One of the main concerns when two different d ...
... in the donor eye, and enables another biopsy to be taken if the first fails. However, as no healthy conjunctiva is transplanted, improvement of local microenvironment conditions by reducing conjunctival inflammation and replacing goblet cells is limited. One of the main concerns when two different d ...
Sepsis
... Identify major causative organisms and routes of transmission of sepsis. Discuss clinical manifestations and modalities used in diagnosis of sepsis. Describe antibiotic therapy used in the treatment of neonatal sepsis. ...
... Identify major causative organisms and routes of transmission of sepsis. Discuss clinical manifestations and modalities used in diagnosis of sepsis. Describe antibiotic therapy used in the treatment of neonatal sepsis. ...
The role of senescent cells in ageing
... cells impact various biological processes that involve paracrine signalling, including cell proliferation, angiogenesis59, inflammation60, epithelial-tomesenchymal transition (EMT)61, wound healing13, and other types of tissue repair14. Several SASP components, including IL-6, IL-8, WNT16B and GROa, ...
... cells impact various biological processes that involve paracrine signalling, including cell proliferation, angiogenesis59, inflammation60, epithelial-tomesenchymal transition (EMT)61, wound healing13, and other types of tissue repair14. Several SASP components, including IL-6, IL-8, WNT16B and GROa, ...
Piperine inhibits cytokine production by human peripheral blood
... 1997), anti-pyretic (Virinder et al., 1997), anti-microbial (Kumar et al., 2007), and anti-inflammatory activities (Virinder et al., 1997; Pradeep and Kuttan, 2004; Kumar et al., 2007). Sunila and Kuttan (2004) showed that piperine could inhibit solid tumor development in mice induced with Dalton’s ...
... 1997), anti-pyretic (Virinder et al., 1997), anti-microbial (Kumar et al., 2007), and anti-inflammatory activities (Virinder et al., 1997; Pradeep and Kuttan, 2004; Kumar et al., 2007). Sunila and Kuttan (2004) showed that piperine could inhibit solid tumor development in mice induced with Dalton’s ...
case report measles-mumps-rubella vaccination induced
... Van Geet, 2014). In this case, both intravenous immunoglobulin and high dose steroids were given to this patient due to severe bleeding and thrombocytopenia. As a result, his platelet level reached the treatment goal shortly thereafter. However, transient rebound thrombocytosis to 602 x 109 /l was o ...
... Van Geet, 2014). In this case, both intravenous immunoglobulin and high dose steroids were given to this patient due to severe bleeding and thrombocytopenia. As a result, his platelet level reached the treatment goal shortly thereafter. However, transient rebound thrombocytosis to 602 x 109 /l was o ...
BLOOD PHYSIOLOGY
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
Leukemia 2011 June
... are chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). Leukemia is called “lymphocytic” (or “lymphoblastic”) if the cancerous change takes place in a type of marrow cell that forms lymphocytes. Leukemia is called ...
... are chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). Leukemia is called “lymphocytic” (or “lymphoblastic”) if the cancerous change takes place in a type of marrow cell that forms lymphocytes. Leukemia is called ...
Genetic Susceptibility to Type 1 Diabetes Mellitus in
... IDDM18 (5q31.1-q33.1) is a genetic region harboring p40 chain of interleukin 12 (IL-12) (Bergholdt et al. 2004). IL-12 is a disulphide linked heterodimer composed of a heavy chain of Mr 40000, p40, and a light chain of Mr 35000, p35, encoded by their respective genes. The gene for the p35 subunit is ...
... IDDM18 (5q31.1-q33.1) is a genetic region harboring p40 chain of interleukin 12 (IL-12) (Bergholdt et al. 2004). IL-12 is a disulphide linked heterodimer composed of a heavy chain of Mr 40000, p40, and a light chain of Mr 35000, p35, encoded by their respective genes. The gene for the p35 subunit is ...
The Schwann cell
... TGF-β1 act as a Schwann cell mitogen. In one study it has been shown that IL-1α and IL-6 are co-mitogens for Schwann cells, and demonstrated the presence of functional receptor for IL-1 on Schwann cells. ...
... TGF-β1 act as a Schwann cell mitogen. In one study it has been shown that IL-1α and IL-6 are co-mitogens for Schwann cells, and demonstrated the presence of functional receptor for IL-1 on Schwann cells. ...
Defense Mechanisms against Influenza Virus Infection in the
... responses including antigen uptake by APCs and priming of T and B cells for IgA Ab production are induced and the effector sites are the mucosa that covers the internal surface of the whole body, where IgA AFCs are found and where S-IgA Abs play a protective role. Thus, specific IgA AFC precursor po ...
... responses including antigen uptake by APCs and priming of T and B cells for IgA Ab production are induced and the effector sites are the mucosa that covers the internal surface of the whole body, where IgA AFCs are found and where S-IgA Abs play a protective role. Thus, specific IgA AFC precursor po ...
The Blood-Brain Barrier in NeuroAIDS
... BBB and that some of the influences on the BBB arise from peripheral tissues rather than the CNS [7,54,78,80,116]. Saturable transporters can be classified [112] as those requiring energy (active transporters) and those not requiring energy (facilitated diffusion). Many of the saturable transporters ...
... BBB and that some of the influences on the BBB arise from peripheral tissues rather than the CNS [7,54,78,80,116]. Saturable transporters can be classified [112] as those requiring energy (active transporters) and those not requiring energy (facilitated diffusion). Many of the saturable transporters ...
State-of-the-art review about basophil research in immunology and
... hypersensitivity reactions. Although they do have this property, basophils play an important role against many parasites, as well24. Given their similarities to mast cells, basophils have often been neglected and considered as a "redundant" mast cell-like circulating population25; notwithstanding, s ...
... hypersensitivity reactions. Although they do have this property, basophils play an important role against many parasites, as well24. Given their similarities to mast cells, basophils have often been neglected and considered as a "redundant" mast cell-like circulating population25; notwithstanding, s ...
R E V I E W S
... Box 1 | Insights into the molecular basis of granule-mediated cell death The most important recent findings in terms of the physiological function of the granuleexocytosis pathway are listed below. • Perforin and granzymes induce target-cell apoptosis cooperatively. Granzymes are necessary for trigg ...
... Box 1 | Insights into the molecular basis of granule-mediated cell death The most important recent findings in terms of the physiological function of the granuleexocytosis pathway are listed below. • Perforin and granzymes induce target-cell apoptosis cooperatively. Granzymes are necessary for trigg ...
Factors affecting the antigen-antibody reaction (PDF
... equilibrium constant of antibodies produced during the immune response. Typically, early antibodies have equilibrium constants of around 105-106; those produced after a few months show 100-fold greater affinities24. The structural basis of affinity maturation seems to be a decrease in the conformati ...
... equilibrium constant of antibodies produced during the immune response. Typically, early antibodies have equilibrium constants of around 105-106; those produced after a few months show 100-fold greater affinities24. The structural basis of affinity maturation seems to be a decrease in the conformati ...