The regulation of B cell responses in systemic autoimmunity
... and are classified more based on their common function. In the context of innate immunity they play an important role in phagocytosis and cell adhesion [7]. For their ability to bind modified lipids and apoptotic cells they have also been implicated in the context of atherogenesis and autoimmunity ...
... and are classified more based on their common function. In the context of innate immunity they play an important role in phagocytosis and cell adhesion [7]. For their ability to bind modified lipids and apoptotic cells they have also been implicated in the context of atherogenesis and autoimmunity ...
Licentiate thesis from the Department of Immunology,
... which due to its prevalence, virulence and drug resistance is the major cause of the high mortality. But there are many obstacles left before a rational vaccine can be developed, the major one being the limited knowledge of how the immune system is clearing a malaria infection and what protective co ...
... which due to its prevalence, virulence and drug resistance is the major cause of the high mortality. But there are many obstacles left before a rational vaccine can be developed, the major one being the limited knowledge of how the immune system is clearing a malaria infection and what protective co ...
The immune system
... Milestones of immunology Jenner inoculated an eight-year– old boy with fluid from a cowpox pustule and later intentionally infected the child with smallpox viruses. As he predicted, the child did not ...
... Milestones of immunology Jenner inoculated an eight-year– old boy with fluid from a cowpox pustule and later intentionally infected the child with smallpox viruses. As he predicted, the child did not ...
IMMUNOBIOLOGY B cells in early and chronic HIV infection
... study on B-cell responses following ART, Morris and colleagues described a rapid loss of HIVspecific B cells (actively secreting plasmablasts) during therapy, followed by a more gradual decrease in antibody titers against HIV in chronically infected individuals; the loss was even more rapid in early ...
... study on B-cell responses following ART, Morris and colleagues described a rapid loss of HIVspecific B cells (actively secreting plasmablasts) during therapy, followed by a more gradual decrease in antibody titers against HIV in chronically infected individuals; the loss was even more rapid in early ...
Interrelations Between the Middle and Inner Ear in Otitis Media
... Once bacteria overcome the defense mechanisms of the middle-ear mucosa, damage to the inner ear can occur. Pathological events can be caused by a direct effect of the bacteria itself: Bacterial penetration of all three layers of the round-window membrane was demonstrated experimentally and resulted ...
... Once bacteria overcome the defense mechanisms of the middle-ear mucosa, damage to the inner ear can occur. Pathological events can be caused by a direct effect of the bacteria itself: Bacterial penetration of all three layers of the round-window membrane was demonstrated experimentally and resulted ...
The plasmacytoid dendritic cell: at the cross-roads in asthma
... molecules and release of the chemokine IFN-c-induced protein-10 from PBMCs is reduced in atopic adolescents with mild-to-moderate asthma, as compared with healthy controls [70]. Although it was not directly established that the defect was intrinsic to pDCs, others have shown that the capacity of all ...
... molecules and release of the chemokine IFN-c-induced protein-10 from PBMCs is reduced in atopic adolescents with mild-to-moderate asthma, as compared with healthy controls [70]. Although it was not directly established that the defect was intrinsic to pDCs, others have shown that the capacity of all ...
Dooley MA.Clinical and laboratory features of lupus nephritis
... injury. Local cytokine, chemokine and adhesion molecule production leads to further influx of inflammatory cells and production of proinflammatory cytokines, ultimately resulting in renal inflammation, tissue injury and fibrosis. Lupus T cells express increased levels of molecules necessary for homi ...
... injury. Local cytokine, chemokine and adhesion molecule production leads to further influx of inflammatory cells and production of proinflammatory cytokines, ultimately resulting in renal inflammation, tissue injury and fibrosis. Lupus T cells express increased levels of molecules necessary for homi ...
TOPIC: progesterone exert neuroprotective and myelinating effects
... Brain Research Laboratory, Department of Emergency Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. In this article, we review published preclinical and epidemiologic studies that examine progesterone's role in the central nervous system. Its effects on the reproductive and en ...
... Brain Research Laboratory, Department of Emergency Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. In this article, we review published preclinical and epidemiologic studies that examine progesterone's role in the central nervous system. Its effects on the reproductive and en ...
The homeostatic properties of the mannose receptor in health and
... CTLD ligands [++ in green]. Complex formation with multimeric CTLD ligands (yellow shape) will facilitate binding to cell-associated CR-ligands [++ in red] in secondary lymphoid organs and/or kidney. This hypothesis is supported by evidence demonstrating the requirement for CR multimerisation for bi ...
... CTLD ligands [++ in green]. Complex formation with multimeric CTLD ligands (yellow shape) will facilitate binding to cell-associated CR-ligands [++ in red] in secondary lymphoid organs and/or kidney. This hypothesis is supported by evidence demonstrating the requirement for CR multimerisation for bi ...
Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme
... 15 of the 27 patients had antibiotic-refractory arthritis, a rare outcome of the infection, 10 had antibiotic-responsive arthritis, and 2 patients, who were seen in the late 1970s, were not treated with antibiotics. These patients had participated in a study on immunity in Lyme arthritis (32). Clini ...
... 15 of the 27 patients had antibiotic-refractory arthritis, a rare outcome of the infection, 10 had antibiotic-responsive arthritis, and 2 patients, who were seen in the late 1970s, were not treated with antibiotics. These patients had participated in a study on immunity in Lyme arthritis (32). Clini ...
Pathology of Lung Transplantation
... • Cytomegalovirus infection • Other lung infections (RSV, parainfluenza, influenza, adenovirus, rhinovirus) • Chemical injury from aspiration with gastroesophageal reflux disease ...
... • Cytomegalovirus infection • Other lung infections (RSV, parainfluenza, influenza, adenovirus, rhinovirus) • Chemical injury from aspiration with gastroesophageal reflux disease ...
Thesis of Rownok_12376001
... insistent work, blessings, guidance, protection, help and wisdom in all sphere of my life. First and foremost, I have to thank my research supervisors, to Dr. Firdausi Qadri, Senior Scientist and Head of the Immunology Laboratory, Enteric vaccines, International Center for Diarrheal Disease Research ...
... insistent work, blessings, guidance, protection, help and wisdom in all sphere of my life. First and foremost, I have to thank my research supervisors, to Dr. Firdausi Qadri, Senior Scientist and Head of the Immunology Laboratory, Enteric vaccines, International Center for Diarrheal Disease Research ...
Frequency of Cytokine polymorphisms in populations from
... From the Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland (A.M., F.W., O.A.R., D.M.); School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland (O.A.R., D.M.); Department of Epidemiology and Public Health, Que ...
... From the Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland (A.M., F.W., O.A.R., D.M.); School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland (O.A.R., D.M.); Department of Epidemiology and Public Health, Que ...
Publications de l`équipe - Centre de recherche de l`Institut Curie
... VEGF-dependent neovascularization in the adult mouse. Using neutralizing antibodies and lactadherin-deficient animals, we show that lactadherin interacts with alphavbeta3 and alphavbeta5 integrins and alters both VEGF-dependent Akt phosphorylation and neovascularization. In the absence of VEGF, lacta ...
... VEGF-dependent neovascularization in the adult mouse. Using neutralizing antibodies and lactadherin-deficient animals, we show that lactadherin interacts with alphavbeta3 and alphavbeta5 integrins and alters both VEGF-dependent Akt phosphorylation and neovascularization. In the absence of VEGF, lacta ...
Sleep April.indd
... During an immune response, T cell activity critically depends on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in a ...
... During an immune response, T cell activity critically depends on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in a ...
Cytokine Atlas - Thermo Fisher Scientific
... associated with reducing the anti-cancer activity of various treatments. For instance, increased proinflammatory cytokine levels can lead to NFkB activation in cancer cells, thus providing a mechanism for these cells to evade apoptosis.108 Cytokines have also been demonstrated to exacerbate the toxi ...
... associated with reducing the anti-cancer activity of various treatments. For instance, increased proinflammatory cytokine levels can lead to NFkB activation in cancer cells, thus providing a mechanism for these cells to evade apoptosis.108 Cytokines have also been demonstrated to exacerbate the toxi ...
Aloe Vera and the Human Immune System
... effectshavebeenclearlyshownto be of functionalbenefit. Next, it is clear,ffid well known, that the body's fight agairst tumoursis alsomediated throughthe immunesptenl which hasan ability to kill andremovetumotr cells. The outcomeis presumedto be determinedrnainlyby the vigour of the immruresystem re ...
... effectshavebeenclearlyshownto be of functionalbenefit. Next, it is clear,ffid well known, that the body's fight agairst tumoursis alsomediated throughthe immunesptenl which hasan ability to kill andremovetumotr cells. The outcomeis presumedto be determinedrnainlyby the vigour of the immruresystem re ...
Gene expression comparison of resistant and susceptible Atlantic
... of salmonid fish which can cause high mortality and morbidity of cultured Atlantic salmon (Salmo salar L.) and rainbow trout (Oncorhynchus mykiss) and is responsible for serious economic losses to the aquaculture industry. IPNV forms part of the genus Aquabirnavirus and is a member of the Birnavirid ...
... of salmonid fish which can cause high mortality and morbidity of cultured Atlantic salmon (Salmo salar L.) and rainbow trout (Oncorhynchus mykiss) and is responsible for serious economic losses to the aquaculture industry. IPNV forms part of the genus Aquabirnavirus and is a member of the Birnavirid ...
Neural control of the circulation - Advances in Physiology Education
... sympathetic control of the cardiovascular system is that neurally released norepinephrine acts on -adrenergic receptors in the heart to modulate cardiac function and on ␣-adrenergic receptors in the blood vessels to modulate arteriolar resistance and venous capacitance. This foundation can readily ...
... sympathetic control of the cardiovascular system is that neurally released norepinephrine acts on -adrenergic receptors in the heart to modulate cardiac function and on ␣-adrenergic receptors in the blood vessels to modulate arteriolar resistance and venous capacitance. This foundation can readily ...
Effects of Fish Oil and Corn Oil Diets on
... PGE2 levels and, in turn, PGE2-dependent suppressor mecha nisms. However, the suppressed immune competence in tumor bearers has been associated with several different types of immune suppressor mechanisms such as PGE2-secreting mac rophages (25-27) and suppressor T-lymphocytes (28, 29). Re cently, t ...
... PGE2 levels and, in turn, PGE2-dependent suppressor mecha nisms. However, the suppressed immune competence in tumor bearers has been associated with several different types of immune suppressor mechanisms such as PGE2-secreting mac rophages (25-27) and suppressor T-lymphocytes (28, 29). Re cently, t ...
Response of naïve and memory CD8+ T cells to antigen stimulation
... modifications of the primed cell repertoire, including an increased frequency of antigen-specific T cells1–5 and the selection of high affinity clones6–8. These modifications, however, may be transient, and insufficient to ensure long-term memory in the absence of antigen restimulation. It has been ...
... modifications of the primed cell repertoire, including an increased frequency of antigen-specific T cells1–5 and the selection of high affinity clones6–8. These modifications, however, may be transient, and insufficient to ensure long-term memory in the absence of antigen restimulation. It has been ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.