Long-Term Protective Immunity Induced Against
... of drugs that have much diminished past morbidity and mortality rates. Drugs used for treatment are not effective in chronically infected individuals and parasites naturally resistant to chemotherapy have been described in various regions of Latin America (Urbina, 2001; Camandaroba et al., 2003). Th ...
... of drugs that have much diminished past morbidity and mortality rates. Drugs used for treatment are not effective in chronically infected individuals and parasites naturally resistant to chemotherapy have been described in various regions of Latin America (Urbina, 2001; Camandaroba et al., 2003). Th ...
Brain-resident memory T cells represent an autonomous
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
Traumatic Brain Injury and Neurodegenerative Disorders Review of
... • We now know that dementia is not a normal part of aging but is caused by a number of underlying medical conditions that can occur in both elderly and younger persons. • In some cases, dementia can be reversed with proper medical treatment. In most others, it is permanent. • Primary Dementia, lik ...
... • We now know that dementia is not a normal part of aging but is caused by a number of underlying medical conditions that can occur in both elderly and younger persons. • In some cases, dementia can be reversed with proper medical treatment. In most others, it is permanent. • Primary Dementia, lik ...
Brain-resident memory T cells represent an autonomous cytotoxic
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
Downloaded - The Journal of Immunology
... B cell responses modulate disease during infection with Borrelia burgdorferi, the causative agent of Lyme disease, but are unable to clear the infection. Previous studies have demonstrated that B. burgdorferi infection induces predominantly T-independent B cell responses, potentially explaining some ...
... B cell responses modulate disease during infection with Borrelia burgdorferi, the causative agent of Lyme disease, but are unable to clear the infection. Previous studies have demonstrated that B. burgdorferi infection induces predominantly T-independent B cell responses, potentially explaining some ...
as Adobe PDF - Edinburgh Research Explorer
... core glycan structures) cause deficiencies in cellular growth and function and lead to a variety of debilitating diseases called congenital disorders of glycosylation [10]. In contrast, great diversity in the terminal glycan antennae is common. A well-recognized example of this is the existence of AB ...
... core glycan structures) cause deficiencies in cellular growth and function and lead to a variety of debilitating diseases called congenital disorders of glycosylation [10]. In contrast, great diversity in the terminal glycan antennae is common. A well-recognized example of this is the existence of AB ...
Analogues of simple and complex cells in rhesus monkey auditory
... that respond either to the onset or the offset of a small spot of light; complex cells, by contrast, respond with mixed ON and OFF responses throughout their RF. In addition, simple cells show spatial summation within each of their subregions. In both auditory and somatosensory cortex, inhibitory su ...
... that respond either to the onset or the offset of a small spot of light; complex cells, by contrast, respond with mixed ON and OFF responses throughout their RF. In addition, simple cells show spatial summation within each of their subregions. In both auditory and somatosensory cortex, inhibitory su ...
PDF
... There is evidence that the “farm effect” (12) is not confined to childhood but acts on the developing fetal immune system during pregnancy. A farming environment has been associated with increased number and efficiency of regulatory T lymphocytes (Tregs) (15) as well as an altered cytokine profile ...
... There is evidence that the “farm effect” (12) is not confined to childhood but acts on the developing fetal immune system during pregnancy. A farming environment has been associated with increased number and efficiency of regulatory T lymphocytes (Tregs) (15) as well as an altered cytokine profile ...
Individual cells in multicellular organisms are regulated by a vast
... regulation and should prove useful in providing clues regarding in vivo roles for orphan GPCRs and new roles for receptors with known ligands. To test the latter prediction, we sought a possible role for a recently de-orphanized receptor, Gpr91, found in the adipose cluster. Extracellular succinate ...
... regulation and should prove useful in providing clues regarding in vivo roles for orphan GPCRs and new roles for receptors with known ligands. To test the latter prediction, we sought a possible role for a recently de-orphanized receptor, Gpr91, found in the adipose cluster. Extracellular succinate ...
A New Mouse Model That Spontaneously Develops Chronic Liver
... Formation and remodeling of the extracellular matrix is critical during wound healing and scar formation but excessive connective tissue formation, as seen in fibrosis, can be detrimental and lead to organ failure [1]. Local and systemic chronic inflammatory conditions triggered by trauma, toxic dam ...
... Formation and remodeling of the extracellular matrix is critical during wound healing and scar formation but excessive connective tissue formation, as seen in fibrosis, can be detrimental and lead to organ failure [1]. Local and systemic chronic inflammatory conditions triggered by trauma, toxic dam ...
Neural ensemble dynamics underlying a long
... To study ensemble coding, we tested whether CS+ and CS− presentations were identifiable from their evoked activity patterns. We trained three-way, Fisher linear decoders to distinguish baseline conditions from CS+ and CS− presentations on each day. These decoders classified the three conditions accu ...
... To study ensemble coding, we tested whether CS+ and CS− presentations were identifiable from their evoked activity patterns. We trained three-way, Fisher linear decoders to distinguish baseline conditions from CS+ and CS− presentations on each day. These decoders classified the three conditions accu ...
Immunomodulatory Roles of Lymphatic Vessels
... In the lymph nodes, many cell types can take up lymphborne antigen, but perhaps most well studied are lymph node– resident immature dendritic cells (DC). In the absence of stimulatory cytokines or danger signals, antigen uptake by these cells helps to maintain peripheral tolerance to selfantigens be ...
... In the lymph nodes, many cell types can take up lymphborne antigen, but perhaps most well studied are lymph node– resident immature dendritic cells (DC). In the absence of stimulatory cytokines or danger signals, antigen uptake by these cells helps to maintain peripheral tolerance to selfantigens be ...
Anthrax Lethal Toxin-Mediated Killing of Human and Murine
... inactivating MAPK pathways, which renders immune cells, including dendritic cells (DCs), nonresponsive to immune stimulation [11–13]. This may weaken the immune response by limiting the production of inflammatory cytokines [12,14– 16]. However, drastic cytokine induction has been shown in several mur ...
... inactivating MAPK pathways, which renders immune cells, including dendritic cells (DCs), nonresponsive to immune stimulation [11–13]. This may weaken the immune response by limiting the production of inflammatory cytokines [12,14– 16]. However, drastic cytokine induction has been shown in several mur ...
BMC Evolutionary Biology
... A wide range of hypotheses have been proposed to explain why this seemingly vulnerable and unproductive state has evolved, including suggestions that sleep conserves energy when alternative activities would bring little advantage [7], is required for the consolidation of memories and learning [8], o ...
... A wide range of hypotheses have been proposed to explain why this seemingly vulnerable and unproductive state has evolved, including suggestions that sleep conserves energy when alternative activities would bring little advantage [7], is required for the consolidation of memories and learning [8], o ...
MCB 169: Fall 2015
... Antibodies and antigens (Chapter 5) Antigen receptors and MHC molecules (Chapter 6) Antigen presentation (Chapter 6) Ig genes and the generation of diversity (Chapter 8) B cell development and tolerance (Chapter 8) T cell development and tolerance (Chapter 8) B cell activation (Chapter 7 and 11) Aff ...
... Antibodies and antigens (Chapter 5) Antigen receptors and MHC molecules (Chapter 6) Antigen presentation (Chapter 6) Ig genes and the generation of diversity (Chapter 8) B cell development and tolerance (Chapter 8) T cell development and tolerance (Chapter 8) B cell activation (Chapter 7 and 11) Aff ...
Pathobiology of Aspergillus fumigatus, a saprotrophic pathogenic
... habitat, this species is found in high concentration in the environment of compost plants and in the commercial products from composting plants. This may represent a biological hazard for the population, specially since besides polypeptide allergens responsible for asthma and rhinitis, mycotoxins an ...
... habitat, this species is found in high concentration in the environment of compost plants and in the commercial products from composting plants. This may represent a biological hazard for the population, specially since besides polypeptide allergens responsible for asthma and rhinitis, mycotoxins an ...
MS Word Version - Interactive Physiology
... 2. (Page 3, 4.) Put these statements into the correct order for synaptic transmission: a. Neurotransmitter diffuses across the synaptic cleft. b. The presence of calcium inside the cell causes the synaptic vesicles to fuse with the ...
... 2. (Page 3, 4.) Put these statements into the correct order for synaptic transmission: a. Neurotransmitter diffuses across the synaptic cleft. b. The presence of calcium inside the cell causes the synaptic vesicles to fuse with the ...
INDUCTION OF INNATE IMMUNE RESPONSES BY PLANT
... The T Cell Regulates Early Innate Immune Responses ..........................................27 The δ T Cell Priming Response ...........................................................................29 The Phenotype of γδ TCR Signaling .......................................................... ...
... The T Cell Regulates Early Innate Immune Responses ..........................................27 The δ T Cell Priming Response ...........................................................................29 The Phenotype of γδ TCR Signaling .......................................................... ...
Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway
... P. aeruginosa, via the activation of monocytic cells, can accentuate TGF-b1-driven EMT. These in vitro observations may help explain the in vivo clinical observation of a link between acquisition of P. aeruginosa and an increased risk of developing OB. KEYWORDS: Bronchiolitis obliterans syndrome, lu ...
... P. aeruginosa, via the activation of monocytic cells, can accentuate TGF-b1-driven EMT. These in vitro observations may help explain the in vivo clinical observation of a link between acquisition of P. aeruginosa and an increased risk of developing OB. KEYWORDS: Bronchiolitis obliterans syndrome, lu ...
Nervous System PPT
... outside the cytoplasm) on the outside of the membrane (ready for action) Depolarization: A stimulus is initiated (i.e. sound) that converts to electrical charge which allows the “gated” Na+ ions to come into the cytoplasm ...
... outside the cytoplasm) on the outside of the membrane (ready for action) Depolarization: A stimulus is initiated (i.e. sound) that converts to electrical charge which allows the “gated” Na+ ions to come into the cytoplasm ...
The regulation of B cell responses in systemic autoimmunity
... and are classified more based on their common function. In the context of innate immunity they play an important role in phagocytosis and cell adhesion [7]. For their ability to bind modified lipids and apoptotic cells they have also been implicated in the context of atherogenesis and autoimmunity ...
... and are classified more based on their common function. In the context of innate immunity they play an important role in phagocytosis and cell adhesion [7]. For their ability to bind modified lipids and apoptotic cells they have also been implicated in the context of atherogenesis and autoimmunity ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.