Doctoral thesis from the Department of Immunology, the Wenner-Gren
... light (L) chain gene rearrangement. The assembly of the heavy V region of the Ig chain occurs in two steps. First, the recombinase enzymes (RAG-1/RAG-2) catalyses the fusion of one of the DH genes to a JH gene, a process that occurs on both chromosomes. Next, the recombinase joins one of the VH gene ...
... light (L) chain gene rearrangement. The assembly of the heavy V region of the Ig chain occurs in two steps. First, the recombinase enzymes (RAG-1/RAG-2) catalyses the fusion of one of the DH genes to a JH gene, a process that occurs on both chromosomes. Next, the recombinase joins one of the VH gene ...
How MT cells analyze the motion of visual patterns
... Analyzing visual scenes requires the visual system to integrate information from many sources. It is widely believed that the complex of visual areas outside the primary visual cortex (V1) performs such a synthesis, based on a hierarchical elaboration of the information represented by neurons in V1 ...
... Analyzing visual scenes requires the visual system to integrate information from many sources. It is widely believed that the complex of visual areas outside the primary visual cortex (V1) performs such a synthesis, based on a hierarchical elaboration of the information represented by neurons in V1 ...
Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
... global orchestration of antiviral immunity, by linking innate and adaptive immunity through multiple immunoregulatory functions [16]. For instance, IFN-I do not only play a crucial role in the control of the replication of many viruses, but they can also promote NK cell or CD8 T cell antiviral cytot ...
... global orchestration of antiviral immunity, by linking innate and adaptive immunity through multiple immunoregulatory functions [16]. For instance, IFN-I do not only play a crucial role in the control of the replication of many viruses, but they can also promote NK cell or CD8 T cell antiviral cytot ...
... tissue injury [1–3]. The general paradigm of immune granuloma formation suggests a specific, T-cell-mediated response to an antigenic agent that has been processed by macrophages and presented to antigen-specific Tlymphocytes. The T-cell, in turn, directs the accumulation and differentiation of mono ...
Molecular footprints reveal the impact of the - Gut
... a significant number of A*03-positive patients (9/12) compared with the control group (1/33, p¼0.0003). Threonine (T) was also substituted with alanine (A) at position 8 (T1087A) more frequently in A*03-positive patients (6/12) compared with controls (2/33, p¼0.01), and the double substitution of TK ...
... a significant number of A*03-positive patients (9/12) compared with the control group (1/33, p¼0.0003). Threonine (T) was also substituted with alanine (A) at position 8 (T1087A) more frequently in A*03-positive patients (6/12) compared with controls (2/33, p¼0.01), and the double substitution of TK ...
The Role of Dopamine in Locomotor ... 173
... 5.4. Possible synaptic events underlying the establishment of incentive learning ........................................................ 5.5. Possible synaptic events underlying extinction ............................................................................................ ...
... 5.4. Possible synaptic events underlying the establishment of incentive learning ........................................................ 5.5. Possible synaptic events underlying extinction ............................................................................................ ...
Granulomas in Infectious and Non
... Thomas A. Wynn, Paul Kaye and Vishva M. Dixit This meeting addresses the basic mechanisms of granulomatous inflammation and focuses on several chronic inflammatory diseases in which persistent granuloma formation is the central pathogenic mechanism of disease. It runs in parallel with the meeting on ...
... Thomas A. Wynn, Paul Kaye and Vishva M. Dixit This meeting addresses the basic mechanisms of granulomatous inflammation and focuses on several chronic inflammatory diseases in which persistent granuloma formation is the central pathogenic mechanism of disease. It runs in parallel with the meeting on ...
Multiple Organ Dysfunction Syndrome
... • Serum bilirubin>6mg/dl (102.6 umol/L) • Prothrombin time>4sec over control in the absence of ...
... • Serum bilirubin>6mg/dl (102.6 umol/L) • Prothrombin time>4sec over control in the absence of ...
What Is the Nervous System?
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
What Is the Nervous System?
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
Can Oxytocin function as an antidepressant?
... depressed patient display an array of pathological behaviors that are indirectly correlated to a hyperactive HPA axis. They display a lack of concentration and memory, high irritability, which are signs of high stress. Also they show social behavioral patterns less associated to HPA axis activity, s ...
... depressed patient display an array of pathological behaviors that are indirectly correlated to a hyperactive HPA axis. They display a lack of concentration and memory, high irritability, which are signs of high stress. Also they show social behavioral patterns less associated to HPA axis activity, s ...
Section 11.3
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
... of nerves that links the rest of your body to your brain and spinal cord. • The peripheral nervous system carries information to the central nervous system, and then carries responses from the central nervous system to the rest of the body. ...
The heterogeneity of lung macrophages in the susceptibility to disease
... activation and phagocytosis [1, 13]. Alveolar macrophages also release transforming growth factor (TGF)-β, which inhibits immune responses by preventing dendritic cell-mediated activation of effector T-cells [4, 14, 15]. In addition, alveolar macrophages express several scavenger receptors that bind ...
... activation and phagocytosis [1, 13]. Alveolar macrophages also release transforming growth factor (TGF)-β, which inhibits immune responses by preventing dendritic cell-mediated activation of effector T-cells [4, 14, 15]. In addition, alveolar macrophages express several scavenger receptors that bind ...
Physical and immunological aspects of exercise in chronic diseases
... game playing and reading. The amount of time spent being physically inactive predicts ill health [15]. For instance, a large longitudinal Canadian study of 17,013 people over 12 years, demonstrated that those who were inactive for a longer block of time were 50% more likely to die prematurely compar ...
... game playing and reading. The amount of time spent being physically inactive predicts ill health [15]. For instance, a large longitudinal Canadian study of 17,013 people over 12 years, demonstrated that those who were inactive for a longer block of time were 50% more likely to die prematurely compar ...
Epitope Masking in a Murine Model Independently from Red Cell
... successful in preventing immunization of the mother to the D Ag on fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others ...
... successful in preventing immunization of the mother to the D Ag on fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others ...
Complement and its role in innate and adaptive immune
... The mammalian immune system is a remarkable complex of biochemical processes enabling efficient detection and prosecution of pathogens that threaten host viability. The incredible complexity of mammalian immune systems is required to provide adequate defense in spite of the impressive number of path ...
... The mammalian immune system is a remarkable complex of biochemical processes enabling efficient detection and prosecution of pathogens that threaten host viability. The incredible complexity of mammalian immune systems is required to provide adequate defense in spite of the impressive number of path ...
Cerebellar control of the inferior olive
... to slow receptor mechanisms. Slow hyperpolarizing responses have been known since the early 1980s (36). GABAB receptors, which are present in the olive (37), have been shown to mediate IPSPs with onset latencies ranging from 18–50 ms in the hippocampus (38). There is also evidence that the a3 subuni ...
... to slow receptor mechanisms. Slow hyperpolarizing responses have been known since the early 1980s (36). GABAB receptors, which are present in the olive (37), have been shown to mediate IPSPs with onset latencies ranging from 18–50 ms in the hippocampus (38). There is also evidence that the a3 subuni ...
Low Counts of B Cells, Natural Killer Cells, Monocytes, Dendritic
... 84 to 179, 84 to 364, and 84 to 730 were considered; Supplementary Figure 2). For each immune cell subset for which the count appeared to be significantly associated with an infection rate in a subsequent time interval (P < .05), a multivariate analysis (MVA) was performed as Poisson regression, comp ...
... 84 to 179, 84 to 364, and 84 to 730 were considered; Supplementary Figure 2). For each immune cell subset for which the count appeared to be significantly associated with an infection rate in a subsequent time interval (P < .05), a multivariate analysis (MVA) was performed as Poisson regression, comp ...
Novel vaccines from biotechnology
... virulent smallpox. Although vaccine technology has made substantial progress in the 200 years following Jenner, with the development of numerous vaccines against a variety of animal and human diseases, the basic concept remains the same. It is the exploitation of these concepts that has led to the e ...
... virulent smallpox. Although vaccine technology has made substantial progress in the 200 years following Jenner, with the development of numerous vaccines against a variety of animal and human diseases, the basic concept remains the same. It is the exploitation of these concepts that has led to the e ...
Cystic Fibrosis Therapy: A Community Ecology Perspective Douglas
... abundances of bacterial populations (20). They have been isolated from various sites within the human body, including airway secretions (20-25) and lung tissue (15) of CF patients. Significantly, phage were found to be absent from the late stage biofilms in CF lungs, suggesting that biofilm formatio ...
... abundances of bacterial populations (20). They have been isolated from various sites within the human body, including airway secretions (20-25) and lung tissue (15) of CF patients. Significantly, phage were found to be absent from the late stage biofilms in CF lungs, suggesting that biofilm formatio ...
Andrea Cerutti Regulation of B cell Responses by the Innate Immune System
... require a sophisticated system of “sensors” (receptors) that discriminate molecules associated with healthy cells from molecules associated with foreign, dead or abnormal cells (2-3). Any perturbation of this discriminatory capacity can lead to the onset of autoimmunity, inflammation or cancer (4). ...
... require a sophisticated system of “sensors” (receptors) that discriminate molecules associated with healthy cells from molecules associated with foreign, dead or abnormal cells (2-3). Any perturbation of this discriminatory capacity can lead to the onset of autoimmunity, inflammation or cancer (4). ...
The evolution of nervous system centralization
... (Denes et al. 2007), the pan-neural marker elav is not downregulated by exogenously applied BMP4. How can we reconcile these findings? The available data are consistent with a refined evolutionary scenario, which assumes that in early bilaterians the antineurogenic effect of Bmp signalling was only ...
... (Denes et al. 2007), the pan-neural marker elav is not downregulated by exogenously applied BMP4. How can we reconcile these findings? The available data are consistent with a refined evolutionary scenario, which assumes that in early bilaterians the antineurogenic effect of Bmp signalling was only ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.