Folie 1
... infection RIG-I signalling triggered by PU/UC can induce an antiviral response through indirect, paracrine actions of IFN produced from HCV PAMP signalling ...
... infection RIG-I signalling triggered by PU/UC can induce an antiviral response through indirect, paracrine actions of IFN produced from HCV PAMP signalling ...
NK cells and cancer: you can teach innate cells
... highly conserved Fc portion of immunoglobulin G (IgG) antibodies. When human ured by in vitro cytotoxicity assays using the K562 leuIgG1 antibodies bind to specific antigens displayed by infected or transformed cells, kaemia cell line as the target) is only correlative. NK cells these antibodies are ...
... highly conserved Fc portion of immunoglobulin G (IgG) antibodies. When human ured by in vitro cytotoxicity assays using the K562 leuIgG1 antibodies bind to specific antigens displayed by infected or transformed cells, kaemia cell line as the target) is only correlative. NK cells these antibodies are ...
Endogenous collagen peptide activation of CD1d
... specific to the CNS self-antigenic peptide myelin oligodendrocyte glycoprotein 79–96 (MOG79–96) was included for comparison. The mCII707–721–specific NKT cell line showed higher expression of Vα14-Jα18 than the conventional T cell line by real-time quantitative PCR (qPCR) (Figure 3D). Using a panel ...
... specific to the CNS self-antigenic peptide myelin oligodendrocyte glycoprotein 79–96 (MOG79–96) was included for comparison. The mCII707–721–specific NKT cell line showed higher expression of Vα14-Jα18 than the conventional T cell line by real-time quantitative PCR (qPCR) (Figure 3D). Using a panel ...
Measuring Cellular Immunity to Influenza: Methods of Detection
... and/or vaccine antigens can provide invaluable information about the host immune response in disease [68]. As a result, a large number of T-cell assays are designed to monitor cytokine responses. Measurement of the frequency of IFN-γ producing T-cells is most widely used [69] as a result of the role ...
... and/or vaccine antigens can provide invaluable information about the host immune response in disease [68]. As a result, a large number of T-cell assays are designed to monitor cytokine responses. Measurement of the frequency of IFN-γ producing T-cells is most widely used [69] as a result of the role ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
... samples from Hutterite children (Fig. 2A). NeuFigure 1. Ancestries and Environments of Amish and Hutterite Children. trophils from Amish children expressed lower Panel A shows a principal components plot of the first two principal comlevels of the chemokine receptor CXCR4 and the ponents (PC 1 and P ...
... samples from Hutterite children (Fig. 2A). NeuFigure 1. Ancestries and Environments of Amish and Hutterite Children. trophils from Amish children expressed lower Panel A shows a principal components plot of the first two principal comlevels of the chemokine receptor CXCR4 and the ponents (PC 1 and P ...
Gut Microbiota
... supplement & functional food industries People are looking for ‘natural’ or non-drug ways to maintain health or treat disease ...
... supplement & functional food industries People are looking for ‘natural’ or non-drug ways to maintain health or treat disease ...
Signaling pathways
... Signaling induction of cyclin D1. Two signalling pathways contribute to the induction of cyclin D1 transcription in mammary epithelial cells. One pathway, which leads to activation of transcription factor AP1, is activated by growth factors (GF), which bind to receptor tyrosine kinases (RTK). This ...
... Signaling induction of cyclin D1. Two signalling pathways contribute to the induction of cyclin D1 transcription in mammary epithelial cells. One pathway, which leads to activation of transcription factor AP1, is activated by growth factors (GF), which bind to receptor tyrosine kinases (RTK). This ...
Inflammatory Monocytes Activate Memory CD8+ T and
... Adding to this body of literature was the suggestion that dendritic cells (DCs) play a key role in promoting robust memory CD8+ T cell proliferation during a recall infection (Zammit et al., 2005). However, the precise identity of the relevant cell(s) and the mechanisms through which they act, e.g., ...
... Adding to this body of literature was the suggestion that dendritic cells (DCs) play a key role in promoting robust memory CD8+ T cell proliferation during a recall infection (Zammit et al., 2005). However, the precise identity of the relevant cell(s) and the mechanisms through which they act, e.g., ...
Double-Stranded RNA Induces an Antiviral Defense Status in
... immune response genes under the control of NF-B, but also genes under transcriptional control of IRF3. As a consequence, dsRNA, a stimulus for TLR3, protein kinase R (PKR), and the RNA helicases retinoic acid-inducible gene I (RIG-I) and MDA5, induces a status of antiviral defense in keratinocytes. ...
... immune response genes under the control of NF-B, but also genes under transcriptional control of IRF3. As a consequence, dsRNA, a stimulus for TLR3, protein kinase R (PKR), and the RNA helicases retinoic acid-inducible gene I (RIG-I) and MDA5, induces a status of antiviral defense in keratinocytes. ...
Neutrophils in tuberculosis: heterogeneity shapes the way?
... [54, 55]. Thus, a role for neutrophils in “concentrating” antigens has been proposed [55]. For T lymphocytes, neutrophils can serve as antigenpresenting cells [56, 57]. Neutrophils were shown to carry antigens from the peripheral sites to the lymph nodes and bone marrow and facilitate the generation ...
... [54, 55]. Thus, a role for neutrophils in “concentrating” antigens has been proposed [55]. For T lymphocytes, neutrophils can serve as antigenpresenting cells [56, 57]. Neutrophils were shown to carry antigens from the peripheral sites to the lymph nodes and bone marrow and facilitate the generation ...
Human Leukocyte Antigen-Class II-Positive
... Purpose. To achieve a better understanding of the mechanism of corneal immune diseases, including corneal allograft rejection, the authors examined the potential of human corneal epithelial (HCE) cells to activate allogeneic T lymphocytes. Methods. The mixed lymphocyte-HCE cell reaction (MLCER) was ...
... Purpose. To achieve a better understanding of the mechanism of corneal immune diseases, including corneal allograft rejection, the authors examined the potential of human corneal epithelial (HCE) cells to activate allogeneic T lymphocytes. Methods. The mixed lymphocyte-HCE cell reaction (MLCER) was ...
Human Pancreatic Cancer Cells Induce a MyD88
... circulating effector memory Th17:Th1 ratios compared with healthy controls. The TAS response also directly suppressed CD8þ T-cell–mediated cytotoxicity. Overall, our results demonstrate how TAS contributes to the production of an immunosuppressive tumor microenvironment in pancreatic cancer. ...
... circulating effector memory Th17:Th1 ratios compared with healthy controls. The TAS response also directly suppressed CD8þ T-cell–mediated cytotoxicity. Overall, our results demonstrate how TAS contributes to the production of an immunosuppressive tumor microenvironment in pancreatic cancer. ...
Immunotherapy of Metastatic Renal Cell Cancer
... the primary tumor. Reports of significant tumor reductions that facilitate surgery are even rarer, with some authors suggesting that a nephrectomy following a response is more difficult due to the treatment-associated fibrosis and scarring.27 Finally, there is the biological argument, supported by o ...
... the primary tumor. Reports of significant tumor reductions that facilitate surgery are even rarer, with some authors suggesting that a nephrectomy following a response is more difficult due to the treatment-associated fibrosis and scarring.27 Finally, there is the biological argument, supported by o ...
... major cytokine responsible for the regulation of acute phase protein synthesis during chronic immune stimulation [12], other cytokines, including interleukin-1β, tumor necrosis factor-α, and interleukin-8, have also been found to moderately influence the synthesis of acute phase proteins [12–14]. Fe ...
The Imbalance of B-Lymphocyte Subsets in Subjects with Different
... CD19+, B-2, B-1, B-1a, and B-1b cells among different glucose tolerance groups. However, the percentage of B10 cells did not differ between groups. 3.3. B-Cell Subsets Associated with Metabolic Parameter and Disease Status. The correlations between B-cell subsets and clinical parameters regardless of ...
... CD19+, B-2, B-1, B-1a, and B-1b cells among different glucose tolerance groups. However, the percentage of B10 cells did not differ between groups. 3.3. B-Cell Subsets Associated with Metabolic Parameter and Disease Status. The correlations between B-cell subsets and clinical parameters regardless of ...
Peptide Vaccine: Progress and Challenges
... infections. Based on the pathogen being used, such vaccine formulations can contain anywhere between tens of to a few hundred proteins. However, protective immunity is usually dependent upon a few select proteins within such formulations, whereas the majority of proteins are unnecessary for the indu ...
... infections. Based on the pathogen being used, such vaccine formulations can contain anywhere between tens of to a few hundred proteins. However, protective immunity is usually dependent upon a few select proteins within such formulations, whereas the majority of proteins are unnecessary for the indu ...
Publications_files/Sabiiti et al review 2012
... by Cryptococcus. The interaction between Cryptococcus and epithelial cells lining the alveolar spaces is thus critical in regulating cryptococcal entry into the circulation system. The mechanisms that allow Cryptococcus to penetrate human alveolar cells remain largely uncharacterised. Initial invest ...
... by Cryptococcus. The interaction between Cryptococcus and epithelial cells lining the alveolar spaces is thus critical in regulating cryptococcal entry into the circulation system. The mechanisms that allow Cryptococcus to penetrate human alveolar cells remain largely uncharacterised. Initial invest ...
Failure of T cell immunity
... be cleared. Although this hypothesis has been regarded as a solid explanation to the late induction of HCVspecific T cells, the results supporting this hypothesis have been obtained from patient material, which has been cultured prior to experimentation15. As culturing of activated antigen-specific ...
... be cleared. Although this hypothesis has been regarded as a solid explanation to the late induction of HCVspecific T cells, the results supporting this hypothesis have been obtained from patient material, which has been cultured prior to experimentation15. As culturing of activated antigen-specific ...
Plasmacytoid dendritic cells and dermatological - HAL
... with T lymphocytes and DC, considered to belong to Skin-associated Lymphoid Tissue (SALT) and their antigen presenting functions was a matter of debate (11). In another study, the presence of plasmacytoid monocytes was established in 58% of biopsies removed from patients suffering from Jessner-Kano ...
... with T lymphocytes and DC, considered to belong to Skin-associated Lymphoid Tissue (SALT) and their antigen presenting functions was a matter of debate (11). In another study, the presence of plasmacytoid monocytes was established in 58% of biopsies removed from patients suffering from Jessner-Kano ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.