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Food Allergies in Children
Food Allergies in Children

... (antigens) in any form T cells then trigger a series of immunological reactions, mediated by cytokines (the “control chemicals” of the immune system) ...
Chemokines and Chemokine Receptors: Positioning Cells for Host
Chemokines and Chemokine Receptors: Positioning Cells for Host

... independent manner. There are approximately 20 signaling chemokine receptors and 5 nonsignaling chemokine receptors (Table 2). In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning in homeostasis, in acute inflammation ...
Document
Document

... non-elicited and elicited macrophages in a naltrexone reversible manner (Rojavin et al. 1993). Furthermore, in vitro studies have confirmed that morphine acts directly through the μ and δ opioid receptors (Szabo et al. 1993; Tomassini et al. 2004) and that morphine mediated inhibition of phagocytosi ...
Neuronal Selectivities to Complex Object
Neuronal Selectivities to Complex Object

Hypothalamus and Limbic System
Hypothalamus and Limbic System

... • A large number of clinical conditions have symptoms that arise from hypothalamic and/or limbic system brain circuits. • For example, regardless of medical or dental specialty, all of you will encounter patients who have one or more of the following: ...
Denes et al. 2007 - Philosophical Transactions of the Royal Society B
Denes et al. 2007 - Philosophical Transactions of the Royal Society B

... (Denes et al. 2007), the pan-neural marker elav is not downregulated by exogenously applied BMP4. How can we reconcile these findings? The available data are consistent with a refined evolutionary scenario, which assumes that in early bilaterians the antineurogenic effect of Bmp signalling was only ...
FasL is expressed in human breast cancer endothelia. Who
FasL is expressed in human breast cancer endothelia. Who

... that allowed allograft or xenograft survival for longer periods compared with other areas (1). It is well known that FasL (CD95 ligand) (2) is able to induce cell death in Fas-bearing cells (3). The Fas/FasL interaction plays an essential role in the immune system homeostasis (4) and in the preserva ...
Drug Resistance in Acute Viral Infections: Rhinovirus as a Case Study
Drug Resistance in Acute Viral Infections: Rhinovirus as a Case Study

... the attachment of virus to its cellular target. Clinical trials of the drug have shown that its use can reduce both the duration and severity of cold symptoms (Hayden et al., 1999; Rotbart, 2002; Hayden et al., 2003). Given the observed relationship between disease symptoms and infectiousness, this ...
Chapter 22 PPT. - HCC Learning Web
Chapter 22 PPT. - HCC Learning Web

... • 22-6 Discuss the mechanisms of B cell activation and differentiation, describe the structure and function of antibodies, and explain the primary and secondary responses to antigen exposure. • 22-7 Describe the development of immunological competence, list and explain examples of immune disorders a ...
Answers to WHAT DID YOU LEARN questions
Answers to WHAT DID YOU LEARN questions

... pathways are: the spinal nerve pathway, the postganglionic sympathetic pathway, the splanchnic nerve pathway, and the adrenal medulla pathway. In the spinal nerve pathway, the preganglionic axon synapses in the sympathetic trunk, and the postganglionic axon leaves the trunk via a gray ramus communic ...
Equine allogeneic bone marrow-derived mesenchymal stromal cells
Equine allogeneic bone marrow-derived mesenchymal stromal cells

... was assessed in vitro using modified one-way mixed leukocyte reactions, it was found that MHC class II-positive MSCs caused significantly increased responder T-cell proliferation equivalent to that of the positive control of MHC mismatched peripheral blood leukocytes (PBLs) [24]. As the in vitro mix ...
Thomas Davis, MD Celldex Therapeutics, Inc.
Thomas Davis, MD Celldex Therapeutics, Inc.

D9 -Tetrahydrocannabinol attenuates allogeneic host-versus
D9 -Tetrahydrocannabinol attenuates allogeneic host-versus

... spasticity in patients with multiple sclerosis patients [29]. Furthermore, our laboratory recently found that THC treatment significantly reduced symptoms associated with GvHD, where the immune cells from the allograft attack recipient tissue, in a CB-dependent manner [30]. Based on such studies, we ...
Hedgehog Signaling and Maintenance of Homeostasis in the
Hedgehog Signaling and Maintenance of Homeostasis in the

... of highly specialized cells (FIGURE 1) that serve to digest our food and absorb water and nutrients. At the same time, this thin layer is the major barrier that separates us from the large variety of microorganisms present in the lumen of the gut. Under homeostatic conditions, there is a remarkable ...
Immunomodulatory functions of type I interferons
Immunomodulatory functions of type I interferons

... epithelial cells called M cells. ...
Aging of the mammalian gastrointestinal tract: a complex organ system
Aging of the mammalian gastrointestinal tract: a complex organ system

1 Mycology is the study of fungi. Fungi include: yeasts, molds – they
1 Mycology is the study of fungi. Fungi include: yeasts, molds – they

... 1. One antibiotic, griseofulvin (Fulvicin, Grifulvin, Gris-PEG), interferes with nuclear division by preventing the aggregation of microtubules needed for mitosis in superficial mycelial fungi. It is used only for severe dermatophyte infections. 2. The antimetabolites trimethoprim + sulfomethoxazole ...
EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM
EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM

... Some of the earliest evidence for CNS-mediated alterations following increases in physical activity in otherwise healthy animals is based on the elegant work of DiCarlo et al.29,47,48 Although earlier work had provided indirect evidence that training influenced autonomic control of the vasculature,6 ...
Control of Human Viral Infections by Natural Killer Cells
Control of Human Viral Infections by Natural Killer Cells

Nuclear calcium is required for human T cell activation
Nuclear calcium is required for human T cell activation

... calcium signals for intracellular processing of information and the induction of appropriate biological responses through activating specific gene expression programs (Berridge et al., 2000; Clapham, 2007). To generate diversity in signal transduction using a single second messenger, cells exploit t ...
Immunogenicity of Pluripotent Stem Cells and Their
Immunogenicity of Pluripotent Stem Cells and Their

... miHAs are peptides derived from normal cellular proteins that show polymorphism among related and unrelated individuals, and when transplanted, can be sufficiently antigenic to induce CD4+ and CD8+ T cells alloresponses.46, 47 The importance of miHA in human transplantation is proven by the observat ...
B Lymphocytes in Cancer Immunology
B Lymphocytes in Cancer Immunology

... infiltrates, albeit usually a minor population compared to T cells. However, in early ductal breast carcinoma in situ, infiltrating B cells are found in excess of T cells and form the predominant intratumoral lymphocyte population [43]. It is also interesting to note that medullary breast cancer, wh ...
Olefsky on Ouchi Science
Olefsky on Ouchi Science

... adipose tissue adds a new layer to our understanding of obesity and raises several questions. Activation of the noncanonical Wnt pathway in various cell types has pleiotropic effects on many different biological processes, including cell adhesion, migration, actin cytoskeletal organization, lymphopo ...
Immune responses to vaccines involving a combined antigen
Immune responses to vaccines involving a combined antigen

... emulsion was formed by sonication (120 W; Digital Sonifier 450, Branson Ultrasonics Corp., Danbury, CT, USA) in a tube over an ice bath for 1 min (4 s on and 2 s off). To prepare the double emulsion, the resulting primary emulsion was added into 65 mL external water phase containing 1.5% w/v PVA and ...
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a

... type I and autophagic cell death, or type II) or passive (necrosis or type III). Pyroptosis is categorized as programmed cell death, as it requires metabolic energy and is mediated by specific cellular pathways, namely, the inflammasome and caspase-1. Pyroptotic cells display a distinct set of morph ...
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Psychoneuroimmunology



Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.
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