Cytolytic T lymphocytes from HLA-B8 donors ’s lymphoma frequently recognize the Hodgkin
... peptide pulsed dendritic cells. We demonstrate that LMP2345-352 specific CD8+ T cells secrete IFN-g and kill both peptide pulsed targets as well as HLA-B8 matched LCL and LMP2 expressing Hodgkin’s lymphoma cells. We suggest that cytotoxic CD8+ T cell responses against LMP2 coexist with the immunodom ...
... peptide pulsed dendritic cells. We demonstrate that LMP2345-352 specific CD8+ T cells secrete IFN-g and kill both peptide pulsed targets as well as HLA-B8 matched LCL and LMP2 expressing Hodgkin’s lymphoma cells. We suggest that cytotoxic CD8+ T cell responses against LMP2 coexist with the immunodom ...
Poster
... Story: Class I MHC molecules are cell-surface proteins synthesized by ribosomes in the Rough Endoplasmic Reticulum (RER). HHV-7 proteins are synthesized on ribosomes located either in the cytoplasm or in the RER depending upon their function. Misfolded viral proteins are degraded by a proteasome, a ...
... Story: Class I MHC molecules are cell-surface proteins synthesized by ribosomes in the Rough Endoplasmic Reticulum (RER). HHV-7 proteins are synthesized on ribosomes located either in the cytoplasm or in the RER depending upon their function. Misfolded viral proteins are degraded by a proteasome, a ...
Phagocytosis, a cellular immune response in insects
... active antimicrobial and proinflammatory phenotype. This change is known as activation of phagocytic cells. The signals delivered to the cell by the various receptors determine the final activation stage of the leukocyte. At later times, these activated leukocytes can process and present antigens to ...
... active antimicrobial and proinflammatory phenotype. This change is known as activation of phagocytic cells. The signals delivered to the cell by the various receptors determine the final activation stage of the leukocyte. At later times, these activated leukocytes can process and present antigens to ...
Role of Fusobacterium nucleatum in Periodontal Health and Disease
... species. However, the net charge (negative charge) of F. nucleatum was not so strong compared with those of other Gram-negative bacteria. Therefore, the high susceptibility of F. nucleatum is not only due to the net charge, but also involves other factors (maybe chemical composition of LPS and/or th ...
... species. However, the net charge (negative charge) of F. nucleatum was not so strong compared with those of other Gram-negative bacteria. Therefore, the high susceptibility of F. nucleatum is not only due to the net charge, but also involves other factors (maybe chemical composition of LPS and/or th ...
Immune memory in CD4+ CD45RA+ T cells
... present in low numbers at birth but increase with age.9 Recent thymic emigrants in the rat are of the RO+ (CD45RC−) phenotype10 but rapidly express CD45RA. The same has been reported for newborn infants.11 T-helper type 1 ( Th1) and Th2 patterns of cytokine production are reportedly imprinted in mem ...
... present in low numbers at birth but increase with age.9 Recent thymic emigrants in the rat are of the RO+ (CD45RC−) phenotype10 but rapidly express CD45RA. The same has been reported for newborn infants.11 T-helper type 1 ( Th1) and Th2 patterns of cytokine production are reportedly imprinted in mem ...
PDF
... Figure 1 illustrates a typical example of recording from an axon in the TB. After staining, the axon was traced back to the CN and found to arise from a cell in the AVCN (Fig. 1C). Although the dendritic tree was not completely stained, the neuron was identified as bushy cell by virtue of its “clust ...
... Figure 1 illustrates a typical example of recording from an axon in the TB. After staining, the axon was traced back to the CN and found to arise from a cell in the AVCN (Fig. 1C). Although the dendritic tree was not completely stained, the neuron was identified as bushy cell by virtue of its “clust ...
Microbiota-mediated colonization resistance against intestinal
... commensal10,122 and pathogenic122–124 intestinal bacteria and prevents the associated inflammation. Sampling of luminal bacteria by CX3CR1+ mononuclear phagocytes and by CD103+ DCs can also direct the differentiation of lamina propria-resident CD4+ T helper 17 (TH17) cells125 that control attaching ...
... commensal10,122 and pathogenic122–124 intestinal bacteria and prevents the associated inflammation. Sampling of luminal bacteria by CX3CR1+ mononuclear phagocytes and by CD103+ DCs can also direct the differentiation of lamina propria-resident CD4+ T helper 17 (TH17) cells125 that control attaching ...
The Regulatory Role of Invariant NKT Cells in Tumor Immunity
... iNKT cells (ref. 37; Fig. 1); the a-linked glycan in a-GalCer has since been shown to be a structural motif common to many of the identified a-linked bacterial pathogens, which can directly and potently activate iNKT cells (38–41). Recently, a b-linked lipid, Asperamide B, was identified as the first e ...
... iNKT cells (ref. 37; Fig. 1); the a-linked glycan in a-GalCer has since been shown to be a structural motif common to many of the identified a-linked bacterial pathogens, which can directly and potently activate iNKT cells (38–41). Recently, a b-linked lipid, Asperamide B, was identified as the first e ...
Figure 6. p16INK4a-deficiency results in an alteration - HAL
... The CDKN2A locus, which contains the tumor suppressor gene p16INK4a, is associated with an increased risk of age-related inflammatory diseases, such as cardiovascular disease and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize towards classically (CAM) or alternati ...
... The CDKN2A locus, which contains the tumor suppressor gene p16INK4a, is associated with an increased risk of age-related inflammatory diseases, such as cardiovascular disease and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize towards classically (CAM) or alternati ...
exemplars and commentary
... Basal cells found close to the surface of the cervix are immature. The HPV virus invades these cells and reproduces within them. As the cells divide and mature into squamous cells, they rise to the surface and the infectious virus particles are released from the mature squamous cells, to then furthe ...
... Basal cells found close to the surface of the cervix are immature. The HPV virus invades these cells and reproduces within them. As the cells divide and mature into squamous cells, they rise to the surface and the infectious virus particles are released from the mature squamous cells, to then furthe ...
WHO Meeting on Immunological Endpoints for TB Vaccine Trials
... studies of BCG-induced immunity[13,14], and is currently the primary screening assay to test multiple novel TB antigens in large Gates-funded consortiums[15]. Both these applications have involved measuring IFN-γ as the primary endpoint. IFN-γ is an example of a cytokine that is stable in culture an ...
... studies of BCG-induced immunity[13,14], and is currently the primary screening assay to test multiple novel TB antigens in large Gates-funded consortiums[15]. Both these applications have involved measuring IFN-γ as the primary endpoint. IFN-γ is an example of a cytokine that is stable in culture an ...
MicroRNAs and respiratory diseases REVIEW
... better-known small interfering RNAs (siRNAs) that knock down transcription of single genes, as a single miRNA may target several hundred different mRNAs. Table 1 summarises some of the differences between miRNAs and siRNAs. Several human diseases have been associated with deregulated miRNA expressio ...
... better-known small interfering RNAs (siRNAs) that knock down transcription of single genes, as a single miRNA may target several hundred different mRNAs. Table 1 summarises some of the differences between miRNAs and siRNAs. Several human diseases have been associated with deregulated miRNA expressio ...
The effects of environmental mycobacteria on VLP and MVA based vaccines against tuberculosis
... ACKNOWLEDGEMENTS I would like to thank almighty first who has blessed me with this wonderful year and professional opportunity. It will be less no matter how much I thank my family for supporting me in every way possible. Thank you mom for being with me in the times of emotional distress! It will b ...
... ACKNOWLEDGEMENTS I would like to thank almighty first who has blessed me with this wonderful year and professional opportunity. It will be less no matter how much I thank my family for supporting me in every way possible. Thank you mom for being with me in the times of emotional distress! It will b ...
Nanoparticle surface charge impacts distribution, uptake and lymph
... antigens. 3,5-7,10,16,25 To date, the role of NP charge on lung APC association remains poorly understood, as the majority of vaccination studies have focused on anionic NP carriers. 4,5 These formulations follow design principles of pathogen mimicry, as the majority of both bacteria and viruses hav ...
... antigens. 3,5-7,10,16,25 To date, the role of NP charge on lung APC association remains poorly understood, as the majority of vaccination studies have focused on anionic NP carriers. 4,5 These formulations follow design principles of pathogen mimicry, as the majority of both bacteria and viruses hav ...
Glycosylation and Fc Receptors
... system is a critical sensing and defense mechanism. Effective immunity also requires the ability of cells to communicate with each other, to extravasate from blood vessels to sites of infection and to fight the source of infection and maintain normal cellular homeostasis, critical functions mediated ...
... system is a critical sensing and defense mechanism. Effective immunity also requires the ability of cells to communicate with each other, to extravasate from blood vessels to sites of infection and to fight the source of infection and maintain normal cellular homeostasis, critical functions mediated ...
IMMUNOLOGY LEARNING OBJECTIVES
... T cells therefore, CD4+ cells can also be cytotoxic o Helper (TH) – enhance immune system Express CD4 (CD4+) Produce and secrete cytokines: IL-2 (TH cell proliferation via binding IL-2 receptors that have also been Ag-induced = autocrine stimulation that expands Ag-selected T cell clone) Hel ...
... T cells therefore, CD4+ cells can also be cytotoxic o Helper (TH) – enhance immune system Express CD4 (CD4+) Produce and secrete cytokines: IL-2 (TH cell proliferation via binding IL-2 receptors that have also been Ag-induced = autocrine stimulation that expands Ag-selected T cell clone) Hel ...
Recent progress in vaccines
... people in vast areas of the earth. Major obstacles that have hindered, and still continue to have an impact on, the development of fungal vaccines have been discussed elsewhere by ourselves and others [1,2,3,4,5], and these ...
... people in vast areas of the earth. Major obstacles that have hindered, and still continue to have an impact on, the development of fungal vaccines have been discussed elsewhere by ourselves and others [1,2,3,4,5], and these ...
EFFECT OF EXERCISE-INDUCED PHYSIOLOGICAL STRAIN ON
... similarities with clinical stressors [1,15]. Acute exercise affects the number and the function of circulating cells of both innate and adaptive immune system [21] and changes the release and concentration of numerous hormones, including norepinephrine, epinephrine, growth hormone (GH), cortisol, β- ...
... similarities with clinical stressors [1,15]. Acute exercise affects the number and the function of circulating cells of both innate and adaptive immune system [21] and changes the release and concentration of numerous hormones, including norepinephrine, epinephrine, growth hormone (GH), cortisol, β- ...
Epithelial antimicrobial peptides and proteins: their role in
... epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture studies and results from bronchial xenografts generated ...
... epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture studies and results from bronchial xenografts generated ...
Software Modeling of the Complement System and its role in
... a. Vasodilation – An increase in the diameter of blood vessels of nearby capillaries occurs as the vessels that carry blood away from the affected area constrict, resulting in a swelling of the capillary network. Because of these engorged capillaries there is tissue redness and an increase in tissue ...
... a. Vasodilation – An increase in the diameter of blood vessels of nearby capillaries occurs as the vessels that carry blood away from the affected area constrict, resulting in a swelling of the capillary network. Because of these engorged capillaries there is tissue redness and an increase in tissue ...
The vitamin D receptor and T cell function
... in regulation of a wide range of genes and as VDR’s inhibition of NFAT1 appears not to include a canonical VDRE sequence in the promoter regions (Towers and Freedman, 1998), the transcriptional control of VDR’s target genes is likely far more widespread than first anticipated. Today, a direct effect ...
... in regulation of a wide range of genes and as VDR’s inhibition of NFAT1 appears not to include a canonical VDRE sequence in the promoter regions (Towers and Freedman, 1998), the transcriptional control of VDR’s target genes is likely far more widespread than first anticipated. Today, a direct effect ...
Chemokines and Chemokine Receptors: Positioning Cells for Host
... independent manner. There are approximately 20 signaling chemokine receptors and 5 nonsignaling chemokine receptors (Table 2). In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning in homeostasis, in acute inflammation ...
... independent manner. There are approximately 20 signaling chemokine receptors and 5 nonsignaling chemokine receptors (Table 2). In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning in homeostasis, in acute inflammation ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.