Do bacterial infections cause reduced ejaculate
... suggested that the adaptive significance of immunosuppression by testosterone was related to the antigenicity of sperm. Because spermatozoa are differentiated at puberty, after the immune system has acquired a tolerance to all ‘‘self,’’ they are perceived as ‘‘non-self.’’ Males are consequently expo ...
... suggested that the adaptive significance of immunosuppression by testosterone was related to the antigenicity of sperm. Because spermatozoa are differentiated at puberty, after the immune system has acquired a tolerance to all ‘‘self,’’ they are perceived as ‘‘non-self.’’ Males are consequently expo ...
T Cell Receptor (TCR)
... MHC expression on cells-II Expression of MHC molecules is increased by cytokines produced during innate & adaptive immune cells, e.g. IFN ...
... MHC expression on cells-II Expression of MHC molecules is increased by cytokines produced during innate & adaptive immune cells, e.g. IFN ...
Crosstalk between cancer and immune cells: role of
... such as IL-10, IL-6 and VEGF, which are crucial for both tumour growth and immunosuppression, activate STAT3 to create an efficient ‘feedforward’ mechanism to ensure increased STAT3 activity both in tumour cells and in tumour-associated immune cells. In normal cells, and under physiological conditio ...
... such as IL-10, IL-6 and VEGF, which are crucial for both tumour growth and immunosuppression, activate STAT3 to create an efficient ‘feedforward’ mechanism to ensure increased STAT3 activity both in tumour cells and in tumour-associated immune cells. In normal cells, and under physiological conditio ...
Metchnikoff and the phagocytosis theory - BU Blogs
... century. Indeed, the clonal selection theory and the elucidation of the molecular biology of the immune response count among the great advances in biology during our own era5. Metchnikoff has been assigned to the wine cellar of history, to be pulled out on occasion and celebrated as an old hero. How ...
... century. Indeed, the clonal selection theory and the elucidation of the molecular biology of the immune response count among the great advances in biology during our own era5. Metchnikoff has been assigned to the wine cellar of history, to be pulled out on occasion and celebrated as an old hero. How ...
AN INTEGRATIVE THEORY OF LOCUS
... phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is proposed to facilitate ensuing behaviors and to help optimize task performance (exploitation). When utility in the task wanes, LC neurons exhibit a tonic activity mode, associated with disengage ...
... phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is proposed to facilitate ensuing behaviors and to help optimize task performance (exploitation). When utility in the task wanes, LC neurons exhibit a tonic activity mode, associated with disengage ...
Peripheral blood mononuclear cells from neovascular age
... diet, hypertension, cardiovascular disease) [2, 3] as well as gene polymorphisms (e.g. complement-related genes (CFH, C3), Toll-like receptors (TLRs) and chemokine receptors (CX3CR1)) [4–7] increase the risk of AMD. Many of the genes involved in AMD are associated with the immune system, suggesting ...
... diet, hypertension, cardiovascular disease) [2, 3] as well as gene polymorphisms (e.g. complement-related genes (CFH, C3), Toll-like receptors (TLRs) and chemokine receptors (CX3CR1)) [4–7] increase the risk of AMD. Many of the genes involved in AMD are associated with the immune system, suggesting ...
Copyright Information of the Article Published Online TITLE New
... organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. N ...
... organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. N ...
REVIEWS
... immune system, antibodies can interact with other immune components. Some mechanisms of antibody action, such as toxin and virus neutralization and complement activation, and direct antimicrobial functions, such as the generation of oxidants, are independent of other host immune components. By contr ...
... immune system, antibodies can interact with other immune components. Some mechanisms of antibody action, such as toxin and virus neutralization and complement activation, and direct antimicrobial functions, such as the generation of oxidants, are independent of other host immune components. By contr ...
THE IMMUNOLOGICAL BASIS OF ME/CFS: what is already
... term, (the interviews) revealed four dominant uses – ‘not organic’; a physical disability; a brain disorder and a psychiatric problem – as well as considerable ambiguity….The ambiguity was seen as useful when engaging with patients. The survey (found) a majority adhering to a strict interpretation o ...
... term, (the interviews) revealed four dominant uses – ‘not organic’; a physical disability; a brain disorder and a psychiatric problem – as well as considerable ambiguity….The ambiguity was seen as useful when engaging with patients. The survey (found) a majority adhering to a strict interpretation o ...
Kynurenines in CNS disease: regulation by inflammatory cytokines
... The metabolic fate of tryptophan (TRP), an essential amino acid, is conversion into a variety of neuroactive substances including the well-known neurotransmitters serotonin and melatonin, as well as a range of kynurenine metabolites such as kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quin ...
... The metabolic fate of tryptophan (TRP), an essential amino acid, is conversion into a variety of neuroactive substances including the well-known neurotransmitters serotonin and melatonin, as well as a range of kynurenine metabolites such as kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quin ...
Immunogold Labeling of Rosette Terminal Cellulose
... freeze-fracture techniques, in which harsh acid treatments customarily have been used to remove cell and tissue components. Antibody interactions with the gold label and the rosette TC are shown diagrammatically and to scale in Figure 2. The SDS-FRL technique as applied to plants is shown diagrammat ...
... freeze-fracture techniques, in which harsh acid treatments customarily have been used to remove cell and tissue components. Antibody interactions with the gold label and the rosette TC are shown diagrammatically and to scale in Figure 2. The SDS-FRL technique as applied to plants is shown diagrammat ...
Antiviral Protection Cell Cross-Presentation, CTL Responses, and
... Address correspondence and reprint requests to Dr. David M. Segal, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 10 Center Drive, Bethesda, MD 20892-1360. E-mail address: ...
... Address correspondence and reprint requests to Dr. David M. Segal, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 10 Center Drive, Bethesda, MD 20892-1360. E-mail address: ...
Adaptive Gain and Optimal Performance
... mode, associated with disengagement from the current task and a search for alternative behaviors (exploration). Monkey LC receives prominent, direct inputs from the anterior cingulate (ACC) and orbitofrontal cortices (OFC), both of which are thought to monitor task-related utility. We propose that t ...
... mode, associated with disengagement from the current task and a search for alternative behaviors (exploration). Monkey LC receives prominent, direct inputs from the anterior cingulate (ACC) and orbitofrontal cortices (OFC), both of which are thought to monitor task-related utility. We propose that t ...
35-2 The Nervous System
... Moments after binding to receptors, neurotransmitters are released from the cell surface. The neurotransmitters may then be broken down by enzymes, or taken up and recycled by the axon terminal. ...
... Moments after binding to receptors, neurotransmitters are released from the cell surface. The neurotransmitters may then be broken down by enzymes, or taken up and recycled by the axon terminal. ...
the program guide
... concern today. The symptomatic and reductive approach of the modern medical system finds these disorders non-curable and focuses on immune suppression, which leads to many other serious health issues and complications. The self-destructive nature of autoimmune diseases reflects both the ‘dushana swa ...
... concern today. The symptomatic and reductive approach of the modern medical system finds these disorders non-curable and focuses on immune suppression, which leads to many other serious health issues and complications. The self-destructive nature of autoimmune diseases reflects both the ‘dushana swa ...
- Wiley Online Library
... secreted preferentially from the periphery of the medulla and exhibits a higher threshold and steeper stimulus-secretion function than norepinephrine. Elevated stimulation of the whole nerve specifically enhances epinephrine release from the peripheral medulla. Our data further show that elimination ...
... secreted preferentially from the periphery of the medulla and exhibits a higher threshold and steeper stimulus-secretion function than norepinephrine. Elevated stimulation of the whole nerve specifically enhances epinephrine release from the peripheral medulla. Our data further show that elimination ...
PDF - The Journal of Experimental Medicine
... and cell lines (Kaplan et al., 1998; Dunn et al., 2005). Its relevance to humans treated with anti–PD-1 therapy has been highlighted by the description of patients who developed acquired resistance to the therapy through new truncating mutations in JAK1 or JAK2 (Zaretsky et al., 2016). These were pa ...
... and cell lines (Kaplan et al., 1998; Dunn et al., 2005). Its relevance to humans treated with anti–PD-1 therapy has been highlighted by the description of patients who developed acquired resistance to the therapy through new truncating mutations in JAK1 or JAK2 (Zaretsky et al., 2016). These were pa ...
Differential switching to IgG and IgA healthy controls
... ABSTRACT: Several studies have demonstrated the presence of B-cell follicles and autoantibodies in chronic obstructive pulmonary disease (COPD). It is unclear against which antigens this B-cell response is directed and whether it contributes to development or worsening of disease. We assessed differ ...
... ABSTRACT: Several studies have demonstrated the presence of B-cell follicles and autoantibodies in chronic obstructive pulmonary disease (COPD). It is unclear against which antigens this B-cell response is directed and whether it contributes to development or worsening of disease. We assessed differ ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.