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ImmunLec21-2010 - 81-493
ImmunLec21-2010 - 81-493

... This work indicated that T cells recognize both MHC and specific antigen fragments. Does one receptor recognize the MHC and another receptor recognize the antigen fragment embedded in the binding site on the MHC ? Or is there one receptor with specificity for MHC in combination with a specific an ...
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Kuby Immunology 6/e - Dr. Jennifer Capers, PhD

... ○ Early genes (1-2 hours from recognition)  IL-2, IL2R, IL-6, IFN-γ ○ Late genes (more than 2 days later)  Encode adhesion molecules ...
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... Why wouldn’t an eradication program always work? ...
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... Refers to antigen-specific defense mechanisms that take several days to become protective and are designed to remove a specific antigen. This is the immunity one develops throughout life. There are two major branches of the adaptive immune responses: 1. Humoral immunity : involves the production of ...
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Introduction to the immune system

... for day or two before settling down in various tissues in body! •  Mature and enlarge in resident tissue and become known as macrophages (“large eaters”)! –  Life span can range from several months to years! •  Become professional phagocytes and can act as antigen presenting cells! •  Note: Dendriti ...
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... Adaptive immune responses comprise the second category. These responses involve T-cells and B-cells, two cell types that require “training” or education to learn not to attack our own cells and to become more efficient for eliminating invading germs. In contrast to the innate immune system, adaptive ...
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... response  During this time, effector B cells called plasma cells are generated, and T cells are activated to their effector forms  In the secondary immune response, memory cells facilitate a faster, more efficient response ...
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... Pemphigus is a rare skin disorder characterized by blistering of the skin and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on the skin and in mouth. Autoantibodies attack desmosomes. Antigen: Desmoglein 3 ...
11.1 Immunity Notes - Twanow
11.1 Immunity Notes - Twanow

... – Response is 2-7 days; your body makes more effectors cells than in a primary response, and antibodies/cells have a higher affinity for the antigen – You won’t get sick because your body remembers how to fight effectively ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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