antibodies
... a growing tumor early during cancer development, namely damage-associated molecular pattern molecules (DAMPs) [24,25], released either directly from the dying tumor cells or damaged tissues ingrown by invasive tumors. DAMPs can be detected by different receptor types inducing a type I interferon ans ...
... a growing tumor early during cancer development, namely damage-associated molecular pattern molecules (DAMPs) [24,25], released either directly from the dying tumor cells or damaged tissues ingrown by invasive tumors. DAMPs can be detected by different receptor types inducing a type I interferon ans ...
Telomeres and Telomerase
... – Telomerase’s RNA template is rich in guanine. – Platinum based drugs such as cisplatin, carboplatin, and Ptquin8 have a high affinity for these guanines in the N7 position. – Does not completely inhibit telomerase, but enough to destabilize telomeric homeostasis ...
... – Telomerase’s RNA template is rich in guanine. – Platinum based drugs such as cisplatin, carboplatin, and Ptquin8 have a high affinity for these guanines in the N7 position. – Does not completely inhibit telomerase, but enough to destabilize telomeric homeostasis ...
Role of NKT cells in the digestive system. IV. The role of canonical
... either by measuring mRNA for the canonical ␣-chain TCRs (mNKT and iNKT cells) or by flow cytometry using CD1d tetramers loaded with ␣GalCer (iNKT cells). Up to 4% of mouse small intestine (SI) intraepithelial lymphocytes (IELs) (4, 18, 25, 39), 8 –10% of large intestine (LI) IELs (4, 25), and 7% of ...
... either by measuring mRNA for the canonical ␣-chain TCRs (mNKT and iNKT cells) or by flow cytometry using CD1d tetramers loaded with ␣GalCer (iNKT cells). Up to 4% of mouse small intestine (SI) intraepithelial lymphocytes (IELs) (4, 18, 25, 39), 8 –10% of large intestine (LI) IELs (4, 25), and 7% of ...
A novel adenosine A receptor antagonist optimized for high potency
... environment and restored cytokine production even in the presence of high concentrations of A2A agonists. Furthermore, our compound was able to potently increase CD8 T cell cytotoxicity in a cytotoxicity assay with CD8 T cells as effectors and cancer cells as targets. These results suggest that iTeo ...
... environment and restored cytokine production even in the presence of high concentrations of A2A agonists. Furthermore, our compound was able to potently increase CD8 T cell cytotoxicity in a cytotoxicity assay with CD8 T cells as effectors and cancer cells as targets. These results suggest that iTeo ...
WHIP2015 book - Marine Biological Laboratory
... “New Paradigms of Host Resistance to African Trypanosomiasis” 12:15 – 13:30 LUNCH SWOPE LYMPHOCYTES – CHAIRs Chris Hunter & Georgia Perona Wright 13:30 Jennifer Cnops -‐-‐-‐ NK, NKT ...
... “New Paradigms of Host Resistance to African Trypanosomiasis” 12:15 – 13:30 LUNCH SWOPE LYMPHOCYTES – CHAIRs Chris Hunter & Georgia Perona Wright 13:30 Jennifer Cnops -‐-‐-‐ NK, NKT ...
LFA-1 is required for retention of effector CD8 T cells in mouse lungs
... an allergic inflammatory response in a mouse model of asthma.22 In an adoptive transfer model for alloreactive CD4 T cells, adherence of T cells in the lungs was shown to be partially dependent on LFA-1 and its receptor ICAM-1.23 Bacterial or viral infection has been shown to generate effector and m ...
... an allergic inflammatory response in a mouse model of asthma.22 In an adoptive transfer model for alloreactive CD4 T cells, adherence of T cells in the lungs was shown to be partially dependent on LFA-1 and its receptor ICAM-1.23 Bacterial or viral infection has been shown to generate effector and m ...
Pre-infection transcript levels of FAM26F in peripheral blood
... T lymphocyte (CTL) effector mechanism and non-classical CD8 T-cell mediated non-cytolytic antiviral response (CNAR) (Mackewicz et al., 2003; Walker et al., 1986, 1991). CNAR refers to the property of CD8+ T-lymphocytes to suppress HIV-1 replication in acutely infected CD4+ cells without killing them ...
... T lymphocyte (CTL) effector mechanism and non-classical CD8 T-cell mediated non-cytolytic antiviral response (CNAR) (Mackewicz et al., 2003; Walker et al., 1986, 1991). CNAR refers to the property of CD8+ T-lymphocytes to suppress HIV-1 replication in acutely infected CD4+ cells without killing them ...
- Vancouver Bioinformatics User Group
... Traditionally, the immune response divided into two different branches the adaptive immune response and the innate immune response. ...
... Traditionally, the immune response divided into two different branches the adaptive immune response and the innate immune response. ...
Efficient isolation of live microglia with preserved phenotypes from
... inflammatory molecules. Hence, to enable direct analysis of microglial activities ex vivo, an efficient, reliable, and reproducible method of microglial isolation is needed. Methods: After enzymatic digestion of brain tissues and myelin removal, CD11b+ cells were isolated using immunomagnetic separa ...
... inflammatory molecules. Hence, to enable direct analysis of microglial activities ex vivo, an efficient, reliable, and reproducible method of microglial isolation is needed. Methods: After enzymatic digestion of brain tissues and myelin removal, CD11b+ cells were isolated using immunomagnetic separa ...
the emergence of immuno-oncology in clinical cancer research
... Unlike specific targeted therapies directed against a driver mutation, immuno-therapy is not restricted by the expression of genomic abnormalities that are the targets of precision medicine. And as with many other successful approaches in cancer therapy, combinations of immuno-therapy and other targ ...
... Unlike specific targeted therapies directed against a driver mutation, immuno-therapy is not restricted by the expression of genomic abnormalities that are the targets of precision medicine. And as with many other successful approaches in cancer therapy, combinations of immuno-therapy and other targ ...
1. Malar rash
... Generally, lupus that is caused by a drug exposure goes away once the drug is stopped. 3. Infection: There has been continuing interest in the possibility that infectious agents might initiate or flare SLE. ...
... Generally, lupus that is caused by a drug exposure goes away once the drug is stopped. 3. Infection: There has been continuing interest in the possibility that infectious agents might initiate or flare SLE. ...
Aplastic anemia (AA) is a bone marrow failure disease, which mainly
... maintenance treatment, can reduce the mortality rate of graft-versus-host disease (GVHD) with survival rate can be improved distinctly[4]. In 2000, Horowitz MM[5] reported that allogeneic stem cell transplantation could make the 5 years survival rate of AA to 77%, and 90% for children. It is importa ...
... maintenance treatment, can reduce the mortality rate of graft-versus-host disease (GVHD) with survival rate can be improved distinctly[4]. In 2000, Horowitz MM[5] reported that allogeneic stem cell transplantation could make the 5 years survival rate of AA to 77%, and 90% for children. It is importa ...
Major Histocompatibility Complex 02/28/06
... ~100,000 MHC molecule variants per cell ~ 100 MHC-peptide complexes required for T cytotoxic cell recognition ...
... ~100,000 MHC molecule variants per cell ~ 100 MHC-peptide complexes required for T cytotoxic cell recognition ...
Preparative separation of foreign antigens for highly efficient
... mechanisms of protective immunity to infectious pathogens is dependent on simple and reproducible methods for the assessment of T cell responses. Unlike antibodies which bind to conformational epitopes directly, T cells recognise antigens presented as linear epitopes in association with MHC molecule ...
... mechanisms of protective immunity to infectious pathogens is dependent on simple and reproducible methods for the assessment of T cell responses. Unlike antibodies which bind to conformational epitopes directly, T cells recognise antigens presented as linear epitopes in association with MHC molecule ...
10Hypersensitivity Reaction
... 2. Characteristics of type III a. IgM and IgG-mediated b. When antigen and antibody meet at the appropriate concentrations, they form insoluble antigen-antibody complexes(IC). c. IC can activate the complement cascade. Release of certain products of complements (C3a and C5a) causes a local increase ...
... 2. Characteristics of type III a. IgM and IgG-mediated b. When antigen and antibody meet at the appropriate concentrations, they form insoluble antigen-antibody complexes(IC). c. IC can activate the complement cascade. Release of certain products of complements (C3a and C5a) causes a local increase ...
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
... that control the initial development, cellular composition and functional maintenance of these structures are shared. However, ELS formation is distinct from the preprogrammed ontogenic processes that are associated with secondary lymphoid organogenesis and it does not occur in all patients. Conseq ...
... that control the initial development, cellular composition and functional maintenance of these structures are shared. However, ELS formation is distinct from the preprogrammed ontogenic processes that are associated with secondary lymphoid organogenesis and it does not occur in all patients. Conseq ...
T Cell Expression of MyD88 Is + CD4 Essential for Normal Resolution of
... also been observed in models of infection and autoimmunity. In a murine model of Toxoplasma gondii infection, control of infection was impaired even when MyD88-deficient adaptive immune cells were activated in the presence of normal APCs (43). These findings were recapitulated in two independent stu ...
... also been observed in models of infection and autoimmunity. In a murine model of Toxoplasma gondii infection, control of infection was impaired even when MyD88-deficient adaptive immune cells were activated in the presence of normal APCs (43). These findings were recapitulated in two independent stu ...
Cell-Mediated Immunity to Bordetella pertussis: Role of Thl
... Generation of pertussis-specific T-cell lines. CD4+ T-cell lines specific for FHA were established as previously described for influenza virus-specific T-cell clones (33). Briefly, spleen cells (2 x 106) from convalescent mice were stimulated in vitro with purified FHA (0.5 ,ug/ml) for 4 days, and t ...
... Generation of pertussis-specific T-cell lines. CD4+ T-cell lines specific for FHA were established as previously described for influenza virus-specific T-cell clones (33). Briefly, spleen cells (2 x 106) from convalescent mice were stimulated in vitro with purified FHA (0.5 ,ug/ml) for 4 days, and t ...
Autoimmunity and pulmonary hypertension: a perspective REVIEW
... [66]. Conversely, autoimmune diseases such as Sjögren’s disease and systemic lupus erythematosis, are distinguished by pathogenic auto-antibody production in the setting of apparently compromised Treg function. Autoimmunity in PAH may more closely resemble the latter group of diseases. As discussed ...
... [66]. Conversely, autoimmune diseases such as Sjögren’s disease and systemic lupus erythematosis, are distinguished by pathogenic auto-antibody production in the setting of apparently compromised Treg function. Autoimmunity in PAH may more closely resemble the latter group of diseases. As discussed ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑