Hematopoietic stem cell transplantation for multiple sclerosis: is it a
... design. Moreover, enhancing the yield and purity of hematopoietic stem cells during isolation along with the utility of appropriate conditioning agents has provided a clearer foundation for clinical translation studies. To support this approach, preclinical data derived from animal models of MS, exp ...
... design. Moreover, enhancing the yield and purity of hematopoietic stem cells during isolation along with the utility of appropriate conditioning agents has provided a clearer foundation for clinical translation studies. To support this approach, preclinical data derived from animal models of MS, exp ...
maturation of humoral immune responses
... have acted as evolutionary pressures leading to the emergence of various protective mechanisms. In vertebrates, mechanical barriers like skin and mucosa act as a first way to stop the entry of a wide variety of harmful organisms, pathogens, e.g. bacteria, viruses and parasites. The body also possess ...
... have acted as evolutionary pressures leading to the emergence of various protective mechanisms. In vertebrates, mechanical barriers like skin and mucosa act as a first way to stop the entry of a wide variety of harmful organisms, pathogens, e.g. bacteria, viruses and parasites. The body also possess ...
Immune recognition and rejection of allogeneic skin grafts
... The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate ...
... The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate ...
... stimulation. B and T cells that have matured and associate in the lymph nodes, but have not encountered antigen are considered naïve cells. However, once antigen presenting cells (APC’s) or more specifically dendritic cells (another white blood cell derived from the same type of hematopoietic stem c ...
Immune Abnormalities in Patients Meeting New Diagnostic Criteria
... CFS/ME, according to the 1994 CDC and ICC. The findings indicate that the ICC is invaluable in identifying immunological differences that have consistently been shown to be decreased in CFS/ME patients diagnosed with the 1994 CDC. The ICC is able to determine additional differences within immunologi ...
... CFS/ME, according to the 1994 CDC and ICC. The findings indicate that the ICC is invaluable in identifying immunological differences that have consistently been shown to be decreased in CFS/ME patients diagnosed with the 1994 CDC. The ICC is able to determine additional differences within immunologi ...
the BLIS K12TM Brochure for more information
... this particular K12TM strain of Streptococcus salivarius secretes antimicrobial molecules called BLIS (Bacteriocin-Like-Inhibitory Substances). These have the ability to inhibit harmful bacteria such as the bacteria responsible for bad breath, sore throats, upper respiratory tract and ear infections ...
... this particular K12TM strain of Streptococcus salivarius secretes antimicrobial molecules called BLIS (Bacteriocin-Like-Inhibitory Substances). These have the ability to inhibit harmful bacteria such as the bacteria responsible for bad breath, sore throats, upper respiratory tract and ear infections ...
5.2. general texts on biological products
... from a single production cell culture inoculated with the same working seed lot or a suspension derived from the working seed lot, incubated, and harvested in a single production run. Monovalent pooled harvest. Pooled material containing a single strain or type of micro-organism or antigen and deriv ...
... from a single production cell culture inoculated with the same working seed lot or a suspension derived from the working seed lot, incubated, and harvested in a single production run. Monovalent pooled harvest. Pooled material containing a single strain or type of micro-organism or antigen and deriv ...
Trends and advances in tumor immunology and lung cancer
... protein receptor expressed on the surface of CTL following their full activation. The binding between CTLA-4 and B7-1 (CD80) or B7-2 (CD86) on APCs prevents the overactivity of T cells under normal conditions. During cancer, T cells express a high level of CTLA-4, so that, cancer can evade the cytot ...
... protein receptor expressed on the surface of CTL following their full activation. The binding between CTLA-4 and B7-1 (CD80) or B7-2 (CD86) on APCs prevents the overactivity of T cells under normal conditions. During cancer, T cells express a high level of CTLA-4, so that, cancer can evade the cytot ...
Transcutaneous vaccination via laser microporation
... Most vaccines are administered to muscle or subcutaneous tissue by injection using needle and syringe. Whereas the transcutaneous route was heavily employed during the smallpox eradication campaign by scarification with a bifurcated needle [1], currently only Bacille Calmette Guérin vaccine against ...
... Most vaccines are administered to muscle or subcutaneous tissue by injection using needle and syringe. Whereas the transcutaneous route was heavily employed during the smallpox eradication campaign by scarification with a bifurcated needle [1], currently only Bacille Calmette Guérin vaccine against ...
Memmler`s The Human Body in Health and Disease 11th
... Lippincott Williams & Wilkins, 2001.) What type of lymphatic vessel carries lymph into a ...
... Lippincott Williams & Wilkins, 2001.) What type of lymphatic vessel carries lymph into a ...
NIH Public Access - IUPUI ScholarWorks
... The acquisition of IAV antigen in the lung by cRDC prior to their egress from the inflamed lung is most likely achieved by direct infection of RDC. Different DC subsets in both mice and humans differ in susceptibility to IAV infection. In case of IAV H1N1 PR/8 infection in mice, CD103+ RDCs, unlike ...
... The acquisition of IAV antigen in the lung by cRDC prior to their egress from the inflamed lung is most likely achieved by direct infection of RDC. Different DC subsets in both mice and humans differ in susceptibility to IAV infection. In case of IAV H1N1 PR/8 infection in mice, CD103+ RDCs, unlike ...
Origins of antinuclear antibodies
... the Y5 small RNA molecule [26], with which both antigens associate, and autoantibodies to DNA and histones (chromatin) are associated with one another. Thus, the macromolecular complexes illustrated in Figure 13.2C appear to be seen by the immune system as units. This is analogous to the immune resp ...
... the Y5 small RNA molecule [26], with which both antigens associate, and autoantibodies to DNA and histones (chromatin) are associated with one another. Thus, the macromolecular complexes illustrated in Figure 13.2C appear to be seen by the immune system as units. This is analogous to the immune resp ...
Nerve activates contraction
... • Chemokines constitute a group of about 50 different proteins that bind to receptors on many types of leukocytes and induce numerous other changes central to inflammation. • For example, they induce the production of toxic forms of oxygen in phagocyte lysosomes and the release of histamine from bas ...
... • Chemokines constitute a group of about 50 different proteins that bind to receptors on many types of leukocytes and induce numerous other changes central to inflammation. • For example, they induce the production of toxic forms of oxygen in phagocyte lysosomes and the release of histamine from bas ...
Reaching the Biological Cure - Diabetes Research Institute
... daily balancing act that requires constant vigilance and attention. In other words, there are no breaks because technology cannot ideally mimic the exquisite, biological function of a healthy pancreas. Why? Pancreatic islet cells, which make up only one to two percent of the organ, have a built-in g ...
... daily balancing act that requires constant vigilance and attention. In other words, there are no breaks because technology cannot ideally mimic the exquisite, biological function of a healthy pancreas. Why? Pancreatic islet cells, which make up only one to two percent of the organ, have a built-in g ...
Immunological and fibrotic mechanisms in Cardiac Allograft
... The human immune system contains a variety of cells. After transplantation of a solid organ, the recipient’s immune system recognizes the graft as foreign and attacks it. In this process there are many different immune cells involved. The main reason why a graft is rejected is because there are majo ...
... The human immune system contains a variety of cells. After transplantation of a solid organ, the recipient’s immune system recognizes the graft as foreign and attacks it. In this process there are many different immune cells involved. The main reason why a graft is rejected is because there are majo ...
Regulation of mucosal immune responses in effector sites
... with ovalbumin. Using this protocol, it was possible to demonstrate that the initial feeds resulted in immunological priming rather than tolerance, and that this process was associated with delayed-type hypersensitivity reactivity and mild intestinal pathology (Stokes et al. 1983). Again, the implic ...
... with ovalbumin. Using this protocol, it was possible to demonstrate that the initial feeds resulted in immunological priming rather than tolerance, and that this process was associated with delayed-type hypersensitivity reactivity and mild intestinal pathology (Stokes et al. 1983). Again, the implic ...
Obstacles to ideal anti-HIV antibody-dependent cellular cytotoxicity
... potential of NK cells by genetic determinants through an ontological process termed education [25–28]. As such, it is uncertain that all individuals carry NK cells capable of mediating sufficient Ab-dependent effector functions to provide protection against incoming viral infections via this immune r ...
... potential of NK cells by genetic determinants through an ontological process termed education [25–28]. As such, it is uncertain that all individuals carry NK cells capable of mediating sufficient Ab-dependent effector functions to provide protection against incoming viral infections via this immune r ...
Viruses: Biological background
... It carries RNA as its nucleic acid, which it converts into DNA by using the enzyme reverse transcriptase. ...
... It carries RNA as its nucleic acid, which it converts into DNA by using the enzyme reverse transcriptase. ...
Intestinal bacteria and inflammatory bowel disease
... be unknown, there is little doubt that both humoral and cellular immune pathways are activated in the inflamed mucosa. Important role play intestinal microorganisms. Intestinal inflammation in patients with IBD is thought to result from an overwhelming uncontrolled activation of the mucosal immune s ...
... be unknown, there is little doubt that both humoral and cellular immune pathways are activated in the inflamed mucosa. Important role play intestinal microorganisms. Intestinal inflammation in patients with IBD is thought to result from an overwhelming uncontrolled activation of the mucosal immune s ...
Using Transfer Factor to Strengthen Cell
... Transfer factors might be able to convey protection against infections via Th1 immunity “Avian influenza…presents a threat of producing a pandemic. We present arguments for the use of cell mediated immunity for the prevention of the infection as well as for the treatment of infected patients. Trans ...
... Transfer factors might be able to convey protection against infections via Th1 immunity “Avian influenza…presents a threat of producing a pandemic. We present arguments for the use of cell mediated immunity for the prevention of the infection as well as for the treatment of infected patients. Trans ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑