Granulocyte-Macrophage Colony-Stimulating
... been broadly explored to increase tumor cell immunogenicity. Inter- fluorescent protein (GFP) (9). The nucleotide sequence of the fusion product leukin (IL)-2 and granulocyte-macrophage colony-stimulating factor of GM-CSF and IL-2 cDNAs was confirmed by DNA sequencing at the (GM-CSF) are among the m ...
... been broadly explored to increase tumor cell immunogenicity. Inter- fluorescent protein (GFP) (9). The nucleotide sequence of the fusion product leukin (IL)-2 and granulocyte-macrophage colony-stimulating factor of GM-CSF and IL-2 cDNAs was confirmed by DNA sequencing at the (GM-CSF) are among the m ...
Immune Response to Self Nuclear Autoantigen Determines the Fate
... which are a prototype model of human SLE, the pathway of peripheral tolerance to eliminate self-reactive lymphocytes is impaired due to the deficient Fas/Fas ligand system (8). The importance of peripheral tolerance has already been demonstrated using Tg mice in which the extrathymic organs express ...
... which are a prototype model of human SLE, the pathway of peripheral tolerance to eliminate self-reactive lymphocytes is impaired due to the deficient Fas/Fas ligand system (8). The importance of peripheral tolerance has already been demonstrated using Tg mice in which the extrathymic organs express ...
Full Text PDF - J
... Early researches have shown that the bursa of Fabricius is a critical organ for development of B lymphocytes in birds. Exogenous proteins from the gut lumen or the environment are taken up by the follicle-associated epithelium and enter into the bursal follicle. Not all of the B lymphocytes in the b ...
... Early researches have shown that the bursa of Fabricius is a critical organ for development of B lymphocytes in birds. Exogenous proteins from the gut lumen or the environment are taken up by the follicle-associated epithelium and enter into the bursal follicle. Not all of the B lymphocytes in the b ...
Mycoplasma-like Organisms from Plants with `Yellows
... IgG and conjugated to horse-radish peroxidase (Miles, Slough, U.K.) (1 :2000). Bound conjugate was developed with the substrate 4-chloro-1-naphthol which gives rise to a blue coloured insoluble product (Hawkes et al., 1982). Molecular weights were calculated with reference to standards of known mole ...
... IgG and conjugated to horse-radish peroxidase (Miles, Slough, U.K.) (1 :2000). Bound conjugate was developed with the substrate 4-chloro-1-naphthol which gives rise to a blue coloured insoluble product (Hawkes et al., 1982). Molecular weights were calculated with reference to standards of known mole ...
Abstract
... Kruize, Floris PJG Lafeber, Joel AG van Roon. University Medical Center Utrecht, Utrecht, Netherlands Background In patients with primary Sjögren’s syndrome (pSS) local T cell-driven inflammation can contribute to destruction of exocrine glands associated with clinical symptoms of dryness. Evidence ...
... Kruize, Floris PJG Lafeber, Joel AG van Roon. University Medical Center Utrecht, Utrecht, Netherlands Background In patients with primary Sjögren’s syndrome (pSS) local T cell-driven inflammation can contribute to destruction of exocrine glands associated with clinical symptoms of dryness. Evidence ...
CARMA1 Is Critical for the Development of Allergic Airway
... Previous research has demonstrated that members of the NF-B family are important in the pathogenesis of allergic airway inflammation in murine models of asthma (16, 17). Specifically, mice that lack the p50 subunit of NF-B are unable to develop allergic airway inflammation due to a defect in Th2 c ...
... Previous research has demonstrated that members of the NF-B family are important in the pathogenesis of allergic airway inflammation in murine models of asthma (16, 17). Specifically, mice that lack the p50 subunit of NF-B are unable to develop allergic airway inflammation due to a defect in Th2 c ...
Figure 1 - Open Biology
... Figure 1. A zigzag model of the plant immune system [28]. PTI: PAMP-triggered immunity; ETS: effector-triggered susceptibility; ETI: effector-triggered immunity; PAMPs: pathogen-associated molecular patterns; HR: hypersensitive cell death response. This model can be divided into four stages. In phas ...
... Figure 1. A zigzag model of the plant immune system [28]. PTI: PAMP-triggered immunity; ETS: effector-triggered susceptibility; ETI: effector-triggered immunity; PAMPs: pathogen-associated molecular patterns; HR: hypersensitive cell death response. This model can be divided into four stages. In phas ...
Federica Chessa Dr. sc. hum. Dendritic cell function in different renal
... subgroup of bone marrow-derived leukocytes which also includes renal macrophages. Renal mononuclear phagocytes form a network of stellate cells which spans the interstitial spaces between the renal tubules. Renal DCs are essential for the maintenance of tissue homeostasis, as they sample innocuous a ...
... subgroup of bone marrow-derived leukocytes which also includes renal macrophages. Renal mononuclear phagocytes form a network of stellate cells which spans the interstitial spaces between the renal tubules. Renal DCs are essential for the maintenance of tissue homeostasis, as they sample innocuous a ...
TISSUE STRUCTURE - Trinity College Dublin
... Definition of Epithelium is: a single tissue; plural, epithelia; adjective, epithelial ...
... Definition of Epithelium is: a single tissue; plural, epithelia; adjective, epithelial ...
Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
Human Leukocyte Antigen-Class II-Positive
... endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corneal fibroblasts, treated with IFN-y and expressed class II antigen, were not capable of inducing the primary response of allogenic lymphocytes.26'27 The ab ...
... endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corneal fibroblasts, treated with IFN-y and expressed class II antigen, were not capable of inducing the primary response of allogenic lymphocytes.26'27 The ab ...
Different Subsets of T Cells, Memory, Effector Functions, and
... profiles (Figure 2)recently [10]. These CD4 cell immunotherapy [5,6]. For example, T different memory stem cells (T SCM ) from a CD45RA+ T immune and effector response functions of T cells [10]. All CD4+ Th subsets are differentiated from populationnaive withCD4 a high expression of CD62L, CD95, and ...
... profiles (Figure 2)recently [10]. These CD4 cell immunotherapy [5,6]. For example, T different memory stem cells (T SCM ) from a CD45RA+ T immune and effector response functions of T cells [10]. All CD4+ Th subsets are differentiated from populationnaive withCD4 a high expression of CD62L, CD95, and ...
The role of lymph node sinus macrophages in host defense
... macrophage biology. Below we will summarize our current knowledge on the role of these sessile LNresident macrophages in host defense. Cellular “flypaper” When pathogens enter an organism by breaching through the skin or mucosal membranes, innate responses usually eliminate or contain the infectious ...
... macrophage biology. Below we will summarize our current knowledge on the role of these sessile LNresident macrophages in host defense. Cellular “flypaper” When pathogens enter an organism by breaching through the skin or mucosal membranes, innate responses usually eliminate or contain the infectious ...
Heba Rasmy Mohamed Abdel-Baset_chapter 3 HLA 28-09
... increased prevalence of Enteropathy-associated T-cell Lymphoma, and ...
... increased prevalence of Enteropathy-associated T-cell Lymphoma, and ...
Diagnosis and treatment of patients with virus induced inflammatory cardiomyopathy U. Kühl
... that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and escapes regular control mechanisms[12] (see the review by Afanasyeva and Rose, in the present supplement). Resulting immune-mediated injury may further increase ventricular dysfunc ...
... that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and escapes regular control mechanisms[12] (see the review by Afanasyeva and Rose, in the present supplement). Resulting immune-mediated injury may further increase ventricular dysfunc ...
030710 Medium- and Large
... and large-vessel arteritis are characteristics of two entities — giant-cell (temporal) arteritis and Takayasu’s arteritis. These arteritides involve similar histologic abnormalities1 but differ in the age of onset and the vascular structures that are preferentially targeted.2,3 They share pathogenic ...
... and large-vessel arteritis are characteristics of two entities — giant-cell (temporal) arteritis and Takayasu’s arteritis. These arteritides involve similar histologic abnormalities1 but differ in the age of onset and the vascular structures that are preferentially targeted.2,3 They share pathogenic ...
Immunology for CME 11.7.14.cdr
... Dr. Sachin Srinivasan Chief – People Tree Rheumatology, People Tree Hospitals, Bangalore Cytokines and other mediators of immune response in pathology and physiology ...
... Dr. Sachin Srinivasan Chief – People Tree Rheumatology, People Tree Hospitals, Bangalore Cytokines and other mediators of immune response in pathology and physiology ...
Apoptosis of Effector Th2 Cells in the Lung through the Inhibition of
... inflammatory leukocytes in the lung. Although there are limitations when mouse models are translated to the human diseases, much has been learned from these investigations. After Ag recognition by the TCR, naive CD4 T cells undergo clonal expansion followed by differentiation into functional effecto ...
... inflammatory leukocytes in the lung. Although there are limitations when mouse models are translated to the human diseases, much has been learned from these investigations. After Ag recognition by the TCR, naive CD4 T cells undergo clonal expansion followed by differentiation into functional effecto ...
Immunotherapy for prostate cancer: the next step?
... There was no difference in the primary endpoint of PFS. Common adverse events were fever, nausea, fatigue and injection site reactions.14 It is not yet clear at which stage of disease PROSTVAC-VF will be most effective; the results of studies evaluating its use in non-metastatic hormone-sensitive pr ...
... There was no difference in the primary endpoint of PFS. Common adverse events were fever, nausea, fatigue and injection site reactions.14 It is not yet clear at which stage of disease PROSTVAC-VF will be most effective; the results of studies evaluating its use in non-metastatic hormone-sensitive pr ...
Inflammation response in AD - UvA-DARE
... more poisonous (Carrotta et al., 2006). This is supported by the fact that the concentration of soluble Aβ shows a strong correlation with cognitive dysfunction, while the number of senile plaques is poorly correlated to the severity of the disease (Kokubo, Kayed, Glabe and Yamaguchi, 2005). Moreove ...
... more poisonous (Carrotta et al., 2006). This is supported by the fact that the concentration of soluble Aβ shows a strong correlation with cognitive dysfunction, while the number of senile plaques is poorly correlated to the severity of the disease (Kokubo, Kayed, Glabe and Yamaguchi, 2005). Moreove ...
Regulation of innate and adaptive immune responses by
... TLRs are widely expressed in many cell types, including epithelial and endothelial cells, although these non-hematopoietic cell types normally express only selected subsets of TLRs (12, 57). In contrast, hemotopoetically derived cells, such as monocytes, macrophages, neutrophils and dendritic cells ...
... TLRs are widely expressed in many cell types, including epithelial and endothelial cells, although these non-hematopoietic cell types normally express only selected subsets of TLRs (12, 57). In contrast, hemotopoetically derived cells, such as monocytes, macrophages, neutrophils and dendritic cells ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑