Lymphatic System and Immunity
... Fine reticular fiber network that holds lymphocytes in place and traps microorganisms ...
... Fine reticular fiber network that holds lymphocytes in place and traps microorganisms ...
Apocynin, a plant-derived, cartilage-saving drug, might be useful in
... which was mildly enhanced upon bacterial antigen stimulation (on average ~3 times), was slightly stimulated by apocynin: an increase of only 55% in [3H ]thymidine incorporation was observed (not statistically significant; data not shown). Dissociation of T-cell proliferation and cytokine production ...
... which was mildly enhanced upon bacterial antigen stimulation (on average ~3 times), was slightly stimulated by apocynin: an increase of only 55% in [3H ]thymidine incorporation was observed (not statistically significant; data not shown). Dissociation of T-cell proliferation and cytokine production ...
Stem Cell-Based Cellular Therapy in Rheumatoid
... been characterized by the ease of isolation and rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. MSCs are characterized by the capacity to adhere to plastic surface, the phenotyp ...
... been characterized by the ease of isolation and rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. MSCs are characterized by the capacity to adhere to plastic surface, the phenotyp ...
Document
... dental follicle stem cells (DFSCs), stem cells from apical papilla (SCAP), stem cells from human exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), and gingival mesenchymal stem cells (GMSCs). These stem cells have various useful applications in clinical dentistry that is d ...
... dental follicle stem cells (DFSCs), stem cells from apical papilla (SCAP), stem cells from human exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), and gingival mesenchymal stem cells (GMSCs). These stem cells have various useful applications in clinical dentistry that is d ...
Kynurenines and Multiple Sclerosis: The Dialogue between the
... Another pathological feature of progressive MS is cortical demyelination, which is probably one of the causes of the cognitive disability suffered by the patients [3,4]. While early relapsing and remitting disease is associated with the appearance of focal plaques in the white matter, cortical demye ...
... Another pathological feature of progressive MS is cortical demyelination, which is probably one of the causes of the cognitive disability suffered by the patients [3,4]. While early relapsing and remitting disease is associated with the appearance of focal plaques in the white matter, cortical demye ...
(or Rheumatic) Disease
... In 2003, the total cost of arthritis was $128 billion—nearly $81 billion in direct costs and $47 billion in indirect costs, equal to 1.2% of the 2003 U.S. gross domestic product. Arthritis is not just an old person’s disease. Nearly two-thirds of people with arthritis are younger than 65. Although a ...
... In 2003, the total cost of arthritis was $128 billion—nearly $81 billion in direct costs and $47 billion in indirect costs, equal to 1.2% of the 2003 U.S. gross domestic product. Arthritis is not just an old person’s disease. Nearly two-thirds of people with arthritis are younger than 65. Although a ...
Chapter 15 Biogenesis and Functions of Exosomes and
... formation of intraluminal vesicles (ILVs) by inward budding of the endosomal membrane, which gives rise to multivesicular bodies (MVBs) [13] (Fig. 2a). The process of MVB biogenesis is mediated by at least two distinct pathways and involves the sorting of various molecules into ILVs. The first pathw ...
... formation of intraluminal vesicles (ILVs) by inward budding of the endosomal membrane, which gives rise to multivesicular bodies (MVBs) [13] (Fig. 2a). The process of MVB biogenesis is mediated by at least two distinct pathways and involves the sorting of various molecules into ILVs. The first pathw ...
Immune modulation of some autoimmune diseases: the critical role
... changes the cytokine conformation leading to its dimerization with IL-10R2, which activate Jak1/STAT3 signalling pathways [55]. These macrophages are engaged in a complex bidirectional interaction with neutrophils. They also can drive the development of the innate and acquired immune responses by co ...
... changes the cytokine conformation leading to its dimerization with IL-10R2, which activate Jak1/STAT3 signalling pathways [55]. These macrophages are engaged in a complex bidirectional interaction with neutrophils. They also can drive the development of the innate and acquired immune responses by co ...
New roles for estrogens in rheumatoid arthritis
... (16-18). As a matter of fact, the aromatase enzyme complex is involved in the peripheral conversion of androgens (testosterone and androstenedione) to estrogens (estrone and estradiol, respectively) (see Fig.1). In tissues rich in macrophages a significant correlation was found between aromatase act ...
... (16-18). As a matter of fact, the aromatase enzyme complex is involved in the peripheral conversion of androgens (testosterone and androstenedione) to estrogens (estrone and estradiol, respectively) (see Fig.1). In tissues rich in macrophages a significant correlation was found between aromatase act ...
Multiple routes to B-cell memory
... The immune system has one fundamental function—to recognize foreign invaders and reject them from the body, while ensuring that such defense mechanisms do not destroy the host. This function remains the center around which the immune system, at the cellular, biochemical, genetic and Introduction epi ...
... The immune system has one fundamental function—to recognize foreign invaders and reject them from the body, while ensuring that such defense mechanisms do not destroy the host. This function remains the center around which the immune system, at the cellular, biochemical, genetic and Introduction epi ...
Update on mesenchymal stem cell-based therapy in lupus and scleroderma Open Access
... CD14 or CD11b, CD79a, or CD19. MSCs show intermediate levels of major histocompatibility complex (MHC) class I molecules on their cell surface and have no detectable levels of MHC class II, mainly HLA-DR, and co-stimulatory molecules (CD40, CD80, and CD86), which allow their transplantation across M ...
... CD14 or CD11b, CD79a, or CD19. MSCs show intermediate levels of major histocompatibility complex (MHC) class I molecules on their cell surface and have no detectable levels of MHC class II, mainly HLA-DR, and co-stimulatory molecules (CD40, CD80, and CD86), which allow their transplantation across M ...
PubMed - Institute for Immunity, Transplantation and Infection
... characterized by TH2-skewed inflammation with elevated pulmonary levels of IL-4, IL-5, and IL-13 levels. Although there are early forays into targeting TH2 immunity, less-specific corticosteroid therapy remains the immunomodulator of choice. Innate immune injury mediated by complement components als ...
... characterized by TH2-skewed inflammation with elevated pulmonary levels of IL-4, IL-5, and IL-13 levels. Although there are early forays into targeting TH2 immunity, less-specific corticosteroid therapy remains the immunomodulator of choice. Innate immune injury mediated by complement components als ...
HIV: A DISCOVERY OPENING THE ROAD TO NOVEL SCIENTIFIC KNOWLEDGE
... a complex interplay between innate and adaptive immune systems. Natural killer (NK) cells might control HIV by directly eliminating infected cells or by providing the optimal cytokine environment. HIV-specific CD8 cells with cytotoxic properties could also play a key role in controlling HIV infectio ...
... a complex interplay between innate and adaptive immune systems. Natural killer (NK) cells might control HIV by directly eliminating infected cells or by providing the optimal cytokine environment. HIV-specific CD8 cells with cytotoxic properties could also play a key role in controlling HIV infectio ...
Regulatory mechanisms that control T-follicular helper and
... immune cells in the environment to initiate a somewhat prototypic cytokine response to the pathogen.21–23 For instance, the conserved components of bacteria and viruses (for example, pathogen-associated molecular patterns) are recognized by pattern recognition receptors, such as the Toll-like recept ...
... immune cells in the environment to initiate a somewhat prototypic cytokine response to the pathogen.21–23 For instance, the conserved components of bacteria and viruses (for example, pathogen-associated molecular patterns) are recognized by pattern recognition receptors, such as the Toll-like recept ...
Early life cytokines, viral infections and IgE
... as phagocytic cells that are able to ingest and destroy pathogens, and cells that are able to release anti-microbial substances, e.g. basophils and natural killer (NK) cells. Besides, the complement proteins, as well part of the innate defence mechanisms, interact in highly regulated enzymatic react ...
... as phagocytic cells that are able to ingest and destroy pathogens, and cells that are able to release anti-microbial substances, e.g. basophils and natural killer (NK) cells. Besides, the complement proteins, as well part of the innate defence mechanisms, interact in highly regulated enzymatic react ...
Allergic Reactions - Northeast School of Botanical Medicine
... 5) Allergic asthma- Asthmatic hypersensitivity reactions may be caused by a variety of inhaled aeroallergens including pollen, animal dander, mold and dust mites. Symptoms include difficulty in breathing, wheezing, anxiousness, cough with thick bronchial mucous. Exercise, sudden temperature changes ...
... 5) Allergic asthma- Asthmatic hypersensitivity reactions may be caused by a variety of inhaled aeroallergens including pollen, animal dander, mold and dust mites. Symptoms include difficulty in breathing, wheezing, anxiousness, cough with thick bronchial mucous. Exercise, sudden temperature changes ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑