Gene regulation - Local.brookings.k12.sd.us
... Gene is on when tryptophan is needed Repressor protein exists as an inactive form Cell makes enzymes for tryptophan synthesis ...
... Gene is on when tryptophan is needed Repressor protein exists as an inactive form Cell makes enzymes for tryptophan synthesis ...
3 - Mit
... copper across the plasma membrane, delivering it to at least three chaperones: CCS, Cox17, Atx1 N-terminus has 8 putative Cu motifs (MXMXXM) C-terminus has 2 CXC motifs Atx1, the copper chaperone for Ccc2 Ccc2, a cation transporting ATPase; has CXXC sites Fet3, a multicopper ferroxidase Note the con ...
... copper across the plasma membrane, delivering it to at least three chaperones: CCS, Cox17, Atx1 N-terminus has 8 putative Cu motifs (MXMXXM) C-terminus has 2 CXC motifs Atx1, the copper chaperone for Ccc2 Ccc2, a cation transporting ATPase; has CXXC sites Fet3, a multicopper ferroxidase Note the con ...
Introduction
... Very little patient data spanning DNA/RNA/ protein/phenotype across a single cohort Need to obtain “robust” sample sizes to avoid incidental findings due to multiple testing [1] ...
... Very little patient data spanning DNA/RNA/ protein/phenotype across a single cohort Need to obtain “robust” sample sizes to avoid incidental findings due to multiple testing [1] ...
- Information Extraction and Text Mining Group
... Two distinct forms of oxidases catalysing the oxidative deamidation of D-alpha-amino acids have been identified in human tissues:
... Two distinct forms of oxidases catalysing the oxidative deamidation of D-alpha-amino acids have been identified in human tissues:
D-amino acid oxidase
andD-aspartate oxidase
. The enzymes differ in their electrophoretic properties, tissue distribution, binding with flavine adenine denu ...
Gene Section TRPM1 (transient receptor potential cation channel, subfamily M, member 1)
... TRPM1 is alternatively spliced and the splice variants are strongly depending on the cell type. Northern blot and RT-PCR analysis showed that the alternative splicing of TRPM1 mRNA produces short TRPM1 mRNAs derived from the 5' or 3' ends of the full length TRPM1. One of the major isoforms is predic ...
... TRPM1 is alternatively spliced and the splice variants are strongly depending on the cell type. Northern blot and RT-PCR analysis showed that the alternative splicing of TRPM1 mRNA produces short TRPM1 mRNAs derived from the 5' or 3' ends of the full length TRPM1. One of the major isoforms is predic ...
PEPTIDE HORMONES
... Sizes, origins and fate: Due to the force of custom, “peptide hormones” is a collective name that has been applied to peptides, polypeptides and proteins that all function as hormones. The name “factor” has also been given to some of these peptides and originates from a time when their peptide/prot ...
... Sizes, origins and fate: Due to the force of custom, “peptide hormones” is a collective name that has been applied to peptides, polypeptides and proteins that all function as hormones. The name “factor” has also been given to some of these peptides and originates from a time when their peptide/prot ...
A Comprehensive Functional Analysis of Ancestral Human Signal
... ongoing positive selection of alleles have been described, and these alleles have in some cases been functionally characterized. However, evolutionary changes that are fixed in current humans, but occurred after the human evolutionary lineage diverged from the chimpanzee lineage, are more difficult ...
... ongoing positive selection of alleles have been described, and these alleles have in some cases been functionally characterized. However, evolutionary changes that are fixed in current humans, but occurred after the human evolutionary lineage diverged from the chimpanzee lineage, are more difficult ...
Two Structural Domains Mediate Two Sequential y-Zein
... Arabidopsis root explants. Figure 2A is a schematic representation of the proteins encoded by pl9yZ and the truncated gene constructs plSHbP, plSDC, and pl9RcP pl9yZ encodes the wild-type y-zein (223 amino acids); pl9HbP encodes a y-zein derivative, the HbP protein. This protein was deleted in the P ...
... Arabidopsis root explants. Figure 2A is a schematic representation of the proteins encoded by pl9yZ and the truncated gene constructs plSHbP, plSDC, and pl9RcP pl9yZ encodes the wild-type y-zein (223 amino acids); pl9HbP encodes a y-zein derivative, the HbP protein. This protein was deleted in the P ...
lecture notes-molecular biology-web
... • Induction of allolactose might not be sufficient for maximum transcription if a carbon-energy source (e.g. glucose) preferred to lactose is present. • Only when glucose is depleted, the cell will expend energy to create a pathway to utilize the less favorable carbon-energy source lactose. ...
... • Induction of allolactose might not be sufficient for maximum transcription if a carbon-energy source (e.g. glucose) preferred to lactose is present. • Only when glucose is depleted, the cell will expend energy to create a pathway to utilize the less favorable carbon-energy source lactose. ...
BIOLOGY
... The complexities of the 3D structure of proteins are not the only difficulty in characterizing proteins. Many proteins contain additional chemicals that modify their structure. The final structure of a protein may include any number of modifications that occur during and after the synthesis of the p ...
... The complexities of the 3D structure of proteins are not the only difficulty in characterizing proteins. Many proteins contain additional chemicals that modify their structure. The final structure of a protein may include any number of modifications that occur during and after the synthesis of the p ...
Vocabulary: Did you know?
... Genotype-‐ Your genotype is the composition of alleles you have for a particular gene or genes. Remember than many genes come in two or more different “flavors” or alleles—one version (or allele) may ...
... Genotype-‐ Your genotype is the composition of alleles you have for a particular gene or genes. Remember than many genes come in two or more different “flavors” or alleles—one version (or allele) may ...
Parenteral Alimentation in Surgery
... Too frequently it is considered an enemy rather than an essential to normal metabolism. For example, it is a precursor to bile acids, a precursor to steroid hormones, a regulator of cell permeability, an insulator for axons, and perhaps has other important functions. Just why chole terol is found wi ...
... Too frequently it is considered an enemy rather than an essential to normal metabolism. For example, it is a precursor to bile acids, a precursor to steroid hormones, a regulator of cell permeability, an insulator for axons, and perhaps has other important functions. Just why chole terol is found wi ...
Exam 6-8 Review Sheet
... net coupled reaction would be classified as exergonic or endergonic (subtracting the ΔG values for each reaction from each other) ...
... net coupled reaction would be classified as exergonic or endergonic (subtracting the ΔG values for each reaction from each other) ...
Materials and Methods - UROP
... of substrate). The biosensor device contrasts the old method of viewing enzymes, which only examines average effects, typically looking at the starting and ending points. Significantly, the biosensor device can not only be used to study the behavior of unknown proteins, but could also potentially b ...
... of substrate). The biosensor device contrasts the old method of viewing enzymes, which only examines average effects, typically looking at the starting and ending points. Significantly, the biosensor device can not only be used to study the behavior of unknown proteins, but could also potentially b ...
Trichohyalin, an Intermediate Filament
... arginine-rich fraction, termed trichohyalin precipitate (TRPPT), was shown to contain suitable substrates for both peptidyl-arginine deiminase and hair follicle transglutaminase (34). Histochemical and immunochemical studies have located hair follicle transglutaminase and suitable substrate proteins ...
... arginine-rich fraction, termed trichohyalin precipitate (TRPPT), was shown to contain suitable substrates for both peptidyl-arginine deiminase and hair follicle transglutaminase (34). Histochemical and immunochemical studies have located hair follicle transglutaminase and suitable substrate proteins ...
HGSS2: DCG
... features characteristic of Alzheimer's disease. The brains of the transgenic PDAPP (PDGF promoter expressing amyloid precursor protein) mice have abundant -amyloid deposits (made up of the A peptide), dystrophic neurites, activated glia, and overall decreases in synaptic density. ...
... features characteristic of Alzheimer's disease. The brains of the transgenic PDAPP (PDGF promoter expressing amyloid precursor protein) mice have abundant -amyloid deposits (made up of the A peptide), dystrophic neurites, activated glia, and overall decreases in synaptic density. ...
Bioinformatics tools as JAWB (Just another Western Blot)
... Proteins that have coevolved share a function • If protein A has co-evolved with protein B, they are likely to be involved in the same process • Looking for proteins that coevolved will help prediction social networks of proteins • There are many methods to look for co-evolution of proteins – Phylo ...
... Proteins that have coevolved share a function • If protein A has co-evolved with protein B, they are likely to be involved in the same process • Looking for proteins that coevolved will help prediction social networks of proteins • There are many methods to look for co-evolution of proteins – Phylo ...
Cysteine-mutated FXYD proteins enhance the anti
... • the number 1 cause of death globally • accounting for 17.3 million deaths per year • a number that is expected to grow to >23.6 million by 2030 http://www.who.int/cardiovascular_diseases/en/ ...
... • the number 1 cause of death globally • accounting for 17.3 million deaths per year • a number that is expected to grow to >23.6 million by 2030 http://www.who.int/cardiovascular_diseases/en/ ...
Seasonal regulation of a 24-kDa protein from red
... Total and CaCl2-extractable proteins were isolated from C. sericea wood throughout the year and analyzed by SDSPAGE (Figures 1 and 2). Among total protein extracts, the accumulation of a 24-kDa protein correlated with periods of cold acclimation. The 24-kDa protein was abundant in January and March, ...
... Total and CaCl2-extractable proteins were isolated from C. sericea wood throughout the year and analyzed by SDSPAGE (Figures 1 and 2). Among total protein extracts, the accumulation of a 24-kDa protein correlated with periods of cold acclimation. The 24-kDa protein was abundant in January and March, ...
Genetic Variability of Drosophila melanogaster at the Alcohol
... is generally due to yeasts, which release ethanol and higher alcohol that may partly inhibit the growth of competing organisms. Fruit flies thrive in this otherwise poisonous ecological niche, in part because they have evolved metabolic enzymes that confer tolerance to the toxic effects of alcohols. ...
... is generally due to yeasts, which release ethanol and higher alcohol that may partly inhibit the growth of competing organisms. Fruit flies thrive in this otherwise poisonous ecological niche, in part because they have evolved metabolic enzymes that confer tolerance to the toxic effects of alcohols. ...
SP1 Protein production order form
... If yes, how many, which type and which order: Does the construct contain TEV cleavage site: ...
... If yes, how many, which type and which order: Does the construct contain TEV cleavage site: ...
Interaction of TCF4 with DP103 and FHL3
... β-catenin are low, and T cell factor 4 (TCF4) in the nucleus is repressed. In stimulated cells, the cytoplasmic protein Dishvelled is recruited to the membrane and inhibiting the Axin complex by directly binding to it. Therefore, β-catenin accumulates and eventually translates into the nucleus where ...
... β-catenin are low, and T cell factor 4 (TCF4) in the nucleus is repressed. In stimulated cells, the cytoplasmic protein Dishvelled is recruited to the membrane and inhibiting the Axin complex by directly binding to it. Therefore, β-catenin accumulates and eventually translates into the nucleus where ...
GoFigure: Automated Gene Ontology annotation
... sequence, the minimum covering graph (MCG) is a sub-graph of the GO directed acyclic graph (DAG) rooted at a GO term that subsumes all the terms from the set T. The MCG is minimized in that the root of the MCG is the term with the greatest depth from the root of the GO DAG that covers all the terms ...
... sequence, the minimum covering graph (MCG) is a sub-graph of the GO directed acyclic graph (DAG) rooted at a GO term that subsumes all the terms from the set T. The MCG is minimized in that the root of the MCG is the term with the greatest depth from the root of the GO DAG that covers all the terms ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.