Angiotensin I Converting Enzyme and the Changes
... ACE, derived mostly from hindsight and now knowing about captopril, it would have been better to do no other research but work on congeners of penicillamine.) Ferreira9 used a peptide from Bothrops jararaca venom to potentiate the action of bradykinin, although the kininase inhibited was not charact ...
... ACE, derived mostly from hindsight and now knowing about captopril, it would have been better to do no other research but work on congeners of penicillamine.) Ferreira9 used a peptide from Bothrops jararaca venom to potentiate the action of bradykinin, although the kininase inhibited was not charact ...
Variations in amino acid composition in bacterial single stranded
... The crystal structure of EcoSSB proved that the functional protein exists as a homotetramer (6). Since then, most eubacterial SSBs have been shown to function as homoteramers (7). Each SSB monomer contains two distinct domains: an N-terminal domain and a C-terminal (Ct) domain. The N-terminal domain ...
... The crystal structure of EcoSSB proved that the functional protein exists as a homotetramer (6). Since then, most eubacterial SSBs have been shown to function as homoteramers (7). Each SSB monomer contains two distinct domains: an N-terminal domain and a C-terminal (Ct) domain. The N-terminal domain ...
Effect of Tannic Acid on Growth and Acid Production of Candida
... present study was carried out to investigate the effect of Tannic acid (TA) on the growth and acid production of C. albicans. Various concentrations of TA prepared with Sabourand’s dextrose broth were inoculated with C. albicans and incubated at 37°C. Growth was monitored by optical density (OD) at ...
... present study was carried out to investigate the effect of Tannic acid (TA) on the growth and acid production of C. albicans. Various concentrations of TA prepared with Sabourand’s dextrose broth were inoculated with C. albicans and incubated at 37°C. Growth was monitored by optical density (OD) at ...
DESIGNING OF A POTENT ANALOG AGAINST DRUG RESISTANT HIV-1 PROTEASE:... STUDY Research Article
... and in a semi open state. The results clearly indicate that the area of the active site binding pocket increases from 581.9Å to 996.5Å with the increase in the rate of mutation. It was further inferred upon that the mutation in some of active site residues (V82A, I84V) led to the random loss in the ...
... and in a semi open state. The results clearly indicate that the area of the active site binding pocket increases from 581.9Å to 996.5Å with the increase in the rate of mutation. It was further inferred upon that the mutation in some of active site residues (V82A, I84V) led to the random loss in the ...
Communication
... was exposed to ONOO2 (Fig. 1B). The product yield of otyrosine and o,o9-dityrosine in LDL oxidized by ONOO2 was ,1% of the yield of 3-nitrotyrosine. These results confirm that 3-nitrotyrosine is a major product of protein oxidation by ONOO2. They also suggest that nitration of protein tyrosine resid ...
... was exposed to ONOO2 (Fig. 1B). The product yield of otyrosine and o,o9-dityrosine in LDL oxidized by ONOO2 was ,1% of the yield of 3-nitrotyrosine. These results confirm that 3-nitrotyrosine is a major product of protein oxidation by ONOO2. They also suggest that nitration of protein tyrosine resid ...
Activation and Stabilization of Penicillin V Acylase from
... agents for proteins at moderate concentrations (Mozhaev et al., 1989). Despite this, there are some polyhydric cosolvents that may improve enzyme stability. These cosolvents such as glycerol and glycols, are well-known protective agents against thermal denaturation, and they are less deleterious at ...
... agents for proteins at moderate concentrations (Mozhaev et al., 1989). Despite this, there are some polyhydric cosolvents that may improve enzyme stability. These cosolvents such as glycerol and glycols, are well-known protective agents against thermal denaturation, and they are less deleterious at ...
Journal of Agricultural and Food Chemistry
... 7S type; polypeptides with an average MWs of 31.538.0 and 20-27 kDa that can be related to the 11S type; and some other components with MWs of <18 kDa (Gorinstein et al., 1991, 1996; Barba de la Rosa et al., 1992; Marcone and Yada, 1992; Segura-Nieto et al., 1994). Globulins from quinoa had polypept ...
... 7S type; polypeptides with an average MWs of 31.538.0 and 20-27 kDa that can be related to the 11S type; and some other components with MWs of <18 kDa (Gorinstein et al., 1991, 1996; Barba de la Rosa et al., 1992; Marcone and Yada, 1992; Segura-Nieto et al., 1994). Globulins from quinoa had polypept ...
STRUCTURAL AND FUNCTIONAL STUDIES OF PYRIDOXINE 5’-PHOSPHATE SYNTHASE E. COLI Doctoral Thesis
... Pyridoxal 5’-phosphate is the biocatalytically active form of vitamin B6, being one of nature’s most versatile cofactors that plays a central role in the metabolism of amino acids. Whereas microorganisms and plants can synthetise vitamin B6 de novo, mammals have to obtain one of the B6 vitamers with ...
... Pyridoxal 5’-phosphate is the biocatalytically active form of vitamin B6, being one of nature’s most versatile cofactors that plays a central role in the metabolism of amino acids. Whereas microorganisms and plants can synthetise vitamin B6 de novo, mammals have to obtain one of the B6 vitamers with ...
Molecular and Phylogenetic Characterization of Cytokine Genes
... The cloned cDNA of Seba’s short-tailed bat TNF was 675 nt and encodes approximately 96% of the TNF coding region. The nucleotide sequence was translated using MacVector’s default translation table and then aligned with orthologous mammalian sequences. The nucleotide sequence encodes nearly all of th ...
... The cloned cDNA of Seba’s short-tailed bat TNF was 675 nt and encodes approximately 96% of the TNF coding region. The nucleotide sequence was translated using MacVector’s default translation table and then aligned with orthologous mammalian sequences. The nucleotide sequence encodes nearly all of th ...
structure and mechanism of dna polymerases
... every 109–1010 bases replicated (Echols and Goodman, 1991). This remarkable accuracy is achieved by a combination of different mechanisms working in unison. The initial discrimination is carried out during the nucleotide incorporation stage in which a DNA polymerase accurately selects a nucleotide ( ...
... every 109–1010 bases replicated (Echols and Goodman, 1991). This remarkable accuracy is achieved by a combination of different mechanisms working in unison. The initial discrimination is carried out during the nucleotide incorporation stage in which a DNA polymerase accurately selects a nucleotide ( ...
Small decrease of plastid transketolase activity in
... (PEP) and erythrose-4-phosphate (Ery4P). Because chloroplasts lack glycolysis downstream of glycerate-3-phosphate (3PGA) (Stitt, 1997), in leaves PEP is provided via an envelope membrane PEP:Pi translocator that exchanges Pi and PEP between the cytosol and the plastids (Fischer et al., 1997). Insert ...
... (PEP) and erythrose-4-phosphate (Ery4P). Because chloroplasts lack glycolysis downstream of glycerate-3-phosphate (3PGA) (Stitt, 1997), in leaves PEP is provided via an envelope membrane PEP:Pi translocator that exchanges Pi and PEP between the cytosol and the plastids (Fischer et al., 1997). Insert ...
VTC4 Is a Bifunctional Enzyme That Affects
... losic compounds (for review, see Loewus, 2006) and, in some organisms, ascorbate (for review, see Linster and Van Schaftingen, 2007). Thus, myoinositol synthesis and catabolism affect metabolites involved in many different and critical biochemical pathways. Although organisms incorporate myoinositol ...
... losic compounds (for review, see Loewus, 2006) and, in some organisms, ascorbate (for review, see Linster and Van Schaftingen, 2007). Thus, myoinositol synthesis and catabolism affect metabolites involved in many different and critical biochemical pathways. Although organisms incorporate myoinositol ...
No Evidence of Neandertal mtDNA Contribution to Early Modern
... remains. Thus, we fail to detect any evidence of mtDNA gene flow from Neandertals to early modern humans or from early modern humans to Neandertals. However, a relevant question is what extent of gene flow between Neandertals and early modern humans the current data allow us to exclude. In this regard ...
... remains. Thus, we fail to detect any evidence of mtDNA gene flow from Neandertals to early modern humans or from early modern humans to Neandertals. However, a relevant question is what extent of gene flow between Neandertals and early modern humans the current data allow us to exclude. In this regard ...
Toxicology 177:
... formed as the primary oxidized products. Until recently, phenoxyl radicals had been difficult to detect by static electron spin resonance (ESR) because they rapidly change to non-radical products. Application of Zn exerts spin-stabilizing effects on phenoxyl radicals that enables us to analyze the f ...
... formed as the primary oxidized products. Until recently, phenoxyl radicals had been difficult to detect by static electron spin resonance (ESR) because they rapidly change to non-radical products. Application of Zn exerts spin-stabilizing effects on phenoxyl radicals that enables us to analyze the f ...
mbe.oxfordjournals.org - Oxford Academic
... Research on the biogenesis of ribosomal subunits concentrating on rRNA transcription, processing, and maturation has neglected the influence of ribosomal proteins in the assembly process. However, in 2005, Milkereit’s group (Ferreira-Cerca et al. 2005) demonstrated that eukaryotic ribosomal proteins ...
... Research on the biogenesis of ribosomal subunits concentrating on rRNA transcription, processing, and maturation has neglected the influence of ribosomal proteins in the assembly process. However, in 2005, Milkereit’s group (Ferreira-Cerca et al. 2005) demonstrated that eukaryotic ribosomal proteins ...
The outer frontier: the importance of lipid metabolism in the skin
... the two that are absolutely essential for survival are the barrier to the movement of water and electrolytes (permeability barrier) and the barrier against invasive and toxic microorganisms (antimicrobial barrier). Lipids play an essential role in the formation and maintenance of both the permeabili ...
... the two that are absolutely essential for survival are the barrier to the movement of water and electrolytes (permeability barrier) and the barrier against invasive and toxic microorganisms (antimicrobial barrier). Lipids play an essential role in the formation and maintenance of both the permeabili ...
Biosynthesis
Biosynthesis (also called biogenesis or anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined together to form macromolecules. This process often consists of metabolic pathways. Some of these biosynthetic pathways are located within a single cellular organelle, while others involve enzymes that are located within multiple cellular organelles. Examples of these biosynthetic pathways include the production of lipid membrane components and nucleotides.The prerequisite elements for biosynthesis include: precursor compounds, chemical energy (e.g. ATP), and catalytic enzymes which may require coenzymes (e.g.NADH, NADPH). These elements create monomers, the building blocks for macromolecules. Some important biological macromolecules include: proteins, which are composed of amino acid monomers joined via peptide bonds, and DNA molecules, which are composed of nucleotides joined via phosphodiester bonds.