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... generation by conjugation of a drug-like core molecule to a surrounding randomized library peptide via the 10BASEd-T (Figure 1). As the model drug-like core molecule, commercially available 4-iodoacetamidosalicylic acid (Sal-IA) was used because it is one of the smallest pharmaceutical molecules pos ...
... generation by conjugation of a drug-like core molecule to a surrounding randomized library peptide via the 10BASEd-T (Figure 1). As the model drug-like core molecule, commercially available 4-iodoacetamidosalicylic acid (Sal-IA) was used because it is one of the smallest pharmaceutical molecules pos ...
Disorders of Propionate and Methylmalonate Metabolism
... together and focus attention on the enzymes and coenzymes that participate in the pathway responsible for the formation of propionate and its conversion to succinate. Oberholzer,10 Stokke,11 and their colleagues described infants with profound metabolic acidosis and hyperglycinemia (or hyperglycinur ...
... together and focus attention on the enzymes and coenzymes that participate in the pathway responsible for the formation of propionate and its conversion to succinate. Oberholzer,10 Stokke,11 and their colleagues described infants with profound metabolic acidosis and hyperglycinemia (or hyperglycinur ...
Molecular and metabolic changes of cherelle wilt of cacao and its
... a hemibiotrophic fungus, going through two phases during the development of FPR [9]. During the biotrophic phase, M. roreri mycelia are haploid. The biotrophic phase typically lasts thirty or more days, during which malformations may be the only visible symptoms [8]. Pod necrosis occurs during the s ...
... a hemibiotrophic fungus, going through two phases during the development of FPR [9]. During the biotrophic phase, M. roreri mycelia are haploid. The biotrophic phase typically lasts thirty or more days, during which malformations may be the only visible symptoms [8]. Pod necrosis occurs during the s ...
Dietary tryptophan depletion in humans using a simplified two amino
... tryptophan (TRP). Because 5-HT is not able to pass the blood-brain barrier (BBB), it is synthesized from its physiological precursor, the amino acid (AA) TRP, in the brain. A small proportion of TRP reaches the central nervous system through passive diffusion. The majority of free TRP uses the activ ...
... tryptophan (TRP). Because 5-HT is not able to pass the blood-brain barrier (BBB), it is synthesized from its physiological precursor, the amino acid (AA) TRP, in the brain. A small proportion of TRP reaches the central nervous system through passive diffusion. The majority of free TRP uses the activ ...
Ch 4: Cellular Metabolism
... into the Krebs cycle. Krebs cycle is the next step of oxidative respiration and takes place in mitochondria. Occurs in three stages: Acetyl-CoA binds a fourcarbon molecule and produces a six-carbon molecule. Two carbons are removed as CO2. Four-carbon starting material is regenerated. ...
... into the Krebs cycle. Krebs cycle is the next step of oxidative respiration and takes place in mitochondria. Occurs in three stages: Acetyl-CoA binds a fourcarbon molecule and produces a six-carbon molecule. Two carbons are removed as CO2. Four-carbon starting material is regenerated. ...
Planta
... histidines at the N-terminal end of the protein, allowing a one-step puri®cation of the resulting protein. The resulting vectors were named pQE50iso and pQE30iso. As the peptide sequence preceding the pair of arginines was similar to a plastidial transit peptide (Fig. 1), a sequence lacking this 5¢ ...
... histidines at the N-terminal end of the protein, allowing a one-step puri®cation of the resulting protein. The resulting vectors were named pQE50iso and pQE30iso. As the peptide sequence preceding the pair of arginines was similar to a plastidial transit peptide (Fig. 1), a sequence lacking this 5¢ ...
Chlamydia Exploit the Mammalian Tryptophan-Depletion
... distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academ ...
... distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academ ...
Absence of translationally selected synonymous codon usage
... G-ending codons in Hel. pylori. The abundance of various tRNA species in Hel. pylori is not known. However, in E. coli, major variations in the abundance of different isoaccepting tRNAs are correlated with the copy numbers of the genes for those tRNAs, whereas in Hel. pylori only one tRNA (that for ...
... G-ending codons in Hel. pylori. The abundance of various tRNA species in Hel. pylori is not known. However, in E. coli, major variations in the abundance of different isoaccepting tRNAs are correlated with the copy numbers of the genes for those tRNAs, whereas in Hel. pylori only one tRNA (that for ...
Isolation and Fractionation 2
... sediment to the bottom of the tube whilst the less dense lysosomes rise to the interface of the 14.3% and 34.5% sucrose. The lysosomal layer can be removed, harvested by further centrifugation and then resuspended in iso-osmotic 0.25 M sucrose. Conversely lysosomes can be made more dense by injectin ...
... sediment to the bottom of the tube whilst the less dense lysosomes rise to the interface of the 14.3% and 34.5% sucrose. The lysosomal layer can be removed, harvested by further centrifugation and then resuspended in iso-osmotic 0.25 M sucrose. Conversely lysosomes can be made more dense by injectin ...
Processing of the Presequence of the Schizosaccharomyces pombe
... upon closer examination of the autoradiographs small amounts of mature length protein were detected. To show this more clearly, an altered S. cerevisiae iron-sulfur protein in which the processing by MPP was slowed down considerably by converting Arg-21 to Gly (21) was imported into S. pombe mitocho ...
... upon closer examination of the autoradiographs small amounts of mature length protein were detected. To show this more clearly, an altered S. cerevisiae iron-sulfur protein in which the processing by MPP was slowed down considerably by converting Arg-21 to Gly (21) was imported into S. pombe mitocho ...
Vitamin C
... • Vitamin C acts as an electron donor for 8 different enzymes: • Three enzymes participate in collagen hydroxylation. • Two enzymes are necessary for synthesis of carnitine. • Three remaining enzymes have the following functions in common, but have other functions as well: • Dopamine β-hydroxylase p ...
... • Vitamin C acts as an electron donor for 8 different enzymes: • Three enzymes participate in collagen hydroxylation. • Two enzymes are necessary for synthesis of carnitine. • Three remaining enzymes have the following functions in common, but have other functions as well: • Dopamine β-hydroxylase p ...
Chapter 2 - Carbon dioxide assimilation and respiration
... sucrose-6-phosphate from the reaction of fructose-6-phosphate and UDP-glucose. The phosphate group is removed by the action of sucrose-6-phosphatase. This Pi is transported back into the chloroplast where it is available for ATP synthesis. For each molecule of triose phosphate exported from a chloro ...
... sucrose-6-phosphate from the reaction of fructose-6-phosphate and UDP-glucose. The phosphate group is removed by the action of sucrose-6-phosphatase. This Pi is transported back into the chloroplast where it is available for ATP synthesis. For each molecule of triose phosphate exported from a chloro ...
Rate at which glutamine enters TCA cycle influences carbon atom
... TCA cycle using the CO2 ratios approach (15). In this experiment, cells were incubated with either [1-14C]glutamine or [U-14C]glutamine as tracers, with either 5 mmol/l glutamine or 5 mmol/l each of glutamine and glucose, and in either the absence or presence of 2 mmol/l AOA. Cell suspensions were p ...
... TCA cycle using the CO2 ratios approach (15). In this experiment, cells were incubated with either [1-14C]glutamine or [U-14C]glutamine as tracers, with either 5 mmol/l glutamine or 5 mmol/l each of glutamine and glucose, and in either the absence or presence of 2 mmol/l AOA. Cell suspensions were p ...
Mutations to nonsense codons in human genetic
... discernible from the paper describing the mutation they were determined from the published sequence or from the EMBL and Genbank databases held at Daresbury, UK. Where the site of the mutation is known, this is indicated as either the number of the codon preceded by the altered amino acid (in single ...
... discernible from the paper describing the mutation they were determined from the published sequence or from the EMBL and Genbank databases held at Daresbury, UK. Where the site of the mutation is known, this is indicated as either the number of the codon preceded by the altered amino acid (in single ...
Screening of Lactic Acid Bacteria Capable to Breakdown Citric Acid
... from fermenting cocoa failed to produce acetoin from citrate. In contrast, acetoin or diacetal production from citrate have been generally observed in lactic acid bacteria from samples other than cocoa. Our results suggest that LAB isolated from cocoa, do not use entirely pII metabolic pathway, turn ...
... from fermenting cocoa failed to produce acetoin from citrate. In contrast, acetoin or diacetal production from citrate have been generally observed in lactic acid bacteria from samples other than cocoa. Our results suggest that LAB isolated from cocoa, do not use entirely pII metabolic pathway, turn ...
Screening of Lactic Acid Bacteria Capable to Breakdown Citric Acid
... from fermenting cocoa failed to produce acetoin from citrate. In contrast, acetoin or diacetal production from citrate have been generally observed in lactic acid bacteria from samples other than cocoa. Our results suggest that LAB isolated from cocoa, do not use entirely pII metabolic pathway, turn ...
... from fermenting cocoa failed to produce acetoin from citrate. In contrast, acetoin or diacetal production from citrate have been generally observed in lactic acid bacteria from samples other than cocoa. Our results suggest that LAB isolated from cocoa, do not use entirely pII metabolic pathway, turn ...
patrick_tb_ch18b
... d. Testosterone propionate Type: multiple choice question Title: Chapter 18b Question 13 13) The following diagram is representative of a group of naturally occurring compounds that are used in combination therapy to treat a variety of tumours: ...
... d. Testosterone propionate Type: multiple choice question Title: Chapter 18b Question 13 13) The following diagram is representative of a group of naturally occurring compounds that are used in combination therapy to treat a variety of tumours: ...
Glycolic acid production in the engineered yeasts Saccharomyces
... Background: Glycolic acid is a C2 hydroxy acid that is a widely used chemical compound. It can be polymerised to produce biodegradable polymers with excellent gas barrier properties. Currently, glycolic acid is produced in a chemical process using fossil resources and toxic chemicals. Biotechnologic ...
... Background: Glycolic acid is a C2 hydroxy acid that is a widely used chemical compound. It can be polymerised to produce biodegradable polymers with excellent gas barrier properties. Currently, glycolic acid is produced in a chemical process using fossil resources and toxic chemicals. Biotechnologic ...
glycolysis, gluconeogenesis, and the pentose phosphate pathway
... in glycolysis are the D isomers, we will usually omit the D designation except when emphasizing stereochemistry. Fructose 1,6-bisphosphate is split to yield two three-carbon molecules, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (step 4 ); this is the “lysis” step that gives the pathwa ...
... in glycolysis are the D isomers, we will usually omit the D designation except when emphasizing stereochemistry. Fructose 1,6-bisphosphate is split to yield two three-carbon molecules, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (step 4 ); this is the “lysis” step that gives the pathwa ...
CHEMICAL SYNTHESIS OF PROTEINS : A TOOL FOR PROTEIN
... protein synthesis that allow the manipulation of proteins structure [Hahn, M.E. & Muir, T.W. 2005; Kent, S.B.H. 2009]. Among these approaches, the Native Chemical Ligation (NCL) appear as the most useful and advantageous strategy [Dawson, P.E. et al. 1994]. The method leads to the formation of a pro ...
... protein synthesis that allow the manipulation of proteins structure [Hahn, M.E. & Muir, T.W. 2005; Kent, S.B.H. 2009]. Among these approaches, the Native Chemical Ligation (NCL) appear as the most useful and advantageous strategy [Dawson, P.E. et al. 1994]. The method leads to the formation of a pro ...
Biosynthesis
Biosynthesis (also called biogenesis or anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined together to form macromolecules. This process often consists of metabolic pathways. Some of these biosynthetic pathways are located within a single cellular organelle, while others involve enzymes that are located within multiple cellular organelles. Examples of these biosynthetic pathways include the production of lipid membrane components and nucleotides.The prerequisite elements for biosynthesis include: precursor compounds, chemical energy (e.g. ATP), and catalytic enzymes which may require coenzymes (e.g.NADH, NADPH). These elements create monomers, the building blocks for macromolecules. Some important biological macromolecules include: proteins, which are composed of amino acid monomers joined via peptide bonds, and DNA molecules, which are composed of nucleotides joined via phosphodiester bonds.