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Chemical approaches to study metabolic networks
Chemical approaches to study metabolic networks

... metabolites to products (e.g., hexokinase converts glucose to glucose-6-phosphate), a series of enzymes may catalyze the conversion of one metabolite, through a series of interconversions, to form a penultimate product (e.g., glucose to pyruvate by glycolysis)—a metabolic pathway. These pathways can ...
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... Overproduction or underexcretion can lead to the formation of uric acid crystals – frequently starting in the gravitationally lowest joints – i.e. the big toe. • That condition is gout, which is often extremely painful. ...
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... Thiamine or thiamin or vitamin B1 , named as the "thio-vitamine" ("sulfur-containing vitamin") is a water-soluble vitamin of the B complex. Its phosphate derivatives are involved in many cellular processes. The best-characterized form is thiamine pyrophosphate(TPP), a coenzyme in the catabolism of ...
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...  As a scientist employed by the FDA, you've been asked to sit on a panel to evaluate a pharmaceutical company's application for approval of a new weight loss drug called Fat Away. The company has submitted a report summarizing the results of their animal and human testing. In the report, it was not ...
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... biosynthesis, and serine, glycine and threonine degradation). It would be particularly interesting to focus on the amino-acids which are precursors for other essential metabolic components (alanine, aspartate for example) or are involved in adaptation to environmental changes (proline and osmotic s ...
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Preview Sample 3

CHAP NUM="9" ID="CH
CHAP NUM="9" ID="CH

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... consists only of protein. • Many enzymes are active only when they combine with cofactors such as metal ions or small molecules. • A coenzyme is a cofactor that is a small organic molecule such as a vitamin. • A holoenzyme is the enzyme + cofactor, an apoenzyme is the enzyme – cofactor. ...
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...  Describe the difference between atoms, elements and compounds.  Distinguish between covalent bonds, hydrogen bonds, and ionic bonds.  Evaluate the importance of energy to living things.  Relate energy and chemical reactions.  Describe the role of enzymes in chemical reactions.  Analyze the pr ...
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Carbohydrate Metabolism
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... only slowly due to defect in the carrier mechanism. Because fructose is not absorbed by the carrier system, its absorption is normal. Monosaccharides (glucose, galactose and fructose) resulting from carbohydrate digestion are absorbed and undergo the following: ...
Carnitine-acylcarnitine translocase deficiency: metabolic
Carnitine-acylcarnitine translocase deficiency: metabolic

... Glucose is the major source of energy for the fetus [1]. Immediately after birth free fatty acids are mobilized from adipose tissue stores. A rapid increase in the activity of carnitine palmitoyltransferase I and II and a rise in the capacity to oxidize fatty acids is found in liver [2] and in heart ...
Enzymes
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... Polysaccharides and synthetic polymers having ion-exchange centers are usually used as carriers Advantages : the enzyme to carrier linkages is much stronger for ionic binding Disadvantages : the binding forces between enzyme proteins and carriers are weaker than those in covalent binding ...
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l-Carnitine - Pure Encapsulations

... l-Carnitine is an amino acid found abundantly in skeletal and heart muscle. It functions primarily to support fat utilization by acting as a carrier of fatty acids into the mitochondria, where they are oxidized and converted to energy. l-Carnitine also facilitates the removal of short and medium cha ...
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Metabolism



Metabolism (from Greek: μεταβολή metabolē, ""change"") is the set of life-sustaining chemical transformations within the cells of living organisms. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism.Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter by way of cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. Usually, breaking down releases energy and building up consumes energy.The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into another chemical, by a sequence of enzymes. Enzymes are crucial to metabolism because they allow organisms to drive desirable reactions that require energy that will not occur by themselves, by coupling them to spontaneous reactions that release energy. Enzymes act as catalysts that allow the reactions to proceed more rapidly. Enzymes also allow the regulation of metabolic pathways in response to changes in the cell's environment or to signals from other cells.The metabolic system of a particular organism determines which substances it will find nutritious and which poisonous. For example, some prokaryotes use hydrogen sulfide as a nutrient, yet this gas is poisonous to animals. The speed of metabolism, the metabolic rate, influences how much food an organism will require, and also affects how it is able to obtain that food.A striking feature of metabolism is the similarity of the basic metabolic pathways and components between even vastly different species. For example, the set of carboxylic acids that are best known as the intermediates in the citric acid cycle are present in all known organisms, being found in species as diverse as the unicellular bacterium Escherichia coli and huge multicellular organisms like elephants. These striking similarities in metabolic pathways are likely due to their early appearance in evolutionary history, and their retention because of their efficacy.
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