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Hox Genes: Let`s Work Together
Hox Genes: Let`s Work Together

... showed Ubx binding on the promoters of all anterior Hox genes and not posterior Hox genes (Slattery et al., 2011). This observation provides an evidence for direct Ubx-mediated transcriptional regulation of anterior Hox genes. Suppression through Non-coding RNAs Sense and anti-sense long non-coding ...
Gene Section EXT2 (exostoses (multiple) 2) Atlas of Genetics and Cytogenetics
Gene Section EXT2 (exostoses (multiple) 2) Atlas of Genetics and Cytogenetics

... Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (JVMGB) Published in Atlas Database: January 2000 Online updated version : http://AtlasGeneticsOncology.org/Genes/EXT2ID213.html DOI: 10.4267/2042/37576 This work is licensed under a Creative Commons Attribution-Nonco ...
Leapfrogging: primordial germ cell transplantation
Leapfrogging: primordial germ cell transplantation

... germline (Blackler, 1960; Blackler and Fischberg, 1961). We aimed to develop a more efficient transplantation procedure, combined with CRISPR/Cas9 mutagenesis, to accelerate research on identifying the functions of thousands of embryonic lethal genes. In Xenopus and other anurans, germplasm is first ...
AnsteadSeniorHonorsThesis
AnsteadSeniorHonorsThesis

... associated with chromatin following entry of cells into quiescence, making Mcms effective markers of proliferation (Madine, M. 2000). However, this study focused on all of the Mcm proteins, rather than Mcm10 specifically. This serves to represent the deficiency in our knowledge of Mcm10 in multicell ...
MS26/CYP704B is required for anther and pollen wall
MS26/CYP704B is required for anther and pollen wall

... are often adverse environmental conditions. The intine is composed of cellulosic material whereas the major component of exine is sporopollenin (reviewed in Quilichini et al. [1]). Sporopollenin fortifies the exine as the foundation of a skeletal structure as well as through formation of a durable c ...
Investigation of Four Genes Responsible for Autosomal Recessive
Investigation of Four Genes Responsible for Autosomal Recessive

... that the highest concentrations are usually found in the lens cortex. Taking these results further, we tried to investigate the existence of a possible association between one or more of these genes (EPHA2, GALK1, GCNT2, and CRYBB1) and studied phenotypes in the four Tunisian families (ARCC, MR and ...
Determining the cause of patchwork HBA1 and HBA2 genes
Determining the cause of patchwork HBA1 and HBA2 genes

... respectively, followed by heteroduplex formation, mismatch repair, and finally synthesis of the complementary strand of the recipient gene directed by the donor strand as template. This results in the formation of either an α212-like or α121-like patchwork gene, but not both. Although it has been su ...
The importance of chromosomes from the sixth homeologic group in
The importance of chromosomes from the sixth homeologic group in

... sterility restoration in triticale with the T. timopheevii cytoplasm. Within the studied population, the remaining chromosomes of the sixth homeologic group (6A and 6B) were also found to be important for male fertility. The lowest effect on pollen fertility was identified for loci located on the 1B ...
Mendel: Darwin`s Savior or Opponent?
Mendel: Darwin`s Savior or Opponent?

... In the month of June 1906, San Diego was visited by one of the greatest scientists of that time. His arrival was announced in the list of guests of the Coronado Hotel for 4 June 1906, where he was listed as Col. Hugo de Vries, Amsterdam. The "Col." cannot be a southern title, for Hugo de Vries never ...
20 years and 22 papers with Bernard Moret
20 years and 22 papers with Bernard Moret

... • The DCM1 phase produces a collection of trees (one for each threshold), and the SQS phase picks the “best” tree. • For a given threshold, the base method is used to construct trees on small subsets (defined by the threshold) of the taxa. These small trees are then combined into a tree on the full ...
AtMetExpress Development: A Phytochemical
AtMetExpress Development: A Phytochemical

... Because the metabolic profile data and MS2T libraries were acquired by using compatible analytical conditions, we could obtain MS/MS spectral data of a metabolite signal in the metabolic profile data by identifying the MS2T data acquired from the same metabolite. This means that metabolite signals i ...
video slide
video slide

... Behavior of a Chromosome Pair • In one experiment, Morgan mated male flies with white eyes (mutant) with female flies with red eyes (wild type) – The F1 generation all had red eyes – The F2 generation showed the 3:1 red:white ...
Multiple Mechanisms Contribute to Lateral Transfer of an
Multiple Mechanisms Contribute to Lateral Transfer of an

... end of the seryl tRNA gene of Sphingobium japonicum. The opd gene cluster on pPDL2 was found to be part of an active catabolic transposon with mobile elements y4qE and Tn3 at its flanking ends. Besides the previously reported opd cluster, this transposon contains genes coding for protocatechuate diox ...
Identifying 3D expression domains by graph clustering
Identifying 3D expression domains by graph clustering

... Before the publication of the TRIP method this generally required low throughput analyses as  reporters could only target specific genomic loci. The process of mapping the integration sites is  extremely laborious and not suitable for genome­wide interrogation[22]. TRIP solves these  problems by usi ...
Evolutionary dynamics of nematode operons
Evolutionary dynamics of nematode operons

... abundant in nematode genomes. The “one-way street” hypothesis asserts that once formed by chance, operons are very difficult to break, because the breakage would leave downstream genes in an operon without a promoter, and hence, unexpressed. To test this hypothesis, we analyzed the presence and abse ...
Click here to presentation
Click here to presentation

... • these controls enable understanding of the array quality in screening & XPO1 /p65 siRNA will give different phenotype to control – XPO1 will accumulate p65 in the nucleus – p65 will reduce p65 levels in the cells ...
Ribosomal Protein RPL27a Promotes Female Gametophyte
Ribosomal Protein RPL27a Promotes Female Gametophyte

... 2012; McCann and Baserga, 2013; Terzian and Box, 2013). Currently it is not known how ribosomal proteins modulate development. Potentially specific developmental phenotypes in ribosomal protein mutants are an outcome of ribosome haploinsufficiency and reduced global protein synthesis or reduced tran ...
Integrated analysis of whole-exome sequencing and transcriptome
Integrated analysis of whole-exome sequencing and transcriptome

... previous hypothesis which suggested that a large number of genes confer risk to ASD and reinforce the idea that much larger cohorts will be necessary to carry out this type of analyses [19]. The identification of new genes involved in ASD will eventually lead to the definition of common effects of g ...
Contribution of X chromosomal and autosomal genes to species
Contribution of X chromosomal and autosomal genes to species

... mechanisms, the former ones being significantly stronger than the latter ones (Coyne & Orr 1997, Noor 1997). Songs produced by male wing vibration during courtship are an effective mechanism preventing interspecific matings and maintaining sexual isolation between species in wild (Liimatainen & Hoik ...
Mice homozygous for a targeted disruption of Hoxd-3
Mice homozygous for a targeted disruption of Hoxd-3

... mouse Hox genes may also function during development as master switches specifying regional information along the anteroposterior axis of the mammalian embryo. Targeted mutational analysis of Hoxa-1, Hoxa-3, Hoxb-4 and Hoxc8 has supported this hypothesis (Chisaka and Capecchi, 1991; Lufkin et al., 1 ...
cluster analysis I
cluster analysis I

Etiology : cytogenetics and microdeletions - HAL
Etiology : cytogenetics and microdeletions - HAL

... efficiency from 18% to 25% of this cohort. However, since these studies were based on FISH, real time quantitative PCR (qPCR) and quantitative multiplex PCR of short fluorescent fragments, these pilot evaluations were restricted the to known HPE genes [Bendavid and others 2006a; Bendavid and others ...
here
here

... The Problem with Keeping the Current Classification Current classification is fundamentally anchored in a division that is not biologically based. This division artificially partitions the scientific community This situation leads to erroneous conclusions based on ...
Package `LDheatmap`
Package `LDheatmap`

... # positions to the LD heat map has been changed from black to orange. #### Draw a resized heat map (in a 'blue-to-red' color scale #### grid.newpage() ...
PDF
PDF

... H3K27me3 distribution over its targets is not uniform, but can be grouped into several different clusters that correlate with different levels of repression. Furthermore, we demonstrate that H3K27me3 has a preferential chromosomal localization toward telomeric and subtelomeric regions. For the first ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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