Classifying Gene Expression Data using an Evolutionary Algorithm
... Microarray technology has provided biologists with the ability to measure the expression levels of thousands of genes in a single experiment. The vast amount of raw gene expression data leads to statistical and analytical challenges. One challenge area in the studies of gene expression data is the c ...
... Microarray technology has provided biologists with the ability to measure the expression levels of thousands of genes in a single experiment. The vast amount of raw gene expression data leads to statistical and analytical challenges. One challenge area in the studies of gene expression data is the c ...
Reveal—visual eQTL analytics
... To construct the graph, each gene in the dataset is represented by a node. We use the chromosomal location of SNPs to associate them with genes, i.e. each SNP is associated with its closest gene (lying inside or close to the gene’s locus). This allows us, for each gene, to determine the number of si ...
... To construct the graph, each gene in the dataset is represented by a node. We use the chromosomal location of SNPs to associate them with genes, i.e. each SNP is associated with its closest gene (lying inside or close to the gene’s locus). This allows us, for each gene, to determine the number of si ...
Genetic of PWS – Explanation for the Rest of Us - Prader
... During the early 1980s, scientists puzzled over why some people who seemed to have PWS did not have the chromosome 15 deletion, and why some people with the chromosome 15 deletion seemed to have a different condition from PWS. Dr. Merlin Butler and colleagues began unraveling the puzzle when they re ...
... During the early 1980s, scientists puzzled over why some people who seemed to have PWS did not have the chromosome 15 deletion, and why some people with the chromosome 15 deletion seemed to have a different condition from PWS. Dr. Merlin Butler and colleagues began unraveling the puzzle when they re ...
Multiple Barriers to Nonhomologous DNA End Joining
... construction of a new double mutant stock and observed a similar suppression in g-H2AV persistence (P , 0.0001, Figure 2). In contrast, mei-218; spn-A double mutants exhibited similar levels of persistent g-H2AV foci to that of spn-A single mutants (P = 0.2841), indicating mei-218 mutants retain the ...
... construction of a new double mutant stock and observed a similar suppression in g-H2AV persistence (P , 0.0001, Figure 2). In contrast, mei-218; spn-A double mutants exhibited similar levels of persistent g-H2AV foci to that of spn-A single mutants (P = 0.2841), indicating mei-218 mutants retain the ...
The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE
... recombination between palindromes. We screened 1,237 men that originated from a previous study (Repping et al., 2003) or from a consecutive cohort of men that attended the Center for Reproductive Medicine of the Academic Medical Center as part of an infertile couple. We identified eight unrelated me ...
... recombination between palindromes. We screened 1,237 men that originated from a previous study (Repping et al., 2003) or from a consecutive cohort of men that attended the Center for Reproductive Medicine of the Academic Medical Center as part of an infertile couple. We identified eight unrelated me ...
Chapter 15 ppt - Bremen High School District 228
... If these two genes were on different chromosomes, the alleles from the F1 dihybrid would sort into gametes independently, and we would expect to see equal numbers of the four types of offspring. If these two genes were on the same chromosome, we would expect each allele combination, B+ vg+ and b vg, ...
... If these two genes were on different chromosomes, the alleles from the F1 dihybrid would sort into gametes independently, and we would expect to see equal numbers of the four types of offspring. If these two genes were on the same chromosome, we would expect each allele combination, B+ vg+ and b vg, ...
(1977) New Genes for Resistance to the Brown Planthopper in Rice
... Twenty-eight rice cultivars that IRRI entomologists (9) identified as resistant to brown planthopper were studied (Table 1). All were crossed with ’TNI’, which is highly susceptibie to the brown planthopper; the F1 and F2 progenies were studied to determine the mode of inheritance. Wealso studied F~ ...
... Twenty-eight rice cultivars that IRRI entomologists (9) identified as resistant to brown planthopper were studied (Table 1). All were crossed with ’TNI’, which is highly susceptibie to the brown planthopper; the F1 and F2 progenies were studied to determine the mode of inheritance. Wealso studied F~ ...
iron-regulatory protein 1
... corresponding to the three genes (Figure 2B). In each mutant, the transcript corresponding to the mutated gene was undetectable, indicating that the mutants isolated are true knockout lines. The relative mRNA accumulation of the two remaining genes was not affected in any of the three mutants (Figur ...
... corresponding to the three genes (Figure 2B). In each mutant, the transcript corresponding to the mutated gene was undetectable, indicating that the mutants isolated are true knockout lines. The relative mRNA accumulation of the two remaining genes was not affected in any of the three mutants (Figur ...
Biological interpretation of genome-wide association studies using
... and prioritizes genes that share predicted functions with genes from the other associated loci more often than expected by chance. In addition, DEPICT utilizes a set of 37,427 human microarrays to identify tissue/cell types in which genes from associated loci are highly expressed. DEPICT uses precom ...
... and prioritizes genes that share predicted functions with genes from the other associated loci more often than expected by chance. In addition, DEPICT utilizes a set of 37,427 human microarrays to identify tissue/cell types in which genes from associated loci are highly expressed. DEPICT uses precom ...
Chromosomal Basis of
... If these two genes were on different chromosomes, the alleles from the F1 dihybrid would sort into gametes independently, and we would expect to see equal numbers of the four types of offspring. If these two genes were on the same chromosome, we would expect each allele combination, B+ vg+ and b vg, ...
... If these two genes were on different chromosomes, the alleles from the F1 dihybrid would sort into gametes independently, and we would expect to see equal numbers of the four types of offspring. If these two genes were on the same chromosome, we would expect each allele combination, B+ vg+ and b vg, ...
2003 Nimbkar et al.: EXPRESSION OF THE FecB GENE IN
... of FecBB+ ewes being 2.09 ± 0.1 compared to 1.08 ± 0.06 in FecB++ ewes). The effect of one copy of the FecB gene on LS in ¼ G ewes was 0.52, 0.61 and 1.03 for the first, second and third parities respectively. The effect appears to increase with parity. However, the third parity LS is based on a sma ...
... of FecBB+ ewes being 2.09 ± 0.1 compared to 1.08 ± 0.06 in FecB++ ewes). The effect of one copy of the FecB gene on LS in ¼ G ewes was 0.52, 0.61 and 1.03 for the first, second and third parities respectively. The effect appears to increase with parity. However, the third parity LS is based on a sma ...
Are Incomplete Denitrification Pathways a Common Trait in Thermus
... study tested the hypothesis that incomplete denitrification is a common characteristic of the genus Thermus, regardless of geographic origin or species affiliation, which would implicate them in the efflux of nitrous oxide (a strong greenhouse gas) to the atmosphere. In this study, we cultivated 25 ...
... study tested the hypothesis that incomplete denitrification is a common characteristic of the genus Thermus, regardless of geographic origin or species affiliation, which would implicate them in the efflux of nitrous oxide (a strong greenhouse gas) to the atmosphere. In this study, we cultivated 25 ...
Handouts BIO301-Essentials of Genetics Virtual University of Pakistan
... Sickle cell anemia Cystic fibrosis ...
... Sickle cell anemia Cystic fibrosis ...
induction of instability at selected loci in maize
... 1:3 ratio will occur if the plants are not homozygous for the mutation (i.e. there is only one a1m‐4). 1/2 of gametes wil posses Ac, while only 1/4 of the gametes will possess the mutation. Therefore, less kernels will the mutation in which Ds can "jump out" of, producing less variegated kernels. 2 ...
... 1:3 ratio will occur if the plants are not homozygous for the mutation (i.e. there is only one a1m‐4). 1/2 of gametes wil posses Ac, while only 1/4 of the gametes will possess the mutation. Therefore, less kernels will the mutation in which Ds can "jump out" of, producing less variegated kernels. 2 ...
The evolution of photosynthesis and chloroplasts
... uses two photosystems: photosystem II (PSII; lightinduced water plastoquinone oxidoreductase3) and photosystem I (PSI)19. There must be an OEC attached to the type 2 photosystem to make it a true PS II. The two photosystems must be connected in series to generate sufficient difference in redox poten ...
... uses two photosystems: photosystem II (PSII; lightinduced water plastoquinone oxidoreductase3) and photosystem I (PSI)19. There must be an OEC attached to the type 2 photosystem to make it a true PS II. The two photosystems must be connected in series to generate sufficient difference in redox poten ...
Hox, ParaHox, ProtoHox: facts and guesses
... Group3 and Posterior). In this case, Cnidarians would have lost PG3 and Xlox, and the increase in complexity at the origin of Bilaterians would have been linked only to the origin of a Central Hox gene. This model squares better with the close phylogenetic relationship of PG3 and Xlox. However, the ...
... Group3 and Posterior). In this case, Cnidarians would have lost PG3 and Xlox, and the increase in complexity at the origin of Bilaterians would have been linked only to the origin of a Central Hox gene. This model squares better with the close phylogenetic relationship of PG3 and Xlox. However, the ...
Mouse Genome Informatics (MGI)
... We have seen that MGI makes it easy to find genotypes associated with particular phenotypes but the web forms currently do not allow you to export genotype details in tab-delimited formats. If you used the Mammalian Phenotype (MP) Browser to find genotypes associated with emphysema (MP:0001958) and ...
... We have seen that MGI makes it easy to find genotypes associated with particular phenotypes but the web forms currently do not allow you to export genotype details in tab-delimited formats. If you used the Mammalian Phenotype (MP) Browser to find genotypes associated with emphysema (MP:0001958) and ...
Ethylene 2013
... How to genetically dissect a pathway 1. Identify a phenotype that is specific to the process you are interested in 2. Design appropriate screen for isolating mutants based on this phenotype 3. Clone the corresponding gene by map-based cloning ...
... How to genetically dissect a pathway 1. Identify a phenotype that is specific to the process you are interested in 2. Design appropriate screen for isolating mutants based on this phenotype 3. Clone the corresponding gene by map-based cloning ...
Test Info Sheet
... The clinical sensitivity of sequencing and deletion/duplication analysis of the genes included in this panel depends in part on the patient’s clinical phenotype. Specific information about the diagnostic yield for each gene in selected populations is summarized in the following table. The technical ...
... The clinical sensitivity of sequencing and deletion/duplication analysis of the genes included in this panel depends in part on the patient’s clinical phenotype. Specific information about the diagnostic yield for each gene in selected populations is summarized in the following table. The technical ...
Functional Genomics
... Project stimulated developments both in high-throughput DNA sequencing, which were essential for the success of the project, and in powerful computational tools for sequence analysis. Without the project, it is very unlikely that these improvements would have been developed. The data were the cataly ...
... Project stimulated developments both in high-throughput DNA sequencing, which were essential for the success of the project, and in powerful computational tools for sequence analysis. Without the project, it is very unlikely that these improvements would have been developed. The data were the cataly ...
Enolase and Glycolytic Flux Play a Role in the Regulation
... in the double-mutant ⌬Sceno1⌬Sceno2 since it is inviable on glucose or glycerol media (see below). KlENO transcription was examined by a Northern blot analysis. The level of the KlENO transcript is slightly higher (twofold) when the cells are grown on 2% glucose (Figure 3B) than when they are cultiv ...
... in the double-mutant ⌬Sceno1⌬Sceno2 since it is inviable on glucose or glycerol media (see below). KlENO transcription was examined by a Northern blot analysis. The level of the KlENO transcript is slightly higher (twofold) when the cells are grown on 2% glucose (Figure 3B) than when they are cultiv ...
Genomic Analysis of Hox Clusters in the Sea Lamprey
... clone, which had a unique restriction map. Nucleotide sequences are available in GenBank, accession numbers AF410908–AF410925. The deduced amino acid sequences are shown aligned to mouse and amphioxus sequences in Figure 2. To assign genes to Hox cognate groups, the complete homeodomain amino acid s ...
... clone, which had a unique restriction map. Nucleotide sequences are available in GenBank, accession numbers AF410908–AF410925. The deduced amino acid sequences are shown aligned to mouse and amphioxus sequences in Figure 2. To assign genes to Hox cognate groups, the complete homeodomain amino acid s ...
123 Author`s personal copy
... Various explanations of partial linkage were given.11 I will only present Morgan’s explanation, which finally prevailed. It consists of a double hypothesis. First, one assumes the existence of “linkage groups”, that is, groups of genes that are linked together in some way, and therefore tend to be in ...
... Various explanations of partial linkage were given.11 I will only present Morgan’s explanation, which finally prevailed. It consists of a double hypothesis. First, one assumes the existence of “linkage groups”, that is, groups of genes that are linked together in some way, and therefore tend to be in ...
Archaeal phylogenomics provides evidence in support of a
... hypotheses that the eukaryotes descend from an ancient and uncharacterized archaeal lineage [12]. However, most phylogenetic reconstructions using informational gene sequence data recover a root for the eukaryotes in the Crenarchaea: known as the ‘eocytes’ hypothesis [13,14,24 – 30]. This multitude ...
... hypotheses that the eukaryotes descend from an ancient and uncharacterized archaeal lineage [12]. However, most phylogenetic reconstructions using informational gene sequence data recover a root for the eukaryotes in the Crenarchaea: known as the ‘eocytes’ hypothesis [13,14,24 – 30]. This multitude ...
123 Author`s personal copy
... Various explanations of partial linkage were given.11 I will only present Morgan’s explanation, which finally prevailed. It consists of a double hypothesis. First, one assumes the existence of “linkage groups”, that is, groups of genes that are linked together in some way, and therefore tend to be i ...
... Various explanations of partial linkage were given.11 I will only present Morgan’s explanation, which finally prevailed. It consists of a double hypothesis. First, one assumes the existence of “linkage groups”, that is, groups of genes that are linked together in some way, and therefore tend to be i ...