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... At present, there are more than 300 different ESBL variants, and these have been clustered into nine different structural and evolutionary families based on amino acid sequence. TEM and sulphydryl variable SHV were the major types. However, CTX-M type is more common in some countries (Paterson, 2003 ...
... At present, there are more than 300 different ESBL variants, and these have been clustered into nine different structural and evolutionary families based on amino acid sequence. TEM and sulphydryl variable SHV were the major types. However, CTX-M type is more common in some countries (Paterson, 2003 ...
Gsp1 Triggers the Sexual Developmental Program
... (Sager and Ramanis, 1974; Sager et al., 1981). Gillham et al. (1987) isolated three mutations, mat-3-1, 3-2, and 3-3, that are linked to the mt+ locus, all showing increased transmission of the mt2 cpDNA. However, the mat-3 cells are unusually small and contain significantly reduced amounts of cpDNA, ...
... (Sager and Ramanis, 1974; Sager et al., 1981). Gillham et al. (1987) isolated three mutations, mat-3-1, 3-2, and 3-3, that are linked to the mt+ locus, all showing increased transmission of the mt2 cpDNA. However, the mat-3 cells are unusually small and contain significantly reduced amounts of cpDNA, ...
Evolutionary origin and consequences of uniparental mitochondrial
... cytoplasmic genomes such as the mitochondrial genome are inherited (almost) exclusively through only one, usually the maternal, parent. This rule probably evolved to minimize the potential spread of selfish cytoplasmic genomic mutations through a species. Maternal inheritance creates an asymmetry be ...
... cytoplasmic genomes such as the mitochondrial genome are inherited (almost) exclusively through only one, usually the maternal, parent. This rule probably evolved to minimize the potential spread of selfish cytoplasmic genomic mutations through a species. Maternal inheritance creates an asymmetry be ...
Genetics of allergic disease
... includes asthma, rhinitis and dermatitis. Asthma has been defined as a chronic inflammatory disease in the airways of the lung, characterised by variable airway obstruction and airway hyper-responsiveness accompanied by symptoms such as wheeze, breathlessness or cough. Asthma generally develops in c ...
... includes asthma, rhinitis and dermatitis. Asthma has been defined as a chronic inflammatory disease in the airways of the lung, characterised by variable airway obstruction and airway hyper-responsiveness accompanied by symptoms such as wheeze, breathlessness or cough. Asthma generally develops in c ...
Review Article
... infection; then they will need to obtain nutrients and to multiply while at the same time evading the host defence mechanisms. In some instances, they may need to invade host cells for survival or further dissemination within the host (Finlay & Falkow, 1989). The recognition that bacterial pathogeni ...
... infection; then they will need to obtain nutrients and to multiply while at the same time evading the host defence mechanisms. In some instances, they may need to invade host cells for survival or further dissemination within the host (Finlay & Falkow, 1989). The recognition that bacterial pathogeni ...
Supplementary Legends - Word file
... Generally, analysis after ASS was impossible if microtubule-based pulling forces were strongly reduced, if spindle assembly or positioning was severely affected, or if the cortex of the embryo displayed vigorous movements. In some cases we could obtain a result by performing ASS plus aster ablation. ...
... Generally, analysis after ASS was impossible if microtubule-based pulling forces were strongly reduced, if spindle assembly or positioning was severely affected, or if the cortex of the embryo displayed vigorous movements. In some cases we could obtain a result by performing ASS plus aster ablation. ...
Gsp1 Triggers the Sexual Developmental Program
... (Sager and Ramanis, 1974; Sager et al., 1981). Gillham et al. (1987) isolated three mutations, mat-3-1, 3-2, and 3-3, that are linked to the mt+ locus, all showing increased transmission of the mt2 cpDNA. However, the mat-3 cells are unusually small and contain significantly reduced amounts of cpDNA, ...
... (Sager and Ramanis, 1974; Sager et al., 1981). Gillham et al. (1987) isolated three mutations, mat-3-1, 3-2, and 3-3, that are linked to the mt+ locus, all showing increased transmission of the mt2 cpDNA. However, the mat-3 cells are unusually small and contain significantly reduced amounts of cpDNA, ...
Whole Exome Re-Sequencing Implicates CCDC38 and
... population cohorts have successfully identified at least 26 genes or gene regions associated with lung function and a number of these also show association with chronic obstructive pulmonary disease (COPD). However, these findings explain a small proportion of the heritability of lung function. Alth ...
... population cohorts have successfully identified at least 26 genes or gene regions associated with lung function and a number of these also show association with chronic obstructive pulmonary disease (COPD). However, these findings explain a small proportion of the heritability of lung function. Alth ...
PDF - Oxford Academic - Oxford University Press
... Longevity is often defined as age at death or survival to an exceptional age such as 90 years or older or 100 years or older. Because life expectancy has improved dramatically across birth cohorts since 1900, care must be taken when study designs compare long-lived with younger cohorts. Women live l ...
... Longevity is often defined as age at death or survival to an exceptional age such as 90 years or older or 100 years or older. Because life expectancy has improved dramatically across birth cohorts since 1900, care must be taken when study designs compare long-lived with younger cohorts. Women live l ...
Methods for detecting positive selection and examples among fungi
... positive selection, using either divergence (i.e., variation representing substitutions between species) or polymorphism data. We then illustrate applications of such methods, using relevant studies where selected genes have been identified in pathogens, providing insight into host–pathogen coevoluti ...
... positive selection, using either divergence (i.e., variation representing substitutions between species) or polymorphism data. We then illustrate applications of such methods, using relevant studies where selected genes have been identified in pathogens, providing insight into host–pathogen coevoluti ...
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics
... further "dysmorphologies"). In-depth sequencing of the candidate regions has shown that the expression of DLX6 depends upon the activity of conserved regulatory elements shared with DLX5, and located both within the DLX5/DLX6 intergenic territory and outside of the locus (see Figure 1; Lango Allen e ...
... further "dysmorphologies"). In-depth sequencing of the candidate regions has shown that the expression of DLX6 depends upon the activity of conserved regulatory elements shared with DLX5, and located both within the DLX5/DLX6 intergenic territory and outside of the locus (see Figure 1; Lango Allen e ...
Tissue Polarity Genes of Drosophila Regulate the Subcellular
... demarcated by wing veins (see also Fig. 3 a). We considered the polarity of each region separately and schematically used five equally sized stripes to represent the five regions (see Fig. 5). We subdivided each region into 5 or 8 equal-length parts along the proximal-distal axis. For any subdivisio ...
... demarcated by wing veins (see also Fig. 3 a). We considered the polarity of each region separately and schematically used five equally sized stripes to represent the five regions (see Fig. 5). We subdivided each region into 5 or 8 equal-length parts along the proximal-distal axis. For any subdivisio ...
20060710_GOannotCamp_Stanford
... some don’t (S. pombe, E. coli, Gramene). (Broader question: What constitutes a valid gene-paper association?) Conclusions? - Metrics - How to measure depth?: 1. Number of papers associated to each gene (MODs need to know this number, may not have to transmit this info to GO.) 2. % of papers curated ...
... some don’t (S. pombe, E. coli, Gramene). (Broader question: What constitutes a valid gene-paper association?) Conclusions? - Metrics - How to measure depth?: 1. Number of papers associated to each gene (MODs need to know this number, may not have to transmit this info to GO.) 2. % of papers curated ...
Mechanisms and constraints shaping the evolution of body plan
... while in genome-based models transcription factor binding sites and genes encoding transcription factors (TFs) may evolve independently. When network-based models are combined with an initially small number of genes, this introduces a bias towards evolving interactions between genes present early du ...
... while in genome-based models transcription factor binding sites and genes encoding transcription factors (TFs) may evolve independently. When network-based models are combined with an initially small number of genes, this introduces a bias towards evolving interactions between genes present early du ...
Genetics of fibrosing lung diseases REVIEW
... autosomal dominant trait with reduced penetrance [3, 8, 9]. An interesting observation in this respect has been made by BITTERMAN et al. [9]. They evaluated 17 unaffected members of three families with an autosomal dominant form of IPF and found evidence of alveolar inflammation in approximately hal ...
... autosomal dominant trait with reduced penetrance [3, 8, 9]. An interesting observation in this respect has been made by BITTERMAN et al. [9]. They evaluated 17 unaffected members of three families with an autosomal dominant form of IPF and found evidence of alveolar inflammation in approximately hal ...
Day and Night
... missing only 10 hours of sleep, found scientists from the Neurosciences Institute in San Diego, California. Scientists noticed that other genes in these mutated flies were less active after sleep deprivation. These genes, which produce "heat shock" proteins, were artificially stimulated prior to sle ...
... missing only 10 hours of sleep, found scientists from the Neurosciences Institute in San Diego, California. Scientists noticed that other genes in these mutated flies were less active after sleep deprivation. These genes, which produce "heat shock" proteins, were artificially stimulated prior to sle ...
(base) sequence of the genome might reflect biological information
... of chromosome II was enlarged to 990 nt (Figure 2(c), 648 ~ 1,638), or 1,584 nt (Figure 2(d), 54 ~ 1,638), respectively. That is, the base sequence of the complete ATP1 gene had self-similarity to the gene-position on chromosome II. Other genes of S. cerevisiae were highly homologous with the gene-p ...
... of chromosome II was enlarged to 990 nt (Figure 2(c), 648 ~ 1,638), or 1,584 nt (Figure 2(d), 54 ~ 1,638), respectively. That is, the base sequence of the complete ATP1 gene had self-similarity to the gene-position on chromosome II. Other genes of S. cerevisiae were highly homologous with the gene-p ...
Comparative Genetics of Nucleotide Binding Site
... is consistent with previous results that were carried out on a smaller sequence set that contained a mixture of cereal and dicotyledon species (Pan et al. 2000). The internal stability of the two major branches is strongly supported by the bootstrapping experiment (500/500 for major group divisions) ...
... is consistent with previous results that were carried out on a smaller sequence set that contained a mixture of cereal and dicotyledon species (Pan et al. 2000). The internal stability of the two major branches is strongly supported by the bootstrapping experiment (500/500 for major group divisions) ...
The chromatin remodelling factor Brg1 interacts with catenin to
... targeted to the promoters of speci®c genes via a sequence-speci®c DNA-binding domain in the Tcfs and mediates transcriptional activation by virtue of potent transactivation domains present in the C-terminus of b-catenin (van de Wetering et al., 1997; Hecht et al., 1999). In the absence of nuclear b- ...
... targeted to the promoters of speci®c genes via a sequence-speci®c DNA-binding domain in the Tcfs and mediates transcriptional activation by virtue of potent transactivation domains present in the C-terminus of b-catenin (van de Wetering et al., 1997; Hecht et al., 1999). In the absence of nuclear b- ...
Investigating the importance of anatomical homology for
... Todd J. Vision Department of Biology, University of North Carolina at Chapel Hill Chapel Hill, NC 27599, USA Email: [email protected] There is growing use of ontologies for the measurement of cross-species phenotype similarity. Such similarity measurements contribute to diverse applications, such as i ...
... Todd J. Vision Department of Biology, University of North Carolina at Chapel Hill Chapel Hill, NC 27599, USA Email: [email protected] There is growing use of ontologies for the measurement of cross-species phenotype similarity. Such similarity measurements contribute to diverse applications, such as i ...
Introduction - bei DuEPublico
... 2) evasion of apoptosis 3) insensitivity to antigrowth signals 4) sustained angiogenesis 5) limitless replicative potential and 6) capacity to invade tissue and grow at metastatic sites The number of mutations required to gain these abilities varies. For example, in some cells mutation of the TP53 g ...
... 2) evasion of apoptosis 3) insensitivity to antigrowth signals 4) sustained angiogenesis 5) limitless replicative potential and 6) capacity to invade tissue and grow at metastatic sites The number of mutations required to gain these abilities varies. For example, in some cells mutation of the TP53 g ...
BGS 99, Lesser internode number 1, lin1
... Triple Bearded Mariout (BGS 57) made study of lin1 locus difficult in some environments; therefore, a new BGS number was recommended (2). In some six-rowed cultivars such as Morex, the reduction in rachis internodes associated with the lin1 gene is less obvious (1). A significant reduction triplet n ...
... Triple Bearded Mariout (BGS 57) made study of lin1 locus difficult in some environments; therefore, a new BGS number was recommended (2). In some six-rowed cultivars such as Morex, the reduction in rachis internodes associated with the lin1 gene is less obvious (1). A significant reduction triplet n ...
Wnt Signaling and an APC-Related Gene Specify Endoderm in
... by defects in P2-EMS signaling suggests that the wrm-1 gene plays an essential role in P 2-EMS signaling in wildtype embryogenesis. To test if wrm-1 was required for the different apparent levels of POP-1 protein observed in the MS and E nuclei of wild-type embryos (Figure 4a), we stained 8-cell sta ...
... by defects in P2-EMS signaling suggests that the wrm-1 gene plays an essential role in P 2-EMS signaling in wildtype embryogenesis. To test if wrm-1 was required for the different apparent levels of POP-1 protein observed in the MS and E nuclei of wild-type embryos (Figure 4a), we stained 8-cell sta ...
The relationship between higher‑order chromatin structure and
... sediments more slowly than bulk chromatin or a non‑expressed gene, whereas it sediments with bulk chromatin in non‑expressing cells [8,9,11]. However, can the β‑globin locus, whose regulation is known to be very complex in mammalian cells, be used as a paradigm for the other ∼25 000 genes in the gen ...
... sediments more slowly than bulk chromatin or a non‑expressed gene, whereas it sediments with bulk chromatin in non‑expressing cells [8,9,11]. However, can the β‑globin locus, whose regulation is known to be very complex in mammalian cells, be used as a paradigm for the other ∼25 000 genes in the gen ...
Part 3 - Bioinformatics.ca
... How does Segway work? • Goal is to segment the genome into sub-classes. In each case, the tools identify certain data properties that subsets of the genome. Based on the groupings, the presence of known features (e.g. transcription start regions) is scored to suggest the functional meaning of the c ...
... How does Segway work? • Goal is to segment the genome into sub-classes. In each case, the tools identify certain data properties that subsets of the genome. Based on the groupings, the presence of known features (e.g. transcription start regions) is scored to suggest the functional meaning of the c ...