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Foundations of Biology - Geoscience Research Institute
Foundations of Biology - Geoscience Research Institute

... homology between different sequences is not evident, thus there could be no standard sequence that was tacked on as genes were moved from mitochondria to nucleus Alternatively, if genes for mitochondrial proteins existed in the nucleus prior to loss of genes in the mitochondria, the problem remains, ...
Bacterial plasmids - Micro-Rao
Bacterial plasmids - Micro-Rao

... Plasmids are defined as double stranded, extrachromosomal genetic elements that replicate independently of the host cell chromosome and are stably inherited. Plasmids capable of integration into the chromosome were earlier called episomes. Plasmids differ from chromosomes in being small and coding f ...
View PDF
View PDF

... its parents, as shown in Figure 11–3. In each cross, the nature of the other parent, with regard to each trait, seemed to have disappeared. From these results, Mendel drew two conclusions. His first conclusion formed the basis of our current understanding of inheritance. An individual’s characteristi ...
Uria_et_al_2006 _ADH paper
Uria_et_al_2006 _ADH paper

... Oceans are vast untapped reservoirs of highly diverse and unique natural products accumulated in marine organisms. Enzymes belong to the most interesting natural products from both scientific and industrial perpectives. They are enjoying increasing popularity in the chemical and pharmaceutical indus ...
MicroRNAs: key participants in gene regulatory networks
MicroRNAs: key participants in gene regulatory networks

... Four decades ago, the Central Dogma was formulated and simplified as ‘DNA makes RNA, and RNA makes protein’. As a result, RNAs have been looked as simple molecules that merely convert genetic information into protein. However, it has been estimated that although most of the genome is transcribed, al ...
Biology 164 Laboratory Genetic Mutants of the Prodigiosin
Biology 164 Laboratory Genetic Mutants of the Prodigiosin

... The method for studying the genetic control of biochemical pathways is quite simple once the underlying principles are understood. The wild-type strain (prototroph) of the organism is able to produce the end product of the biochemical pathway being studied. The pathway is functional in the prototrop ...
pdf
pdf

... Phylogenetics is a powerful tool for visualizing the relationships between various clades that make up all organismal life. While perspectives regarding the fundamental selection process dictating a clade’s position on the tree have shifted, from morphometrics to genetics [1]; there is no doubt that ...
Assaying … promoter activity
Assaying … promoter activity

... showed that the rate of plasmid loss after integration is very low. Either explain the “true breeding experiment” fully in Materials and Methods or include more detail here. …the plasmid integrated into the genome by homologous recombination with the nimB and ORF5468 gene. We tested the stability of ...
Complete comparative genomic analysis of two field isolates of
Complete comparative genomic analysis of two field isolates of

... Analysis of all variations showed that 398 point mutations, six insertions totalling 30 bp and 20 deletions totalling 1326 bp occur in predicted ORFs; 65 point mutations, three insertions (13 bp) and five deletions (102 bp) occur in intergenic regions; and 58 point mutations, two insertions (79 bp) ...
Conservation of Brachyury (T) genes in amphioxus and vertebrates
Conservation of Brachyury (T) genes in amphioxus and vertebrates

... sequence identity throughout their coding regions (94% amino acid identity over 444 sites), but differ markedly over their 5′ and 3′ untranslated regions (UTRs). The lengths of the 3′ UTRs are also quite different, being 825 nt for AmBra-1 and 377 nt for AmBra-2 (excluding stop codon and terminal A ...
Wolbachia – a Heritable Endosymbiont
Wolbachia – a Heritable Endosymbiont

... interact with DNA binding proteins – These may be similar to H1, histones ...
Genetic dissection of Helicobacter pylori AddAB role in homologous
Genetic dissection of Helicobacter pylori AddAB role in homologous

... modeling the AddAB complex structure, we investigated using a genetics approach the in vivo roles of the H. pylori addA and addB gene products during recombinational repair, exogenous DNA incorporation and intrachromosomal recombination. Furthermore, using double or triple mutants in HR genes, we de ...
Visualization, description and analysis of the Drosophila melanogaster
Visualization, description and analysis of the Drosophila melanogaster

... least partially among generations (Lewontin 1970; Endler 1986). DNA is the molecule that carries the genetic information (Avery et al. 1944), and among its properties two are essential to the evolutionary process. On one hand, the molecule is intrinsically mutable, being this the origin of genetic v ...
The Complex Inheritance of Maize Domestication Traits and Gene
The Complex Inheritance of Maize Domestication Traits and Gene

... was given to shepherd them to completion. Every day and conversation I have had with John as my advisor has made me into a better scientist and I am extremely thankful for the opportunity I was given six years ago when I joined the Doebley lab. I have been fortunate enough to also work in an outstan ...
Mitochondrial DNA - Circle
Mitochondrial DNA - Circle

... prevailing theory in saying that mitochondria must have been present then lost after they had transferred some of their genetic information to the nucleus. The hydrogenosome, a structure involved in carbohydrate metabolism found in some Archezoans (Muller, 1992), is now thought to represent a mitoch ...
Manuscript - Imperial Spiral
Manuscript - Imperial Spiral

... (the only notable exception coming from Gram-positive bacteria in which they are apparently clustered), but the same genes or gene clusters (e.g., the pilMNOPQ cluster, the pilW gene and the pilFDG cluster encoding the traffic ATPase, the prepilin peptidase gene and the conserved inner membrane prot ...
Identification of chromosome intervals from 129 and C57BL/6 mouse
Identification of chromosome intervals from 129 and C57BL/6 mouse

... autoimmunity in this congenic strain was indistinguishable to that observed in a mouse carrying a deletion of the Apcs gene, located within the lupus-linked genomic region on distal chromosome 1 and considered as a candidate gene for murine SLE.6 Therefore, backgroundderived genes can significantly ...
Algorithms for Finding Gene Clusters
Algorithms for Finding Gene Clusters

... the bioinformatic problem of finding conserved clusters of genes in data derived from completely sequenced genomes we further extended the above algorithm to additional types of permutations. Genomes of higher organisms generally consist of several linear chromosomes while bacterial, archaeal, and m ...
Epidermolysis Bullosa Letalis - Center for Arab Genomic Studies
Epidermolysis Bullosa Letalis - Center for Arab Genomic Studies

... and mucous membranes after minor trauma. The disease appears to be one of the most frequent monogenic causes of infant mortality among Arabs. The disease is traditionally classified into three groups according to the level of cleavage within the skin: Epidermolysis bullosa simplex results from separ ...
ch 11_4
ch 11_4

... The linkage groups assorted independently, but all of the genes in one group were inherited together. As it turns out, Drosophila has four linkage groups and four pairs of chromosomes. ...
Meiosis I - scecinascience
Meiosis I - scecinascience

... The linkage groups assorted independently, but all of the genes in one group were inherited together. As it turns out, Drosophila has four linkage groups and four pairs of chromosomes. ...
PDF File - Friends Science Publishers
PDF File - Friends Science Publishers

... properties of chromosomes are related to functional aspects. High variability is demonstrated by the fitness to range of environment and resistance to different biotic stresses. However, the functional background of this variation is not well understood. An improved knowledge of the influence of arc ...
Open Access
Open Access

... phenotypic changes is evolutionary developmental biology (also called Evo-Devo) [1]. As most of our knowledge is based on a few well-characterized model systems that are separated by large evolutionary distances, evolutionary comparisons are often descriptive and have little functional depth. Typica ...
DNA phosphorothioation inStreptomyces lividans: mutational
DNA phosphorothioation inStreptomyces lividans: mutational

... are dnd-specific and the Dnd proteins are correctly expressed in vivo. In the meantime, these expression plasmids carrying individual dnd genes could also rescue the Dnd phenotype of other corresponding mutants including HXY1 and HXY2 (data not shown). These complementation results from different mu ...
2 - Genetics
2 - Genetics

... Mutant frequencies: Five tubes containing the appropriate media were inoculated with a mutant-free inoculum containing a few thousand cells and grown overnight with aeration at 37". Samples from each tube were plated on appropriate selective plates and simultaneously diluted in saline for total cell ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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