glycosphingolipid degradation - Limes-Institut-Bonn
... The enzymatic degradation of ganglioside GM2, the main storage material in Tay-Sachs disease, requires B-hexosaminidase A and a lysosomal ganglioside-binding protein, the GM2 activatorz6. The GM2 activator binds ganglioside GM2, as well as related gangliosides, and forms watersoluble complexes (most ...
... The enzymatic degradation of ganglioside GM2, the main storage material in Tay-Sachs disease, requires B-hexosaminidase A and a lysosomal ganglioside-binding protein, the GM2 activatorz6. The GM2 activator binds ganglioside GM2, as well as related gangliosides, and forms watersoluble complexes (most ...
Batteries convert chemically stored energy to electrical energy, and
... unfavorable) reactions. Many of their reactions involve oxidation/reduction couples. So the cell has energy. What do they use it for? Three main activities 1. Chemical energy - synthesis of complex biological molecules. In other words, to make more of themselves. 2. Transport - Cells often live in d ...
... unfavorable) reactions. Many of their reactions involve oxidation/reduction couples. So the cell has energy. What do they use it for? Three main activities 1. Chemical energy - synthesis of complex biological molecules. In other words, to make more of themselves. 2. Transport - Cells often live in d ...
Pymol Tutorial
... It is advisable to place them as cartoon. We can put both together as in cartoon 'all' → 'S + as + cartoon': ...
... It is advisable to place them as cartoon. We can put both together as in cartoon 'all' → 'S + as + cartoon': ...
enzyme
... • Enzymes use a variety of mechanisms to lower activation energy and speed a reaction. • The active site orients substrates in the correct orientation for the reaction. • As the active site binds the substrate, it may put stress on bonds that must be broken, making it easier to reach the transition ...
... • Enzymes use a variety of mechanisms to lower activation energy and speed a reaction. • The active site orients substrates in the correct orientation for the reaction. • As the active site binds the substrate, it may put stress on bonds that must be broken, making it easier to reach the transition ...
Cellular Respiration - LaPazColegioWiki2013-2014
... Lactic acid fermentation ONLY ATP gained comes from glycolysis (the step ...
... Lactic acid fermentation ONLY ATP gained comes from glycolysis (the step ...
The Loss of Glutamate-GABA Harmony in Anxiety Disorders
... channels through signal transduction mechanisms that induces the opening or closing of the channels (Ango et al., 2000). Metabotropic receptors on the presynaptic membrane can inhibit or, more rarely, facilitate neurotransmitter release from the presynaptic neuron (Schmitz et al., 2001). There is on ...
... channels through signal transduction mechanisms that induces the opening or closing of the channels (Ango et al., 2000). Metabotropic receptors on the presynaptic membrane can inhibit or, more rarely, facilitate neurotransmitter release from the presynaptic neuron (Schmitz et al., 2001). There is on ...
Millionaire Cells 2
... higher concentration outside the cell to an area of lower concentration inside the cell during this process ...
... higher concentration outside the cell to an area of lower concentration inside the cell during this process ...
Model 1
... Model 1 : Diffusion – trapping of channels Model 2 : Static channels Model results Experimental setup Study on adaptation ...
... Model 1 : Diffusion – trapping of channels Model 2 : Static channels Model results Experimental setup Study on adaptation ...
INSILICO APPROACHES TOWARDS THE DRUG TARGET AURORKINASES USING THE ORTHO
... Lipinski’s rule of 5.further, it was taken for the receptor-ligand interaction analysis. Receptor-ligand interaction Docking is frequently used to predict the binding orientation of small molecule drug candidates to their protein targets in order to in turn predict the affinity and activity of the s ...
... Lipinski’s rule of 5.further, it was taken for the receptor-ligand interaction analysis. Receptor-ligand interaction Docking is frequently used to predict the binding orientation of small molecule drug candidates to their protein targets in order to in turn predict the affinity and activity of the s ...
Gastrointestinal Stromal Tumours(GIST)
... • In normal cells activation of the of the c-kit tyrosine kinase requires the presence of an endogenous ligand (KIT ligand, ckit ligand, or stem cell factor) • Approx 80 % of GISTs have KIT protooncogene mutations that lead to activation of the c-kit receptor resulting in spontaneous receptor activa ...
... • In normal cells activation of the of the c-kit tyrosine kinase requires the presence of an endogenous ligand (KIT ligand, ckit ligand, or stem cell factor) • Approx 80 % of GISTs have KIT protooncogene mutations that lead to activation of the c-kit receptor resulting in spontaneous receptor activa ...
Reece9e_Lecture_C05
... o Basic R groups have amino groups with positive charge. o All amino acids have carboxyl and amino groups. The terms acidic and basic in this context refer only to these groups in the R groups. Amino acids are joined together when a dehydration reaction removes a hydroxyl group from the carboxyl end ...
... o Basic R groups have amino groups with positive charge. o All amino acids have carboxyl and amino groups. The terms acidic and basic in this context refer only to these groups in the R groups. Amino acids are joined together when a dehydration reaction removes a hydroxyl group from the carboxyl end ...
Chapter 8. Movement across the Membrane
... Move from HIGH to LOW concentration through a protein channel passive transport no energy needed facilitated = with help ...
... Move from HIGH to LOW concentration through a protein channel passive transport no energy needed facilitated = with help ...
The metabolic advantage of tumor cells Open Access Maurice Israël
... 1- Oncogenes express proteins of “Tyrosine kinase receptor pathways”, a receptor family including insulin or IGFGrowth Hormone receptors. Other oncogenes alter the PP2A phosphatase brake over these kinases. 2- Experiments on pancreatectomized animals; treated with pure insulin or total pancreatic ex ...
... 1- Oncogenes express proteins of “Tyrosine kinase receptor pathways”, a receptor family including insulin or IGFGrowth Hormone receptors. Other oncogenes alter the PP2A phosphatase brake over these kinases. 2- Experiments on pancreatectomized animals; treated with pure insulin or total pancreatic ex ...
Topological characterization of the essential Escherichia coli cell
... ftsW gene. To generate L-lactamase fusions we followed the method described by [17]. Various truncated forms of the ftsW gene (at the 3P end) were ampli¢ed by PCR from the E. coli chromosomal DNA using as primers oligonucleotides generating a KpnI site. The oligonucleotide A60 (5P-CGTACCAGGTACCGCCTG ...
... ftsW gene. To generate L-lactamase fusions we followed the method described by [17]. Various truncated forms of the ftsW gene (at the 3P end) were ampli¢ed by PCR from the E. coli chromosomal DNA using as primers oligonucleotides generating a KpnI site. The oligonucleotide A60 (5P-CGTACCAGGTACCGCCTG ...
Cell Bio!!!!
... b) directly activates genes that cause a plant to undergo skotomorphogenesis. c) acts in the nucleus when the plant is in the light. d) forms a heterodimer with phytochrome to activate genes involved in photomorphogenesis when the plant is in the light. e) represses genes involved in photomorphogene ...
... b) directly activates genes that cause a plant to undergo skotomorphogenesis. c) acts in the nucleus when the plant is in the light. d) forms a heterodimer with phytochrome to activate genes involved in photomorphogenesis when the plant is in the light. e) represses genes involved in photomorphogene ...
REVISION: CELL DIVISION 20 MARCH 2013 Key Concepts
... At the beginning of interphase the cell grows quickly. More organelles are made and there is an increase in the number of chemical reactions. The cell may become specialised for its function in the body or it may store nutrients and get ready for mitosis. Towards the end of interphase the chromatin ...
... At the beginning of interphase the cell grows quickly. More organelles are made and there is an increase in the number of chemical reactions. The cell may become specialised for its function in the body or it may store nutrients and get ready for mitosis. Towards the end of interphase the chromatin ...
Serotonin 5-HT Receptors: Chemical Neuronatomy in the
... receptor binding sites are located in the stratum lacunosum molecular, whereas in the human hippocampus the pyramidal layer is enriched in these receptors. There are also differences in [3H]mesulergine binding sites in human brain when compared with monkey (Macaca fascicularis) brain. High densities ...
... receptor binding sites are located in the stratum lacunosum molecular, whereas in the human hippocampus the pyramidal layer is enriched in these receptors. There are also differences in [3H]mesulergine binding sites in human brain when compared with monkey (Macaca fascicularis) brain. High densities ...
Surveying Protein Structure and Function Using Bis
... bipartite tetracysteine variants of aPP (F24P,Y31P) bind FlAsH and ReAsH (25 nM) with diminished affinities relative to the wild-type bipartite tetracysteine constructs. (c) Schematic representation of intermolecular bipartite tetracysteine display. (d) Monomeric bipartite tetracysteine variants of ...
... bipartite tetracysteine variants of aPP (F24P,Y31P) bind FlAsH and ReAsH (25 nM) with diminished affinities relative to the wild-type bipartite tetracysteine constructs. (c) Schematic representation of intermolecular bipartite tetracysteine display. (d) Monomeric bipartite tetracysteine variants of ...
BCM 101 BIOCHEMISTRY BIOCHEMISTRY “Chemistry of proteins”
... The word “protein” is derived from the Greek word “proteios”, which means “of primary importance”. In fact, proteins plays an important role in all biochemical and physiological body processes; they act as enzymes, hormones, receptors, antibodies and are required for the structural integrity of cell ...
... The word “protein” is derived from the Greek word “proteios”, which means “of primary importance”. In fact, proteins plays an important role in all biochemical and physiological body processes; they act as enzymes, hormones, receptors, antibodies and are required for the structural integrity of cell ...
Understanding the cell cycle
... other marine invertebrates) and vice versa. Whereas geneti- on the other hand, purified MPF, and found that it was also a cists were taught that the nucleus controls the cytoplasm by protein kinase. It was shown to consist of two subunits12: one issuing genetic messages, embryologists had learned th ...
... other marine invertebrates) and vice versa. Whereas geneti- on the other hand, purified MPF, and found that it was also a cists were taught that the nucleus controls the cytoplasm by protein kinase. It was shown to consist of two subunits12: one issuing genetic messages, embryologists had learned th ...
Current Microbiology
... occurrence of insect resistance to Cry proteins call for the strategies of resistance management [11]. It has been reported that the insect resistance was due to the reduction of the binding affinity of the active toxin to the membrane receptor in insect midgut [18]. This fact has led many researche ...
... occurrence of insect resistance to Cry proteins call for the strategies of resistance management [11]. It has been reported that the insect resistance was due to the reduction of the binding affinity of the active toxin to the membrane receptor in insect midgut [18]. This fact has led many researche ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.