poster PDF
... 3b. The large activation loop of the kinase (navy) opens up, revealing the active site of the enzyme 3c. The kinase can now bind ATP (magenta) and modify tyrosine amino acids in other signaling proteins (pink) ...
... 3b. The large activation loop of the kinase (navy) opens up, revealing the active site of the enzyme 3c. The kinase can now bind ATP (magenta) and modify tyrosine amino acids in other signaling proteins (pink) ...
Document
... chemical-gated ion channels called neuroreceptors. These have specific binding sites for neurotransmitters. ...
... chemical-gated ion channels called neuroreceptors. These have specific binding sites for neurotransmitters. ...
HOMOLOGY MODELING OF ARYL HYDROCARBON RECEPTOR AND DOCKING OF AGONISTS
... the site directed mutagenesis results and the homology modeling. Then we decided to dock some of the antagonists. To the best of our knowledge, no report appears in the literature regarding the docking of antagonists into the AhR. The antagonists of AhR can be classified into two types, the compound ...
... the site directed mutagenesis results and the homology modeling. Then we decided to dock some of the antagonists. To the best of our knowledge, no report appears in the literature regarding the docking of antagonists into the AhR. The antagonists of AhR can be classified into two types, the compound ...
Wnt Signaling and a Hox Protein Cooperatively Regulate PSA
... ‘‘late’’ indicate before and after the V6 cell division, respectively, which occurs w30 min after the T cell division. The signal intensity representing ‘‘strong expression’’ (black bars) or ‘‘weak expression’’ (gray bars) was more or less than five times higher than background (no signal, open bars ...
... ‘‘late’’ indicate before and after the V6 cell division, respectively, which occurs w30 min after the T cell division. The signal intensity representing ‘‘strong expression’’ (black bars) or ‘‘weak expression’’ (gray bars) was more or less than five times higher than background (no signal, open bars ...
Slide 1
... 6.13 Fermentation enables cells to produce ATP without oxygen Fermentation is a way of harvesting chemical energy that does not require oxygen. Fermentation – takes advantage of glycolysis, – produces 2 ATP molecules per glucose, and – oxidizes NADH back to NAD+ ...
... 6.13 Fermentation enables cells to produce ATP without oxygen Fermentation is a way of harvesting chemical energy that does not require oxygen. Fermentation – takes advantage of glycolysis, – produces 2 ATP molecules per glucose, and – oxidizes NADH back to NAD+ ...
Cell Growth and Reproduction
... 3. When the cytoplasm divides and you officially have 2 new cells, it is called cytokinesis. ...
... 3. When the cytoplasm divides and you officially have 2 new cells, it is called cytokinesis. ...
Mechanisms of enveloped RNA virus budding
... Second, viral proteins often achieve this by mimicking the structures and functions of cellular proteins. Third, different viruses, as well as cells themselves, frequently use similar mechanisms to accomplish difficult molecular transformations. Finally, whenever possible, viruses modify their cellu ...
... Second, viral proteins often achieve this by mimicking the structures and functions of cellular proteins. Third, different viruses, as well as cells themselves, frequently use similar mechanisms to accomplish difficult molecular transformations. Finally, whenever possible, viruses modify their cellu ...
AthPEX10, a nuclear gene essential for peroxisome and storage
... containing either type of peroxisomal targeting signal as well as for the elaboration of the peroxisome lumen; loss of PEX10p leads to accumulation of membrane sheets (8, 9). In H. polymorpha, PEX10-deficient mutants contain no peroxisome-like structures, and peroxisomal enzymes are located in the c ...
... containing either type of peroxisomal targeting signal as well as for the elaboration of the peroxisome lumen; loss of PEX10p leads to accumulation of membrane sheets (8, 9). In H. polymorpha, PEX10-deficient mutants contain no peroxisome-like structures, and peroxisomal enzymes are located in the c ...
What is “membrane potential”
... “Neuro transmitters” are the chemical signal passed from cell-to-cell Common examples -- Dopamine -- Serotonin -- Acetylcholine Some are inhibitory -- GABA ...
... “Neuro transmitters” are the chemical signal passed from cell-to-cell Common examples -- Dopamine -- Serotonin -- Acetylcholine Some are inhibitory -- GABA ...
The Cytoskeleton
... GTPases: cdc42: its activation triggers actin polymerization and bundling at ...
... GTPases: cdc42: its activation triggers actin polymerization and bundling at ...
![Mouse (monoclonal) anti-β-Catenin [pY86]](http://s1.studyres.com/store/data/013277785_1-9ecc4a36fe4e6b90692b9558e5656402-300x300.png)
Mouse (monoclonal) anti-β-Catenin [pY86]
... The α-, β- and γ-catenins are cytoplasmic proteins mediating the interaction of Ca2+-dependent transmembrane adhesion molecules (cadherins) with the cytoskeletal network. The direct interaction of β-catenin with the cytoplasmic domain of cadherins plays a crucial role for cell-cell adhesion and sign ...
... The α-, β- and γ-catenins are cytoplasmic proteins mediating the interaction of Ca2+-dependent transmembrane adhesion molecules (cadherins) with the cytoskeletal network. The direct interaction of β-catenin with the cytoplasmic domain of cadherins plays a crucial role for cell-cell adhesion and sign ...
The peripheral auditory system
... loud sinusoids (140dB) at low frequencies in recently deceased humans using stroboscopic illumination • Bekesy found a relative bandwidth of 0.6 – e.g., 600 Hz 10dB bandwidth when CF is 1000 Hz – Too high to account for sharp frequency resolution of ear and auditory neurons! ...
... loud sinusoids (140dB) at low frequencies in recently deceased humans using stroboscopic illumination • Bekesy found a relative bandwidth of 0.6 – e.g., 600 Hz 10dB bandwidth when CF is 1000 Hz – Too high to account for sharp frequency resolution of ear and auditory neurons! ...
Transport 1 Fox Chapter 6 pt 1
... 3. Closely related molecules can compete for transporters on the cell surface (different cell types express different transporters) Facilitated Diffusion Transported molecule is moved down its concentration gradient. Does not require extra energy from the cell (uses potential energy of concentration ...
... 3. Closely related molecules can compete for transporters on the cell surface (different cell types express different transporters) Facilitated Diffusion Transported molecule is moved down its concentration gradient. Does not require extra energy from the cell (uses potential energy of concentration ...
serotonin
... have marked effects on the functional properties of proteins. For example, RNA editing changes a single amino acid in the  subunit of the AMPA (␣-amino-3-hydroxy-5-methyl4-isoxazole propionic acid) receptor, which dictates the gating properties of this ligand-gated ion channel (see ref. 12 for revi ...
... have marked effects on the functional properties of proteins. For example, RNA editing changes a single amino acid in the  subunit of the AMPA (␣-amino-3-hydroxy-5-methyl4-isoxazole propionic acid) receptor, which dictates the gating properties of this ligand-gated ion channel (see ref. 12 for revi ...
Three-Dimensional Structure of the Muscle Fatty-Acid
... of the desert locust Schistocerca gregaria has been solved and refined to a crystallographic R-value of 18.5% for all measured X-ray data from 30.0- to 2.2-A resolution. Crystals employed in the investigation were grown from 2.6 to 2.8 M ammonium sulfate solutions, buffered at p H 7.5 and containing ...
... of the desert locust Schistocerca gregaria has been solved and refined to a crystallographic R-value of 18.5% for all measured X-ray data from 30.0- to 2.2-A resolution. Crystals employed in the investigation were grown from 2.6 to 2.8 M ammonium sulfate solutions, buffered at p H 7.5 and containing ...
Polyamines Regulate Growth Factor
... Grb2 or Shc via its SH2 domain, to bind to phosphotyrosine residue. Shc becomes phosphorylated on tyrosine residues in response to growth factors and src family kinases (3). This signaling protein is constitutively phosphorylated at tyrosine residue (s) in a number of breast cancer cell lines but no ...
... Grb2 or Shc via its SH2 domain, to bind to phosphotyrosine residue. Shc becomes phosphorylated on tyrosine residues in response to growth factors and src family kinases (3). This signaling protein is constitutively phosphorylated at tyrosine residue (s) in a number of breast cancer cell lines but no ...
Protein Kinase C–dependent Activation of Cytosolic
... AA and its eicosanoid metabolites (e.g., prostaglandins and leukotrienes) play critical roles in the initiation or modulation of a broad spectrum of physiological responses and certain abnormal (e.g., inflammatory) processes in mammalian cells (1, 2). This fatty acid is not freely stored in cells bu ...
... AA and its eicosanoid metabolites (e.g., prostaglandins and leukotrienes) play critical roles in the initiation or modulation of a broad spectrum of physiological responses and certain abnormal (e.g., inflammatory) processes in mammalian cells (1, 2). This fatty acid is not freely stored in cells bu ...
Docking Studies in Target Proteins Involved in Antibacterial Action
... extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, ...
... extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, ...
Document
... • Nuclear envelope = a pair of membrane bilayers, which are joined at the pore complexes, an additional layer called nuclear lamina (a mesh of filament proteins) underlie the inner membrane. • Lamina may organize chromatin into functional domains, provide structure to nucleus; • breaks down in mitos ...
... • Nuclear envelope = a pair of membrane bilayers, which are joined at the pore complexes, an additional layer called nuclear lamina (a mesh of filament proteins) underlie the inner membrane. • Lamina may organize chromatin into functional domains, provide structure to nucleus; • breaks down in mitos ...
A Mammalian Cell Cycle Checkpoint Pathway - Wafik S. El
... of GADD45 was investigated. After demonstrating that IR induction of GADD45 is dependent on a wild-type p53 phenotype, a conserved p53-binding site was identified in the human and hamster GAD045 genes and binding of p53 protein to this sequence was evaluated. Based on the results of these investigat ...
... of GADD45 was investigated. After demonstrating that IR induction of GADD45 is dependent on a wild-type p53 phenotype, a conserved p53-binding site was identified in the human and hamster GAD045 genes and binding of p53 protein to this sequence was evaluated. Based on the results of these investigat ...
TGF beta signalling and its role in tumour pathogenesis
... TGF-β dimer binds to Type II receptors which leads to association with Type I receptors, conformational changes and activation of kinase domains of the receptors. Smad 2/3 proteins are cytoplasmic molecules which, aer receptor activation, are phosphorylated by an active form of Type I receptor and ...
... TGF-β dimer binds to Type II receptors which leads to association with Type I receptors, conformational changes and activation of kinase domains of the receptors. Smad 2/3 proteins are cytoplasmic molecules which, aer receptor activation, are phosphorylated by an active form of Type I receptor and ...
Mid Term Solutions - Department of Chemistry ::: CALTECH
... a. (5 points) If a 50 amino acid polypeptide were to sample all of its possible conformations in order to fold, how long would this process take? Assume that each amino acid residue can have three different conformations and it takes one picosecond (10-12) to convert between structures. b. (5 points ...
... a. (5 points) If a 50 amino acid polypeptide were to sample all of its possible conformations in order to fold, how long would this process take? Assume that each amino acid residue can have three different conformations and it takes one picosecond (10-12) to convert between structures. b. (5 points ...
In Vitro Protein Synthesis of Perdeuterated Proteins for NMR Studies
... It is well documented that high levels of deuteration are indispensable for solution NMR studies of polypeptides in structures of sizes above 40 kDa (Fiaux et al., 2002; LeMaster 1989; Pachter et al. 1992). In addition to studies on protein structure and dynamics, obtaining a perdeuterated backgroun ...
... It is well documented that high levels of deuteration are indispensable for solution NMR studies of polypeptides in structures of sizes above 40 kDa (Fiaux et al., 2002; LeMaster 1989; Pachter et al. 1992). In addition to studies on protein structure and dynamics, obtaining a perdeuterated backgroun ...
techniques of investigation and current concepts in the physiology
... the reproductive potential of the organism. Experiments conducted during the past 10 years, using the techniques of ablation or localized hormone implantation clearly demonstrate that many regulatory functions exerted by hormones occur via interactions at the level of the central nervous system. Dir ...
... the reproductive potential of the organism. Experiments conducted during the past 10 years, using the techniques of ablation or localized hormone implantation clearly demonstrate that many regulatory functions exerted by hormones occur via interactions at the level of the central nervous system. Dir ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.