CD38 positive natural killer cells may be involved in progression of
... Abstract: This study is to investigate the role of CD38 positive natural killer (NK) cells in peripheral blood (PB) and synovial fluid (SF) in the pathogenesis of rheumatoid arthritis (RA). Paired samples of PB and synovial fluid (SF) were obtained from patients with RA, osteoarthritis (OA), and ura ...
... Abstract: This study is to investigate the role of CD38 positive natural killer (NK) cells in peripheral blood (PB) and synovial fluid (SF) in the pathogenesis of rheumatoid arthritis (RA). Paired samples of PB and synovial fluid (SF) were obtained from patients with RA, osteoarthritis (OA), and ura ...
(March – May 2016) Dates Trainings Contents No. of Days
... Regular: 15000 Student UAF: 9000 Employee UAF: 10500 Other Govt. Institutions: 12000 ...
... Regular: 15000 Student UAF: 9000 Employee UAF: 10500 Other Govt. Institutions: 12000 ...
Targeting lactate metabolism for cancer therapeutics
... based compounds have been developed that inhibit LDHA more potently than LDHB, and these agents impair the proliferation of cancer cell lines and primary cancer cultures with micromolar IC50 activity (58). Collectively, these agents are promising starting points for LDHA inhibitors, although there i ...
... based compounds have been developed that inhibit LDHA more potently than LDHB, and these agents impair the proliferation of cancer cell lines and primary cancer cultures with micromolar IC50 activity (58). Collectively, these agents are promising starting points for LDHA inhibitors, although there i ...
3did: a catalog of domain-based interactions of
... DDIs occur when two globular domains form a stable interface. Interfaces in DDIs are usually relatively large [2000 Å2 on average (24)]. Several possible definitions of domains are available based on conserved globular structure or on evolutionary conserved residue sequences. For instance, SCOP (18) ...
... DDIs occur when two globular domains form a stable interface. Interfaces in DDIs are usually relatively large [2000 Å2 on average (24)]. Several possible definitions of domains are available based on conserved globular structure or on evolutionary conserved residue sequences. For instance, SCOP (18) ...
antibodies
... Although she was in relative good health as our case history ended, her outlook for survival was very poor. Recently, bone marrow transplants have been used to cure patients with multiple myeloma. /Myeloma proteins have played an important part in the history of immunology. (Bence-Jones protein, sub ...
... Although she was in relative good health as our case history ended, her outlook for survival was very poor. Recently, bone marrow transplants have been used to cure patients with multiple myeloma. /Myeloma proteins have played an important part in the history of immunology. (Bence-Jones protein, sub ...
Dormancy and growth of metastatic breast cancer cells
... There is evidence that disruption of the dormant tumor cell niche may trigger recurrence of dormant cells many years after primary treatment. Local trauma, wounding, or injury may spur tumor cells to grow. Chronic inflammation and/or immunosuppression also are important factors to be considered in c ...
... There is evidence that disruption of the dormant tumor cell niche may trigger recurrence of dormant cells many years after primary treatment. Local trauma, wounding, or injury may spur tumor cells to grow. Chronic inflammation and/or immunosuppression also are important factors to be considered in c ...
A Directed Mutagenesis Screen in Drosophila
... normally functions to inhibit Hh signaling. This becomes obvious as the ptc loss-of-function phenotype in Drosophila embryos is identical to the phenotype caused by overexpression of hh (Ingham 1993). In fact, ptc encodes the only protein yet known to bind the Hh protein directly (Stone et al. 1996) ...
... normally functions to inhibit Hh signaling. This becomes obvious as the ptc loss-of-function phenotype in Drosophila embryos is identical to the phenotype caused by overexpression of hh (Ingham 1993). In fact, ptc encodes the only protein yet known to bind the Hh protein directly (Stone et al. 1996) ...
Convergence and extension at gastrulation require a
... tailbud-stage embryos, where it is found in the notochord and somites, as well as in the developing eye, brain and branchial arches (Fig. 1A). In confocal section, the somites of a late-neurula-stage embryo were strongly outlined, indicating that MHC-B is concentrated in somitic cell cortices that f ...
... tailbud-stage embryos, where it is found in the notochord and somites, as well as in the developing eye, brain and branchial arches (Fig. 1A). In confocal section, the somites of a late-neurula-stage embryo were strongly outlined, indicating that MHC-B is concentrated in somitic cell cortices that f ...
Chapter 1: The Microbial World and You
... - Cell is defined as the fundamental living unit of any ...
... - Cell is defined as the fundamental living unit of any ...
Regeneration in plants and animals: dedifferentiation
... mononucleation of muscle fibers, which was reported as the structural marker of a prior state of the cell in classical experiments [25,26]. In support of these cells changing their identity at a molecular level, the homeobox-containing transcription factor Msx-1, known to be expressed during embryog ...
... mononucleation of muscle fibers, which was reported as the structural marker of a prior state of the cell in classical experiments [25,26]. In support of these cells changing their identity at a molecular level, the homeobox-containing transcription factor Msx-1, known to be expressed during embryog ...
Mathematical models of radiation action on living cells: From the
... – 2) The actual nature of the sensitive cellular targets was not consensual: they can be sub-populations of certain cells or some part of the nucleus. – 3) The survival of irradiated cells was considered as the result of the absence of any hit on sensitive cells. 2.2. The basic ballistic models 2.2. ...
... – 2) The actual nature of the sensitive cellular targets was not consensual: they can be sub-populations of certain cells or some part of the nucleus. – 3) The survival of irradiated cells was considered as the result of the absence of any hit on sensitive cells. 2.2. The basic ballistic models 2.2. ...
Science Quarter 4 Lessons
... It is recommended that the content statements be combined and taught as a whole (e.g., levels of organization can be interwoven with the concept of cells as the fundamental unit of life). Cells perform specialized functions in multicellular organisms. Groups of specialized cells form a tissue such a ...
... It is recommended that the content statements be combined and taught as a whole (e.g., levels of organization can be interwoven with the concept of cells as the fundamental unit of life). Cells perform specialized functions in multicellular organisms. Groups of specialized cells form a tissue such a ...
Synaptic basis for intense thalamocortical activation of feedforward
... cells than in RS cells (17 of 21 paired comparisons; Fig. 2c Ginhibitory). The average Gi of FS cells was 3.2-fold greater than that of RS cells (Fig. 2c). Nevertheless, the functional inhibition produced in RS cells is likely to be stronger because the resting input conductances of FS cells are fiv ...
... cells than in RS cells (17 of 21 paired comparisons; Fig. 2c Ginhibitory). The average Gi of FS cells was 3.2-fold greater than that of RS cells (Fig. 2c). Nevertheless, the functional inhibition produced in RS cells is likely to be stronger because the resting input conductances of FS cells are fiv ...
Kang, J., A. Volkmann, and D.H. Raulet. 2001. Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. J Exp Med 193:689-698.
... described (4). PCRs of serially diluted (three- or fourfold) cDNA and genomic DNA samples were performed using published primers (4, 21) in the presence of 1.0 Ci of [␣-32P]dCTP. All PCRs entailed 28 cycles except those for TCR-␥ or -␦ gene rearrangements/transcripts, which entailed 35–38 cycles. T ...
... described (4). PCRs of serially diluted (three- or fourfold) cDNA and genomic DNA samples were performed using published primers (4, 21) in the presence of 1.0 Ci of [␣-32P]dCTP. All PCRs entailed 28 cycles except those for TCR-␥ or -␦ gene rearrangements/transcripts, which entailed 35–38 cycles. T ...
Transcription factor AP-2 is tissue-specific in
... The AP-2 consensus binding sequence matches the central core of the KTF-1 binding site (CCCTGAGG) at 7 out of 9 positions. AP-2 sites are found in the promoters of a number of viral and cellular genes and, in many cases, these sites are important in regulating transcription. There is evidence suppor ...
... The AP-2 consensus binding sequence matches the central core of the KTF-1 binding site (CCCTGAGG) at 7 out of 9 positions. AP-2 sites are found in the promoters of a number of viral and cellular genes and, in many cases, these sites are important in regulating transcription. There is evidence suppor ...
Full PDF - Cancer Research
... mice (Fig. 1D), indicating the obligate contribution of T cells and TRIF-dependent signals to the therapeutic effect. Altogether, 11% of WT mice were completely protected from melanoma by the sequential therapeutic regimen (Fig. 1C), and 67% among the tumor-free mice developed long-term protective i ...
... mice (Fig. 1D), indicating the obligate contribution of T cells and TRIF-dependent signals to the therapeutic effect. Altogether, 11% of WT mice were completely protected from melanoma by the sequential therapeutic regimen (Fig. 1C), and 67% among the tumor-free mice developed long-term protective i ...
MB-JASS 2007 – Session III – Properties of Channels Formed by
... This result is consistent with the single channel conductance data where anions had a somewhat stronger influence on the single channel conductance of Vip1Ac as compared to cations (Leuber et al, 2006). Analysis of the zero-current membrane potentials using the Goldman-Hodgkin-Katz equation showed t ...
... This result is consistent with the single channel conductance data where anions had a somewhat stronger influence on the single channel conductance of Vip1Ac as compared to cations (Leuber et al, 2006). Analysis of the zero-current membrane potentials using the Goldman-Hodgkin-Katz equation showed t ...
Poor Devils: The Plight of the Tasmanian Devils
... cell and a skin cancer cell)? What is similar and different about the cancer cells in each case? What is evolution by natural selection? What are the necessary steps required for this to occur? How is cancer an echo of evolution by natural selection? How can infectious agents cause cancer? (Note: yo ...
... cell and a skin cancer cell)? What is similar and different about the cancer cells in each case? What is evolution by natural selection? What are the necessary steps required for this to occur? How is cancer an echo of evolution by natural selection? How can infectious agents cause cancer? (Note: yo ...
Nucleotide sequences and further characterization of human
... CaSki cellular DNA using primer combinations based on previously determined restriction maps. These amplicons were directly sequenced, and the proposed junctional nucleotides confirmed in the respective clones by manual sequencing. The putative left noncontiguous viral junction of clone p895 (Baker ...
... CaSki cellular DNA using primer combinations based on previously determined restriction maps. These amplicons were directly sequenced, and the proposed junctional nucleotides confirmed in the respective clones by manual sequencing. The putative left noncontiguous viral junction of clone p895 (Baker ...
The epidermal intermediate filament proteins of
... The cDNA sequence of S. clava B protein (Fig. 1; accession number AJ271144) predicts a protein of molecular weight 51 923 with an isoelectric point of 5.02, which extends at the Nterminal side the sequence previously given for the S. plicata protein (Riemer and Weber, 1998). Reinvestigating the cDNA ...
... The cDNA sequence of S. clava B protein (Fig. 1; accession number AJ271144) predicts a protein of molecular weight 51 923 with an isoelectric point of 5.02, which extends at the Nterminal side the sequence previously given for the S. plicata protein (Riemer and Weber, 1998). Reinvestigating the cDNA ...
Active Stable Maintenance Functions in Low Copy
... The ε and ζ genes can also be expressed from the weak Pε promoter which is not subject to Omega regulation (Sitkiewicz, PhD Thesis, 2002). The activity of the Pε promoter may explain the observation that only after more than 90 generations of growth, the absence of ω gene provokes a decrease of ε-ζ ...
... The ε and ζ genes can also be expressed from the weak Pε promoter which is not subject to Omega regulation (Sitkiewicz, PhD Thesis, 2002). The activity of the Pε promoter may explain the observation that only after more than 90 generations of growth, the absence of ω gene provokes a decrease of ε-ζ ...
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... spectra that were identical with those of M. The identity was further confirmed by 1H NMR spectra. It remains open at this stage of analysis whether M is an artefact or a bona fide natural product. 2.3. Accumulation in infected tissue The majority of compounds 1–11 increased more or less strongly duri ...
... spectra that were identical with those of M. The identity was further confirmed by 1H NMR spectra. It remains open at this stage of analysis whether M is an artefact or a bona fide natural product. 2.3. Accumulation in infected tissue The majority of compounds 1–11 increased more or less strongly duri ...
An in silico analysis of the mitochondrial protein import apparatus of
... In plants, the presence of plastids in cells also adds to the complexity of protein sorting required to avoid mis-targeting of proteins to organelles. Plastidic and mitochondrial targeting signals, referred to as transit peptides and presequences respectively, are typically located at the N-terminal ...
... In plants, the presence of plastids in cells also adds to the complexity of protein sorting required to avoid mis-targeting of proteins to organelles. Plastidic and mitochondrial targeting signals, referred to as transit peptides and presequences respectively, are typically located at the N-terminal ...
Recovery response of dividing cells in the thymus of
... ]ackson and and Christensen 1,972). It was concluded that the mechanism responsiblefor thymus cell-death is radiation-induced interphase death followed by cell lysis (Jackson, Christensen and Forkey 1968, Okada t970). More recently, from dose-fractionation studies, it was suggestedthat the mitotical ...
... ]ackson and and Christensen 1,972). It was concluded that the mechanism responsiblefor thymus cell-death is radiation-induced interphase death followed by cell lysis (Jackson, Christensen and Forkey 1968, Okada t970). More recently, from dose-fractionation studies, it was suggestedthat the mitotical ...