Regulation of the endothelial cell cycle by the ubiquitin
... from E2 to the target protein. Substrates can be modified with a single Ub or with Ub chains, but only poly-ubiquitination addresses proteins for degradation by the 26S-proteasome. In fact, monoubiquitination rather modulates growth factor endocytosis, PCNA activity during DNA-repair, and is involve ...
... from E2 to the target protein. Substrates can be modified with a single Ub or with Ub chains, but only poly-ubiquitination addresses proteins for degradation by the 26S-proteasome. In fact, monoubiquitination rather modulates growth factor endocytosis, PCNA activity during DNA-repair, and is involve ...
REVIEW CELL DIVISION FROM A GENETIC PERSPECTIVE
... D N A replication upon a shift to the restrictive temperature; both mutants have execution points near the end of the D N A synthetic period (20, 26). The coincident occurrence of execution point and diagnostic landmark, found for these and many other mutants of S. cerevisiae (23), also obtains for ...
... D N A replication upon a shift to the restrictive temperature; both mutants have execution points near the end of the D N A synthetic period (20, 26). The coincident occurrence of execution point and diagnostic landmark, found for these and many other mutants of S. cerevisiae (23), also obtains for ...
- blogs@NTU
... plants confirmed the localization of VPS45 (Supplementary information, Figure S3A-S3C) and corroborate with previous reports describing a SYP41/SYP61/VTI12 SNARE complex [16, 19, 29]. Other SYP4 members such as SYP43 were also found in the SYP61 vesicle proteome, establishing new protein association ...
... plants confirmed the localization of VPS45 (Supplementary information, Figure S3A-S3C) and corroborate with previous reports describing a SYP41/SYP61/VTI12 SNARE complex [16, 19, 29]. Other SYP4 members such as SYP43 were also found in the SYP61 vesicle proteome, establishing new protein association ...
ERK Nuclear Translocation Is Dimerization
... The precise mechanism of ERK transport across the nuclear pore is not fully understood. ERK lacks a nuclear localization sequence, leading to the suggestion that ERK may enter by a piggyback mechanism via binding to nuclear localization sequence-containing proteins (5). Nuclear localization sequence ...
... The precise mechanism of ERK transport across the nuclear pore is not fully understood. ERK lacks a nuclear localization sequence, leading to the suggestion that ERK may enter by a piggyback mechanism via binding to nuclear localization sequence-containing proteins (5). Nuclear localization sequence ...
The Role of Endocytosis in the Creation of the Cortical Division Zone
... the cytoplasm underlying PPBs, the non-coated, darkly stained vesicles were found to be further away from the plasma membrane (74.4 ± 2.6 nm, mean ± SEM, n=168) than the clathrin-coated vesicles (52.8 ± 6.4 nm, mean ± SEM, n=29). This supports the idea that the non-coated, darkly stained vesicles we ...
... the cytoplasm underlying PPBs, the non-coated, darkly stained vesicles were found to be further away from the plasma membrane (74.4 ± 2.6 nm, mean ± SEM, n=168) than the clathrin-coated vesicles (52.8 ± 6.4 nm, mean ± SEM, n=29). This supports the idea that the non-coated, darkly stained vesicles we ...
review cell division from a genetic perspective
... D N A replication upon a shift to the restrictive temperature; both mutants have execution points near the end of the D N A synthetic period (20, 26). The coincident occurrence of execution point and diagnostic landmark, found for these and many other mutants of S. cerevisiae (23), also obtains for ...
... D N A replication upon a shift to the restrictive temperature; both mutants have execution points near the end of the D N A synthetic period (20, 26). The coincident occurrence of execution point and diagnostic landmark, found for these and many other mutants of S. cerevisiae (23), also obtains for ...
THE NEUROLOGIC EXAMINATION Ralph F
... pontine nuclei are intermingled with the pyramidal tract. Among the tracts, the medial longitudinal fasciculus, which serves as the “highway” connecting brainstem nuclei, is prominent3. Fibers exiting the cerebellum via the superior cerebellar peduncle are also seen. The medial lemniscus has a more ...
... pontine nuclei are intermingled with the pyramidal tract. Among the tracts, the medial longitudinal fasciculus, which serves as the “highway” connecting brainstem nuclei, is prominent3. Fibers exiting the cerebellum via the superior cerebellar peduncle are also seen. The medial lemniscus has a more ...
The World of Cells Kinds of Cells Tour of a Eukaryotic Cell Transport
... ones, are not powerful enough to resolve many structures within cells. For example, a membrane is only 5 nanometers thick. Why not just add another magnifying stage to the microscope and so increase its resolving power? Because when two objects are closer than a few hundred nanometers, the light bea ...
... ones, are not powerful enough to resolve many structures within cells. For example, a membrane is only 5 nanometers thick. Why not just add another magnifying stage to the microscope and so increase its resolving power? Because when two objects are closer than a few hundred nanometers, the light bea ...
Genetic Analysis of the Yeast Cytoskeleton.
... The cytoskeleton has been genetically analyzed, to different degrees, in various mammaliancells (20) and organisms including Drosophila rnelanogaster (28a, 41, 64, 65), Caenorhabditis elegans (7, 26, 45), Chlamydomohas reinhardtii (4, 47), Aspergillus nidulans (53), Physarumpolycephalurn (67, 72), a ...
... The cytoskeleton has been genetically analyzed, to different degrees, in various mammaliancells (20) and organisms including Drosophila rnelanogaster (28a, 41, 64, 65), Caenorhabditis elegans (7, 26, 45), Chlamydomohas reinhardtii (4, 47), Aspergillus nidulans (53), Physarumpolycephalurn (67, 72), a ...
ch4 Jeopardy-11 - Room 189`s Wiki at PACS
... a. They have an extensive cytoskeleton. b. They have no lysosomes. c. They are composed of inclusions of many different substances used for energy. d. They use vacuoles for buoyancy. ANSWER BACK TO GAME ...
... a. They have an extensive cytoskeleton. b. They have no lysosomes. c. They are composed of inclusions of many different substances used for energy. d. They use vacuoles for buoyancy. ANSWER BACK TO GAME ...
The fission yeast cdc19+ gene encodes a member of the MCM
... been identified biochemically by its weak association with the DNA polymerase alpha complex (Thömmes et al., 1992). Other related sequences in metazoan systems have been identified by genome sequencing, by PCR or by screens for conserved epitopes (Hu et al., 1993; Todorov et al., 1994). We are inter ...
... been identified biochemically by its weak association with the DNA polymerase alpha complex (Thömmes et al., 1992). Other related sequences in metazoan systems have been identified by genome sequencing, by PCR or by screens for conserved epitopes (Hu et al., 1993; Todorov et al., 1994). We are inter ...
Identification of Target Messenger RNA Substrates for the Murine
... identify mRNAs from mouse testis extract that were specifically bound by an mDAZL protein fused to the GST domain (GST-mDAZL). The immobilized GST-mDAZL fusion protein was incubated with testis total extract, and mRNP complexes bound by GST-mDAZL were extracted. Testis total extract, which contains ...
... identify mRNAs from mouse testis extract that were specifically bound by an mDAZL protein fused to the GST domain (GST-mDAZL). The immobilized GST-mDAZL fusion protein was incubated with testis total extract, and mRNP complexes bound by GST-mDAZL were extracted. Testis total extract, which contains ...
review cell division from a genetic perspective
... Execution points of mutants can be informative in yet another way. When one examines several alleles of the same gene, one frequently finds that mutants fall into two classes: those having alleles ...
... Execution points of mutants can be informative in yet another way. When one examines several alleles of the same gene, one frequently finds that mutants fall into two classes: those having alleles ...
Fulltext PDF - Indian Academy of Sciences
... Characterization of the ppGpp0 strain showed it to filament upon nutritional down shift, suggesting a role for (p)ppGpp in the process of cell division (Xiao et al. 1991). Insights of its role in cell division came from the studies carried out in the D’Ari lab to understand the function of PBP2 (pen ...
... Characterization of the ppGpp0 strain showed it to filament upon nutritional down shift, suggesting a role for (p)ppGpp in the process of cell division (Xiao et al. 1991). Insights of its role in cell division came from the studies carried out in the D’Ari lab to understand the function of PBP2 (pen ...
1-1 Test Bank Huether: Understanding Pathophysiology, 4th Edition
... 3. A eukaryotic cell is undergoing DNA replication. In which region of the cell would most of the genetic information be contained? A. Mitochondria B. Ribosome C. Nucleolus D. Nucleus ANS: C ...
... 3. A eukaryotic cell is undergoing DNA replication. In which region of the cell would most of the genetic information be contained? A. Mitochondria B. Ribosome C. Nucleolus D. Nucleus ANS: C ...
cell cycle
... In unicellular organisms, division of one cell reproduces the entire organism Cell division enables multicellular eukaryotes to develop from a single cell and, once fully grown, to renew, repair, or replace cells as needed Cell division is an integral part of the cell cycle, the life of a cel ...
... In unicellular organisms, division of one cell reproduces the entire organism Cell division enables multicellular eukaryotes to develop from a single cell and, once fully grown, to renew, repair, or replace cells as needed Cell division is an integral part of the cell cycle, the life of a cel ...
RiceRBP: a resource for experimentally identified RNA
... 2009; Wienkoop et al., 2010; Agrawal and Rakwal, 2011). They have also been used to explore protein interactions with other proteins, complexes and particular affinity matrices, which is ultimately important for understanding systems biology (Baginsky, 2009). The use of affinity purification techniques ...
... 2009; Wienkoop et al., 2010; Agrawal and Rakwal, 2011). They have also been used to explore protein interactions with other proteins, complexes and particular affinity matrices, which is ultimately important for understanding systems biology (Baginsky, 2009). The use of affinity purification techniques ...
Cell A.
... and DAG from the cell membrane. IP3 then binds to a ligand-gated ion channel on the ER causing the release of calcium ions, which bind to calmodulin & causes the cytoskeleton to change shape. 8.The binding of a sperm to an egg initiates a G protein pathway that releases IP3 & DAG. This releases Ca2+ ...
... and DAG from the cell membrane. IP3 then binds to a ligand-gated ion channel on the ER causing the release of calcium ions, which bind to calmodulin & causes the cytoskeleton to change shape. 8.The binding of a sperm to an egg initiates a G protein pathway that releases IP3 & DAG. This releases Ca2+ ...
Identification of novel nucleus pulposus markers
... Analysing the NP phenotype: gene expression profiling In molecular biology, gene expression profiling is the measurement of the activity of genes being expressed by a given cell in a specific moment. Extensive characterisation of these genes is permitted by the use of powerful technologies, such as ...
... Analysing the NP phenotype: gene expression profiling In molecular biology, gene expression profiling is the measurement of the activity of genes being expressed by a given cell in a specific moment. Extensive characterisation of these genes is permitted by the use of powerful technologies, such as ...
Regulatory Roles for Long ncRNA and mRNA
... synthesized by the same RNA polymerase II transcriptional machinery, 5' capped and are often spliced with similar exon/intron lengths [23,24]. Moreover, most long non-coding transcripts are polyadenylated [25–27]. Alternatively, some lncRNAs are generated via alternative pathways, and are for exampl ...
... synthesized by the same RNA polymerase II transcriptional machinery, 5' capped and are often spliced with similar exon/intron lengths [23,24]. Moreover, most long non-coding transcripts are polyadenylated [25–27]. Alternatively, some lncRNAs are generated via alternative pathways, and are for exampl ...
MB207_10 - MB207Jan2010
... Hydrophobic regions are embedded within the membrane interior in a way that makes these molecules difficult to remove from membrane. Hydrophilic regions that extend outward from the membrane into an aqueous phase on one or both sides of the membrane. Protruding from one side of the bilayer: integral ...
... Hydrophobic regions are embedded within the membrane interior in a way that makes these molecules difficult to remove from membrane. Hydrophilic regions that extend outward from the membrane into an aqueous phase on one or both sides of the membrane. Protruding from one side of the bilayer: integral ...
pensum for kjb 491-1997
... Mechanisms of autophagosome biogenesis (Rubinsztein, D.C., Shpilka, T., and Elazar, Z. Current Biology 22 (2012) R29-R34 (5 pages)). Endosomal coat proteins and sorting Structures and mechanisms of vesicle coat components and multisubunit tethering complexes (Jackson, L.P., Kümmel, D., Reinisch, K. ...
... Mechanisms of autophagosome biogenesis (Rubinsztein, D.C., Shpilka, T., and Elazar, Z. Current Biology 22 (2012) R29-R34 (5 pages)). Endosomal coat proteins and sorting Structures and mechanisms of vesicle coat components and multisubunit tethering complexes (Jackson, L.P., Kümmel, D., Reinisch, K. ...
Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel) is a membrane-enclosed organelle found in eukaryotic cells. Eukaryotes usually have a single nucleus, but a few cell types have no nuclei, and a few others have many.Cell nuclei contain most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these chromosomes are the cell's nuclear genome. The function of the nucleus is to maintain the integrity of these genes and to control the activities of the cell by regulating gene expression—the nucleus is, therefore, the control center of the cell. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm, and the nucleoskeleton (which includes nuclear lamina), a network within the nucleus that adds mechanical support, much like the cytoskeleton, which supports the cell as a whole.Because the nuclear membrane is impermeable to large molecules, nuclear pores are required that regulate nuclear transport of molecules across the envelope. The pores cross both nuclear membranes, providing a channel through which larger molecules must be actively transported by carrier proteins while allowing free movement of small molecules and ions. Movement of large molecules such as proteins and RNA through the pores is required for both gene expression and the maintenance of chromosomes. The interior of the nucleus does not contain any membrane-bound sub compartments, its contents are not uniform, and a number of sub-nuclear bodies exist, made up of unique proteins, RNA molecules, and particular parts of the chromosomes. The best-known of these is the nucleolus, which is mainly involved in the assembly of ribosomes. After being produced in the nucleolus, ribosomes are exported to the cytoplasm where they translate mRNA.