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Effects of melatonin on the nitric oxide treated retina
Effects of melatonin on the nitric oxide treated retina

... consistent with earlier data reported on the protection of melatonin in acute inflammation.22 This protective effect was not apparent in the present study, however, after 4 days. It is likely that ONOO2 might have induced a self propagating chain reaction of oxidative damage in the retina. The secon ...
Identification of an H Antigen-like Blood Group
Identification of an H Antigen-like Blood Group

... Sera from patients or normal individuals were diluted adequately with PBS containing 0.1% BSA and 0.01% normal mouse serum and placed in the wells of microplates coated with MAb C12 or UEA. The plates were incubated for 16 h at 4°Cand washed twice with PBS. Fifty ti\ of [I2!I]UEA or [125I]MAb C12 ( ...
Management_of_sickle_cell_disease
Management_of_sickle_cell_disease

... Pain control often requires large quantities of opiod analgesics. The exact amount varies, and depends in part on the frequency with which the person requires opiods. For many patients, 4 to 8 mg of hydromorphone can be given as an intravenous bolus over 15 to 20 minutes followed by another 4 mg in ...
Arthropods
Arthropods

... • Aquatic arthropods have gills used for respiration • Terrestrial arthropods have tracheae, which are chitin lined tubes that lead from the internal organs to the outside of the body where they end in little holes called spiracles that are used for breathing ...
Exploiting the chick embryonic environment to reprogram
Exploiting the chick embryonic environment to reprogram

... advice, I couldn’t have asked for a better supervisor. And of course I can’t express enough gratitude for The Neuroblastoma Society, who funded this project. They are an amazing charity run by volunteers, whose trustees and members are all so friendly and enthusiastic about the work. Thanks also to ...
Micronuclei Bearing Acentric Extrachromosomal Chromatin Are
Micronuclei Bearing Acentric Extrachromosomal Chromatin Are

... papilloma virus (19), Epstein-Barr virus (20), Kaposi’s sarcoma – associated herpes virus (21), and SV40 (22), also segregate into daughter cells by tethering to the mitotic chromosomes. Thus, the intracellular behavior of DMs and the process by which they are extracellularly eliminated may be commo ...
Intercostal Artery Laceration Following
Intercostal Artery Laceration Following

... post-thoracentesis monitoring, did not avoid intercostal artery laceration in our patient, but the close monitoring did allow for early diagnosis and treatment. The possibility that catheter diameter and distortion of our patient’s intercostal anatomy may have caused the intercostal artery laceratio ...
IRK-1 Potassium Channels Mediate Peptidergic Inhibition
IRK-1 Potassium Channels Mediate Peptidergic Inhibition

... G-protein signaling. Vulval muscles express two Gq-coupled serotonin receptors that promote muscle contraction: SER-1 and SER-7 (Carnell et al., 2005; Hobson et al., 2006). Egg-laying behavior is inhibited by Go signaling in the HSNs (Mendel et al., 1995; Ségalat et al., 1995; Tanis et al., 2008). ...
Up-regulation of junctophilin-2 prevents ER stress and apoptosis in
Up-regulation of junctophilin-2 prevents ER stress and apoptosis in

... phospholipase and consequently accelerates the degradation of membrane phospholipids [10]. As a result, plasma and organelle membranes are dysfunctional. Once the cells lose the permeability barrier, the cellular damage becomes irreversible, and necrosis ensues [11]. Accordingly, the crucial step to ...
Introduction
Introduction

... 4. Wherever “observe” comes, carry out the observation and fill up the observations in the space provided for observations and documentation or in your notebook. The sequence of different observations is indicated by numbers 1,2,3 etc. Record observations in the correct sequence. Try noting down the ...
PDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen

... generated upon microbial invasion itself, but when detectable harm is done to the body. The ligands involved in danger-associated PRR-stimulation, the so-called dangerassociated molecular patterns (DAMPs), are generated or released upon tissue or cell damage. DAMPs are proteins/products that are usu ...
biofilms as complex differentiated communities
biofilms as complex differentiated communities

... shear stresses were more rigid and stronger than those biofilms grown at lower shear. It is yet unclear if the increased density and strength of biofilms exposed to higher shear stresses are regulated at the genetic level, occur through selection processes (i.e., only those cells that produce strong ...
MAC Multi-Lumen Central Venous Access
MAC Multi-Lumen Central Venous Access

... and chlorhexidine that would be found would be less than the blood levels found after clinical usage of these compounds in established safe dosages as administered via mucous membranes and skin.11 The potential exposure of patients to the two agents, silver sulfadiazine and chlorhexidine, on the ant ...
Protozoa - Dr Magrann
Protozoa - Dr Magrann

... Most are heterotrophic feeding on other protists, small metazoans, fungi, bacteria and detritus. Manys spp. Found in fossil record. Some up to 15 cm ...
Comparative microanatomy and ultrastructure of the excretory
Comparative microanatomy and ultrastructure of the excretory

Endoplasmic reticulum potassium–hydrogen exchanger and small
Endoplasmic reticulum potassium–hydrogen exchanger and small

... Calcium pumping into the endoplasmic reticulum (ER) lumen is thought to be coupled to a countertransport of protons through sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) and the members of the ClC family of chloride channels. However, pH in the ER lumen remains neutral, which suggests a ...
Intermediate Filaments Regulate Tissue Size and Stiffness in the
Intermediate Filaments Regulate Tissue Size and Stiffness in the

... elastically recover its starting shape within very narrow tolerances. The lens has many unusual properties that enable it to adapt to its unique function. To minimize light absorbance and scatter, the lens lacks blood vessels, nerves, and connective tissue and consists of a single cell type that ran ...
Structural types
Structural types

... Shape- The body is elongate and cyclindrical with eel-like appearance. The head and trun kare cylindrical but the tail is laterally compressed. Colour- The dorsal surface of the body is greenish brown to bluish but the ventral and lateral sides are white or silvery. External structure- The slimy, ee ...
6.3. La supervivencia de las motoneuronas espinales de pollo mantenidas
6.3. La supervivencia de las motoneuronas espinales de pollo mantenidas

... The members of the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors (GDNF, neurturin, persephin, and artemin) are able to promote in vivo and in vitro survival of different neuronal populations, including spinal cord motoneurons. These factors signal via multicompone ...
Dazl regulates mouse embryonic germ cell development
Dazl regulates mouse embryonic germ cell development

... suggest a link between Dazl and DNA methylation many years ago. All of the members of the Page lab during the last seven years have provided me with a great deal of help and needed criticism, and it is fair to say that this work would not have been possible without their help. My time in graduate sc ...
Mechanisms, Measurement, and Significance of Lung Macrophage
Mechanisms, Measurement, and Significance of Lung Macrophage

... macrophages besides alveolar macrophages. Macrophages exist in small and large airways above and below the mucus. They may release chemotactic factors and a variety of mediatos They ingest and degrade antigens and are microbicidal. Interstitial macrophages are in direct contact with the extracellula ...
The carbohydrates ofPhaeocystisand their degradation in the
The carbohydrates ofPhaeocystisand their degradation in the

... this organic matter is potentially readily degradable by heterotrophic bacteria. However, observations in the field of accumulation of DOM and foam indicate that microbial degradation is hampered. The high C/N and C/P ratios of Phaeocystis organic matter may lead to nutrient limitation of microbial ...
Circulation and Gas Exchange PowerPoint
Circulation and Gas Exchange PowerPoint

... • Cells live in aqueous environments. • The resources that they need, such as nutrients and oxygen, move across the plasma membrane to the cytoplasm. • Metabolic wastes, such as carbon dioxide, move out of the cell. ...
Bronchoalveolar lavage in children ERS TASK FORCE
Bronchoalveolar lavage in children ERS TASK FORCE

... (FRC) with 5±20 mL fractions depending on the patient's size [18]. Others [19] adjust BAL volume to body weight using 3 mL.kg-1 of normal saline divided into three equal fractions in children weighing <20 kg and 3 mL.kg-1 in 20 mL portions in children weighing >20 kg [20]. If the amount of instilled ...
423 Resources - simonbaruchcurriculum
423 Resources - simonbaruchcurriculum

... Click on this icon to return to the table of contents Click on this icon to return to the previous slide Click on this icon to move to the next slide Click on this icon to open the resources file. Click on this icon to go to the end of the presentation. To return to the chapter summary click Escape ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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