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D:\ACTA\3-2003\jozwiak 732.vp
D:\ACTA\3-2003\jozwiak 732.vp

... ratio is considered as an early indicator of oxidative stress. Although considerable progress has been made, the precise role of the GSH-dependent antioxidant system in protection of cells from drug-induced oxidative damage is still poorly understood. The aim of this study was to obtain further insi ...
Efficient planar heterojunction perovskite solar cells by vapour
Efficient planar heterojunction perovskite solar cells by vapour

... entirely compatible with conventional processing methods for siliconwafer-based and thin-film solar cells, the infrastructure could already be in place to scale up this technology. We have built vapour-deposited organometal trihalide perovskite solar cells based on a planar heterojunction thin-film ...
NETosis: how vital is it?
NETosis: how vital is it?

... (ERK) pathway. NADPH assists in the translocation of neutrophil elastase from cytosolic granules into the nucleus where it aids in chromatin breakdown via histone cleavage. MPO is required for chromatin and nuclear envelope breakdown and granular mixing within the NET vacuole. Following 120 minutes ...
Protection of Retinal Ganglion Cells from Natural and Axotomy
Protection of Retinal Ganglion Cells from Natural and Axotomy

... elongation of the primers was catalyzed by Taq DNA polymerase (Promega). Human bcl-2 gene was detected by a series of 40 amplification cycles using a Perkin/Elmer apparatus. ...
Acid-Base Balance - Dr. Salah A. Martin
Acid-Base Balance - Dr. Salah A. Martin

... and protein metabolism • Plays an essential role in neurotransmission, cardiac function, and neuromuscular activity • There is a renal transport maximum for magnesium • Control mechanisms are poorly understood ...
Degenerins - Tavernarakis Lab
Degenerins - Tavernarakis Lab

... One considerable advantage of the C. elegans system is that it is the first metazoan for which the genome was sequenced to completion.16 Investigators can take advantage of genome data to perform “reverse genetics,” directly knocking out genes. In addition, a novel method of generating mutant phenoc ...
Blm10 binds to preactivated proteasome core particles with open
Blm10 binds to preactivated proteasome core particles with open

... Fig 1 | Pre-activated core particles are stabilized by Blm10 in ump1D cells. (A) Affinity-purified wild-type proteasomes (Lehmann et al, 2002) contain Blm10 and Ecm29, as identified by finger print mass spectroscopy; RP and CP subunits are embraced. (B–E) GFP-labelled CPs of isogenic wild-type (wt; ...
The functions of cell wall polysaccharides in composition and
The functions of cell wall polysaccharides in composition and

... Mutants with altered cellulose deposition have been identified directly by loss of birefringence, for example in trichomes (Potikha and Delmer, 1995). Other cell-wall mutations have appeared serendipitously in the course of screens for developmental phenotypes, such as a temperature-sensitive radial ...
Peripheral Vascular Disease - Calgary Emergency Medicine
Peripheral Vascular Disease - Calgary Emergency Medicine

... • bacterial endocarditis can produce septic infartcts can may evolve into abcesses ...
Humoral Immunology
Humoral Immunology

... virus particle may be assembled from several distinct proteins, each of which has its set of oliogopeptide antigens. Imagine, therefore, that a virus is covered with a number of distinct antigenic determinants, A, B, C, D, etc. Each of these determinants is composed of a distinct oligopeptide seque ...
analysis of the significance of a periodic, cell size
analysis of the significance of a periodic, cell size

... haploid and diploid series oiS.pombe, we have calculated mean relative poly(A)+mRNA contents for the small mutant cells of each series as a fraction of wild type. Table 2 (p. 43) shows that these calculated values are in good agreement with the values determined experimentally in asynchronous, expon ...
Body Systems
Body Systems

... frequently involves an allergic response by the lungs. If the lungs are oversensitive to certain allergens (like pollen, molds, animal dander, or dust mites), it can trigger breathing tubes in the lungs to become narrowed, leading to reduced airflow and making it hard for a person to breathe. • Ecze ...
Chapter 25 Student Notes
Chapter 25 Student Notes

... Overview: The key functions of the excretory system are filtration, reabsorption, secretion, and excretion • There are four steps (processes, parts) involved in urine production: • _____________ : happens in the Bowman’s capsule, high pressure _____________ (water) and _____________ from the blood ...
Cell Structure And Function In The Bacteria And Archaea 4
Cell Structure And Function In The Bacteria And Archaea 4

... of organisms. Thanks to the pioneering studies of Carl Woese and his colleagues, it now is quite evident there are two distinctly different groups of “prokaryotes”—the Bacteria and the Archaea (see Chapter 3). Many of the organisms Woese and others studied are organisms that would live a happy life ...
DEPARTEMENT DES RELATIONS EXTERIEURES Communication
DEPARTEMENT DES RELATIONS EXTERIEURES Communication

... heart morphogenesis. The heart is a complex organ that contains four different chambers and different cell types. It is the first organ formed during embryogenesis. During development, it is crucial that a precise number of cardiac progenitors are specified at the correct time, migrate at the correc ...
Game Board - nemsjamma
Game Board - nemsjamma

... BACK TO THE BOARD ...
Akt blocks ligand binding and protects against expanded
Akt blocks ligand binding and protects against expanded

... populations of neurons are affected, despite the widespread distribution of the polyglutamine proteins throughout the central nervous system, implying that not only the mutation, but also the flanking sequences are important for pathogenesis. Expansion of the polyglutamine tract in the androgen rece ...
Nonlysosomal Vesicles (Acidosomes) Are Involved
Nonlysosomal Vesicles (Acidosomes) Are Involved

... To test the effects of cytochalasin B (CB) on vacuole acidification, we first placed a population of cells in medium containing heat-killed, bromcresol green-stained yeast for 15 s before the addition of cytochalasin B (CB) (at 143 #g/ml in a final concentration of 0.4% dimethylsulfoxide [DMSO], vo ...
Comparative analysis of amphibian somite
Comparative analysis of amphibian somite

... Hensen's node) has been examined in stereo with the scanning electron microscope (SEM). Meier (1979) has found that this region is organized into tandemly aligned, repeating circular domains (about 180/tm in diameter). As these structures ('somitomeres') are added to the embryonic axis during neurul ...
SHORT COMMUNICATION Bacterial chemotaxis towards the
SHORT COMMUNICATION Bacterial chemotaxis towards the

... links between members of the Roseobacter clade and H. akashiwo have previously been reported, the potential implications of the chemotactic attraction observed here remain open to further investigation. The variability in the strength of chemotactic response exhibited between bacterial strains teste ...
PDF - Eleanor Maine Research Lab
PDF - Eleanor Maine Research Lab

... Stem cells achieve self-renewal through both the execution of mitotic cell division and maintenance of stem cell fate. Different stem cell types display distinct patterns of self-renewal and differentiation. For example, hematopoetic stem cells divide infrequently compared with ES cells (Orford and ...
POP-1 and Anterior–Posterior Fate Decisions in
POP-1 and Anterior–Posterior Fate Decisions in

... for MS is killed (Mello et al., 1992). Thus, in some lineages, cell fates do not appear to be determined by external, environmental cues within the embryo. Despite the different molecular mechanisms that establish blastomere identities and the very different lineages that blastomeres execute, there ...
4SC08: Organ Systems
4SC08: Organ Systems

... microorganisms out is your skin. Your body has its own defense system too, known as your immune system. Your immune system is made up of special cells, proteins, tissues, and organs that defend your body against germs. You may remember going to the doctor and getting a shot! That may hurt a bit, but ...
hTERT Inhibition Triggers Epstein–Barr Virus Lytic Cycle and
hTERT Inhibition Triggers Epstein–Barr Virus Lytic Cycle and

... and several histone deacetylase inhibitors (9–12). EBVcarrying tumor cells may also be killed by prodrugs, such as ganciclovir or radiolabeled nucleoside analogs, which are activated by EBV lytic proteins, such as the viral thymidine kinase (9, 13, 14). Notably, combined treatment with arginine buty ...
PDF (SLMChapter1)
PDF (SLMChapter1)

... The Xenopus oocyte expression required the engineering of a new amber suppressor tRNA because Schultz's yeast amber suppressor was not orthogonal to this system. The first amber suppressor designed, MN3, was a modified version of the yeast tRNAPhe(CUA) [24]. There was poor orthogonality to this expr ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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