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A Role for Unsaturated Fatty Acids in Mitochondrial Movement and
A Role for Unsaturated Fatty Acids in Mitochondrial Movement and

... component ofcell division is the distribution of cytoplasmic organelles to daughter cells. This A IL intracellular distribution process ensures a continuance of the cytoplasmic organellar population, since mitochondria and other subcellular structures proliferate by the growth and division of pre-ex ...
Plant synapses: actin-based domains for cell-to
Plant synapses: actin-based domains for cell-to

... membrane [16,33]. All this suggests that auxin is not transported directly across the plasma membrane but rather exported from cells via vesicular pathways (Figure 1b), as proposed by several authors [17,34,36]. In this scenario, the auxin efflux carrier PIN1 loads cytoplasmic auxin into endosomes a ...
Needle free injection technology - An overview
Needle free injection technology - An overview

... the nozzle at high velocity (velocity > 100m/s) • The effect of the jet on the skin surface starts the formation of a hole in the skin through erosion, fracture, or other skin failure mechanisms. • Further impingement of the jet increases the depth of the hole in the skin. If the volumetric rate of ...
Nup358 interacts with APC and plays a role in cell polarization
Nup358 interacts with APC and plays a role in cell polarization

... wound-healing assay we demonstrate that Nup358 functions in polarized cell migration. These results reveal a more active role for structural nucleoporins in regulating fundamental cellular processes than previously anticipated. Supplementary material available online at http://jcs.biologists.org/cgi ...
Comparison of Autotransporter and Ice Nucleation Protein as Carrier
Comparison of Autotransporter and Ice Nucleation Protein as Carrier

... many applications such as clinical diagnosis and therapeutics [1], which require antibodies with high antigen affinity and specificity [2]. To achieve this purpose, researchers invented many techniques to display engineered antibody fragments or full IgG on the surface of phage[3], yeast[4] or bacte ...
causal relationship exists between anatomically evident arterial
causal relationship exists between anatomically evident arterial

... • Angiotensin II causes vasoconstriction of both afferent and efferent arterioles, with a preferential affect on the efferent side. Under physiologic conditions, efferent tone is essential to maintain intraglomerular pressure. • In a kidney rendered ischemic by RAS with a reduced afferent blood flow ...
MS Diagnostic Coding
MS Diagnostic Coding

... • The lungs hold about 300-400 million alveoli, each wrapped in capillaries • Total surface area of 83-107 square yards • Function – Gas exchange – external respiration – Oxygen in alveolus passes across the alveolar membrane to enter the bloodstream • 50 of these = thickness of piece of paper ...
Microbial environments confound antibiotic efficacy
Microbial environments confound antibiotic efficacy

... This cell-death pathway also provides insight into how bacteria may evade antibiotics through changes in metabolism. We now have a context for understanding how genetic mutations that seem unrelated to an antibiotic’s primary target protect a microbe against antibiotic attack. For example, genetic m ...
2-3 Blood Clotting
2-3 Blood Clotting

... An anticoagulant is a drug that helps prevent the clotting (coagulation) of blood. These drugs tend to prevent new clots from forming or an existing clot from enlarging. They don't dissolve a blood clot. Anticoagulants are also given to certain people at risk for forming blood clots, such as those w ...
Detecting RNA viruses in living mammalian cells by fluorescence microscopy Author's personal copy
Detecting RNA viruses in living mammalian cells by fluorescence microscopy Author's personal copy

... owing to the ease of standardization and higher sensitivity [6]. However, most of these above mentioned techniques serve primarily as detection tools and provide minimal information on infectivity. In addition, very few insights about the molecular mechanisms involved in viral replication and the pa ...
TGF beta signalling and its role in tumour pathogenesis
TGF beta signalling and its role in tumour pathogenesis

... it to the extracellular matrix. Cellular recognition of extracellular matrix-associated LTBP and subsequent recognition of latent TGF-β are essential steps in its activation (Hyytiainen et al., 2004). The latency proteins also contribute to the cytokine stability. Free TGF-β has a half life of about ...
Force development by the contractile vacuole
Force development by the contractile vacuole

... and the mineral oil, the CV rounded against this force during its rounding phase. It can, therefore, be supposed that the tension at the surface of the CV increases during the rounding phase. We previously proposed a hypothesis (Tominaga et al., 1998a; Tominaga et al., 1999) that an increase in the ...
Pathway in Gliomas Cannabinoids Inhibit the Vascular Endothelial
Pathway in Gliomas Cannabinoids Inhibit the Vascular Endothelial

... glioblastoma multiforme. The patients had failed standard therapy, which included surgery, radiotherapy (60 Gy), and temozolomide chemotherapy (4 cycles). Patients had clear evidence of tumor progression on sequential magnetic resonance scanning before enrollment in the study, had received no antica ...
Document
Document

... Kidney diseases are diseases of the kidney substance that alter the structure and function of the kidney. There are many diseases of the kidneys such as glomerulonephritis, pyelonephritis & polycystic kidney.The treatment and potential for recovery depends on the type of disease. Kidney diseases can ...
Pass the bicarb: the importance of HCO3 – for mucin release
Pass the bicarb: the importance of HCO3 – for mucin release

... colleagues show that mucin — the heavily glycosylated protein contained within mucus — requires CFTR and bicarbonate in order to be released from mouse intestine (see the related article beginning on page 2613). The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurre ...
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

... have viewed the application of long-circulating particles in sustained-release of drugs within vasculature, transfusion medicine (artificial erythrocytes), and targeting. The latter is defined either as passive or active. With regard to passive targeting, this article identifies and discusses the op ...
MAIT Cells Precursor Derivatives Activating Mouse Derived Riboflavin
MAIT Cells Precursor Derivatives Activating Mouse Derived Riboflavin

... are required for Ag recognition by MAIT cells, regardless of Vb2 Jb usage (12). These residues are conserved in mammals (13, 14). Although MAIT cell TCRs use preferential Vb segments, mutagenesis of individual residues within the CDRb regions indicates that the TCRb-chain of the MAIT cell TCRs did n ...
Whole-cell biocatalysts by design - Microbial Cell Factories
Whole-cell biocatalysts by design - Microbial Cell Factories

... cost-competitive with fermentation [12, 15–19]. Efficient whole-cell biocatalysts are very important for an economically feasible biocatalysis process with optimal titre, yield and productivity. The principles for designing whole-cell biocatalysts for bioconversions are quite different from those fo ...
Expression and function of cell adhesion molecules during neural
Expression and function of cell adhesion molecules during neural

... types. NC cell-cell and cell-matrix interactions are an essential part of the migration ...
Carbohydrates and Glycobiology
Carbohydrates and Glycobiology

... photosynthesis converts more than 100 billion metric tons of CO2 and H2O into cellulose and other plant products. Certain carbohydrates (sugar and starch) are a dietary staple in most parts of the world, and the oxidation of carbohydrates is the central energy-yielding pathway in most nonphotosynthe ...
Cell Processes: Nernst Potential
Cell Processes: Nernst Potential

... gates. Once a channel is open, ions are free to move in both directions - but the NET movement of ions will be down a gradient. (More on that later.) 2. By a pump: Membranes also contain tiny ATP-driven protein pumps. When these pumps operate, the energy stored in ATP is used to move ions in ONE dir ...
Human granulocyte-macrophage colony
Human granulocyte-macrophage colony

... short lived and constantly need replacement throughout the lifespan. This process of blood formation is termed as hematopoiesis and is highly complex1 owing to different types of cells that must be produced. Hematopoiesis2 is capable of bringing about rapid adjustments in the number of cell sub-sets ...
Electrocardioqraphic criteria for predicting the site of coronary artery
Electrocardioqraphic criteria for predicting the site of coronary artery

... transfer by pheromone induction[5]. (ii)The transfer of plasmids by transposon mechanism that occurs at low frequency on filter, and many explain the spread of Rgene to many different species . As opposed to ordinary transposons , which can jump within cell from one DNA location to another, conjugat ...
Document
Document

... 51. Explain why the heating of your home is an example of a negative feedback mechanism. Ans: In a home, when the temperature drops below the level set on the thermostat, the thermostat will signal the furnace to switch on. The furnace produces heat that is transported throughout the house and the ...
Annotation Extension (col 16)
Annotation Extension (col 16)

... • For MFs this would be appropriate only where where a catalytic activity can create >1 choice of output • If you find you need to use this for MF either: – bring up your example at annotation call – request a new GO term ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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