Endomembrane proton pumps: connecting membrane and vesicle
... [5]. Vma-mutants fail to grow at neutral pH, but surprisingly the identity of the cellular organelle whose acidification is essential is still not known. The fact that other yeast mutants that have defects in vacuolar acidification are viable at neutral pH argues, however, that it is not the vacuol ...
... [5]. Vma-mutants fail to grow at neutral pH, but surprisingly the identity of the cellular organelle whose acidification is essential is still not known. The fact that other yeast mutants that have defects in vacuolar acidification are viable at neutral pH argues, however, that it is not the vacuol ...
The GARP complex is required for cellular sphingolipid homeostasis
... Figure 1. A chemical biology screen reveals the retrograde endosome to Golgi trafficking machinery as a key regulator of sphingolipid homeostasis. (A) A chemical genetic screen for interactions with myriocin. Calculated T-scores are plotted against colony size on control plates. Genes are color-code ...
... Figure 1. A chemical biology screen reveals the retrograde endosome to Golgi trafficking machinery as a key regulator of sphingolipid homeostasis. (A) A chemical genetic screen for interactions with myriocin. Calculated T-scores are plotted against colony size on control plates. Genes are color-code ...
Plant Cell
... important for the propagation of the ROS wave in plants (Romeis and Herde, 2014). ROS generated in the apoplast by an RBOHD protein of a neighboring cell (as part of the ROS wave) could therefore enter a nonactivated cell via aquaporins and trigger the release of Ca2+ by channels such as TPC1. The r ...
... important for the propagation of the ROS wave in plants (Romeis and Herde, 2014). ROS generated in the apoplast by an RBOHD protein of a neighboring cell (as part of the ROS wave) could therefore enter a nonactivated cell via aquaporins and trigger the release of Ca2+ by channels such as TPC1. The r ...
pH and Cancer: Acidic pH Levels Can Lead To Cancer
... indefinitely and without order. This is cancer. As you can see, he is describing, from a different point of view, the link between pH and cancer, a process by which low oxygen levels turn some cells cancerous. Alkaline water (including the water in cells) holds a lot of oxygen. Acidic water holds ve ...
... indefinitely and without order. This is cancer. As you can see, he is describing, from a different point of view, the link between pH and cancer, a process by which low oxygen levels turn some cells cancerous. Alkaline water (including the water in cells) holds a lot of oxygen. Acidic water holds ve ...
Developmental origin and lineage plasticity of endogenous cardiac
... WT1+ proepicardium-derived cells. Postnatally, CD45+ cells form clusters within a matrix-rich niche in the proximity of the coronary vessels (Balmer et al., 2014). Lineage tracing has shown that CD45+ epicardial cells can differentiate into pericytes, although their broader functions and lineage des ...
... WT1+ proepicardium-derived cells. Postnatally, CD45+ cells form clusters within a matrix-rich niche in the proximity of the coronary vessels (Balmer et al., 2014). Lineage tracing has shown that CD45+ epicardial cells can differentiate into pericytes, although their broader functions and lineage des ...
Monoclonal antibody 7G3 recognizes the N
... cells.'-6 Recently, IL-3 has also been shown to regulate vascular endothelial cell functions, enhancing adhesion molecule expression, neutrophil transmigration, and cytokine prod~ction.~,' Although some of the effects of IL-3 may be desirable and have prompted its clinical use in bone marrow reconst ...
... cells.'-6 Recently, IL-3 has also been shown to regulate vascular endothelial cell functions, enhancing adhesion molecule expression, neutrophil transmigration, and cytokine prod~ction.~,' Although some of the effects of IL-3 may be desirable and have prompted its clinical use in bone marrow reconst ...
Plant Gravitropism. Unraveling the Ups and
... bodies and depend on the buoyancy of lipid globules to transmit a signal when tilted horizontally (Schimek et al., 1999). Therefore, Chara sp. are examples of organisms that could display more than one type of gravity-sensing systems, whereas certain species of Phycomyces depend on both sedimentatio ...
... bodies and depend on the buoyancy of lipid globules to transmit a signal when tilted horizontally (Schimek et al., 1999). Therefore, Chara sp. are examples of organisms that could display more than one type of gravity-sensing systems, whereas certain species of Phycomyces depend on both sedimentatio ...
The Nucleolus under Stress
... Although most examples of mechanisms for modulating ribosome subunit biogenesis upon cellular stress involve control of RNA Pol I activity, alternative pathways may also exist. For instance, it has been shown recently that infection of human cells with herpes simplex virus type 1 (HSV-1) affects rRN ...
... Although most examples of mechanisms for modulating ribosome subunit biogenesis upon cellular stress involve control of RNA Pol I activity, alternative pathways may also exist. For instance, it has been shown recently that infection of human cells with herpes simplex virus type 1 (HSV-1) affects rRN ...
Pap and HPV Testing
... For a woman receiving Pap and HPV cotesting: If a woman is found to have a normal Pap test result with a positive HPV test that detects the group of high-risk HPV types, the doctor will usually have her return in a year for repeat screening to see if the HPV infection persists and whether any cell c ...
... For a woman receiving Pap and HPV cotesting: If a woman is found to have a normal Pap test result with a positive HPV test that detects the group of high-risk HPV types, the doctor will usually have her return in a year for repeat screening to see if the HPV infection persists and whether any cell c ...
Power tools for gene expression and clonal analysis in
... The GAL80 repressor of GAL4 can be used with the GAL4-UAS system (or the LexA-lexAop system) for additional control, for example, in intersectional strategies of transgene expression15–17 (Fig. 1b). GAL80 represses activation of GAL4 by acting specifically through the GAL4 activation domain. It can ...
... The GAL80 repressor of GAL4 can be used with the GAL4-UAS system (or the LexA-lexAop system) for additional control, for example, in intersectional strategies of transgene expression15–17 (Fig. 1b). GAL80 represses activation of GAL4 by acting specifically through the GAL4 activation domain. It can ...
Article Full Text - Aerosol and Air Quality Research
... ratio of viable bacterial cells to total bacterial cells) by measuring total and non-viable cells with different dyes and obtained the viability by subtracting non-viable cell counts from total cell counts. A counter, the Ultraviolet Aerodynamic Particle Sizer (UV-APS) which is a fluorescence-based ...
... ratio of viable bacterial cells to total bacterial cells) by measuring total and non-viable cells with different dyes and obtained the viability by subtracting non-viable cell counts from total cell counts. A counter, the Ultraviolet Aerodynamic Particle Sizer (UV-APS) which is a fluorescence-based ...
Renal disorders
... post infectious (C3, C4, antiDNAse B, ASOT), Wegener’s (anti GBM antibodies, ANCA), HBV, HCV ...
... post infectious (C3, C4, antiDNAse B, ASOT), Wegener’s (anti GBM antibodies, ANCA), HBV, HCV ...
Blood First Edition Paper, prepublished online September 13, 2012
... (PRP+PPP, PRP+WBC and PRP+RBC) were constructed, and their response to a 5 pM Tf stimulus was compared to that of the source whole blood. In all cases, reconstitution of PRP with other fractions was performed to achieve the physiologic platelet and peripheral blood cell concentrations measured in ea ...
... (PRP+PPP, PRP+WBC and PRP+RBC) were constructed, and their response to a 5 pM Tf stimulus was compared to that of the source whole blood. In all cases, reconstitution of PRP with other fractions was performed to achieve the physiologic platelet and peripheral blood cell concentrations measured in ea ...
Enhancement of Hippocampal Pyramidal Cell Excitability by the
... current, it would be beneficial to revisit the question with more selective blockers to understand the contribution of the current per se to cell excitability. We have previously described the sAHP inhibitor UCL2027 (Shah et al., 2001). Although this particular blocker suppressed the sAHP in dissoci ...
... current, it would be beneficial to revisit the question with more selective blockers to understand the contribution of the current per se to cell excitability. We have previously described the sAHP inhibitor UCL2027 (Shah et al., 2001). Although this particular blocker suppressed the sAHP in dissoci ...
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Plasma [CREATININE] - Department of Pathology
... Plasma [creatinine] is not within normal range Renal impairment is not severe No inhibition of tubular secretion of creatinine by medications ...
... Plasma [creatinine] is not within normal range Renal impairment is not severe No inhibition of tubular secretion of creatinine by medications ...
The Neuron & Action Potential
... When a neuron is resting there is a balance of excitatory and inhibitory signals. When one of these exceeds the other stimulus threshold is reached triggering the neuron to transmit an electrical impulse down its axon (action potential) How do you feel something that is intense? More neurons fir ...
... When a neuron is resting there is a balance of excitatory and inhibitory signals. When one of these exceeds the other stimulus threshold is reached triggering the neuron to transmit an electrical impulse down its axon (action potential) How do you feel something that is intense? More neurons fir ...
Insulin and insulin-like growth factor I (IGF I) in early
... insulin, which can bind to the specific receptors and IGF receptors type I (Hill and Milner, 1985), or by the locally secreted IGF I (autocrine and paracrine growth control) (D'Ercole et al. 1980). Indirect regulation is mediated by insulin (Brinsmead and Liggins, 1979; Philips and Vassilopoulou-Sel ...
... insulin, which can bind to the specific receptors and IGF receptors type I (Hill and Milner, 1985), or by the locally secreted IGF I (autocrine and paracrine growth control) (D'Ercole et al. 1980). Indirect regulation is mediated by insulin (Brinsmead and Liggins, 1979; Philips and Vassilopoulou-Sel ...
The Neuron & Action Potential
... When a neuron is resting there is a balance of excitatory and inhibitory signals. When one of these exceeds the other stimulus threshold is reached triggering the neuron to transmit an electrical impulse down its axon (action potential) How do you feel something that is intense? More neurons fir ...
... When a neuron is resting there is a balance of excitatory and inhibitory signals. When one of these exceeds the other stimulus threshold is reached triggering the neuron to transmit an electrical impulse down its axon (action potential) How do you feel something that is intense? More neurons fir ...
Leishmania Flagellum
... Bin/Amphiphysin/Rvs (BAR) domains are 200-amino-acid modular elements found in many eukaryotic multi-domain proteins [14]. Although their amino acid sequence may be poorly conserved and therefore difficult to identify, their structure is well conserved throughout evolution [15]. The archetype BAR do ...
... Bin/Amphiphysin/Rvs (BAR) domains are 200-amino-acid modular elements found in many eukaryotic multi-domain proteins [14]. Although their amino acid sequence may be poorly conserved and therefore difficult to identify, their structure is well conserved throughout evolution [15]. The archetype BAR do ...
BETA LACTAM ANTIBIOTICS AND OTHER INHIBITORS OF CELL
... • Interior of bacterium is hyperosmotic • Osmotic drive occurs • CWD form swell and bursts • Lysis of bacteria- BACTERICIDAL ...
... • Interior of bacterium is hyperosmotic • Osmotic drive occurs • CWD form swell and bursts • Lysis of bacteria- BACTERICIDAL ...
FVIII-specific human chimeric antigen receptor T
... induction (ITI), a process that is expensive, time-consuming and not entirely effective. The development of effective tolerogenic therapies to prevent, as well as reverse, inhibitor formation is clearly needed. Recently, regulatory T cells (Tregs) have been proposed as a potential clinical therapy f ...
... induction (ITI), a process that is expensive, time-consuming and not entirely effective. The development of effective tolerogenic therapies to prevent, as well as reverse, inhibitor formation is clearly needed. Recently, regulatory T cells (Tregs) have been proposed as a potential clinical therapy f ...
A Cellular Adventure
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
, Extracellular Matrix-associated Molecules Collaborate with Ciliary
... tube. These cells give rise to a spectacular diversity of nerve cells, as well as to various kinds of supporting (glial) cells. The generation of diverse cell types. at specific times and locations is thought to depend on interactions between cells, although little is known about the nature of the s ...
... tube. These cells give rise to a spectacular diversity of nerve cells, as well as to various kinds of supporting (glial) cells. The generation of diverse cell types. at specific times and locations is thought to depend on interactions between cells, although little is known about the nature of the s ...
BETA LACTAM ANTIBIOTICS AND OTHER INHIBITORS OF CELL
... • Interior of bacterium is hyperosmotic • Osmotic drive occurs • CWD form swell and bursts • Lysis of bacteria- BACTERICIDAL ...
... • Interior of bacterium is hyperosmotic • Osmotic drive occurs • CWD form swell and bursts • Lysis of bacteria- BACTERICIDAL ...