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... contractile protein expression in mouse and quail aorta suggest that vascular SMC differentiation is induced in mesenchymal cells that line the endothelium (Hungerford et al., 1996; Takahashi et al., 1996). The contractile proteins are first expressed on the ventral side of the vessel, and it has be ...
Systems-Wide Analysis of Acclimation Responses to Long
Systems-Wide Analysis of Acclimation Responses to Long

... remained unclear. Top-down systems biology approaches, where responses at multiple system levels are monitored over time and integrated to a more holistic picture, appear helpful to shed light on the many open questions regarding responses of plant cells to HS. In fact, Chlamydomonas is an ideal pla ...
Isolation and Characterization of Conditional-Lethal Mutations in the TUB1 alpha-Tubulin Gene of the Yeast Saccharomyces cerevisiae .
Isolation and Characterization of Conditional-Lethal Mutations in the TUB1 alpha-Tubulin Gene of the Yeast Saccharomyces cerevisiae .

... that would not grow on the 5-FOA plates at 14" and/or 37", but would grow on the control plates at all temperatures. These strains were picked and retested on the same plates at 14", 26" and 37". Of these strains,160 were chosen that failed to grow on 5-FOA plates at any temperature. These strains, ...
The Domino Effect
The Domino Effect

... When the first domino is toppled, it begins a chain reaction in which each subsequent domino is toppled until there are no more dominoes to topple. This chain reaction has certain properties that can be related to the propagation of an impulse along the membrane of a neuron: The first domino must be ...
Role of Phospholipid Head Groups in Ethanol
Role of Phospholipid Head Groups in Ethanol

... The plasma membrane is eonsidered to be the prim0 target of ethanol action in yeast (Ingram & Buttke, 1984). It seemsthat both the structure and function ofthe yeast plasma membrane are affected (Ingram & Buttke, 1984; Ingram, 1986). Amongst various membrane components, lipids are the chief targets ...
Blood ph and other details
Blood ph and other details

... in pH will be detected by your brain and it will try to shut the blood circulation to your brain in order to try to limit the damages... the result? You faint! After fainting, you will resume normal breathing because the reflex breathing will kick in so that CO2 concentration and pH in the blood wi ...
Plastid degeneration in Tillandsia (Bromeliaceae) provides
Plastid degeneration in Tillandsia (Bromeliaceae) provides

... As in animals, plant MLBs consist of several concentric membranes, packed together in a vesicle-like compartment. Plants MLBs have been observed in the cytosol and in vacuoles, but have apparently not been reported to deposit their cargo in the apoplast. In contrast to MLBs in animals, no informatio ...
Ligand Maintenance of Regulatory T Cells via GITR for B Cells in
Ligand Maintenance of Regulatory T Cells via GITR for B Cells in

... Recently, the role of B cells in autoimmune diseases has been further studied by their depletion using anti-CD20, which targets B cells from the pre-B cell to memory stages. Plasma cells, which do not express CD20, are not eliminated. In EAE, anti-CD20 depletion of B cells before induction of EAE wi ...
Primary Mediastinal Seminomas: Evidence of Single KIT
Primary Mediastinal Seminomas: Evidence of Single KIT

... Primary Mediastinal Seminomas: Evidence of Single and Multiple KIT Mutations Ronald M. Przygodzki, Alan E. Hubbs, Feng-Qi Zhao, and Timothy J. O’Leary Armed Forces Institute of Pathology, Department of Cellular Pathology and Genetics, Rockville, Maryland SUMMARY: Primary mediastinal seminomas (MS) a ...
Genetic Control of Fusion Pore Expansion in the Epidermis of
Genetic Control of Fusion Pore Expansion in the Epidermis of

... protein (GFP) on the AJ of these epithelial cells (Knust and Bossinger, 2002). The dynamic behavior of AJs in C. elegans is a reliable assay for cell fusion of epithelial cells (Kenyon, 1986; Priess and Hirsh, 1986; Baird et al., 1991; Podbilewicz and White, 1994; Mohler et al., 1998, 2002; Nguyen e ...
Open the publication - UEF Electronic Publications
Open the publication - UEF Electronic Publications

... computed   tomography   (SPECT)   combined   with   CT   is   one   example   where   functionality  of  a  contrast  agent  can  be  accurately  localized  anatomically.   For   successful   SPECT   imaging   both   chemically   and   physically   appropriate   radionuclides   are   required.   Sin ...
Neurotoxin-induced degeneration of dopamine neurons
Neurotoxin-induced degeneration of dopamine neurons

... cells is blocked by nanomolar concentrations of imipramine and nisoxetine (16). In addition, we found that 6-OHDA is a potent inhibitor of [3H]dopamine (50 nM, 5 min, 37°C) transport in vitro, with an IC50 of 341 # 127 nM (n ' 5) in transfected COS cells. To determine whether C. elegans dopamine neu ...
Chapter (25): Excretion
Chapter (25): Excretion

... 30) Which of the following statements about blood clotting is true? ‫العبارات التالية عن تخثر الدم هو الصحيح؟‬ A) The first response to an injury is dilation of the damaged blood vessels. B) During the clotting response, platelets rapidly congregate in the interstitial fluid. C) Fibrin is enzymatica ...
Metaplastic carcinoma of the breast: A clinicopathological review
Metaplastic carcinoma of the breast: A clinicopathological review

... ResultsAll are females. A total of 11Metaplastic carcinomas were included in this report. Five cases had biphasic phenotype showing mixed Epithelial andSarcomatoid or spindle cell phenotypes. Four cases had adenocarcinoma and the remaining one case showed SCC as Epithelial component. Two cases showe ...
Biology: Concepts and Connections, 6e (Campbell)
Biology: Concepts and Connections, 6e (Campbell)

... 30) Which of the following statements about blood clotting is true? ‫العبارات التالية عن تخثر الدم هو الصحيح؟‬ A) The first response to an injury is dilation of the damaged blood vessels. B) During the clotting response, platelets rapidly congregate in the interstitial fluid. C) Fibrin is enzymatica ...
Mechanical Response of Porous Scaffolds for Cartilage Engineering
Mechanical Response of Porous Scaffolds for Cartilage Engineering

... body and cell structures have been developed recently. Although ceramic and metallic materials have been widely accepted for the development of implants, its non-resorbability and necessity of second surgical operation, which induces extra stress for the patients, limit their wide applications (Cheu ...
Starfish ApDOCK protein essentially functions in larval
Starfish ApDOCK protein essentially functions in larval

... larva, corresponding to B1% of the total cell number. Most of these cells are distributed beneath the ectodermal and endodermal walls, which are composed of an epithelial monolayer. Each mesenchyme cell develops cellular processes to contact other mesenchyme cells. The location of cells fluctuates i ...
Running title: Mode of Bactericidal Action of the Jatropha curcas
Running title: Mode of Bactericidal Action of the Jatropha curcas

... extracts of Jatropha curcas Linn. plant on Staphylococcus aureus S1434 and Escherichia coli E216. At double MIC (minimum inhibitory concentration) value, cell viability of S. aureus S1434 was inhibited by all extracts, but only kernel meal and root wood extracts inhibited E. coli E216. At half MIC, ...
Induction and Activation of Plant Secondary Metabolism by External
Induction and Activation of Plant Secondary Metabolism by External

... 2.2 Participation of Ca2+ as a second messenger When elicitor-active pectic fragments were analyzed by ion exchange and gel-filtration chromatography, the activity was found to be distributed in many fractions, suggesting that the elicitor consists not of a single molecule but a mixture of several a ...
Guide for Manufacturers of General Class In
Guide for Manufacturers of General Class In

... Manufacturer - The natural or legal person with responsibility for the design, manufacture, packaging and labelling of a device before it is placed on the market under his own name, regardless of whether these operations are carried out by that person himself or on his behalf by a third party. The o ...
Document
Document

... • Mammals have alveoli, oxygen rich and poor air move in and out through same passage, always oxygen poor air trapped in lungs • Birds have one way air flow so always have fresh oxygen, allows flight at high altitudes ...
TESIS DOCTORAL
TESIS DOCTORAL

... threshold and overwhelms myocardial cellular repair mechanisms. After MI, myocardial tissue lacks the ability to significantly regenerate itself and as a consequence, ischemia might cause moderate or severe tissue death. Tissue Engineering is an emerging interdisciplinary field focused on the obtain ...
The Balance between Cell Division and Endoreplication Depends
The Balance between Cell Division and Endoreplication Depends

... expressed ubiquitously at similar levels in all organs analyzed (see Supplemental Figure 1A online). This is consistent with microarray data (https://www.genevestigator.ethz.ch/) (Zimmermann et al., 2004). This search revealed that DPB and E2FC have similar expression patterns and levels in the diff ...
Androgen receptor complexes probe DNA for recognition
Androgen receptor complexes probe DNA for recognition

... To verify the parameters obtained by SMM and expand the timescale of measurements on the dynamic behavior of the AR, the cell lines stably expressing AR–YFP and its R585K mutant, which had been used in the single-molecule analysis, were subjected to both FCS and FRAP (Figs 4 and 5, respectively). Fo ...
Update on Reactive Oxygen - Biology Department | UNC Chapel Hill
Update on Reactive Oxygen - Biology Department | UNC Chapel Hill

... physiological responses. Calcium metabolism is intimately related to ROS signaling. Increases in cytosolic Ca21 is also one of the fastest responses upon pathogen infection, and the use of specific inhibitors show that Ca21 influx is required for ROS production after elicitation (Blume et al., 2000; ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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