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Research Databases
Research Databases

... believe that mitochondrial metabolism is the key to aging," says Hemachandra Reddy of Oregon Health & Science University in Beaverton. Even before scientists suspected a role in common diseases, mitochondria had some biological celebrity. The sometimes tubular, sometimes bean-shaped structures are r ...
Lipid raft–associated protein sorting in exosomes
Lipid raft–associated protein sorting in exosomes

... From www.bloodjournal.org by guest on August 3, 2017. For personal use only. HEMATOPOIESIS ...
About 100 cases of small cell carcinoma
About 100 cases of small cell carcinoma

... metastasis is present, are defined as early gastric cancer • EGC represents between 15% and 21% of all newly diagnosed gastric cancers, whereas in Japan it accounts for over 50% of cases.[6–9] • A higher prevalence of gastric cancer, more liberal use of upper endoscopy and chromoendoscopy, and diffe ...
Virus-induced hepatocellular carcinomas cause antigen
Virus-induced hepatocellular carcinomas cause antigen

... observed in PBMCs or liver biopsies obtained from patients with chronic HCV infection (4, 16–18). Heterogeneity within individuals, difficulties in analyzing local T cell responses, and the need of in vitro manipulation and expansion for functional analysis of HCV-specific T cells make firm conclusi ...
SC.5.L.14.1 Human Body Organs
SC.5.L.14.1 Human Body Organs

... 2. Your liver makes bile to help break down food. 3. Muscles cover your bones but work separately to help you move. 4. Kidneys are a pair of filters that clean the blood. 5. Your heart pumps blood through vessels to some parts of the body. 6. The large intestine absorbs water from digested food and ...
4-4 Connective Tissue
4-4 Connective Tissue

... An Introduction to Tissues • Learning Outcomes • 4-4 Compare the structures and functions of the various types of connective tissues. • 4-5 Describe how cartilage and bone function as a supporting connective tissue. • 4-6 Explain how epithelial and connective tissues combine to form four types of t ...
Tissues
Tissues

... An Introduction to Tissues • Learning Outcomes • 4-4 Compare the structures and functions of the various types of connective tissues. • 4-5 Describe how cartilage and bone function as a supporting connective tissue. • 4-6 Explain how epithelial and connective tissues combine to form four types of t ...
Article - Columbia University
Article - Columbia University

... Trophic Effects of Androgen in X. laevis to bias introduced by sectioning or counting methodology (West, 1993). However, we have taken precautions to reduce the possibility that our conclusions could be compromised by such bias. For example, bias may be introduced if the objects being counted are l ...
Cystic fibrosis airway epithelial cell polarity and bacterial flagellin
Cystic fibrosis airway epithelial cell polarity and bacterial flagellin

... surfaces, there were no clear patterns (e.g. gene categories or cell signalling pathways) that emerged from careful inspection of the apical or basal datasets (see Supplementary material, Table S1). However, cytokine genes were all regulated during apical or, even more prominently, basal exposure of ...
Renal disorders
Renal disorders

...  post infectious (C3, C4, antiDNAse B, ASOT), Wegener’s (anti GBM antibodies, ANCA), HBV, HCV ...
Phloem Structure and Function
Phloem Structure and Function

... are numerous and often grouped as pit fields along the common wall. Thus, the cytoplasm of sieve elements is well connected to that of its associated cell type. In comparison with ordinary plasmodesmata, the pore–plasmodesma contacts are distinguished by an increased size-exclusion limit, the full ex ...
Macrophage-pathogen interactions in infectious diseases: new
Macrophage-pathogen interactions in infectious diseases: new

... This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. ...
zoo 365 - chordates - The Federal University of Agriculture, Abeokuta
zoo 365 - chordates - The Federal University of Agriculture, Abeokuta

... habitat they occupy, all chordates hve a common basic plan of organization. Originally this plan is essentially that of a coelomate, marine, long-bodied, free-swimming creature which displays the following three main futures: The presence of a notochord, an axial rod of the skeleton, which extends i ...
NO 3
NO 3

... of water and air filled spaces of the cell wall and is in close contact with the soil medium, the contact often being enhanced by numerous root hairs. Water free space(水分自由空间) and Donnan free space( 杜南自由空间) Cations interact with the fixed anions in the cell wall (pectin and proteins) and hence their ...
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to

... Myo5a mutations have been identified both in dilute mice, which exhibit defects in the trafficking of skin melanosomes (Mercer et al., 1991), and in patients affected by Griscelli syndrome (Pastural et al., 2000). Moreover, several studies on skin melanocytes have led to the conclusion that Rab27A r ...
Expression and transcriptional activity of progesterone receptor A
Expression and transcriptional activity of progesterone receptor A

... were transfected into CV-1 or HS578T cells, but not into HepG2 cells. PRA had similar anti-estrogenic effects on endogenous estrogen receptor activation of a minimal estrogen-responsive reporter in MCF-7 breast cancer cells in the presence of RU 38486 [8]. When the estrogen-responsive region of the ...
Motoneurons Derived from Induced Pluripotent Stem Cells Develop
Motoneurons Derived from Induced Pluripotent Stem Cells Develop

... Regenerative Biology, and 7Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, and 8National Research Council, Institute for Marine Biosciences, Nova Scotia, Canada B3H 3Z1 ...
New Phytologist
New Phytologist

... and then sterilized for 15 min in 5% (v/v) aqueous sodium hypochlorite. Macroptilium atropurpureum seeds were similarly sterilized for 15 min in 5% (v/v) sodium hypochlorite. Surface-sterilized seeds were rinsed six times in sterile distilled water, and germinated on 1% (w/v) agar plates in darkness ...
Citační ohlasy podle WoS – F. Cvrčková (k 31.1.2005)
Citační ohlasy podle WoS – F. Cvrčková (k 31.1.2005)

... Skn7 response regulator in budding yeast. MOLECULAR BIOLOGY OF THE CELL 10 (10): 3389-3400. 41. Levine, K; Kiang, L; Jacobson, MD; Fisher, RP; Cross, FR. 1999. Directed evolution to bypass cyclin requirements for the Cdc28p cyclin-dependent kinase. MOLECULAR CELL 4 (3): 353-363. 42. Luukkonen, BGM; ...
Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in
Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in

... Next, we wanted to explore Gal-3 expression and its localization in osteoclast precursor cells during osteoclastogenesis. Then, we firstly examined Gal-3 expression in osteoclast precursor cells of Raw 264.7 (mouse), which also share the characteristics of monocyte/macrophage and Poietics (human), an ...
Angioplasty and Stent Education Guide
Angioplasty and Stent Education Guide

... clots from forming and adhering to the surface of the stent. These medications will include aspirin and blood thinning drugs such as Plavix®, Ticlid® or Effient® (Prasugrel). It is extremely important that you follow your doctor’s instructions on what medications to take. If you stop taking these me ...
Hierarchies of plant stiffness
Hierarchies of plant stiffness

... shape by the pattern of branching [3,8]. However, in a small herbaceous annual such as Arabidopsis, these factors are less important, and have not been studied. For some background on stiffness at the whole plant level, we refer you to [8–12]. 2.2. Organ level As primary load-bearing structures for ...
Sample pages 1 PDF
Sample pages 1 PDF

... influx into root cells is a fundamental requisite for plant life in high salt conditions. Balancing Na+ influx with Na+ export from the cytoplasm back into the apoplast (also sometimes termed ‘futile cycling’) is one way of reducing the Na+ load (Britto and Kronzucker 2006; Malagoli et al. 2008). Th ...
Massive Expansion of Antigen-Specific CD8 T Cells during an Acute
Massive Expansion of Antigen-Specific CD8 T Cells during an Acute

... transgenic for a TCR that recognizes LCMV gp33/Db (Pircher et al., 1990). We transferred 105 P14 spleen cells containing 30% CD81 T cells into Thy1 congenic B6.PL host mice. These PL/P14 chimeras and B6.PL control mice (three per group) were infected with LCMV. Spleen cells were prepared and analyze ...
Regulation of cdk2 Activity in Endothelial Cells That Are Inhibited
Regulation of cdk2 Activity in Endothelial Cells That Are Inhibited

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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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