Control of organ shape - Development
... complex developmental process where multiple levels of regulation have to be coordinated spatially and temporally. Several questions remain unanswered regarding organ formation. (1) What early signaling events select the correct site within the primordial field for the initial cell shape changes? (2 ...
... complex developmental process where multiple levels of regulation have to be coordinated spatially and temporally. Several questions remain unanswered regarding organ formation. (1) What early signaling events select the correct site within the primordial field for the initial cell shape changes? (2 ...
Gene Section PTPRJ (protein tyrosine phosphatase, receptor type, J)
... ERK1/2, irrespective of ERK1/2 phosphorylation state and by dephosphorylating the ERK1/2 activation loop. Loss of heterozygosity, and missense mutations in the DEP-1 gene have been identified in several human cancers including colon, lung, and breast, which have also been associated with aberrant He ...
... ERK1/2, irrespective of ERK1/2 phosphorylation state and by dephosphorylating the ERK1/2 activation loop. Loss of heterozygosity, and missense mutations in the DEP-1 gene have been identified in several human cancers including colon, lung, and breast, which have also been associated with aberrant He ...
Regulation of plasmodesmal transport by phosphorylation of
... through plant intercellular connections, the plasmodesmata, is mediated by a specialized viral movement protein (MP). In vivo studies using transgenic tobacco plants showed that MP is phosphorylated at its C-terminus at amino acid residues Ser258, Thr261 and Ser265. When MP phosphorylation was mimic ...
... through plant intercellular connections, the plasmodesmata, is mediated by a specialized viral movement protein (MP). In vivo studies using transgenic tobacco plants showed that MP is phosphorylated at its C-terminus at amino acid residues Ser258, Thr261 and Ser265. When MP phosphorylation was mimic ...
Notice of Restricted Use
... shows filtration and reabsorption in a state of equilibrium with very little to no loss of capillary fluid. The diagram on the right illustrates the revised Starling’s principle of fluid filtration throughout the capillary surface with no reabsorption into the capillary. The entire filtrate will bec ...
... shows filtration and reabsorption in a state of equilibrium with very little to no loss of capillary fluid. The diagram on the right illustrates the revised Starling’s principle of fluid filtration throughout the capillary surface with no reabsorption into the capillary. The entire filtrate will bec ...
Article PDF
... group of Prof. Schwab at the German Cancer Research Center (DKFZ) to establish a physical map of distal 1p36 as a basis for identifying a neuroblastoma tumor suppressor gene. After receiving his diploma he moved within the DKFZ to the group of Prof. Poustka to establish a novel method for an array b ...
... group of Prof. Schwab at the German Cancer Research Center (DKFZ) to establish a physical map of distal 1p36 as a basis for identifying a neuroblastoma tumor suppressor gene. After receiving his diploma he moved within the DKFZ to the group of Prof. Poustka to establish a novel method for an array b ...
DAZL is essential for stress granule formation
... male germ cells of Dazl-knockout mice. The DAZL-containing SGs played a protective role against heat stress-induced apoptosis by the sequestration of specific signaling molecules, such as RACK1, and the subsequent blockage of the apoptotic MAPK pathway. Based on these results, we propose that DAZL i ...
... male germ cells of Dazl-knockout mice. The DAZL-containing SGs played a protective role against heat stress-induced apoptosis by the sequestration of specific signaling molecules, such as RACK1, and the subsequent blockage of the apoptotic MAPK pathway. Based on these results, we propose that DAZL i ...
cells
... “optical sectioning” of fluorescently-stained specimens. Only a single plane of focus is illuminated; out-of-focus fluorescence above and below the plane is subtracted by a computer. A sharp image results, as seen in stained nervous tissue (top), where nerve cells are green, support cells are red, a ...
... “optical sectioning” of fluorescently-stained specimens. Only a single plane of focus is illuminated; out-of-focus fluorescence above and below the plane is subtracted by a computer. A sharp image results, as seen in stained nervous tissue (top), where nerve cells are green, support cells are red, a ...
osmotic drug delivery system
... Delivery may be delayed or pulsed, if desired. For oral osmotic systems, drug release is independent of gastric pH and hydrodynamic conditions which is mainly attributed to the unique properties of semipermeable membrane (SPM) employed in coating of osmotic formulations. ...
... Delivery may be delayed or pulsed, if desired. For oral osmotic systems, drug release is independent of gastric pH and hydrodynamic conditions which is mainly attributed to the unique properties of semipermeable membrane (SPM) employed in coating of osmotic formulations. ...
Respiratory System
... The blood flow is known as blood circulation. Blood is moving by means of an organ known as the heart, which is a muscular pump that draws blood in when it relaxes and pushes it out at great force when it contracts. Blood will take 30 seconds to complete one circulation around the body. 5 litres of ...
... The blood flow is known as blood circulation. Blood is moving by means of an organ known as the heart, which is a muscular pump that draws blood in when it relaxes and pushes it out at great force when it contracts. Blood will take 30 seconds to complete one circulation around the body. 5 litres of ...
Active Uptake and Extravesicular Storage of m
... radiopharmaceutical in this tumor category. The present study demonstrates for the first time extensive extravesicular storage of MIBG in a single in vitro model of human neuroblastoma. Obviously, nongranular storage will have an important, al though as yet unknown, impact on the biological half-lif ...
... radiopharmaceutical in this tumor category. The present study demonstrates for the first time extensive extravesicular storage of MIBG in a single in vitro model of human neuroblastoma. Obviously, nongranular storage will have an important, al though as yet unknown, impact on the biological half-lif ...
42-Circulation and Gas Exchange
... science fiction film, but it’s actually an axolotl, a salamander native to shallow ponds in central Mexico. The feathery red appendages jutting out from the head of this albino adult are gills. Although external gills are uncommon in adult animals, they help satisfy the need shared by all animals to ...
... science fiction film, but it’s actually an axolotl, a salamander native to shallow ponds in central Mexico. The feathery red appendages jutting out from the head of this albino adult are gills. Although external gills are uncommon in adult animals, they help satisfy the need shared by all animals to ...
Is fibroblast growth factor 23 a harbinger of mortality in CKD
... Figure 2: Fibroblast growth factor 23 (FGF23) increases cell size in a dose-dependent manner. Panel A. Representative forwardscatter histograms (FSC-H) of HL-1 cardiomyocytes treated with vehicle or FGF23 (900 pg/ml) for 48 h. Panel B. Summary of forward-scatter (FSC-H) data on cardiomyocytes treate ...
... Figure 2: Fibroblast growth factor 23 (FGF23) increases cell size in a dose-dependent manner. Panel A. Representative forwardscatter histograms (FSC-H) of HL-1 cardiomyocytes treated with vehicle or FGF23 (900 pg/ml) for 48 h. Panel B. Summary of forward-scatter (FSC-H) data on cardiomyocytes treate ...
Protein Synthesis within Dendrites: Glycosylation
... antibody AP14 (1:100), which recognizes MAP2, a specific marker of the dendritic compartment (Cáceres et al., 1984). The coverslips were incubated for 1 hr with biotinylated goat anti-mouse IgG (Vector Laboratories, Burlingame, CA) (1:250). For the detection of biotinylated secondary antibodies, pr ...
... antibody AP14 (1:100), which recognizes MAP2, a specific marker of the dendritic compartment (Cáceres et al., 1984). The coverslips were incubated for 1 hr with biotinylated goat anti-mouse IgG (Vector Laboratories, Burlingame, CA) (1:250). For the detection of biotinylated secondary antibodies, pr ...
Localization of Green Fluorescent Protein Fusions
... BFA at low concentrations (5–10 mg/mL) caused Golgi apparatus to form typical BFA-induced aggregates, this drug did not affect MVBs in tobacco BY-2 cells (Tse et al., 2004). In contrast, wortmannin at 15 to 33 mM caused MVBs to swell and led to a reduction in the number of internal vesicles, while t ...
... BFA at low concentrations (5–10 mg/mL) caused Golgi apparatus to form typical BFA-induced aggregates, this drug did not affect MVBs in tobacco BY-2 cells (Tse et al., 2004). In contrast, wortmannin at 15 to 33 mM caused MVBs to swell and led to a reduction in the number of internal vesicles, while t ...
07-Feinstein 614.indd - The octopus research group at the Hebrew
... The highly mobile and active predatory lifestyle of octopuses and other modern cephalopods (Coleoidea) differs from that of other mollusks. In the octopods this evolution of mobility and predation was accompanied by the molluscan foot evolving into eight long and flexible arms. The arms are equipped ...
... The highly mobile and active predatory lifestyle of octopuses and other modern cephalopods (Coleoidea) differs from that of other mollusks. In the octopods this evolution of mobility and predation was accompanied by the molluscan foot evolving into eight long and flexible arms. The arms are equipped ...
幻灯片 1
... -Glucose goes into glycolysis and the respiratory cycle, where multiple high-energy ATP molecules are produced by oxidation -Dependent on the ATP:ADP ratio, and hence blood glucose levels, the ATPdependent potassium channels (K+) close and the cell membrane depolarizes -On depolarization, voltage co ...
... -Glucose goes into glycolysis and the respiratory cycle, where multiple high-energy ATP molecules are produced by oxidation -Dependent on the ATP:ADP ratio, and hence blood glucose levels, the ATPdependent potassium channels (K+) close and the cell membrane depolarizes -On depolarization, voltage co ...
Document
... Dissection and examination of a pig heart 1 Identify the left and right sides, the dorsal and ventral sides, and the major blood vessels of a pig heart. ...
... Dissection and examination of a pig heart 1 Identify the left and right sides, the dorsal and ventral sides, and the major blood vessels of a pig heart. ...
Osmotic Effects on the Electrical Properties of
... triple-ion, pH, and potential-measuring electrodes (Felle, 1994; Miller et al., 2001), it is known that vacuolar and cytoplasmic [K⫹] varies in response to changes in K⫹ supply (Walker et al., 1996), cell type, and salt stress (Cuin et al., 2003). Because the vacuole must remain at the same osmotic ...
... triple-ion, pH, and potential-measuring electrodes (Felle, 1994; Miller et al., 2001), it is known that vacuolar and cytoplasmic [K⫹] varies in response to changes in K⫹ supply (Walker et al., 1996), cell type, and salt stress (Cuin et al., 2003). Because the vacuole must remain at the same osmotic ...
Newman and Zahs, J Neurosci., 18:4022-8, 1998.
... Recently, we demonstrated that intercellular C a 21 waves can also be propagated through networks of glial cells in situ in the freshly isolated mammalian retina (Newman and Z ahs, 1997). These waves are initiated by electrical or mechanical stimuli as well as focal application of neurotransmitters. ...
... Recently, we demonstrated that intercellular C a 21 waves can also be propagated through networks of glial cells in situ in the freshly isolated mammalian retina (Newman and Z ahs, 1997). These waves are initiated by electrical or mechanical stimuli as well as focal application of neurotransmitters. ...
Preview the material
... structural supports and prevent these structures from closing with the passage of air. Ligaments are bands of tissue that connect one bone to another and maintain the structural integrity of the joints. Tendons are very much like ligaments in their structure but they have a very different function. ...
... structural supports and prevent these structures from closing with the passage of air. Ligaments are bands of tissue that connect one bone to another and maintain the structural integrity of the joints. Tendons are very much like ligaments in their structure but they have a very different function. ...
Determination of the Structure and Composition of the ` Sulphur
... elementary analyses of the ' sulphur granules ' and Actinomyces P 2 s organisms grown in vitro were done by Galbraith Laboratories Inc. (Knoxville, Tennessee). About 10-12 mg. dry weight of ' sulphur granules ' or Actinomyces bovis organisms were combusted in a porcelain crucible to constant weight ...
... elementary analyses of the ' sulphur granules ' and Actinomyces P 2 s organisms grown in vitro were done by Galbraith Laboratories Inc. (Knoxville, Tennessee). About 10-12 mg. dry weight of ' sulphur granules ' or Actinomyces bovis organisms were combusted in a porcelain crucible to constant weight ...
Localization of TGN38 to the trans-Golgi Network
... processing, the TGN is a major sorting compaaia~ient for proteins destined to more distal organelles of the secretory pathway, such as lysosomes, endosomes, secretory granules, and different domains of the plasma membrane (Griffiths and Simons, 1986). The differentiated structure and function of the ...
... processing, the TGN is a major sorting compaaia~ient for proteins destined to more distal organelles of the secretory pathway, such as lysosomes, endosomes, secretory granules, and different domains of the plasma membrane (Griffiths and Simons, 1986). The differentiated structure and function of the ...
"Molecular Motors in Plant Cells". In: Molecular Motors
... Analysis of the recently completed Arabidopsis genome sequence with the conserved motor domain of KLPs has resulted in identification of 61 KLPs in the model plant (Reddy and Day, 2001b). A corresponding cDNA or EST (Expressed Sequence Tag) was found for 37 of these KLPs (Tab. 18.2), suggesting that ...
... Analysis of the recently completed Arabidopsis genome sequence with the conserved motor domain of KLPs has resulted in identification of 61 KLPs in the model plant (Reddy and Day, 2001b). A corresponding cDNA or EST (Expressed Sequence Tag) was found for 37 of these KLPs (Tab. 18.2), suggesting that ...
Introduction to Antibody Drug Conjugates (ADC)
... • Lysosomal protease sensitive linkers – This strategy uses lysosomal proteases such as Cathepsin B that recognise and cleave a dipeptide bond to release the free drug from the antibody. – Valine-citrulline dipeptide linkers are common in this class • e.g. Adcetris (Seattle Genetics/Millennium). • A ...
... • Lysosomal protease sensitive linkers – This strategy uses lysosomal proteases such as Cathepsin B that recognise and cleave a dipeptide bond to release the free drug from the antibody. – Valine-citrulline dipeptide linkers are common in this class • e.g. Adcetris (Seattle Genetics/Millennium). • A ...