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Are You Shark Smart
Are You Shark Smart

... over the gill slits so oxygen can be removed • Spiracle: Help bring water into the mouth for breathing when the shark’s mouth is closed ...
mpges
mpges

... the CIA model. Levels of IL-17 were significantly increased after CII stimulation in splenocytes of WT mice. However, significantly lower levels of IL-17 were observed in mPGES-1–/– splenocytes compared to WT on exposure to CII (Fig. 4). Likewise, the genetic deletion of mPGES-1 resulted in a failur ...
2012 Alston Publishing House Pte Ltd Science SMART Teacher`s
2012 Alston Publishing House Pte Ltd Science SMART Teacher`s

...  Blood delivers substances such as oxygen and nutrients to all parts of the body and transports waste substances such as carbon dioxide away.  Blood is transported through blood vessels.  Blood does not flow on its own. It needs a heart to pump it to all parts of the body through the blood vessel ...
Involvement of reactive oxygen species in lanthanum
Involvement of reactive oxygen species in lanthanum

... Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, China *  These authors have contributed equally to this work. ...
Cholinergic Responses and Intrinsic Membrane Properties of
Cholinergic Responses and Intrinsic Membrane Properties of

... Off-line analyses were performed using Clampfit 10 software (Molecular Devices). Only cells with action potential amplitude higher than 50 mV and stable resting membrane potential (if not spontaneously firing, more negative than ⫺45 mV) were included in the statistical analysis. The following intrin ...
Renal cell carcinoma of native and allograft kidneys in
Renal cell carcinoma of native and allograft kidneys in

... Malignancies following transplantation are more aggressive and developed at a more advanced stage than those in patients without transplants, and represent a significant cause of patient death following kidney transplantation. Renal cell carcinoma (RCC) is the most common urologic cancer in both nat ...
PDF 51 - The Open University
PDF 51 - The Open University

... employed by cells. Then we shall go into greater detail to show you exactly how the key molecular players operate including receptors and intracellular signalling molecules. In the final section, we shall consider specific examples of signal transduction pathways regulating cellular responses involv ...
Single-cell absolute contact probability detection reveals
Single-cell absolute contact probability detection reveals

... peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
The putative phosphatase All1758 is necessary for normal growth
The putative phosphatase All1758 is necessary for normal growth

... manganese-dependent serine/threonine protein phosphatase of the PPP family DevT (Alr4674) accumulates in mature heterocysts, is not regulated by NtcA and appears to have a role in the later steps of heterocyst differentiation (Espinosa et al., 2010). In this study, the isolation and characterization ...
Basophils and Autoreactive IgE in the Pathogenesis of
Basophils and Autoreactive IgE in the Pathogenesis of

... associated with the levels of autoantibodies. These auto-reactive antibodies are produced by plasma cells derived from auto-reactive B cells. Minimal data is available on how tolerance is broken leading to the accumulation of auto-reactive lymphocytes. However, there is considerable evidence that th ...
6-Phosphogluconate Dehydrogenase and Glucose-6
6-Phosphogluconate Dehydrogenase and Glucose-6

... acute pyelonephritis, and other infectious diseases have also been reported to have increased incidence or severity during pregnancy (8 –12). Second, autoimmune diseases with a substantial inflammatory component improve during pregnancy, but relapse after delivery. It has been known for some time, b ...
NuMA assembles into an extensive filamentous structure when
NuMA assembles into an extensive filamentous structure when

... addition to these proposed specific functions for NuMA within the cell nucleus, there have also been proposals that NuMA is only localized in the nucleus to sequester it away from the cytoplasmic microtubules during the interphase stages of mitosis (Compton et al., 1992). Indeed, we have recently pr ...
The retinoblastoma homolog RBR1 mediates localization of the
The retinoblastoma homolog RBR1 mediates localization of the

... To understand the cellular basis of the reduced root growth of rbr1 under DNA-damaging conditions, we analyzed the root tips of rbr1 plants grown for 10 days on BLM-containing plates. As control for the treatment, we used ku70 mutants. Similar to ku70, rbr1 mutants already showed slightly elevated c ...
pdf: Baskin 2013
pdf: Baskin 2013

... instead to describe the end of the root. Note that some plant cell biologists have used apical for cell polarity with reference to the shoot apex only, so that under their terminology apical points away from the root’s apex; however, an alternative terminology for cell polarity has been recently pro ...
Yeasts as a model for human diseases
Yeasts as a model for human diseases

... many bona fide yeast laboratories, has probably contributed most to the field. Because of the good annotation and the fact that fewer and fewer genes are of unknown function, it serves as a reference genome for the annotation of new ones. For all these reasons, several ‘omics’ approaches were develo ...
Transcriptional Control of Endothelial Cell Development
Transcriptional Control of Endothelial Cell Development

... numerous diseases, including cancer, atherosclerosis, retinopathy, and stroke. Vasculogenesis, the de novo formation of endothelial cells from mesodermal precursors, occurs prior to the onset of blood circulation and results in the formation of the extra-embryonic yolk sac vasculature, the paired ao ...
OSMOSIS (A self-instructional package)
OSMOSIS (A self-instructional package)

... volume of isotonic saline containing enough malonamide (about 8 mM at 37C) to contribute 0.2 atm to the osmotic pressure of the solution, what will be the initial rate of red cell shrinking? ...
Refraction effect in an in-plane-switching blue
Refraction effect in an in-plane-switching blue

... diameter and short coherence length, and (3) optically isotropic dark state. Since no surfactant is needed to generate uniform molecular alignment for PS-BPLC, the device fabrication process can be much simplified. And fast response time is particularly desirable because it not only reduces motion b ...
Lactose Uptake Driven by Galactose Efflux in Streptococcus
Lactose Uptake Driven by Galactose Efflux in Streptococcus

... directly as the means of heterologous exchange (Fig. 3B). In this system, downhill galactose efflux would drive uptake of lactose. This model would imply that galactose and lactose uptake systems occur via a common carrier, as suggested by Poolman et al. (18). The relatively high affinity of galacto ...
NSC 203 - National Open University of Nigeria
NSC 203 - National Open University of Nigeria

... of 25/0 mmHg. By the time blood reaches the pulmonary capillaries, the pressure has fallen to an average of 10mmHg. Since the plasma oncotic pressure is 25mmHg, no fluid moves out of the pulmonary capillaries into the interstitial space. This is important because if fluid moves out of the arterial e ...
Membrane receptors in the gastrointestinal tract
Membrane receptors in the gastrointestinal tract

... cytosolic surface of the plasma membrane. The c-ras genes are expressed during normal human development in fetuses at 12 to 18 weeks gestation (29). This time subsequent to embryogenesis coincides with a general situation of rapid cell proliferation and differentiation. The p21 ras protein expresses ...
Autopoiesis and Cognition in the Game of Life
Autopoiesis and Cognition in the Game of Life

... and a reflection, as are states 1 and 3. By identifying each of these pairs of states, the organization is reduced to a limit cycle consisting of two abstract states (Figure 2B). In this diagram, the state labels have been rotated to emphasize their similarities. In the glider’s intrinsic coordinate ...
Full Text  - The International Journal of Developmental Biology
Full Text - The International Journal of Developmental Biology

... Fig. 3 (Left). Expression of IoN-Dl pathway components during the early cleavage stages. (A) IoN: At the 2q stage, all cells in the embryo have a low level of cytoplasmic expression. 2q cells have slightly stronger cytoplasmic expression. All cells in the embryo, with the exception of 1q cells, have ...
Direct killing of Epstein-Barr virus (EBV)–infected B
Direct killing of Epstein-Barr virus (EBV)–infected B

... (HLA) class I peptide tetramers has highlighted the large proportion of CD8 T cells directed to EBV antigens.7,8 These CD8⫹ CTL responses are preferentially directed toward the early lytic proteins, BZLF1 (BamH fragment Z left frame 1) and BMLF1 (BamHI-M leftward reading frame 1)9-12 and to a lesser ...
Lecture 7 Notes CH.7
Lecture 7 Notes CH.7

... Cells recognize other cells by binding to surface molecules, often containing carbohydrates, on the extracellular surface of the plasma membrane ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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