Apoptotic cell clearance: basic biology and therapeutic potential
... For example, in inflamed adipose tissue, dying adipocytes seem to be engulfed by multiple macrophages that form ‘crown-like structures’ around a single adipocyte and ingest smaller fragments of the dying cell6. This has also been observed during the clearance of dying cells by fibroblasts in the abs ...
... For example, in inflamed adipose tissue, dying adipocytes seem to be engulfed by multiple macrophages that form ‘crown-like structures’ around a single adipocyte and ingest smaller fragments of the dying cell6. This has also been observed during the clearance of dying cells by fibroblasts in the abs ...
Molecular Cloning of CD68, a Human Macrophage
... material, and antigen processing and presentation.2 The surface phenotype of mononuclear phagocytes is poorly defined by specific monoclonal antibodies (MoAbs), compared with other hematopoietic lineages. The majority of antigens defining the mononuclear phagocyte lineage are in fact absent from tis ...
... material, and antigen processing and presentation.2 The surface phenotype of mononuclear phagocytes is poorly defined by specific monoclonal antibodies (MoAbs), compared with other hematopoietic lineages. The majority of antigens defining the mononuclear phagocyte lineage are in fact absent from tis ...
Reverse migration of neutrophils: Where, when, how and why
... leads to a net migratory response of recruited neutrophil populations towards the core of an inflammatory insult from which it is proposed they are subsequently cleared through apoptosis and uptake by tissue macrophages. Within the last 10 years, investigations of neutrophil behaviour at single cell ...
... leads to a net migratory response of recruited neutrophil populations towards the core of an inflammatory insult from which it is proposed they are subsequently cleared through apoptosis and uptake by tissue macrophages. Within the last 10 years, investigations of neutrophil behaviour at single cell ...
Satisfying the Immense Energy Demands of the Body, and the
... pumped from the matrix into the inter-membrane space and stores the excess energy within the proton gradient rather than ATP (Elston et al., 1998). Inheritance and Molecular Genetics of ATP6 Only the ATP6 and ATP8 subunits of ATP synthase are encoded in the 16,569 base-pair circular mitochondrial ge ...
... pumped from the matrix into the inter-membrane space and stores the excess energy within the proton gradient rather than ATP (Elston et al., 1998). Inheritance and Molecular Genetics of ATP6 Only the ATP6 and ATP8 subunits of ATP synthase are encoded in the 16,569 base-pair circular mitochondrial ge ...
Identification of an estrogen receptor a non covalent ubiquitin
... Ubiquitin (Ub)-binding domains (UBDs) located in Ub receptors decode the ubiquitination signal by non-covalently engaging the Ub modification on their binding partners and transduce the Ub signalling through Ub-based molecular interactions. In this way, inducible protein ubiquitination regulates div ...
... Ubiquitin (Ub)-binding domains (UBDs) located in Ub receptors decode the ubiquitination signal by non-covalently engaging the Ub modification on their binding partners and transduce the Ub signalling through Ub-based molecular interactions. In this way, inducible protein ubiquitination regulates div ...
Intracellular Signals Direct Integrin Localization to Sites of Function
... other integrin is found distributed diffusely over the cell surface (e.g., Fath et al., 1989). Third, when integrins bind to extracellular ligands, they become clustered, which by itself induces increased tyrosine phosphorylation of intracellular proteins (Miyamoto et al., 1995). If this phosphoryla ...
... other integrin is found distributed diffusely over the cell surface (e.g., Fath et al., 1989). Third, when integrins bind to extracellular ligands, they become clustered, which by itself induces increased tyrosine phosphorylation of intracellular proteins (Miyamoto et al., 1995). If this phosphoryla ...
Inhibition of virulence factor expression and swarming differentiation
... mouse urinary tract better than an isogenic ureasenegative strain [8]. Furthermore, the haemolysin secreted by P. mirabilis is cytotoxic for cultured urinary tract epithelial cells [9]. It was also found that after urinary tract infection, P. mirabilis invades human urothelial cells frequently [10]. ...
... mouse urinary tract better than an isogenic ureasenegative strain [8]. Furthermore, the haemolysin secreted by P. mirabilis is cytotoxic for cultured urinary tract epithelial cells [9]. It was also found that after urinary tract infection, P. mirabilis invades human urothelial cells frequently [10]. ...
Microtubules Regulate Dynamic Organization of Vacuoles in
... actin microfilaments, rather than microtubules, and that their maintenance and distribution are actin dependent (Ovecka et al. 2005, Higaki et al. 2006). To investigate vacuolar morphology and its regulatory mechanisms, we have, in this study, established a new visualization system using the moss, Ph ...
... actin microfilaments, rather than microtubules, and that their maintenance and distribution are actin dependent (Ovecka et al. 2005, Higaki et al. 2006). To investigate vacuolar morphology and its regulatory mechanisms, we have, in this study, established a new visualization system using the moss, Ph ...
Tansley review - Professor Gero Steinberg
... responsible for tip-directed (anterograde) endosome motility of early endosomes, which are thought to support hyphal elongation by apical membrane recycling. In addition, kinesin-3, together with kinesin-1 and myosin-5, appear to deliver secretory vesicles to the hyphal tip. Kinesin-1 also affects e ...
... responsible for tip-directed (anterograde) endosome motility of early endosomes, which are thought to support hyphal elongation by apical membrane recycling. In addition, kinesin-3, together with kinesin-1 and myosin-5, appear to deliver secretory vesicles to the hyphal tip. Kinesin-1 also affects e ...
Fish vs. Human Respiration
... Respiration is a biochemical process by which living organisms take up oxygen, release carbon dioxide and produce energy. There are three main stages of respiration: external, internal and cellular. For a yellow perch (or any species of fish), respiration begins when it opens its mouth to take in wa ...
... Respiration is a biochemical process by which living organisms take up oxygen, release carbon dioxide and produce energy. There are three main stages of respiration: external, internal and cellular. For a yellow perch (or any species of fish), respiration begins when it opens its mouth to take in wa ...
Leukaemia Section Anaplastic large cell lymphoma (ALCL) Atlas of Genetics and Cytogenetics
... 3 main histopathological types are found: - The common type, characterized by large lymphoid cells with horseshoe shaped nuclei with many nucleoli, and large cytoplasm; may be ALK + or - ALCL, - The small cell type, together with the above described cells, show small and medium sized cells; almost e ...
... 3 main histopathological types are found: - The common type, characterized by large lymphoid cells with horseshoe shaped nuclei with many nucleoli, and large cytoplasm; may be ALK + or - ALCL, - The small cell type, together with the above described cells, show small and medium sized cells; almost e ...
Ciliostasis is a key early event during colonization of canine tracheal
... parapertussis is the ciliated respiratory epithelium. Previous studies have implicated adherence of bacteria to cilia, induction of mucus production, induction of ciliostasis and damage to the ciliated epithelium in Bordetella pathogenesis. This paper describes the use of an air-interface organ cult ...
... parapertussis is the ciliated respiratory epithelium. Previous studies have implicated adherence of bacteria to cilia, induction of mucus production, induction of ciliostasis and damage to the ciliated epithelium in Bordetella pathogenesis. This paper describes the use of an air-interface organ cult ...
The influence of chronic stress on T cell immunity
... responses, for instance to prevent the body from harmful excessive immune responses. CNSimmune interactions also play an important role during stress responses. The stress response is essential for the organism since it facilitates all necessary changes (physiological and behavioral) that allow the ...
... responses, for instance to prevent the body from harmful excessive immune responses. CNSimmune interactions also play an important role during stress responses. The stress response is essential for the organism since it facilitates all necessary changes (physiological and behavioral) that allow the ...
Dynamics of Lipid Transfer by Phosphatidylinositol Transfer Proteins
... residues compromises PtdIns binding and transfer without affecting PtdCho binding and transfer (16). Although close to the inositol-headgroup-binding site (Figure 1C), C95 is not essential for lipid transfer as C95A mutation has no effect on lipid transfer ability of PITPa (20). However, chemical mo ...
... residues compromises PtdIns binding and transfer without affecting PtdCho binding and transfer (16). Although close to the inositol-headgroup-binding site (Figure 1C), C95 is not essential for lipid transfer as C95A mutation has no effect on lipid transfer ability of PITPa (20). However, chemical mo ...
Standardization of traffic measurements and models for broadband
... cell traffic variables. Standardized traffic descriptors are defined in terms of an algorithm that determines whether or not each arriving cell is conforming to the traffic descriptor. In contrast, cell traffic variables are parameters that are used in a stochastic model of the cell flow. 2.1. ReÕie ...
... cell traffic variables. Standardized traffic descriptors are defined in terms of an algorithm that determines whether or not each arriving cell is conforming to the traffic descriptor. In contrast, cell traffic variables are parameters that are used in a stochastic model of the cell flow. 2.1. ReÕie ...
Inhalation therapy - Jan 13 - the International Primary Care
... do they manage to do this, so efficiently? The answer is their efficient and unique respiratory system. Their lungs are small and rigid, they do not have a diaphragm but a network of air sacs instead, no alveoli are present gas exchange occurs in air capillaries. The respiratory system takes up abou ...
... do they manage to do this, so efficiently? The answer is their efficient and unique respiratory system. Their lungs are small and rigid, they do not have a diaphragm but a network of air sacs instead, no alveoli are present gas exchange occurs in air capillaries. The respiratory system takes up abou ...
Nitric Oxide Signalling in Plants: Cross
... its control. The effects of NO on Ca2+ channel and transporter activities can be divided into two mechanisms of action: a cGMP-dependent one and a cGMP-independent one. The molecular mechanisms underlying the cGMP-dependent pathway are complex, and at least three processes have been reported. First, ...
... its control. The effects of NO on Ca2+ channel and transporter activities can be divided into two mechanisms of action: a cGMP-dependent one and a cGMP-independent one. The molecular mechanisms underlying the cGMP-dependent pathway are complex, and at least three processes have been reported. First, ...
The acquisition of myelin: An evolutionary perspective
... conductive medium need to be protected from this medium by a non-conductive sheath; it is on this principle that transatlantic cables are built.” (Ranvier, 1878). The second major function of myelin sheath is to accelerate the speed of conduction of nerve influx. There are only two ways transmission ...
... conductive medium need to be protected from this medium by a non-conductive sheath; it is on this principle that transatlantic cables are built.” (Ranvier, 1878). The second major function of myelin sheath is to accelerate the speed of conduction of nerve influx. There are only two ways transmission ...
Lab on a Chip www.rsc.org/loc
... These monolithic materials can be prepared using a very simple process carried out within the confines of a closed container, such as a microfluidic channel. However, routine applications in microfluidic devices still face some challenges. Poor adhesion of the monolith inside native unmodified polym ...
... These monolithic materials can be prepared using a very simple process carried out within the confines of a closed container, such as a microfluidic channel. However, routine applications in microfluidic devices still face some challenges. Poor adhesion of the monolith inside native unmodified polym ...
Avian erythrocytes have functional mitochondria, opening
... potentially deleterious production of mitochondrial ROS [6], with the theoretical benefit of maximizing their lifespan. The potential implication of mitochondrial ROS production in the loss of mitochondria and nucleus throughout evolution for mammals is referred to hereafter as the mitochondrial str ...
... potentially deleterious production of mitochondrial ROS [6], with the theoretical benefit of maximizing their lifespan. The potential implication of mitochondrial ROS production in the loss of mitochondria and nucleus throughout evolution for mammals is referred to hereafter as the mitochondrial str ...
siRNA Screen Identifies Trafficking Host Factors that Modulate
... associates with actin in alphavirus-infected cells and co-localizes with Rac1–PIP5K1-α along actin ...
... associates with actin in alphavirus-infected cells and co-localizes with Rac1–PIP5K1-α along actin ...
Involvement of retinoic acid-inducible gene- BEAS-2B cells
... balance may be important in various pathological conditions. IFN-c is a potent cytokine with a wide range of functions, including antiviral and immunomodulatory activities, and its major source is Th1. IL-4 is known as a major cytokine expressed by Th2. In bronchial epithelial cells, the Th1 cytokin ...
... balance may be important in various pathological conditions. IFN-c is a potent cytokine with a wide range of functions, including antiviral and immunomodulatory activities, and its major source is Th1. IL-4 is known as a major cytokine expressed by Th2. In bronchial epithelial cells, the Th1 cytokin ...
actin filament-membrane attachment: are membrane particles
... actin filaments (38, 39). In these developing spermatids the filaments first appear attached to the acrosomal vacuolar membrane and with time they elongate. Many other cases undoubtedly exist as well, but, in order to distinguish between assembly of filaments from a membrane and secondary attachment ...
... actin filaments (38, 39). In these developing spermatids the filaments first appear attached to the acrosomal vacuolar membrane and with time they elongate. Many other cases undoubtedly exist as well, but, in order to distinguish between assembly of filaments from a membrane and secondary attachment ...