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Deciphering the molecular functions of sterols in cellulose
Deciphering the molecular functions of sterols in cellulose

... accumulation. It is striking that sterol composition differs considerably between the fk, cph/smt1, and hyd1 mutants despite their similar cellulose deficiencies. In particular, fk mutants accumulate Δ8,14 sterols and exhibit a reduction in both sitosterol and campesterol (Schrick et al., 2000), whil ...
Characterization of two bacteriocins produced by Pediococcus
Characterization of two bacteriocins produced by Pediococcus

... produced according to different recipes and with traditional starter cultures. Two isolates (HA-6111-2 and HA-5692-3) from different sausages were identified as strains of Pediococcus acidilactici. Each strain produces a bacteriocin, designated as bacHA-6111-2 and bacHA-5692-3. Both bacteriocins are ...
abscisic acid signal transduction
abscisic acid signal transduction

... were found to require the acidic N-terminal domain of the relevant VP1/ABI3like protein (48, 92), and domain-swapping experiments showed that the acidic N-terminal regions of VP1 (92) and PvALF (19) are indeed functional transcriptional activation domains. Thus, taken together, the above-mentioned r ...
Maternal macho-1 is an intrinsic factor that makes cell
Maternal macho-1 is an intrinsic factor that makes cell

... notochord fate (induced fate). However, another daughter cell follows a muscle or nerve cord fate (default fate) (Kim and Nishida, 1999; Minokawa et al., 2001). (4) Endoderm blastomeres are the inducers, and FGF signaling mediates the induction. Mesenchyme and notochord are induced by the same FGF s ...
LVA and HVA Ca Currents in Ventricular Muscle Cells of the
LVA and HVA Ca Currents in Ventricular Muscle Cells of the

... Ca21 current, neuronal P/Q and R types have no known muscle counterpart, whereas the existence of the N-type channels are extremely rare or absent (Bean 1989b). In vertebrate cardiac muscle, both T- and L-type calcium currents have been shown to be responsible for action potential generation (Hagiwa ...
Dual Modes of Endoplasmic Reticulum-to
Dual Modes of Endoplasmic Reticulum-to

... 1 D, middle). By 15 min after release from Figure 1. Secretory cargo exits the neuronal ER via vesiculotubular carriers that traffic bidirectionally in dendrites. A, the ER, VSVG-GFP was present in many After incubation for 24 hr at 39.5°C, VSVG-YFP has a diffuse somatodendritic distribution and col ...
insight on the molecular mechanisms that control the expression of
insight on the molecular mechanisms that control the expression of

... stimuli. Despite Prrxl1 relevance for the development of the nociceptive system, little was known about the genetic cascade and molecular mechanisms that govern its gene expression and activity in these tissues. Evidence from previous studies pointed to the existence of tissue-specific mechanisms of ...
Research Project Final Report
Research Project Final Report

... Previous MAFF/Defra projects (CE0120 and CE0154) showed that the resistance depends on several mechanisms: papilla-based resistance and low frequency cell death limit colony establishment, and where colonies form, reduced efficiency of haustoria limits growth extending disease latent period and redu ...
schoeneich_oxidants
schoeneich_oxidants

... young people correlates with serum SCN- levels [19]. Furthermore smokers, who have high SCN- levels, have larger numbers of lipid-laden macrophages than non-smokers [20]. Unlike HOCl, which has been shown to react with a wide range of biological targets (though primarily proteins) [21-23], HOSCN rea ...
HELICOBACTER PYLORI VacA, A PARADIGM FOR TOXIN
HELICOBACTER PYLORI VacA, A PARADIGM FOR TOXIN

... The importance of bacterial toxins in infectious diseases was recognized more than a century ago, when it was discovered that culture filtrates of many pathogens contain soluble factors that can damage host tissues1. Over the past century, more than one hundred different toxins that are produced by ...
Damage response of XRCC1 at sites of DNA single strand breaks is
Damage response of XRCC1 at sites of DNA single strand breaks is

... How these functional domains and modifications of XRCC1 affect the repair of SSBs has been investigated in cells. The BRCT I domain of XRCC1 is required for efficient SSBR both in G1 and S-G2 phases and for cell survival following treatment with methyl-methane sulfonate (MMS), whereas the BRCT II do ...
Determinants of the VP1/2A junction cleavage by the 3C protease in
Determinants of the VP1/2A junction cleavage by the 3C protease in

... a substitution (L2P) within the 2A sequence occurred within this rescued virus (Gullberg et al., 2014). ...
Can Carbon Nanotubes Deliver on Their
Can Carbon Nanotubes Deliver on Their

... peripheral dendrites of the cell mediated by potentials flowing in reverse, and require communication between the soma and the dendrites. ADPs were far more prevalent in cells cultured on CNTs than in those on glass, and the effect was consistent with CNTs acting as shortcuts between proximal and dist ...
Sorting of plant vacuolar proteins is initiated in the ER
Sorting of plant vacuolar proteins is initiated in the ER

... However, although individual expression of SNX1 or SNX2a mutants altered transport of the VSR, vacuolar delivery of soluble cargo was only marginally perturbed (Niemes et al., 2009). This raised the question as to whether retromer function is completely inhibited under these conditions, as it has be ...
AtMYB41 activates ectopic suberin synthesis and assembly in
AtMYB41 activates ectopic suberin synthesis and assembly in

... overexpression of AtMYB41 in Arabidopsis led to the production of 4.5 times more suberin-type than cutin-type monomers. As such, this represents a very large flux of acyl-lipids and phenylpropanoid ferulic acid into suberin synthesis without apparent perturbation of cutin synthesis. Observation of y ...
Biochemical Journal
Biochemical Journal

Activation of ryanodine receptors induces calcium influx in a
Activation of ryanodine receptors induces calcium influx in a

... Changes in intracellular Ca2+ concentration serve as major ubiquitous signals triggering a wide spectrum of biological events, including fast responses such as contraction and secretion in addition to slower long-lasting changes in the growth properties of cells [1]. A large number of cells mediate ...
Plant Wnt: deciphering a novel signalling pathway
Plant Wnt: deciphering a novel signalling pathway

... known as -catenin independent Wnt signalling. PCP signalling is involved mainly in the regulation of cell polarity during morphogenesis by activating JNK-dependent transcription factors via small GTPases RAC1 and RhoA along with JUN-N-terminal kinase (JNK) and activator protein-141–43. PCP and -ca ...
Psoriasis - csnanatomy3 / FrontPage
Psoriasis - csnanatomy3 / FrontPage

... • About 80% of people suffering from Psoriasis have this specific type • It is also known as Psoriasis Vulgaris • Characterized by raised, red patches of skin and silvery-white buildup of dead cells in the form of scales, that shed. ...
Exercise 1 - Measurements and Lab Techniques - Lake
Exercise 1 - Measurements and Lab Techniques - Lake

... of atoms bonded to carbon backbones and are most commonly involved in chemical reactions. They impart particular characteristics to larger molecules to which they are attached. For example, any molecule with a carboxyl group behaves as an organic acid like fatty acids or amino acids. Those with a hy ...
development of bioresponsive devic
development of bioresponsive devic

... The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Such is the importance of these gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits o ...
Species-Specific Activity of SIV Nef and HIV-1 Vpu
Species-Specific Activity of SIV Nef and HIV-1 Vpu

... the absence of IFNa induction [1,11]. Virus release was measured by HIV-1 p24 and SIV p27 antigen-capture ELISA at 0, 2, 20 and 200 ng of plasmid DNA for each tetherin expression construct (Fig. 1). Virion release for each strain was then compared as a percentage of maximal particle release in the a ...
MKL1 and MKL2 play redundant and crucial roles in
MKL1 and MKL2 play redundant and crucial roles in

Down-Regulates Expression of Cell Proliferation
Down-Regulates Expression of Cell Proliferation

... and S.S.), the Clayton Foundation for Research, United States Department of Defense Army Breast Cancer Research Program grant BC010610, National Cancer Institute grants P01-CA91844 (on lung chemoprevention) and P50CA97007 (Head and Neck SPORE) (to B.B.A.), and National Cancer Institute institutional ...
Amino Acids and Amines Stimulate Gastrin Release from Canine
Amino Acids and Amines Stimulate Gastrin Release from Canine

... It is particularly noteworthy that somatostatin could not inhibit the effect of amines. In other systems, somatostatin is capable of inhibiting release of cellular products via action at both receptor and postreceptor sites. Indeed, somatostatin has been reported to inhibit secretory events in some ...
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Amitosis

Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.
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